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  • globin gene
  • The present study was conducted in order to investigate the implications of the α‑globin gene deletion on fetal hemoglobin (HbF) and hemoglobin α2 (HbA2) concentrations in patients with transfusion‑dependent β‑thalassemia. (readbyqxmd.com)
  • The precise mechanism of action is not yet clear, but it appears that hydroxycarbamide increases nitric oxide levels, causing soluble guanylyl cyclase activation with a resultant rise in cyclic GMP, and the activation of gamma globin gene expression and subsequent gamma chain synthesis necessary for fetal hemoglobin (HbF) production (which does not polymerize and deform red blood cells like the mutated HbS, responsible for sickle cell disease). (wikipedia.org)
  • Vorinostat
  • To determine the efficacy of vorinostat when administered orally in inducing a 4% absolute increase or a 100% increase in fetal hemoglobin levels in subjects with severe sickle cell disease who have failed prior therapy. (clinicaltrials.gov)
  • To determine the efficacy of vorinostat (suberoylanilide hydroxamic acid, SAHA), when administered orally, in a pulsed fashion, once-a-day for 3 consecutive days every week, in inducing a 4% absolute increase or a 100% increase in fetal hemoglobin percent levels (HbF%) in subjects with severe sickle cell disease who have failed prior therapy. (clinicaltrials.gov)
  • circulation
  • The chorion acts as a barrier between the maternal and fetal circulation so that there is no admixture of maternal and fetal blood. (wikipedia.org)
  • Blood in the maternal circulation is delivered via open ended arterioles to the intervillous space of the chorionic plate, where it bathes the chorionic villi that carry umbilical capillary beds, thereby allowing gas exchange to occur between the maternal and fetal circulation. (wikipedia.org)
  • The fetal RBC percentage is directly measured by flow cytometry and gives the percentage of fetal RBCs in maternal circulation resulting from recent fetal-maternal hemorrhage. (aruplab.com)
  • The fetal (prenatal) circulation works differently from normal postnatal circulation, mainly because the lungs are not in use. (wikipedia.org)
  • The advent of breathing and the severance of the umbilical cord prompt various neuroendocrine changes that shortly transform fetal circulation into postnatal circulation. (wikipedia.org)
  • The fetal circulation of humans has been extensively studied by the health sciences. (wikipedia.org)
  • Much is known also of fetal circulation in other animals, especially livestock and model organisms such as mice, through the health sciences, veterinary science, and life sciences generally. (wikipedia.org)
  • If these fetal vessels rupture the bleeding is from the fetoplacental circulation, and fetal exsanguination will rapidly occur, leading to fetal death. (wikipedia.org)
  • clinical
  • Currently, there is no cure available for hemoglobin disorders, although, some patients have been treated with bone marrow transplantation, whose scope is limited because of the difficulty in finding a histocompatible donor and also due to transplant-associated clinical complications that can arise during the treatment. (readbyqxmd.com)
  • Background -Fetal hemoglobin (HbF) is the major modifier of the clinical course of sickle cell anemia. (ahajournals.org)
  • Jyoti Bhusan Chatterjea (1919-1972) was an Indian hematologist, medical academic and the director of Calcutta School of Tropical Medicine, He was known for his hematological and clinical studies of Hemoglobin E/β-thalassaemia and was an elected fellow of the National Academy of Medical Sciences, and the Indian National Science Academy. (wikipedia.org)
  • His inquiries led to the clinical, hematological, biochemical, biophysical and the genetical studies of Hemoglobin E/β-thalassaemia prevalent in Bengal region. (wikipedia.org)
  • thalassemia
  • The ability of methyl transferase inhibitors such as Adox to efficiently reactivate fetal hemoglobin expression suggests that these agents may provide a means of reactivating fetal globin expression as a therapeutic option for treating sickle cell disease and β-thalassemia. (biomedcentral.com)
  • β-hemoglobin disorders, such as β-thalassemia and sickle cell anemia are among the most prevalent inherited genetic disorders worldwide. (readbyqxmd.com)
