Folate receptor 1. Medical search. Frequent questions

The FOLR1 gene provides instructions for making a protein called folate receptor alpha. (medlineplus.gov)

Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. (wikipedia.org)
Here, we describe a protease-activated anti-folate receptor 1 TCB (Prot-FOLR1-TCB) equipped with an anti-idiotypic anti-CD3 mask connected to the anti-CD3 Fab through a tumor protease-cleavable linker. (unibas.ch)
Mutations in the FOLR1 gene cause cerebral folate transport deficiency. (medlineplus.gov)
Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. (elsevierpure.com)
There are autosomal recessive disorders associated with mutations in genes encoded for SLC46A1 (hereditary folate malabsorption), FOLR1 (cerebral folate deficiency), SLC19A2 (thiamine-responsive megaloblastic anemia), and SLC19A3 (biotin-responsive basal ganglia disease). (elsevierpure.com)

In the metastatic setting, it has been reported that 80% or more of these tumors express folate receptor alpha. (cancernetwork.com)
Materials and Methods: In order to confirm the distribution of the folate receptor alpha (FRα), sections of 20 ovarian tumors and seven normal ovarian tissues were obtained and immunohistochemistry was performed using monoclonal antibody mAb343 to evaluate FRα expression. (illinois.edu)
Seattle Children's doctors and researchers are leaders in developing investigational chimeric antigen receptor (CAR) T-cell immunotherapies for children, teenagers and young adults with central nervous system (CNS) tumors , including DIPG. (seattlechildrens.org)
Our phase 1 CAR T-cell clinical trials against CNS tumors are called BrainChild. (seattlechildrens.org)
STRIvE-01 is a phase 1 trial testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory solid tumors that express the protein EGFR or B7H3. (seattlechildrens.org)
ENLIGHTen-01 is a phase 1 clinical trial testing CAR T cells administered with UB-TT170, a small molecule fluorescein tag that targets folate receptors to mark tumors for clearance by CAR T cells, that is open to teens and young adults with recurrent or refractory osteosarcoma. (seattlechildrens.org)
Folate Receptor as a Biomarker and Therapeutic Target in Solid Tumors. (nih.gov)

The protein encoded by this gene is a member of the folate receptor (FOLR) family. (wikipedia.org)
also folate receptor alpha and folate binding protein 1/FOLBP1) is a 40-50 kDa member of the folate receptor family. (rndsystems.com)
Folate receptor beta, also known as Folate receptor 2, FBP, FOLR2, BETA-HFR, FBP/PL-1, FR-BETA, FR-P3, and is a member of the folate receptor (FOLR) family which mediates delivery of 5-methyltetrahydrofolate to the interior of cells. (biovisi.com)

The FolRα-targeted antibody-drug conjugate (ADC) STRO-002 was found to elicit encouraging responses in heavily pretreated patients with advanced ovarian cancer, according to interim data from the dose-expansion portion of the phase 1 STRO-002-GM1 trial (NCT03748186). (clearityfoundation.org)

Endocytosis of GPI-linked membrane folate receptor-alpha. (rupress.org)
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. (t3db.ca)
And the transmembrane receptor is also noteworthy because it can allow endocytosis of whatever binds to it. (pharmacytimes.com)
Conjugation of folate to proteins permits receptor-mediated endocytosis via the folate receptor (FR) and delivery of the conjugate into the cytoplasm of cells. (openrepository.com)

Cerebral folate transport deficiency is a disorder that develops from a shortage (deficiency) of the B-vitamin folate (also called vitamin B9) in the brain. (medlineplus.gov)
Leukodystrophy contributes to the neurological problems that occur in cerebral folate transport deficiency. (medlineplus.gov)
The prevalence of cerebral folate transport deficiency is unknown. (medlineplus.gov)
Without folate, many processes in the brain are impaired, leading to the neurological problems typical of cerebral folate transport deficiency. (medlineplus.gov)
The signs and symptoms of cerebral folate transport deficiency do not begin until late infancy because other mechanisms can compensate for this loss. (medlineplus.gov)
Cerebral folate transport deficiency results from impaired folate transport across the blood:choroid plexus:cerebrospinal fluid (CSF) barrier. (pediatricneurosciences.com)
We are reporting two children with this treatable cerebral folate transport deficiency. (pediatricneurosciences.com)
In conclusion, cerebral folate transport deficiency should be suspected in every child with global developmental delay, epilepsy, ataxia and neuroimaging showing cerebellar atrophy and calcification. (pediatricneurosciences.com)

