• Patients with advanced nasopharyngeal carcinoma and who were treated with gemcitabine plus cisplatin experienced a longer overall survival and improved progression-free survival vs fluorouracil plus cisplatin. (cancernetwork.com)
  • Patients with recurrent or metastatic nasopharyngeal carcinoma who received first-line gemcitabine plus cisplatin had longer overall survival (OS) compared with fluorouracil plus cisplatin, according to the results of the phase 3 GEM20110714 study (NCT01528618) published in the Journal of Clinical Oncology . (cancernetwork.com)
  • Investigators determined that gemcitabine plus cisplatin yielded a median OS of 22.1 months (95% CI, 19.2-25.0) compared with 18.6 months (95% CI, 15.4-21.7) for fluorouracil plus cisplatin. (cancernetwork.com)
  • The probability of OS was 79.9 at 1 year %, 31.0% at 3 years, and 19.2% at 5 years for gemcitabine plus cisplatin and at 71.8% at 1 year, 20.4% at 3 years, and 7.8% at 5 years for fluorouracil plus cisplatin. (cancernetwork.com)
  • A total of 362 patients were enrolled on the trial and were randomized 1:1 to receive either gemcitabine plus cisplatin (n = 181) or the fluorouracil plus cisplatin (n = 181). (cancernetwork.com)
  • In the control arm, patients were treated with 4 g/m2 of continuous intravenous fluorouracil starting from day 1 and 80 mg/m2 of cisplatin on day 1. (cancernetwork.com)
  • In December of 2020, the duration of follow-up was comparable between the 2 cohorts, including 69.5 months (95% CI, 63.3-75.6) with gemcitabine plus cisplatin and 69.7 months (95% CI, 56.4-83.0) for fluorouracil plus cisplatin. (cancernetwork.com)
  • Of this population, 86.7% died (n = 314), including 81.8% (n = 148) of the gemcitabine plus cisplatin arm and 91.7% (n = 166) of the fluorouracil plus cisplatin arm. (cancernetwork.com)
  • The restricted mean value time for OS was 33.0 months (95% CI, 29.3-37.2) in the gemcitabine plus cisplatin group and 25.4 months (95% CI, 22.4-28.6) in the fluorouracil plus cisplatin group ( P = .003). (cancernetwork.com)
  • After discontinuing treatment, 51.9% (n = 94) of patients in the gemcitabine plus cisplatin group and 55.2% (n = 100) of patients in the fluorouracil plus cisplatin group started a first subsequent systemic therapy. (cancernetwork.com)
  • Within this population, 68.1% (n = 64) and 83.0% (n = 83) received a platinum-based combination therapy in both the gemcitabine plus cisplatin and fluorouracil plus cisplatin groups, respectively. (cancernetwork.com)
  • Patients in the fluorouracil plus cisplatin arm who received a first subsequent therapy had a partial response of 17.0%, 52.0% had stable disease, and 20% developed progressive disease. (cancernetwork.com)
  • Additionally, a second subsequent therapy was administered to 37.2% (n = 35) of patients in the gemcitabine plus cisplatin arm and 47.0% (n = 47) of patients in the fluorouracil plus cisplatin arm. (cancernetwork.com)
  • Background/Aim: This study analyzed the outcomes of docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy and DCF plus concurrent radiotherapy (DCF-RT), both followed by conversion surgery, if possible, in patients with cT4b esophageal cancer. (iiarjournals.org)
  • Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions [skin areas] caused by years of too much exposure to sunlight). (medlineplus.gov)
  • Fluorouracil cream and topical solution are also used to treat a type of skin cancer called superficial basal cell carcinoma if usual types of treatment cannot be used. (medlineplus.gov)
  • Do not apply fluorouracil cream or topical solution to the eyelids or the eyes, nose, or mouth. (medlineplus.gov)
  • Fluorouracil Cream USP is topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite. (nih.gov)
  • If applied twice daily, this would indicate systemic absorption of topical fluorouracil to be in the range of 5 to 6 mg per daily dose of 100 mg. (nih.gov)
  • Fluorouracil Cream USP is recommended for the topical treatment of multiple actinic or solar keratoses. (nih.gov)
  • There are no adequate and well-controlled studies in pregnant women with either the topical or the parenteral forms of fluorouracil. (nih.gov)
  • fluorouracil topical may also be used for purposes not listed in this medication guide. (drugs.com)
  • Fluorouracil topical has an average rating of 7.5 out of 10 from a total of 287 ratings on Drugs.com. (drugs.com)
  • fluorouracil topical side effects in more detail. (drugs.com)
  • Background/aims The aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN). (bmj.com)
  • Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). (kanker-actueel.nl)
  • Efudex Cream or generic Fluorouracil is a topical anti-neoplastic medication your doctor can prescribe to treat low-risk types of skin cancer early, such as basil cell carcinoma (BCC) or squamous cell carcinoma (SCC), and for actinic keratosis (AK) as it is considered a precancerous skin condition. (discountdrugsfromcanada.com)
