McCune-Albright syndrome includes polyostotic fibrous dysplasia as part of its presentation. (wikipedia.org)
I would like to receive information about "fibrous dysplasia," also known as the McCune-Albright syndrome. (drgreene.com)
McCune-Albright syndrome (MAS) consists of at least two of the following three features: (1) polyostotic fibrous dysplasia (PFD), (2) café-au-lait skin pigmentation (see the image below), and (3) autonomous endocrine hyperfunction (eg, gonadotropin-independent precocious puberty). (medscape.com)
People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia. (medlineplus.gov)
Polyostotic fibrous dysplasia may be seen in some syndromes, including McCune-Albright syndrome (polyostotic fibrous dysplasia, café-au-lait spots, and endocrinopathies) and Mazabraud syndrome (polyostotic fibrous dysplasia, intramuscular myxomas). (jbjs.org)
Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. (nih.gov)
The clinical spectrum of fibrous dysplasia varies widely, including single lesions (monostotic), multiple lesions (polyostotic), and the combination of polyostotic fibrous dysplasia with extra-skeletal manifestations such as café-au-lait patches and/or endocrinopathies such as precocious puberty and growth-hormone excess in the McCune-Albright Syndrome or intramuscular myxomas in the Mazabraud's syndrome. (5dok.net)
She also helped to create the first Fibrous Dysplasia/McCune-Albright Syndrome Patient Registry. (washington.edu)
Have you ever gone to a long-awaited medical appointment only to realize the provider isn't familiar with fibrous dysplasia, McCune-Albright syndrome (FD/MAS)? (fdmasalliance.org)
At 13 years old, she is a rollercoaster rider, a swimmer, a Bath & Body Works shopper, a future anesthesiologist, and living every day with McCune-Albright syndrome (MAS) and Polyostotic Fibrous Dysplasia (PFD). (fdmasalliance.org)
For patients with fibrous dysplasia and McCune-Albright syndrome (FD/MAS), a life free of pain, anxiety, and depression is often overlooked in the task of day-to-day living. (fdmasalliance.org)
McCune Albright Syndrome is a rare disease characterized by classic triad of polyostotic fibrous dysplasia, café-au-lait spots and endocrine dysfunction and out of them cushings syndrome is a fatal manifestation which might need bilateral adrenalectomy. (eurospe.org)
Craniofacial4
Boyce AM, Burke A , Peck C, DuFresne CR, Lee JS, Collins MT. Surgical management of polyostotic craniofacial fibrous dysplasia: long-term outcomes and predictors for post-operative regrowth. (washington.edu)
Craniofacial involvement in fibrous dysplasia may be considered a "monostotic" location despite involvement of several craniofacial bones or more rarely be part of a polyostotic fibrous dysplasia. (grayscalecourses.com)
Although more cases are monostotic, a higher proportion of polyostotic cases have craniofacial involvement (50%) versus craniofacial involvement in monostotic cases (25%) - although recall monostotic disease is overall more common. (grayscalecourses.com)
Within craniofacial fibrous dysplasia involvement of the anterior bones is more common than lateral or posterior bones with a recent study in the more sensitive CT era suggesting that ethmoidal involvement is the most common. (grayscalecourses.com)
Osteogenesis4
15. Paget's disease of bone, osteogenesis imperfecta, and fibrous dysplasia. (nih.gov)
Bone diseases associated with an increased risk of osteosarcoma include Ollier's disease, osteogenesis imperfecta, polyostotic fibrous dysplasia, and Paget's disease. (dana-farber.org)
In addition, he serves as an associate investigator in a number of NIH institute and center protocols including research on osteogenesis imperfecta, polyostotic fibrous dysplasia, neonatal onset multisystem inflammatory disease, proteus syndrome, and neurofibromatosis type I. (nih.gov)
Diagnosis is based on typical appearances, predominantly at CT which also assists in differentiating fibrous dysplasia from other osteodystrophies of the skull base, including otosclerosis, osteogenesis imperfecta, Paget's disease, and osteopetrosis. (grayscalecourses.com)
Lesions3
Osteofibrous dysplasia and adamantinoma are typically tibial lesions. (orthopaedicsone.com)
Non-ossifying fibroma, fibrous cortical defects, and chondromyxoid fibroma are eccentric geographic lesions. (orthopaedicsone.com)
This technique is less important in assessment of solitary lesions but can add valuable information in the case of polyostotic involvement. (pdfslide.us)
Tissue10
Fibrous dysplasia is a disorder where bone is replaced by fibrous tissue, leading to weak bones, uneven growth, and deformity. (wikipedia.org)
Replacement of bone with fibrous tissue may lead to fractures, uneven growth, and deformity. (medlineplus.gov)
The bone at these sites is rapidly resorbed and replaced by abnormal fibrous tissue or mechanically abnormal bone. (nih.gov)
The fibrous tissue weakens the bone over time, which can lead to fractures (breaks) and misshapen bones. (nih.gov)
Instead, they produce abnormal fibrous tissue in certain bones. (nih.gov)
Bone pain, which may happen because of fractures or fibrous tissue changes in the bones. (nih.gov)
4,5 This results in increased intracellular levels of cAMP in bone forming cells, leading to replacement of lamellar bone with ill-woven, under mineralized (fibrous) tissue of poor quality, associated with clinical manifestations of pain, deformity and pathological fractures. (5dok.net)
Fibrous dysplasia (FD) is a benign lesion characterized by replacement of normal bone with abnormal connective tissue. (jbstjournal.com)