Autoantibodies to the FRA have been linked to neurodevelopmental diseases, particularly cerebral folate deficiency schizophrenia and autism spectrum disorder. (wikipedia.org)
Cerebral folate deficiency as diagnosed by Ramaekers/Frye is extremely rare. (epiphanyasd.com)
T p.R128W, confirming the diagnosis of cerebral folate deficiency. (pediatricneurosciences.com)
Transferrin receptors, which are blood proteins, may be elevated in persons with iron deficiency. (medscape.com)
Transferrin receptor testing is used to measure the level of soluble transferrin receptors, thereby aiding in the evaluation of iron deficiency and in the diagnosis of iron-deficiency anemia. (medscape.com)
2] Unlike ferritin, the transferrin receptor level is not affected by infection or inflammation and is therefore useful in distinguishing iron deficiency anemia from anemia of chronic disease. (medscape.com)
In the United States, the prevalence of iron-deficiency anemia among children declined during the 1970s in association with increased iron intake during infancy (1-3). (cdc.gov)

Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
Campbell IG, Jones TA, Foulkes WD, Trowsdale J: Folate-binding protein is a marker for ovarian cancer. (t3db.ca)
Expert suggests that mirvetuximab soravtansine-gynx, which received accelerated approval in the platinum-resistant ovarian cancer setting in 2022, is the most promising agent in more than a decade that targets folate receptor alpha. (pharmacytimes.com)
Target Folate Receptor Alpha in Ovarian Cancer? (cancernetwork.com)
At the conference, Dr. Zamarin presented data from a phase II trial at Memorial Sloan Kettering, of a peptide vaccine called TPIV-200 in combination with durvalumab, an anti-PD-1 checkpoint inhibitor antibody, in patients with platinum-resistant ovarian cancer. (cancernetwork.com)
The nice thing about the vaccine against the folate receptor alpha that we are using is that folate receptor alpha is overexpressed in the majority of ovarian cancers. (cancernetwork.com)
In addition, spontaneous immunity against the folate receptor alpha has been previously reported in breast and ovarian cancer patients which suggests that this target can actually be immunogenic. (cancernetwork.com)
In addition, for further in vivo evaluation, five human patients with ovarian cancer were systemically infused with 0.1 mg/kg of the folate-FITC conjugate four hours prior to cytoreductive surgery. (illinois.edu)
Interest in exploiting the folate receptor (FR) for drug targeting applications has rapidly increased because it is a tumor-associated antigen that is overex- pressed in greater than 90% of human ovarian carcinomas and associated with increased biological aggressive- ness of this tumor [1]. (unimore.it)
The over-expression of TS and the others folate cycle enzymes, is one of the major mechanisms of resistance to cisplatin (cDDP), encountered in most of resistant human ovarian cancer cell lines [2], accounting for the more efficient DNA repair and syn- thesis. (unimore.it)
Launched in March 2018, the phase 1 trial enrolled patients with recurrent, platinum-resistant or -refractory ovarian cancer and those who received treatment with at least 2 prior platinum regimens. (clearityfoundation.org)
Use of folate, folic acid, or folate-containing supplements may reduce binding of pafolacianine to folate receptors overexpressed on ovarian cancer cells and could reduce the detection of malignant lesions with. (medscape.com)

Coney LR, Tomassetti A, Carayannopoulos L, Frasca V, Kamen BA, Colnaghi MI, Zurawski VR Jr: Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. (t3db.ca)
1) Dr. Richard Frye on folate receptor alpha antibodies and folinic supplementation in autism . (epiphanyasd.com)
Neutralizing Tregs with antibodies (Abs) against CD25 or folate receptor 4 (FR4) inhibited the Foxp3+ Treg angiogenesis and accumulation in WT mice, but not in mPGES-1 −/− mice. (iiarjournals.org)
Red Labs shares insight on how Folate Receptor Antibodies impacts on Autism , the possible treatments and prevention. (redlaboratories.be)