  • It is associated with hemoglobin subunit delta An individual with delta-beta thalassemia is usually asymptomatic, however microcytosis can occur where the red blood cells are abnormally small. (wikipedia.org)
  • In beta thalassemia, an increase in hemoglobin A2 results. (wikipedia.org)
  • However, the co-existence of a delta-beta thalassemia mutation will decrease the value of the hemoglobin A2 into the normal range, thereby obscuring the diagnosis of beta thalassemia trait The diagnosis of delta-beta thalassemia is done via hypochromic microcytic red cell indices. (wikipedia.org)
  • hematopoietic
  • The objective of this study was to investigate the effect of the methyl transferase inhibitor adenosine-2',3'-dialdehyde (Adox) on induction of human fetal hemoglobin (HbF) in K562 cells and human hematopoietic progenitor cells. (biomedcentral.com)
  • blood
  • This different type of hemoglobin makes the red blood cells change into a crescent shape under certain conditions. (bioportfolio.com)
  • EDTA anti-coagulated blood was used for the determination of haematocrit and the haemoglobin concentration using the 3 part differential fully automated Swelab haematology analyzer. (omicsonline.org)
  • At the 20th day of gestation, a maternal and fetal blood sample were collected for biochemical measurement. (readbyqxmd.com)
  • A variety of tests are used to diagnose blood disorders related to fetal hemoglobin. (ahealthyme.com)
  • Background counting errors can result in estimates of as much as 5 ml fetal blood loss when there actually is no such blood loss, but standard methods available in most laboratories admit an extremely low probability of the return of a false positive when more severe FMH has taken place. (wikipedia.org)
  • Suppose that a KB stain is performed and T C = 5000 {\displaystyle TC=5000} total red blood cells are observed, F C = 200 {\displaystyle FC=200} of which are found to be fetal red blood cells. (wikipedia.org)
  • Then we would conclude that the total percentage of fetal blood lost is approximately P F B = ( 3200 ) ( F C ) ( F W ) ( M C ) = ( 3200 ) ( 200 ) ( 2.0 ) ( 4800 ) = 200 3 = 66.667 {\displaystyle PFB={\frac {(3200)(FC)}{(FW)(MC)}}={\frac {(3200)(200)}{(2.0)(4800)}}={\frac {200}{3}}=66.667} to five significant digits. (wikipedia.org)
  • The blood pressure in the fetal aorta is approximately 30 mmHg at 20 weeks of gestation, and increases to ca 45 mmHg at 40 weeks of gestation. (wikipedia.org)
  • Sickle-cell disease (increases production of fetal hemoglobin that then reduces the tendency of sickle cells to sickle, as well as reducing white blood cells that contribute to the general inflammatory state in sickle cell patients. (wikipedia.org)
  • Alkali denaturation test detects the presence of fetal hemoglobin in vaginal blood, as fetal hemoglobin is resistant to denaturation in presence of 1% NaOH. (wikipedia.org)
  • Tests such as the Ogita Test, Apt test or Londersloot test were previously used to attempt to detect fetal blood in the vaginal blood, to help make the diagnosis. (wikipedia.org)
  • In infants, the Apt test can be used to distinguish fetal hemoglobin from maternal blood. (wikipedia.org)
  • mmHg
  • The fetal pulse pressure is ca 20 mmHg at 20 weeks of gestation, increasing to ca 30 mmHg at 40 weeks of gestation. (wikipedia.org)
  • chains
  • The heme groups are molecular chains of different types and actually create six different hemoglobins that vary in their amino acid composition and also in the genes that control them. (encyclopedia.com)
  • routine
  • Laboratory measures of routine haemoglobin and haematocrit should be included in antenatal care protocol of pregnant women during antenatal visits to facilitate the early diagnosis, treatment and monitoring of pregnant women with anaemia. (omicsonline.org)
  • HbA1c
  • However, despite this revolution, the use of SMBG and electronic reports, although fully supported by the American Diabetes Association, never reached its potential due in part to the popularization of glycosylated hemoglobin (HbA1c) as the primary basis for clinical decision-making. (wikipedia.org)
  • useful
  • The determination of the extent of glucosylation of hemoglobin in an individual's blood provides a useful index of glucose level control in diabetics. (google.com)