  • Fluorouracil is available either as a solution for injection or as a topical cream or topical solution that's applied on the skin. (healthcareforpets.com)
  • The containers of topical cream or topical solution may include the brand names Efudex, Carac, Tolak, and Fluoroplex or state "Fluorouracil. (healthcareforpets.com)
  • Pets can be exposed to fluorouracil by chewing on containers, usually tubes, of topical fluorouracil or by licking the area of your skin where you applied the medicine. (healthcareforpets.com)
  • Because of this, FDA asked makers of fluorouracil topical products to add new wording to the product labels that warn users about the danger to pets. (healthcareforpets.com)
  • Safely storing your fluorouracil topical products can save your pet's life. (healthcareforpets.com)
  • Withhold or permanently discontinue fluorouracil in patients with evidence of acute early-onset or unusually severe toxicity, which may indicate near complete or total absence of dipyrimidine dehydrogenase (DPD) activity. (nih.gov)
  • Withhold fluorouracil for cardiac toxicity. (nih.gov)
  • The identification of genetic factors associated with either responsiveness or resistance to 5-fluorouracil (5-FU) chemotherapy, as well as genetic factors predisposing patients to the development of severe 5-FU-associated toxicity, is increasingly being recognised as an important field of study. (nih.gov)
  • Risk of environmental impact of fluorouracil cannot be excluded, due to the lack of environmental toxicity data. (janusinfo.se)
  • The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
  • For fluorouracil: Patients with dihydropyrimidine dehydrogenase (DPD) deficiency are unable to metabolize fluorouracil normally and may have severe unexpected toxicity to fluorouracil. (medscape.com)
  • Chemotherapy-naïve patients with mCRC, received bevacizumab (5 mg/kg every 2 weeks d 1 ), oxaliplatin (85 mg/m 2 on d 1 ), leucovorin (200 mg/m 2 ) on days 1 and 2 and 5-Fluorouracil (400 mg/m 2 as i.v. bolus and 600 mg/m 2 as 22 h i.v. continuous infusion on days 1 and 2) every 2 weeks. (biomedcentral.com)
  • 1% frequency): Local pain Itchiness Burning Stinging Crusting Weeping Dermatitis Photosensitivity Uncommon (0.1-1% frequency): Hyper- or hypopigmentation Scarring The United States package insert warns that acute cerebellar syndrome has been observed following injection of fluorouracil and may persist after cessation of treatment. (wikipedia.org)
  • These highlights do not include all the information needed to use FLUOROURACIL INJECTION safely and effectively. (nih.gov)
  • See full prescribing information for FLUOROURACIL INJECTION. (nih.gov)
  • How does the Fluorouracil Injection by Hospira medication work? (rxhealthmed.ca)
  • What form(s) does the Fluorouracil Injection by Hospira medication come in? (rxhealthmed.ca)
  • How should I use the Fluorouracil Injection by Hospira medication? (rxhealthmed.ca)
  • Fluorouracil is available as an intravenous (into the vein) injection. (rxhealthmed.ca)
  • Who should NOT take the Fluorouracil Injection by Hospira medication? (rxhealthmed.ca)
  • What side effects are possible with the Fluorouracil Injection by Hospira medication? (rxhealthmed.ca)
  • Fluorouracil Kocak I.V. Injection is a powerful medication used in the treatment of various types of cancer, including colon, rectal, breast, stomach, and pancreatic cancer. (wikikenko.com)
  • Fluorouracil Kocak I.V. Injection is a powerful solution for patients battling colon, rectal, breast, stomach, or pancreatic cancer. (wikikenko.com)
  • Multiple birth defects have been reported in a fetus of a patient treated with intravenous fluorouracil. (nih.gov)
  • Fluorouracil is recommended for administration either as an intravenous bolus or as an intravenous infusion. (nih.gov)
  • 5-Fluorouracil is an intravenous chemotherapy used alone or in combination with other agents for the treatment of certain types of cancer. (singhealth.com.sg)
  • During the same period, she received intravenous chemotherapy, in the form of 790 mg (500 mg/m 2 ) fluorouracil (5-FU) and 32 mg (20 mg/m 2 ) calcium folinate, for 5 consecutive days at 3-week intervals. (psychiatryinvestigation.org)
  • Tegafur, a prodrug of 5-fluorouracil (5-FU), is an oral fluorouracil antitumor drug used for the management of adenocarcinomas. (cun.es)
  • Capecitabine is a prodrug of fluorouracil that undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)
  • In this manner, fluorouracil interferes with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibits the formation of ribonucleic acid (RNA). (nih.gov)
  • The effects of 5-fluorouracil on the synthesis and translation in vitro of polyadenylic acid-containing polysomal RNA [poly(A)RNA] were studied in Ehrlich ascites cells incubated in vitro . (aspetjournals.org)