This receptor is responsible for binding to folic acid and its derivatives, which becomes crucial during fetal development. (wikipedia.org)
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. (t3db.ca)
Has high affinity for folate and folic acid analogs at neutral pH. (t3db.ca)
Folic acid is synthetically produced, and used in fortified foods and supplements on the theory that it is converted into folate, which may not be the case. (epiphanyasd.com)
The folate-gelonin conjugate retains over 99% of toxin activity in a cell-free translational assay compared with unmodified gelonin and is able to bind the FR at the same affinity as free folic acid (10(-10) m). (openrepository.com)
Folate linked to gelonin via amino conjugation exhibits the same affinity for FR as free folic acid but the toxin is 225-fold less active in a cell-free translational assay. (openrepository.com)
folic acid decreases effects of pafolacianine by receptor binding competition. (medscape.com)
A folate transporter interaction has been described, leading to decreases in bioavailability of folic acid. (medscape.com)

Folate derivatives are necessary for important metabolic processes such as DNA, protein and lipid methylation. (wikipedia.org)
Additionally, folate is involved in the production and repair of DNA, regulation of gene activity (expression), and protein production. (medlineplus.gov)
For example, another protein called folate receptor beta is responsible for folate transport before birth and in early infancy. (medlineplus.gov)
MFR-alpha was synthesized as a 32-kD protein and converted in a maturely glycosylated 36-38-kD protein 1 h after synthesis. (rupress.org)
The reduced-folate-carrier, an integral membrane protein capable of translocating (anti-)folates across membranes, was completely excluded from the Triton X-100-resistant membrane domains. (rupress.org)
Elwood PC: Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells. (t3db.ca)
Lacey SW, Sanders JM, Rothberg KG, Anderson RG, Kamen BA: Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. (t3db.ca)
Sadasivan E, Cedeno M, Rothenberg SP: Genomic organization of the gene and a related pseudogene for a human folate binding protein. (t3db.ca)
Analysis of three independent low folate selected clones, FA3, FA7, and FA14, showed that each had a 5- to 6-fold increase in DHFR activity accompanied by a similar increase in DHFR protein level. (researchwithrutgers.com)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
We describe the first example of folate conjugated to a protein via carbohydrate residues, using a novel SH-folate intermediate. (openrepository.com)

Transferrin receptor levels within the reference range indicate normal physiology. (medscape.com)
Transferrin receptor testing is used in the diagnosis of anemia and in deciding adequate treatment. (medscape.com)
Along with other tests in an anemia panel (iron, ferritin, reticulocyte count, lactate dehydrogenase [LDH], vitamin B-12, folate), the type of anemia can be diagnosed based on the transferrin receptor levels. (medscape.com)
Transferrin Receptor: ARUP Lab Tests. (medscape.com)

Folate receptor alpha is produced in largest amounts in the brain, specifically in an area of the brain called the choroid plexus. (medlineplus.gov)
Folate receptor alpha is thought to play a major role in bringing folate from the bloodstream into brain cells. (medlineplus.gov)
Elwood PC, Nachmanoff K, Saikawa Y, Page ST, Pacheco P, Roberts S, Chung KN: The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure. (t3db.ca)
The knowledge of the presence of folate receptor alpha (FRα) overexpression or expression on OC has been longstanding. (pharmacytimes.com)
Overall, the findings suggested that folate receptor alpha is an attractive target for vaccination and generated the rationale for this vaccine. (cancernetwork.com)
In this case, the vaccine is called TPIV-200 and is composed of five long peptides that each target different regions of the folate receptor alpha. (cancernetwork.com)
These cells undergo a 30-fold decrease in intracellular folates, overexpress folate receptor alpha (FRα) and metallothionein II, and display increased sensitivity to the dihydrofolate reductase (DHFR) targeted antifolates methotrexate (MTX) and trimetrexate (TMTX), which can be attributed primarily to the folate pool status. (researchwithrutgers.com)
A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. (lookformedical.com)
If you or any of your family members have a confirmed or suspected diagnosis of Alpha-1 Liver Disease, you may be eligible. (policylab.us)
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. (openrepository.com)

