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  • collagen
  • PTH pretreatment prevented TGF-beta1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h. (nih.gov)
  • Fibronectin also contains domains for fibrin-binding (I1-5, I10-12), collagen-binding (I6-9), fibulin-1-binding (III13-14), heparin-binding and syndecan-binding (III12-14). (wikipedia.org)
  • Type II domain is approximately sixty amino acids long, contains four conserved cysteines involved in disulfide bonds and is part of the collagen-binding region of fibronectin. (wikipedia.org)
  • secretion
  • overexpression of miRNA-21 counteracts the inhibitory effect of BMP-7 on TGF-beta1-induced fibronectin secretion and apoptosis. (nih.gov)
  • Data suggest that valsartan may decrease the secretion of transforming growth factor (TGF-beta) and fibronectin (FN) in a dose-dependent manner via inhibiting angiotensin II-notch1 receptor (AngII-Notch) signaling. (nih.gov)
  • Cdc42 can stabilize protrusions and directed migration via fibronectin secretion while Rac cannot. (biologists.org)
  • receptors
  • In more recent years, the complete sequences of several fibronectin molecules and their genes were determined, the relation between structure and function was understood and much has been learned about cell surface receptors for fibronectins and other adhesive ligands. (springer.com)
  • Fibrillogenesis
  • Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. (abcam.com)
  • receptor
  • Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. (nih.gov)
  • migration
  • Intensive research has focused on their role in platelet function, cell migration, the cytoskeleton, reticuloendothelial function, and on alterations in fibronectin distribution during development and disease. (springer.com)
  • Vivo
  • Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro. (nih.gov)
  • these findings indicated that fibronectin expression is an early and progressive event that occurs during liver fibrogenesis in vivo and in vitro. (nih.gov)