  • These results suggest that impairment in the synthesis of messenger RNA occurs only at high concentrations of 5-fluorouracil, but that the integrity of the translational activity of the RNA is not significantly impaired. (aspetjournals.org)
  • A total of 42 patients who were assigned to the gemcitabine poststudy treatment arm received fluorouracil, capecitabine, tegafur, or S-1. (cancernetwork.com)
  • The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
  • 5-Fluorouracil (5-FU) is a widely used chemotherapeutic agent for breast cancer. (techscience.com)
  • The anti-metabolite - 5-Fluorouracil (5-FU) - is the most widely used chemotherapeutic drug. (dcu.ie)
  • This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). (biomedcentral.com)
  • Introduced in 1958, 5-Fluorouracil (5-FU) is one of the most common chemotherapeutic agents. (psychiatryinvestigation.org)
  • 5-Fluorouracil ( 5-FU ) is one of the most widely applied chemotherapeutic agents with a broad spectrum of activity. (bvsalud.org)
  • Fluorouracil interferes with genetic material (DNA and RNA), which is necessary for the growth and reproduction of cancer cells. (rxhealthmed.ca)
  • 5-Fluorouracil (5-FU) is widely applied in the treatment of various cancers, including colorectal cancer (CRC) [1,2]. (medscimonit.com)
  • Fluorouracil, also called "5-FU" or "5-fluorouracil," is an FDA-approved chemotherapy drug commonly used to treat a wide variety of cancers in people, including some types of skin cancers and a condition called solar or actinic keratosis, which can lead to skin cancer. (healthcareforpets.com)
  • abstract = "Objective: We report a case of sequential interaction of phenytoin (PHT) and phenobarbital (PB) with fluorouracil (5-FU). (elsevierpure.com)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • No fluorouracil dose has been proven safe in patients with absent DPD activity. (nih.gov)
  • If severe, discontinue fluorouracil until resolved or decreased to Grade 1, then resume at a reduced dose. (nih.gov)
  • Withhold fluorouracil until severe myelosuppression resolves, then resume at a reduced dose. (nih.gov)
  • Discontinue fluorouracil until resolved or decreased to Grade 1, then resume at a reduced dose. (nih.gov)
  • Albertsson P, Lennernäs B, Norrby K. Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
  • TY - JOUR T1 - Low-dose continuous 5-fluorouracil infusion stimulates VEGF-A-mediated angiogenesis. (unboundmedicine.com)
  • Bethlehem, PA - September 19, 2018 - Saladax Biomedical Inc., a diagnostics company providing kits to test drug blood levels for personalized dose management and adherence, announced today that it welcomes new guidelines from the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) that "strongly recommend" monitoring levels of 5-Fluorouracil (5-FU) in patients on treatment. (saladax.com)
  • The recommended dose of fluorouracil varies widely according to the specific condition being treated, the response to therapy, and the other medications being used. (rxhealthmed.ca)
  • The dose of fluorouracil is based on body size. (rxhealthmed.ca)
  • For fluorouracil: Liver function should be assessed prior to each cycle for potential dose evaluation. (medscape.com)
  • Withhold fluorouracil and initiate ammonia-lowering therapy. (nih.gov)
  • Case report: A male patient aged 60 under treatment with PHT and PB in which serum concentrations of PHT (32.8 μg/ml) and PB (26.7 μg/ml) increased ∼2-fold after the start of postoperative adjuvant therapy with calcium levofolinate (l-LV) and fluorouracil (5-FU). (elsevierpure.com)
  • Therapy with 5-fluorouracil cream has not been evaluated in controlled studies, frequently causes local irritation, and is not recommended for the treatment of genital warts. (cdc.gov)
  • Hand-foot skin reactions with continuous infusion of fluorouracil may occur after 8 to 9 weeks or earlier. (singhealth.com.sg)
  • If you are using fluorouracil to treat basal cell carcinoma, you should continue using it until the lesions are gone. (medlineplus.gov)
  • Fluorouracil comes as a solution and a cream to apply to the skin. (medlineplus.gov)
  • Apply fluorouracil cream with a nonmetal applicator, a glove, or your finger. (medlineplus.gov)
  • If you apply fluorouracil cream with your finger, be sure to wash your hands well immediately afterwards. (medlineplus.gov)
  • Fluorouracil Cream USP contains 5% fluorouracil in a vanishing cream base consisting of methylparaben, polysorbate 60, propylene glycol, propylparaben, purified water, stearyl alcohol, and white petrolatum. (nih.gov)
  • The success rate with Fluorouracil Cream USP is approximately 93%, based on 113 lesions in 54 patients. (nih.gov)
  • Fluorouracil cream may cause fetal harm when administered to a pregnant woman. (nih.gov)
