• Focal nodular hyperplasia (FNH) is a benign tumor of the liver (hepatic tumor), which is the second most prevalent tumor of the liver (the first is hepatic hemangioma). (wikipedia.org)
  • The most common use for a liver scan is to diagnose a condition called benign focal nodular hyperplasia, or FNH, which causes a non-cancerous mass in the liver. (medlineplus.gov)
  • Moreover, it is also difficult to distinguish HCC from benign hepatocellular tumors such as focal nodular hyperplasia and hepatocellular adenoma [ 11 , 12 ]. (e-ultrasonography.org)
  • Additionally, fibrolamellar carcinoma and focal nodular hyperplasia share several features, such as a stellate central scar on imaging studies and copper accumulation on histological examination, that have prompted some to suggest that focal nodular hyperplasia may be a benign precursor lesion to fibrolamellar carcinoma. (medscape.com)
  • Its association with focal nodular hyperplasia. (medscape.com)
  • Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? (unil.ch)
  • Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia. (wikipedia.org)
  • ACG clinical guideline: The diagnosis and management of focal liver lesions. (msdmanuals.com)
  • Today's discussion is on focal liver lesions. (medscape.com)
  • What do we do with these focal liver lesions? (medscape.com)
  • To investigate the capacity of Superb Microvascular Imaging (SMI) to detect microvascular details and to explore the different SMI features in various focal liver lesions (FLLs) and the correlation between SMI and microvessel density (MVD). (biomedcentral.com)
  • Early detection and diagnosis are important for the prevention and treatment of HCC, and ultrasound (US) has been recommended as the first imaging modality for screening focal liver lesions (FLLs) because it is noninvasive and widely available. (biomedcentral.com)
  • Basing on their characteristic appearance, common B-mode and color Doppler US can detect focal liver lesions, such as focal nodular hyperplasia (FNH) with a spoke-wheel shaped vascular pattern. (biomedcentral.com)
  • According to the American Association for the Study of Liver Diseases (AASLD) guidelines, biopsy is a diagnostic option for focal hepatic lesions depending on the Liver Imaging Reporting and Data System (LI-RADS) category. (e-ultrasonography.org)
  • Focal hepatic lesions on MRI were evaluated according to LI-RADS version 2018. (e-ultrasonography.org)
  • Histologically, the nodular lesions in the ileum showed severe granulomatous enteritis with large areas of necrosis and numerous multinucleated giant cells (Figure, panel A). Ziehl-Neelsen stain demonstrated large numbers of acid-fast bacilli in macrophages and multinucleated giant cells in the intestine ( Figure , panel B). The mesenteric lymph node also exhibited a granulomatous inflammation with multinucleated giant cells. (cdc.gov)
  • Focal nodular hyperplasia (FNH) is a polyclonal tumour-like hepatic lesion characterised by parenchymal nodules, connective tissue septa without interlobular bile ducts, pronounced ductular reaction and inflammation. (aabioetica.org)
  • In large regenerative nodules, focal nodular hyperplasia and liver cell adenoma CD34-positive capillaries reflect afferent parts and CD 34-negative sinusoids the efferent parts of the parenchymal vascular bed. (springer.com)
  • 2016 ) Washout appearance in Gd-EOB-DTPA-enhanced MR imaging: A differentiating feature between hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase and focal nodular hyperplasia-like nodules. (neurotree.org)
  • Focal Nodular Hyperplasia-like Nodules Arising in the Setting of Hepatic Vascular Disorders with Portosystemic Shunting Show β-catenin Activation. (ucsf.edu)
  • Histological examination of the nodules suggested focal nodular hyperplasia (FNH)-like hyperplasia. (bvsalud.org)
  • Hepatocellular adenomas (HCAs) are also known as hepatic adenomas, telangiectatic focal nodular hyperplasia (FNH) or, less commonly, liver cell adenomas. (medscape.com)
  • Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60-70% of cases. (wikipedia.org)
  • Focal nodular hyperplasia: central scar enhancement pattern using Gadoxetate Disodium. (umassmed.edu)
  • You may find that these patients have a characteristic central scar called "focal nodular hyperplasia. (medscape.com)
  • Fibrolamellar hepatocellular carcinoma arising in a background of focal nodular hyperplasia: a report of 2 cases. (medscape.com)
  • Fibrolamellar carcinoma of the liver: the malignant counterpart of focal nodular hyperplasia with oncocytic change. (medscape.com)
  • Hepatocellular carcinoma associated with focal nodular hyperplasia: report of a case with clonal analysis. (ntu.edu.tw)
  • Increasingly, focal nodular hyperplasia is being recognized as an incidental finding because of the widespread use of diagnostic imaging for unrelated conditions. (medscape.com)
  • Mamone G, Caruso S, Cortis K, Miraglia R. Complete spontaneous regression of giant focal nodular hyperplasia of the liver: Magnetic resonance imaging evaluation with hepatobiliary contrast media. (wjgnet.com)
  • A tumour-like development made of various cell types (connective tissue cells, hepatocytes, and bile duct cells) is called Focal Nodular Hyperplasia (FNH). (acko.com)
  • It starts as a diffuse enlargement of the thyroid gland and ends in a nodular enlarged thyroid. (intechopen.com)
  • Additionally, the rabbit had mild suppurative splenitis, mild lymphohistiocytic to granulomatous hepatitis, mild focal lymphocytic interstitial orchitis, and a hyperplasia of the myeloic cell line in the femoral and sternal bone marrow. (cdc.gov)
  • [ 7 ] Knowledge of preceding treatment and the finding of other therapy-related changes, such as glandular atrophy, as well as basal cell hyperplasia, should alert to this differential. (medscape.com)
  • Donadon M, Di Tommaso L, Roncalli M, Torzilli G. Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy. (wjgnet.com)
  • Fibrolamellar hepatocellular carcinoma arising in a background of focal nodular hyperplasia: a report of 2 cases. (nih.gov)
  • Association of hepatocellular adenoma and focal nodular hyperplasia of the liver in a woman on oral contraceptives]. (nih.gov)
  • Benign liver tumors include hepatocellular adenomas (HCAs), hemangiomas, hamartomas, and focal nodular hyperplasia (FNH). (medscape.com)
  • Total hepatectomy and liver transplant for hepatocellular adenomatosis and focal nodular hyperplasia. (pitt.edu)
  • Extensive hepatocellular adenomatosis (HA) and focal nodular hyperplasia (FNH) represent a proliferation of hepatic cells that occurs most frequently in women. (pitt.edu)
  • 14. Retrospective analysis of 29 patients surgically treated for hepatocellular adenoma or focal nodular hyperplasia. (nih.gov)
  • 5. [Diagnosis and treatment of hepatic focal nodular hyperplasia: report of 114 cases]. (nih.gov)
  • 19. [Clinical analysis of 38 cases of hepatic focal nodular hyperplasia and literature review]. (nih.gov)
  • They are adenomas, hemangiomas and focal nodular hyperplasia. (nih.gov)
  • [ 6 ] No lobar predilection exists, and these tumors may be associated with focal nodular hyperplasia. (medscape.com)
  • La tinció immunohistoquímica es fa servir en el diagnòstic de cèl·lules anormals com les que es troben en els tumors cancerosos, entre altres afeccions. (wikipedia.org)
  • 1. [Diagnosis and treatment of focal nodular hyperplasia of liver: report of 23 cases]. (nih.gov)
  • 3. [Diagnosis and treatment of focal nodular hyperplasia of liver]. (nih.gov)
  • 11. The role of diagnostic imaging and liver biopsy in the diagnosis of focal nodular hyperplasia in children. (nih.gov)
  • ACG clinical guideline: The diagnosis and management of focal liver lesions. (msdmanuals.com)
  • Focal nodular hyperplasia: what are the indications for resection? (wikipedia.org)
  • 4. The value of liver resection for focal nodular hyperplasia: resection yes or no? (nih.gov)
  • Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia. (wikipedia.org)
  • Mamone G, Caruso S, Cortis K, Miraglia R. Complete spontaneous regression of giant focal nodular hyperplasia of the liver: Magnetic resonance imaging evaluation with hepatobiliary contrast media. (wjgnet.com)
  • Purpose: To characterize imaging features of histologically proven hepatic adenoma (HA) as well as histologically and/or radiologically proven focal nodular hyperplasia (FNH) using delayed hepatobiliary MR imaging with 0.05 mmol/kg gadoxetic acid. (uni-luebeck.de)
  • When they are larger than 2 cm they may have the hallmark characteristic of peripheral nodular discontinuous enhancement and demonstrate progressive centripetal filling. (medscape.com)
  • As with contrast enhanced CT, they demonstrate peripheral nodular enhancement on arterial phase images with centripetal filling in the delayed phase. (medscape.com)
  • Note that the hemangioma is hyperintense on T2 weighted images and demonstrates peripheral nodular enhancement with progressive infilling with contrast enhancement. (medscape.com)
  • These images reveal the pathognomonic features of a hemangioma, namely, peripheral nodular enhancement and progressive centripetal fill-in (arrow). (medscape.com)
  • Increasingly, focal nodular hyperplasia is being recognized as an incidental finding because of the widespread use of diagnostic imaging for unrelated conditions. (medscape.com)
  • 2. [Focal nodular hyperplasia of the liver: a clinical study of 48 patients]. (nih.gov)
  • 17. [Clinical features of surgically resected focal nodular hyperplasia of the liver]. (nih.gov)
  • Findings probably favor focal nodular hyperplasia, or less likely hepatic adenoma. (cancer.org)
  • 7. [Surgical management of nodular hyperplasia tumor-like hepatic lesions: a study of 72 cases]. (nih.gov)
  • With a suspicion of malignancy, a surgical biopsy was performed which revealed a focal nodular hyperplasia (FNH) without malignancy. (2ndlifelavender.com)
  • 8. Histologic scoring of liver biopsy in focal nodular hyperplasia with atypical presentation. (nih.gov)
  • There is uncertainty regarding the role, if any, of oral contraceptive steroids in the development of focal nodular hyperplasia of the liver. (nih.gov)
  • Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60-70% of cases. (wikipedia.org)
  • Although various chemical agents and drugs have been considered as possible etiologic factors in the development of focal nodular hyperplasia of the liver, cases occurring after intraconazole therapy have not been reported before. (nih.gov)
  • 18. Focal nodular hyperplasia of the liver in children: A report of 2 cases. (nih.gov)
  • Apart from the theoretical considerations with regard to the pathogenesis of nodular hyperplasia of the liver, this case could gain practical importance, as it shows a new adverse effect of a drug that has been used in more than 34 million patients over the past 10 years. (nih.gov)
  • 12. Management and algorithm for focal nodular hyperplasia of the liver in children. (nih.gov)
  • Current information suggests that skin tumor promoters are not mutagenic but bring about a number of important epigenetic changes, such as epidermal hyperplasia, and an increase in polyamines, prostaglandins and dark basal keratinocytes as well as other embryonic conditions. (nih.gov)
  • A 38-year-old woman developed focal nodular hyperplasia of the liver after she had received a 4-month treatment with intraconazole 200 mg/d for a fungal infection of her fingernails. (nih.gov)
  • Both contraceptive steroids and pregnancy, with high levels of endogenous sex steroids, favored tumor growth in this patient, suggesting that focal nodular hyperplasia can be steroid related. (nih.gov)
  • Focal fatty infiltration adjacent to the fissure for the falciform ligament involving the medial segment of the left hepatic lobe. (cancer.org)