• globin gene
  • The present study was conducted in order to investigate the implications of the α‑globin gene deletion on fetal hemoglobin (HbF) and hemoglobin α2 (HbA2) concentrations in patients with transfusion‑dependent β‑thalassemia. (readbyqxmd.com)
  • We found that the LRF/ZBTB7A transcription factor occupies fetal γ-globin genes and maintains the nucleosome density necessary for γ-globin gene silencing in adults, and that LRF confers its repressive activity through a NuRD repressor complex independent of the fetal globin repressor BCL11A. (ox.ac.uk)
  • The precise mechanism of action is not yet clear, but it appears that hydroxycarbamide increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal hemoglobin (HbF) production (which does not polymerize and deform red blood cells like the mutated HbS, responsible for sickle cell disease). (wikipedia.org)
  • circulation
  • The chorion acts as a barrier between the maternal and fetal circulation so that there is no admixture of maternal and fetal blood. (wikipedia.org)
  • Blood in the maternal circulation is delivered via open ended arterioles to the intervillous space of the chorionic plate, where it bathes the chorionic villi that carry umbilical capillary beds, thereby allowing gas exchange to occur between the maternal and fetal circulation. (wikipedia.org)
  • The fetal (prenatal) circulation works differently from normal postnatal circulation, mainly because the lungs are not in use. (wikipedia.org)
  • The advent of breathing and the severance of the umbilical cord prompt various neuroendocrine changes that shortly transform fetal circulation into postnatal circulation. (wikipedia.org)
  • The fetal circulation of humans has been extensively studied by the health sciences. (wikipedia.org)
  • Much is known also of fetal circulation in other animals, especially livestock and model organisms such as mice, through the health sciences, veterinary science, and life sciences generally. (wikipedia.org)
  • If these fetal vessels rupture the bleeding is from the fetoplacental circulation, and fetal exsanguination will rapidly occur, leading to fetal death. (wikipedia.org)
  • clinical
  • Currently, there is no cure available for hemoglobin disorders, although, some patients have been treated with bone marrow transplantation, whose scope is limited because of the difficulty in finding a histocompatible donor and also due to transplant-associated clinical complications that can arise during the treatment. (readbyqxmd.com)
  • Background -Fetal hemoglobin (HbF) is the major modifier of the clinical course of sickle cell anemia. (ahajournals.org)
  • Jyoti Bhusan Chatterjea (1919-1972) was an Indian hematologist, medical academic and the director of Calcutta School of Tropical Medicine, He was known for his hematological and clinical studies of Hemoglobin E/β-thalassaemia and was an elected fellow of the National Academy of Medical Sciences, and the Indian National Science Academy. (wikipedia.org)
  • His inquiries led to the clinical, hematological, biochemical, biophysical and the genetical studies of Hemoglobin E/β-thalassaemia prevalent in Bengal region. (wikipedia.org)
  • thalassemia
  • β-hemoglobin disorders, such as β-thalassemia and sickle cell anemia are among the most prevalent inherited genetic disorders worldwide. (readbyqxmd.com)
  • The ability of methyl transferase inhibitors such as Adox to efficiently reactivate fetal hemoglobin expression suggests that these agents may provide a means of reactivating fetal globin expression as a therapeutic option for treating sickle cell disease and β-thalassemia. (biomedcentral.com)
  • It is associated with hemoglobin subunit delta An individual with delta-beta thalassemia is usually asymptomatic, however microcytosis can occur where the red blood cells are abnormally small. (wikipedia.org)
  • In beta thalassemia, an increase in hemoglobin A2 results. (wikipedia.org)
  • However, the co-existence of a delta-beta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait The diagnosis of delta-beta thalassemia is done via hypochromic microcytic red cell indices. (wikipedia.org)
  • humans
  • In humans, less than a third of this enters the fetal ductus venosus and is carried to the inferior vena cava, while the rest enters the liver proper from the inferior border of the liver. (wikipedia.org)
  • hematopoietic
  • The objective of this study was to investigate the effect of the methyl transferase inhibitor adenosine-2',3'-dialdehyde (Adox) on induction of human fetal hemoglobin (HbF) in K562 cells and human hematopoietic progenitor cells. (biomedcentral.com)