  • One birth defect (cleft lip and palate) has been reported in the newborn of a patient using fluorouracil cream as recommended. (nih.gov)
  • One birth defect (ventricular septal defect) and cases of miscarriage have been reported when fluorouracil cream was applied to mucous membrane areas. (nih.gov)
  • Information is also available online at https: Continue typing to refine, 5 fluorouracil cream. (shopwestcomb.com)
  • If you have concerns about the fluorouracil of your reaction to 5-FU cream, get in touch with your doctor. (shopwestcomb.com)
  • The total area of skin being treated with Efudix at any one time should not exceed cm 2 approximately 23 x 23 cm, 5 fluorouracil cream. (shopwestcomb.com)
  • Sadly, the FDA has received reports involving dogs that were exposed to one type of medicated cream called fluorouracil. (healthcareforpets.com)
  • At 12 months after the end of treatment in patients with multiple actinic keratosis lesions on the head, 5% fluorouracil cream was the most effective of four field-directed treatments," the study authors conclude. (uspharmacist.com)
  • p53, mdm-2, p21, and mib-1 expression were assessed by immunohistochemical methods in primary tumors derived from 134 patients who took part in a randomized multicenter trial comparing docetaxel to sequential methotrexate and 5-fluorouracil (MF) in advanced breast cancer. (lu.se)
  • Fluorouracil is in the antimetabolite and pyrimidine analog families of medications. (wikipedia.org)
  • Systemic absorption studies of topically applied fluorouracil have been performed on patients with actinic keratoses using tracer amounts of 14 C-labeled fluorouracil added to a 5% preparation. (nih.gov)
  • the active immunization to the drug 5-fluorouracil (5-FU) with enhanced antitumor activity resulting from its subsequent systemic administration. (jci.org)
  • Experiments in various species revealed an impairment of fluorouracil fertility and reproductive performance of systemic 5-fluorouracil. (shopwestcomb.com)
  • 5-Fluorouracil is being increasing replaced in clinical trials with 3rd generation 5-FU drugs such as capecitabine. (dcu.ie)
  • In an additional study, negligible amounts of labeled material were found in plasma, urine, and expired CO 2 after 3 days of treatment with topically applied 14 C-labeled fluorouracil. (nih.gov)
  • Furthermore, Fluorouracil may impact fertility in both genders, making it important to avoid breastfeeding while undergoing treatment. (wikikenko.com)
  • Optimal treatment of AK lesions in the elderly depends on several factors, including adherence to treatment regimens fluorouracil modification of regimens to adjust to pharmacokinetic and pharmacodynamic changes that occur. (shopwestcomb.com)
  • Compared with fluorouracil, the hazard ratio for treatment failure was 2.03 (95% CI, 1.36-3.04) with imiquimod, 2.73 (95% CI, 1.87-3.99) with MAL-PDT, and 3.33 (95% CI, 2.29-4.85) with ingenol mebutate ( P ≤.001 for all comparisons), report the researchers, who also add that no unexpected toxic effects were documented. (uspharmacist.com)
  • To evaluate the benefit of cetuximab (Cx) addition to platinum-based and 5-fluorouracil chemotherapy (PFU) in unselected recurrent and/or metastatic head and neck cancer patients (R/MHNC) according to KRAS-LCS6 variant status. (nih.gov)
  • Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). (nih.gov)
  • Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. (wikipedia.org)
  • Fluorouracil is a chemotherapy drug that works by slowing or stopping the growth of cancer cells. (alberta.ca)
  • Once it has been absorbed into your skin cells the active ingredient, Fluorouracil, is incorporated into the cancer cell's DNA or RNA. (discountdrugsfromcanada.com)
  • As well as interfering with the genetic material DNA and RNA of cancer cells, fluorouracil can interfere with some of your normal cells. (rxhealthmed.ca)
  • While Fluorouracil can be highly beneficial in combating cancer, it is essential to be aware of potential side effects. (wikikenko.com)
  • Fluorouracil provides patients in Turkey with an effective tool in their fight against cancer, bringing them one step closer to recovery and a brighter future. (wikikenko.com)
  • There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. (nih.gov)
  • The catabolic metabolism of fluorouracil results in degradation products (e.g. (nih.gov)
  • The effects of DNA and RNA deprivation are most marked on those cells which grow more rapidly and take up fluorouracil at a more rapid rate. (nih.gov)
  • Exposure of cells for 2 hr to concentrations of 5 x 10 -6 -5 x 10 -4 M 5-fluorouracil did not significantly alter the size distribution of poly(A)RNA labeled with either [ 3 H]adenosine or [ 3 H]5-fluorouracil. (aspetjournals.org)
  • For brands that may still be available, search under fluorouracil. (rxhealthmed.ca)