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  • plasma
  • This paper focuses on the development of a novel approach to analyze underivatized fatty acids in human plasma. (uniurb.it)
  • The method limits of detection, varying from 0.53 to 5.35 μM, are satisfactory for the quantitation of non-esterified fatty acids (NEFAs) in plasma at physiological levels. (uniurb.it)
  • The liver converts unburned food metabolites into very low density lipoproteins (VLDL) and secretes them into plasma where they are converted to intermediate density lipoproteins(IDL), which thereafter are converted to low-density lipoprotein (LDL) particles and non-esterified fatty acids, which can affect other body cells. (wikipedia.org)
  • blood
  • proBNP is subsequently cleaved between arginine-102 and serine-103 by a specific convertase (probably furin or corin) into NT-proBNP and the biologically active 32-amino acid polypeptide BNP-32, which are secreted into the blood in equimolar amounts. (wikipedia.org)
  • Blood lipids are mainly fatty acids[citation needed] and cholesterol[citation needed]. (wikipedia.org)
  • Short- and medium chain fatty acids are absorbed directly into the blood via intestine capillaries and travel through the portal vein. (wikipedia.org)
  • After a meal, some of the fatty acids taken up by the liver is converted into very low density lipoproteins (VLDL) and again secreted into the blood. (wikipedia.org)
  • amino acid
  • ANP is a 28-amino acid peptide with a 17-amino acid ring in the middle of the molecule. (wikipedia.org)
  • ANP is closely related to BNP (brain natriuretic peptide) and CNP (C-type natriuretic peptide), which all share a similar amino acid ring structure. (wikipedia.org)
  • When the cells are stimulated, pro-ANP is released and converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin. (wikipedia.org)
  • BNP is synthesized as a 134-amino acid preprohormone (preproBNP), encoded by the human gene NPPB. (wikipedia.org)
  • RESULTS
  • Esterification of the hydroxyl group at carbon 3 with fatty/organic acids or carbohydrates results in plant sterol esters, i.e. oleates, ferulates and (acyl) glycosides. (wikipedia.org)
  • present
  • In conclusion, the present studies have demonstrated a dissociation between fatty-acid-stimulated gluconeogenesis and changes in Fru-2,6-P2 in cultured rat hepatocytes. (biochemj.org)
  • hepatic
  • The spectrum of NAFLD ranges from simple fatty liver (hepatic steatosis), with benign prognosis, to a potentially progressive form, nonalcoholic steatohepatitis (NASH), which may lead to liver fibrosis and cirrhosis, resulting in increased morbidity and mortality. (jci.org)
  • NAFLD
  • Nonalcoholic fatty liver disease (NAFLD) is gaining increasing recognition as a component of the epidemic of obesity in the United States as well as in other parts of the world. (jci.org)
  • Cells
  • Fat storage is an on-going process and fatty acids are constantly entering and exiting fat cells throughout the day. (thefatlosspuzzle.com)
  • The glycerol released from the hydrolysis of triacylglycerols stored in fat cells becomes a significant source of substrate for gluconeogenesis, but the conversion of amino acids derived from protein catabolism into glucose is also an important source. (weebly.com)
  • When the cells are stimulated, pro-ANP is released and converted to the 28-amino-acid C-terminal mature ANP on the cell surface by the cardiac transmembrane serine protease corin. (wikipedia.org)
  • tissues
  • The advancement of gene-based therapeutics to the clinic is limited by the ability to deliver physiologically relevant doses of nucleic acids to target tissues safely and effectively. (biomedsearch.com)
  • intestine
  • Short- and medium chain fatty acids are absorbed directly into the blood via intestine capillaries and travel through the portal vein. (wikipedia.org)
  • Long-chain fatty acids, on the other hand, are too large to be directly released into the tiny intestine capillaries. (wikipedia.org)
  • carbon
  • 18 carbon atoms, 2 double bonds, 6 carbon atoms beyond last double bond) was normal and 18:3 omega 6 was increased, but all subsequent omega 6 acids were subnormal (P less than 0.001), indicating impairment of chain elongation. (biomedsearch.com)
  • mechanisms
  • It has been ascertained that these fatty acids work in part by antagonising the production and actions of arachidonic acid-derived eicosanoids and in part by eicosanoid-independent mechanisms. (southampton.ac.uk)
  • diseases
  • Over the last couple of decades, researchers have successfully employed polymer and lipid based nanoassemblies to deliver nucleic acids for the treatment of a variety of diseases. (biomedsearch.com)
  • found
  • A range of anti-inflammatory and immunomodulatory effects of the n-3 family of polyunsaturated fatty acids, particularly those found in fish oils, have been identified. (southampton.ac.uk)
  • provide
  • The findings of this research aid our knowledge of the health benefits of naturally-occurring fatty acids and provide information to underpin the design of nutritionally-based therapies for use in situations where components of the immune and inflammatory systems are under or over active. (southampton.ac.uk)