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GRB2 Adaptor ProteinAdaptor Proteins, Signal TransducingGRB10 Adaptor ProteinAdaptor Proteins, Vesicular TransportGRB7 Adaptor ProteinShc Signaling Adaptor ProteinsAdaptor Protein Complex 2Adaptor Protein Complex 3Adaptor Protein Complex 1src Homology DomainsAdaptor Protein Complex alpha SubunitsSignal TransductionAdaptor Protein Complex beta SubunitsProteinsProto-Oncogene Proteins c-crkProtein BindingAdaptor Protein Complex mu SubunitsPhosphoproteinsAdaptor Protein Complex 4PhosphorylationAdaptor Protein Complex gamma SubunitsSon of Sevenless ProteinsTyrosineClathrinCarrier ProteinsAdaptor Protein Complex SubunitsAmino Acid SequenceMolecular Sequence DataProtein Structure, TertiaryAdaptor Protein Complex delta SubunitsMyeloid Differentiation Factor 88CRADD Signaling Adaptor ProteinCell LineMembrane ProteinsIntracellular Signaling Peptides and ProteinsAmino Acid MotifsProto-Oncogene Proteins c-cblEndocytosisRecombinant Fusion ProteinsProtein TransportPhosphotyrosineTwo-Hybrid System TechniquesOncogene ProteinsCrk-Associated Substrate ProteinBinding SitesProtein-Tyrosine KinasesCOS CellsMice, KnockoutJurkat CellsClathrin-Coated VesiclesAdaptor Protein Complex sigma SubunitsImmunoprecipitationTransfectionMutationPrecipitin TestsEnzyme ActivationReceptors, Interleukin-1Cytoskeletal ProteinsPhospholipase C gammaMonomeric Clathrin Assembly Proteinssrc-Family KinasesProto-Oncogene ProteinsCARD Signaling Adaptor ProteinsSequence Homology, Amino AcidNerve Tissue ProteinsCells, CulturedEndosomesHEK293 CellsHeLa Cellstrans-Golgi NetworkNuclear ProteinsPaxillinReceptors, Antigen, T-CellModels, BiologicalCell MembraneMice, Inbred C57BLToll-Like ReceptorsProto-Oncogene Proteins pp60(c-src)ImmunoblottingRNA, Small InterferingProtein Interaction Domains and MotifsToll-Like Receptor 4Ubiquitin-Protein LigasesReceptor, Epidermal Growth FactorFas-Associated Death Domain ProteinMitogen-Activated Protein KinasesGlutathione TransferaseProtein Tyrosine Phosphatase, Non-Receptor Type 11Phosphatidylinositol 3-KinasesZAP-70 Protein-Tyrosine KinaseProtein-Serine-Threonine KinasesMembrane Glycoproteinsras Guanine Nucleotide Exchange Factors3T3 CellsReceptor Protein-Tyrosine KinasesRecombinant ProteinsCoated Pits, Cell-MembraneBlotting, WesternSOS1 ProteinRetinoblastoma-Like Protein p130
GRB2 AdaptorMembrane ProteinsSignal TransductionReceptorOncogenePhosphorylationInteractsEmbryogenesisRelated protein complexHumansGeneSerineDifferentiationPathwaysOriginally identifiedSignalsIdentifiesPlay a roleAnimalsComplexFamilyFoundSignal TransducingCarrier ProteinsTyrosineGRB14GenesReceptorMTORKinase1998HomologyMoleculeBindsInteractRegulateNuclearDomainResiduesCalmodulinPhosphorylationFunctionSurvivalGrowthTargetsSymbolStudiesSourceExpression
GRB2 Adaptor3
  • GRB2 Adaptor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "GRB2 Adaptor Protein" by people in this website by year, and whether "GRB2 Adaptor Protein" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "GRB2 Adaptor Protein" by people in Profiles. (uchicago.edu)
Membrane Proteins1
  • Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. (univ-amu.fr)
Signal Transduction3
Receptor5
  • The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. (nih.gov)
  • Predominantly expressed from the maternal allele during embryogenesis, Grb10 encodes an intracellular adaptor protein that can interact with several receptor tyrosine kinases and downstream signalling molecules7. (cardiff.ac.uk)
  • Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. (uchicago.edu)
  • Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (umassmed.edu)
  • Mutations in the gene bone morphogenic protein receptor type 2 ( BMPR2 ) were reported as the most common genetic cause of PAH and have proven to be associated with long-term outcomes in IPAH, HPAH, and anorexigen-associated PAH [ 5 ]. (biomedcentral.com)
Oncogene1
  • Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. (ucdenver.edu)
Phosphorylation1
Interacts1
  • Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
Embryogenesis1
  • Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
Related protein complex1
Humans1
  • The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. (wikipedia.org)
Gene5
  • Although the BCR-ABL fusion protein has been much studied, the function of the normal BCR gene product is still not clear. (wikipedia.org)
  • The translocation produces a fusion protein that is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. (wikipedia.org)
  • Grb10 is, therefore, the first example of an imprinted gene that regulates social behaviour. (cardiff.ac.uk)
  • Thus Grb10 is, so far, a unique imprinted gene, able to influence distinct physiological processes, fetal growth and adult behaviour, owing to actions of the two parental alleles in different tissues. (cardiff.ac.uk)
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
Serine1
  • The protein has serine/threonine kinase activity and is a guanine nucleotide exchange factor for the Rho family of GTPases including RhoA. (wikipedia.org)
Differentiation1
Pathways1
  • They play a role in cell signaling pathways such as those involving G-PROTEINS and the HIPPO-SIGNALING PATHWAY . (nih.gov)
Originally identified1
  • A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. (nih.gov)
Signals1
Identifies1
  • Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. (ucdenver.edu)
Play a role1
Animals1
