Factor xiii deficiency. Medical search. Frequent questions

Acquired factor XIII (FXIII) deficiency can be caused by liver disease, inflammatory bowel disease , and disseminated intravascular coagulation , although controversy surrounds whether the low plasma levels in these conditions actually contribute to clinical bleeding. (medscape.com)
Naderi M, Eshghi P, Cohan N, Miri-Moghaddam E, Yaghmaee M, Karimi M. Successful delivery in patients with FXIII deficiency receiving prophylaxis: report of 17 cases in Iran. (medscape.com)
Activation of factor XIII (FXIII) by thrombin and calcium is a 2-step process. (medscape.com)
Factor XIII (FXIII), which was initially termed fibrin stabilizing factor, is involved in clot preservation. (medscape.com)
FXIII deficiency, an autosomal recessive disorder, is a rare but potentially life-threatening cause of a hemorrhagic diathesis. (medscape.com)
Congenital FXIII deficiency is due principally to defects in the catalytic A subunit of FXIII, with more than 100 mutations throughout the factor XIII A gene identified. (medscape.com)
[ 1 ] Acquired FXIII deficiencies, which result from autoantibodies against FXIII subunits, are extremely rare but may produce severe bleeding diatheses. (medscape.com)
However, these tests cannot be used to screen for FXIII deficiency because the results would be within reference ranges in a patient with isolated severe FXIII deficiency. (medscape.com)
Congenital factor XIII (FXIII) deficiency, originally recognized by Duckert in 1960, is a rare autosomal recessive disease usually associated with a severe bleeding diathesis. (medscape.com)
Fresh frozen plasma (FFP), cryoprecipitate, and factor XIII (FXIII) concentrates have been used for replacement of factor XIII and the treatment of acute bleeding. (medscape.com)
Type I deficiency is a quantitative defect resulting from decreased synthesis of the protein, whereas type II deficiency is characterized by a normal or near‐normal concentration of functionally defective FXIII‐A. Untreated, severe congenital FXIII‐A deficiency causes severe bleeding events in the majority of cases, with intracranial hemorrhage being the major cause of death. (firebaseapp.com)
Factor XIII Deficiency Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. (firebaseapp.com)
Factor XIII (13) deficiency is an inherited bleeding disorder caused when person's body doesn't produce enough of a protein in the blood (factor XIII or FXIII) which helps blood clot or the factor XIII doesn't work properly. (hft.org.au)
Congenital factor XIII deficiency is an inherited bleeding disorder due to reduced levels and activity of factor XIII (FXIII) and characterized by hemorrhagic diathesis frequently associated with spontaneous abortions and defective wound healing. (nih.gov)
The burden and management of FXIII deficiency. (nih.gov)
Congenital factor XIII (FXIII) deficiency is a rare, autosomal-recessive disorder, with most patients having an A-subunit (FXIII-A) deficiency. (ashpublications.org)
The present study was a multinational, open-label, single-arm, phase 3 prophylaxis trial evaluating the efficacy and safety of a novel recombinant FXIII (rFXIII) in congenital FXIII-A subunit deficiency. (ashpublications.org)
range, 7-60) with congenital FXIII-A subunit deficiency were enrolled. (ashpublications.org)
We conclude that rFXIII is safe and effective in preventing bleeding episodes in patients with congenital FXIII-A subunit deficiency. (ashpublications.org)
Factor XIII (FXIII) is a protransglutaminase that, after activation by thrombin and the presence of calcium, becomes transglutaminase, which cross-links γ-glutamyl-ϵ-lysine residues of fibrinogen chains, leading to increased stability of the fibrin clot. (ashpublications.org)
Congenital FXIII deficiency is a severe bleeding disorder transmitted in an autosomal-recessive manner. (ashpublications.org)
Typical bleeding manifestations include umbilical stump bleeding during the first few days of life, postoperative bleeding, and intracranial hemorrhage, which is observed more frequently in FXIII deficiency than in other inherited bleeding disorders. (ashpublications.org)
In addition, FXIII deficiency is associated with recurrent pregnancy losses and delayed wound healing. (ashpublications.org)
2 Most congenital FXIII deficiency is caused by FXIII-A subunit deficiency, which occurs at a frequency of approximately 1 in 2 million. (ashpublications.org)
All index cases previously diagnosed by urea clotting assays will be tested for FXIII activity and typing of deficiency A or B (HEMOÍBA), as well as analyzing the disease-related mutation (UEPB). (isth.org)
The number (n) of people with FXIII deficiency registered at each center was shown. (isth.org)
Congenital disorders include hemophilia A, hemophilia B, and rarer diseases like von Willebrand factors (vWF) deficiency and FXIII deficiency among others [ 4 ]. (hindawi.com)
Introduction (Background): Congenital factor XIII (FXIII) deficiency is an extre. (icbcongress.com)
Iran has a large group of patients with severe congenital factor XIII deficiency (FXIIID) and Trp187Arg mutation that is most disease causing mutation of FXIII in the world is only observed in southeast of Iran with 352 patients with FXIIID. (ac.ir)
Introduction (Background): Congenital factor XIII (FXIII) deficiency is one of t. (icbcongress.com)
The effect of factor XIII A subunit (FXIII-A) Val34Leu polymorphism on the risk of coronary artery disease (CAD) has been extensively studied. (unideb.hu)
In this study we investigated how FXIII-A Val34Leu genotypes influence plasma factor XIII levels in patients with coronary sclerosis (CS) and myocardial infarction (MI) and how fibrinogen level modulates this effect. (unideb.hu)
Coagulation factor XIII (FXIII) exists as heterotetramer (FXIII-A2 B2 ) in the plasma and as dimer (FXIII-A2 ) in cells. (unideb.hu)
FXIII is essential to maintaining haemostasis, and its deficiency causes severe bleeding diathesis. (unideb.hu)
Have you been looking for a treatment for factor XIII (FXIII), or fibrin stabilizing factor, deficiency? (patientworthy.com)

