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  • Novel
  • Novel variants of this new glu 3 ,5 basic fibroblast growth factor, such as those in which cysteine 78 and cysteine 96 are replaced, e.g., with serine or other amino acids, to produce stabilized versions of the glu 3 ,5 basic FGF and eliminate disulfide scrambled forms, are also described. (google.com)
  • Pathways
  • The exact pathways and elements activated depend on the cell type being stimulated plus other factors such as the stimulated cells microenvironment and previous as well as concurrent history of stimulation Activation of the gamma isoforms of phospholipase C (PLCγ) (see PLCG1 and PLCG2 illustrates one mechanism by which FGFR1 activates cell stimulating pathways. (wikipedia.org)
  • mitogenic
  • FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)
  • hormone
  • Acanthosis nigricans has been linked to the use of nicotinic acid, glucocorticoid use, combined oral contraceptive pills, and growth hormone therapy. (wikipedia.org)
  • pituitary
  • In the course of study of these factors, a number have been identified on the basis of the ability of extracts from various tissues, such as brain, pituitary and hypothalamus, to stimulate the mitosis of cultured cells. (google.com)
  • tumor
  • Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. (ebi.ac.uk)
  • The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot and bloody," illustrating that, at least for many tumor types, flush perfusion and even hyperemia are characteristic. (wikipedia.org)
  • expression
  • showed that SFRP1 expression in UMRC3 cells (clear cell renal cell carcinoma cell line) resulted in a growth-inhibited phenotype. (wikipedia.org)
  • angiogenesis
  • The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease. (wikipedia.org)
  • Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. (wikipedia.org)
  • protein
  • Our model gives a quantitative assessment of the amount of cellular death or growth inhibition that result from the ablation of an oncogene's protein product. (biomedcentral.com)
  • cells
  • Dock11 is expressed at lower levels in NIH-3T3 fibroblasts, C2C12 myoblasts and Neuro-2A neuroblastoma cells. (wikipedia.org)
  • It is a lethal rhizomelic (malformations which result in short, underdeveloped limbs) form of dwarfism, exhibiting both skeletal dysplasia (malformations of bone) and fibroblastic dysplasia (abnormal development of fibroblasts, specialized cells that make up fibrous connective tissue, which plays a role in the formation of cellular structure and promotes healing of damaged tissues). (wikipedia.org)
  • Fibrochondrogenesis alters the normal function of chondrocytes, fibroblasts, metaphyseal cells and others associated with cartilage, bone and connective tissues. (wikipedia.org)
  • development
  • This suggests that a decrease in adiponectin production in obese individuals may represent an important causative factor in the development and/or propagation of the insulin resistance, diabetes, and, potentially, other metabolic diseases. (pubmedcentralcanada.ca)
  • mouse
  • Her work led to the ability to isolate permanent trophoblast stem cell lineages using fibroblast growth factor 4 (FGF4) in contact with mouse blastocysts or early postimplantation trophoblasts. (wikipedia.org)
  • important
  • Of the several causes for glaucoma, ocular hypertension (increased pressure within the eye) is the most important risk factor in most glaucomas, but in some populations, only 50% of people with primary open-angle glaucoma actually have elevated ocular pressure. (wikipedia.org)