8] S. Gottschalk, R. J. Cristiano, L. C. Smith, and S. L. Woo, "Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression," Gene Ther. (fujipress.jp)
Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells. (openrepository.com)

Serum folate levels after UVA exposure: a two-group parallel randomised controlled trial. (ncats.io)
Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease. (cdc.gov)

1991 Oct 1;51(19):5329-38. (t3db.ca)

For people with MTHFR gene variations, supplementing with the already activated form of folate (5-MTHF/5- METHYLTETRAHYDROFOLATE/LEVOMEFOLIC ACID) is far more effective in providing this form of folate than introducing the pre-converted form to the body through typical folate supplements. (ncats.io)
Receptor-targeted gene delivery via folate-conjugated polyethylenimine. (openrepository.com)
Gene-gene interactions among the genes in the folate metabolizing pathway were also tested in this study. (louisville.edu)
Estrogen receptor beta gene variant is associated with vascular dementia in elderly women. (cdc.gov)

It appears that in both schizophrenia and autism there is a family of possible folate dysfunctions that range from minor to severe. (epiphanyasd.com)
Without going into the details of Folate Receptor Autoantibodies (FRAs), it is clear that Ramaekers has found the same condition in both Schizophrenia and Autism. (epiphanyasd.com)

Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages. (biovisi.com)

GPI-linked membrane folate receptors (MFRs) have been implicated in the receptor-mediated uptake of reduced folate cofactors and folate-based chemotherapeutic drugs. (rupress.org)
Using fluorescence microscopy, fluorescent dye uptake was seen uniformly on IGROV-1 and SKOV- 3 cell lines and the intensity peaked at one hour and localized to the cell surface with cytosolic staining. (illinois.edu)
Its expression correlates with increased folate uptake ability. (biovisi.com)

where it attaches (binds) to folate, allowing the vitamin to be brought into the cell. (medlineplus.gov)
SCH-23390 maleate also binds with high affinity to the 5-HT 2 and 5-HT 1C receptors . (medchemexpress.com)

Folate is vitamin B9. (epiphanyasd.com)

The proton-coupled folate transporter (PCFT, SLC46A1) is the mechanism by which folates are absorbed across the apical-brush-border membrane of the proximal small intestine. (elsevierpure.com)

Mirtazapine and Folate for Idiopathic Schizophrenia, but for which Autism? (epiphanyasd.com)

Zhao, R & Goldman, ID 2013, ' Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors ', Molecular aspects of medicine , vol. 34, no. 2-3, pp. 373-385. (elsevierpure.com)

2023 Feb;47(1):100917. (nih.gov)

The effect of different conjugation methods on toxin activity and the implications for folate targeting of other glycoproteins are discussed. (openrepository.com)

Genetic polymorphisms in the folate metabolizing pathway and breast cancer survival. (louisville.edu)

2020 Feb 18;11(1):941. (medchemexpress.com)
2020 Aug 20;8(1):120. (medchemexpress.com)

This leads to low CSF 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. (pediatricneurosciences.com)

The reduced folate carrier (RFC, SLC19A1), thiamine transporter-1 (ThTr1, SLC19A2) and thiamine transporter-2 (ThTr2, SLC19A3) evolved from the same family of solute carriers. (elsevierpure.com)

On the contrary, the sensitive A2780 cells are more sensitive to both temperature and folate analogs. (unimore.it)

Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. (louisville.edu)

Folate transporters are routes of delivery of drugs for the treatment of cancer and inflammatory diseases. (elsevierpure.com)

Folate Receptor Expression and Folate Receptor Targeted Chemotherapy in Cisplatin-sensitive and - resistant Human cancer cell lines Marverti G.a, Pirondi S.a, MarracciniC.a, Frassineti C.a, Helleman J.b, Berns E.M.J.J. b, and Costi, M.P. c aDept. (unimore.it)

Safyral is an estrogen/progestin COC (Combined Oral Contraceptive) containing a folate, indicated for use by women to: prevent pregnancy and raise folate levels in women who choose to use an oral contraceptive for contraception. (ncats.io)

