An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP . (nih.gov)
Protein1
Following detailed studies of bacterial systems from the 1940s onwards, it was established that PYR and CG target the dihydrofolate reductase (DHFR) activity of the parasite's bifunctional DHFR-thymidylate synthetase (TS) protein, whereas the sulfa drugs affect the dihydropteroate synthetase (DHPS) activity of the bifunctional hydroxymethylpterin pyrophosphokinase (HPPK)-DHPS protein, all of these drugs acting as competitive inhibitors of the natural substrates. (medscape.com)
Factor1
La enzima, también llamada factor estricto, está localizada en el gen reIA en cepas estrictas de bacterias. (bvsalud.org)