  • Here we demonstrate that within the brain Grb10 is expressed from the paternal allele from fetal life into adulthood and that ablation of this expression engenders increased social dominance specifically among other aspects of social behaviour, a finding supported by the observed increase in allogrooming by paternal Grb10-deficient animals. (cardiff.ac.uk)
Complex1
Family2
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
  • DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)
Found1
  • The BCR-ABL oncoprotein oligomerisation domain found at the N-terminus of BCR is essential for the oncogenicity of the BCR-ABL fusion protein. (wikipedia.org)
Signal Transducing4
  • Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ctsicn.org)
  • This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications. (ctsicn.org)
  • Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles. (ctsicn.org)
  • A signal transducing adaptor protein that contains a single SH2 DOMAIN and is essential for the regulation of SLAM FAMILY RECEPTORS in the immune response. (nih.gov)
Carrier Proteins1
Tyrosine6
  • A binding partner for several RECEPTOR PROTEIN-TYROSINE KINASES, including INSULIN RECEPTOR and INSULIN-LIKE GROWTH FACTOR RECEPTOR. (bvsalud.org)
  • They regulated many cellular functions by interacting with various tyrosine kinase receptors and other phosphorus-containing amino acid proteins. (impactaging.com)
  • May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. (nih.gov)
  • RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. (affbiotech.cn)
  • The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. (affbiotech.cn)
  • Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. (affbiotech.cn)
GRB141
Genes2
  • BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome. (wikipedia.org)
  • FISH confirmed the presence of a tandem duplication encompassing the genes for growth factor receptor-binding protein 10 (GRB10) and insulin-like growth factor-binding proteins 1 and 3 (IGFBP1 and -3) but not that for epidermal growth factor-receptor (EGFR). (nih.gov)
Receptor4
  • Growth factor receptor-binding protein 10 (GRB10) is a member of the adaptor protein superfamily [ 9 ]. (impactaging.com)
  • It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and insulin receptors and regulates receptor signaling. (nih.gov)
  • Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes. (nih.gov)
  • Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. (affbiotech.cn)
MTOR1
  • mTOR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. (medchemexpress.com)
Kinase3
  • The protein has serine/threonine kinase activity and is a guanine nucleotide exchange factor for the Rho family of GTPases including RhoA. (wikipedia.org)
  • death associated protein kinase 2 [Sour. (gsea-msigdb.org)
  • The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy balance and metabolism and binds glycogen, the primary storage form of glucose in liver and skeletal muscle. (edu.au)
19981
  • HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Homology1
Molecule1
  • Vav (Adaptor molecule. (eu.org)
Binds2
  • Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
  • HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Interact2
  • Despite considerable data confirming the binding, molecular-level understanding of exactly how the two proteins interact, and, especially, what are the determinants of the specificity of the SH2 GRB2 domain-phosphorylated BCR (pBCR) recognition are still open questions. (nih.gov)
  • These three phosphorylated proteins then interact with SH2 domain containing signaling proteins. (affbiotech.cn)
Regulate1
  • AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)
Nuclear1
  • Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor. (ctsicn.org)
Domain4
  • The BCR-ABL oncoprotein oligomerisation domain found at the N-terminus of BCR is essential for the oncogenicity of the BCR-ABL fusion protein. (wikipedia.org)
  • The encoded protein contains a gyf protein interaction domain. (nih.gov)
  • HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
  • It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)
Residues1
Calmodulin1
Phosphorylation1
  • We identified several differences in protein expression and phosphorylation in the dorsolateral prefrontal cortex (DLPFC) and cingulate cortex (CC) that correlated with impulsivity in animals, suggesting that the GABAergic synapse pathway may be affected by fluoxetine treatment. (zoores.ac.cn)
Function1
  • 15. Proproliferative function of adaptor protein GRB10 in prostate carcinoma. (nih.gov)
Survival1
  • Especially in gastric cancer, the high GRB10 expression was closely associated with poorer overall survival. (impactaging.com)
Growth1
  • GRB10 lies within the duplicated region and is a strong candidate, since it is a known growth suppressor. (nih.gov)
Targets1
  • Therefore, miR-379-5p and GRB10 were expected to be potential targets for the treatment of gastric cancer. (impactaging.com)
Symbol1
Studies2
  • More and more studies have shown that the abnormal expression of GRB10 is closely related to the occurrence and development of cancer. (impactaging.com)
  • In previous studies, GRB10 was mainly considered to be closely related to the insulin signaling pathway involved in the negative regulation of insulin/IGF signaling [ 11 ]. (impactaging.com)
Source2
Expression2
  • These findings suggested that miR-379-5p suppresses gastric cancer development by downregulating GRB10 expression. (impactaging.com)
  • Immunohistochemistry and Western blot were used to test protein expression levels. (bvsalud.org)