DC-3F/FA3 cells (FA3) were derived from antifolate-sensitive CHL cells by selection for growth in folate-free media containing 15 pM [6S]-5CHOFH4. (researchwithrutgers.com)

Enforced overexpression of FRα in transfectants cultured in nanomolar folate did not confer resistance to MTX but did support a modest 2-fold increase in resistance to TMTX. (researchwithrutgers.com)

sociated with Zika virus disease remains unclear, evi- Seven weeks after symptom onset, single-photon emis- dence of an association between Zika virus infection and sion computed tomography revealed mildly heteroge- diseases of the nervous system is growing ( 1 ). (cdc.gov)

By adding folate supplementation during pregnancy, neural tube defects in the fetus are prevented. (wikipedia.org)
1.2 Folate Supplementation Safyral is indicated in women who choose to use an oral contraceptive as their method of contraception, to raise folate levels for the purpose of reducing the risk of a neural tube defect in a pregnancy conceived while taking the product or shortly after discontinuing the product. (ncats.io)

Results: Angiogenesis was suppressed in mPGES-1 −/− mice compared with WT mice, which was associated with attenuated forkhead box P3 (Foxp3) expression and Foxp3 + Treg accumulation. (iiarjournals.org)
SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. (medchemexpress.com)

Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells. (openrepository.com)
As a result many folate-targeted toxins are a compromise between receptor/ligand interaction and toxin activity. (openrepository.com)

Background/Aim: Microsomal prostaglandin E synthase-1 (mPGES-1) is an enzyme, which catalyzes the final step of prostaglandin E 2 (PGE 2 ) synthesis. (iiarjournals.org)
Microsomal PGE synthase-1 (mPGES-1) is an inducible enzyme that specifically catalyzes the synthesis of PGE 2 in inflammatory conditions. (iiarjournals.org)

2021 Jun 1;147(6):544-552. (nih.gov)
2021 Aug 1;147(8):769-771. (nih.gov)

It takes place under physiological and pathological conditions including embryogenesis, inflammation, and cancer ( 1 , 2 ). (iiarjournals.org)

A subtype of GPI-anchored folate receptors that is expressed in tissues of epithelial origin. (childrensmercy.org)
Materials and Methods: The dorsal subcutaneous tissues of male mPGES-1-deficient (mPGES-1 −/− ) and C57BL/6 wild-type (WT) mice were implanted with polyurethane sponge disks. (iiarjournals.org)

L-Methylfolate (5-MTHF) supplements provide the active form of folate naturally present in the body and available for biological action. (ncats.io)

However, without a properly functioning methylenetetrahydrofolate reductase, MTHFR this conversion cannot take place and folate is not converted to forms that can cross the blood brain barrier. (ncats.io)
Association of methylenetetrahydrofolate reductase polymorphism C677T and dietary folate with the risk of cervical dysplasia. (ncats.io)

The BrainChild studies are phase 1 clinical trials. (seattlechildrens.org)
The PLAT trials are phase 1 and 2 clinical trials testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory acute leukemia or lymphoma. (seattlechildrens.org)

Vaccine on day 1 of life. (mediconotebook.com)

Anatomy5

Diseases6

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Disciplines and Occupations1

Technology, Industry, Agriculture3

Called folate receptor alpha1

FOLR15

Tumors7

Member of the folate receptor3

FOLR1

Endocytosis4

Cerebral folate transport deficiency8

Deficiency7

Ovarian12

Antibodies4

Folic acid8

Protein11

Transferrin receptor4

Alpha10

Tumor cells2

Serum Folate2

19911

Gene4

Schizophrenia and autism2

Conjugates1

Uptake3

Binds2

Vitamin1

Membrane1

Autism1

Molecular1

20231

Glycoproteins1

Genetic1

20202

Metabolism1

Transporter1

Analogs1

Methylation1

Transporters1

Chemotherapy1

Estrogen1

Antifolate1

Overexpression1

Nervous system1

Supplementation2

Expression2

Toxin2

Synthesis2

20212

Inflammation1

Tissues2

Supplements1

Methylenetetrahydrofolate2

Clinical Trials2

Vaccine1