Fibrous Dysplasia (FD) of bone is a benign not hereditary congenital disorder of medullary bone maintenace in which bone undergoing physiologic lysis is replaced by abnormal proliferation of fibrous tissue, resulting in assymmetric distortion and expantion of bone. (rmmg.org)
Disorder4
Polyostotic fibrous dysplasia (PFD) is a sporadic disorder which affects multiple sites in the skeleton. (nih.gov)
Fibrous dysplasia is a genetic, not inheritable, rare bone disorder that was first described in the late nineteen-thirties. (5dok.net)
Beckwith-Wiedemann syndrome an inherited disorder characterized by exomphalos, macroglossia, and gigantism, often associated with visceromegaly, adrenocortical cytomegaly, and dysplasia of the renal medulla. (topgrowupclinic.eu)
Melorheostosis is a rare disorder characterized by mesodermal dysplasia of bone. (jocr.co.in)
Femur4
background: Fibrous dysplasia of the proximal femur presents with heterogeneous clinical manifestations dictating different surgical options. (5dok.net)
conclusion: Our data show that fibrous dysplasia of the proximal femur can be adequately and safely treated with angled blade plates or intramedullary nails, provided that these are used according to specific characteristics of the individual patient. (5dok.net)
Based on published literature and our own experience, we propose an individualized, patient-tailored approach for the surgical management of fibrous dysplasia of the proximal femur. (5dok.net)
The surgical management of fibrous dysplasia of the proximal femur has been particularly challenging due to the high load of mechanical forces acting on this bone. (5dok.net)
Intramuscular myxomas1
Mazabraud syndrome consists of fibrous dysplasia (usually polyostotic form) with multiple intramuscular myxomas affecting the same anatomical region. (webpathology.com)
Bones4
The bony abnormalities are called polyostotic fibrous dysplasia, or ineffective growth in multiple bones. (drgreene.com)
Excess growth hormone secretion may also lead to increased expansion of the fibrous dysplasia in the bones, most visibly in the skull. (medlineplus.gov)
Other people may have multiple affected bones (polyostotic) and experience more symptoms. (nih.gov)
It may be confined to a single bone (monostotic) or involve several bones (polyostotic). (rmmg.org)
Paget's5
1. [Case of Paget's disease, simulating polyostotic fibrous dysplasia]. (nih.gov)
7. Paget's disease and fibrous dysplasia. (nih.gov)
9. Coexisting polyostotic fibrous dysplasia and Paget's disease. (nih.gov)
14. [Fibrous dysplasia: differential diagnosis from Paget's disease]. (nih.gov)
Fractures2
In cases where polyostotic fibrous dysplasia (PFD) is marked, multiple pathologic fractures are prominent early in the history (usually in childhood). (medscape.com)
Fibrous dysplasia of bone (FD) is a rare disease responsible for bone deformities, fractures, nerve compression and bone pain. (biomedcentral.com)
Melorheostosis( synonyms: candle bone disease, melting wax syndrome, Leri disease), first described by Leri and Joanny in 1922[1] , is a rare benign sclerosing bone dysplasia. (jocr.co.in)
Dysplastic bone1
This worsening may be due to the trophic effects of estrogen on fibrous dysplastic bone, which does possess estrogen receptors. (medscape.com)
Temporal Bone1
The appearances are diagnostic of fibrous dysplasia of the left temporal bone. (grayscalecourses.com)
Diagnosis2
Q78.1 is a billable diagnosis code used to specify a medical diagnosis of polyostotic fibrous dysplasia. (icdlist.com)
Bone abnormalities (fibrous dysplasia) are sometimes removed with surgery. (nih.gov)
Albright's1
Dennis had a rare condition called McCune-Albright's polyostotic fibrous dysplasia. (drgreene.com)
Involvement1
Fibrous dysplasia is suspected by multiple bone involvement, deformities, and ground glass appearance. (orthopaedicsone.com)
Malignant3
It occurs in monostotic or polyostotic forms, with a rare but proven potential for malignant transformation. (jbstjournal.com)
4. Mardekian SK, Tuluc M. Malignant sarcomatous transformation of fibrous dysplasia. (jbstjournal.com)
10. Hatano H, Morita T, Arllzumi T, Kawashima H, Ogose A. Malignant transformation of fibrous dysplasia: A case report. (jbstjournal.com)
Descriptor1
Fibrous Dysplasia, Polyostotic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Complications2
The main skeletal feature is fibrous dysplasia, which ranges in severity and can cause various complications. (nih.gov)
20. [Paget disease or fibrous dysplasia of the radius? (nih.gov)
Fibrous dysplasia is not common, but anyone can develop the disease. (nih.gov)
People with a milder form of the disease may not have any symptoms and do not learn they have fibrous dysplasia until they have an x-ray for another reason. (nih.gov)
Orthopedic1
11. Five polyostotic conditions that general orthopedic surgeons should recognize (or should not miss). (nih.gov)
Develops1
however, they have identified the gene and continue to study why fibrous dysplasia develops. (nih.gov)
Cases1
Locally aggressive fibrous dysplasia mimicking malignancy: A report of four cases and review of the literature. (jbstjournal.com)
Pain1
7. Chapurlat RD, Gensburger D, Jimenez-Andrade JM, Ghilardi JR, Kelly M, Mantyh P. Pathophysiology and medical treatment of pain in fibrous dysplasia of bone. (jbstjournal.com)
Single1
17. [Positive scintigraphic representation of single bone fibrous dysplasia of the frontal bone]. (nih.gov)
Means1
This means fibrous dysplasia does not spread from one bone to another. (nih.gov)