Researchers suspect that mild factor XIII deficiency, including the acquired form of the disorder, is underdiagnosed because many affected people never have a major episode of abnormal bleeding that would lead to a diagnosis. (medlineplus.gov)
Karimi M, Peyvandi F, Naderi M, Shapiro A. Factor XIII deficiency diagnosis: challenges and tools. (medscape.com)
Problems relating to the laboratory diagnosis of factor XIII deficiency: a UK NEQAS study. (medscape.com)
Because the clinical bleeding is severe in most patients with hereditary factor XIII deficiency, the diagnosis is made at an early age, often during infancy. (medscape.com)
Auto- and alloantibodies against factor XIII: laboratory diagnosis and clinical consequences. (nih.gov)
Since no clinical symptoms/laboratory findings indicated a malignant or specific autoimmune-mediated disorder, the diagnosis made was thrombotic thrombocytopenic purpura-hemolytic uremic syndrome due to idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency. (biomedcentral.com)
For a better diagnosis of Factor XIII deficiency! (langanbach.ie)
The diagnosis of such hereditary forms is confirmed by stable, life-long insufficiency of factor I, as well as hypofibrinogenemia in the parents and other blood relatives of the patient. (treatment-diabetes-info.com)
ABSTRACT This cross-sectional study was carried out to examine the association between osteoporosis and specific risk factors among 384 women referred to the Radiology Department at King Abdullah University Hospital, Irbid, Jordan during the period September 2009-August 2010 for diagnosis of osteopenia or osteoporosis. (who.int)
Serum ferritin index was as accurate as Hb index in the diagnosis of iron-deficiency anaemia. (who.int)

Inbal A, Oldenburg J, Carcao M, Rosholm A, Tehranchi R, Nugent D. Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency. (medscape.com)
FDA Approves First Treatment for Congenital Factor XIII Deficiency The FDA has approved the first product intended to prevent bleeding in people with congenital factor XIII deficiency. (medscape.com)

Hereditary factor XIII deficiency (FXIIID) is a rare autosomal recessive disease, characterized by late bleeding, including intracranial hemorrhage. (isth.org)

Further diagnostics showed markedly reduced activities of both ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 - also known as von Willebrand factor-cleaving protease) and factor H. Test results for antibodies against both proteins were positive. (biomedcentral.com)
A lack of ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 - also known as von Willebrand factor-cleaving protease), a protease responsible for degrading von Willebrand factor precursors, can cause severe cases of TTP-HUS [ 4 ]. (biomedcentral.com)
Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
Cryo may be used to treat bleeding due to Hemophilia A (factor VIII (8) deficiency) or von Willebrand disease when appropriate factor concentrates are not available and/or desmopressin (DDAVP) is contraindicated or ineffective. (medscape.com)

26 May 2018 Factor XI Deficiency is a genetically inherited disease that's a form of hemophilia. (firebaseapp.com)
Novo Nordisk's NovoSecure is a comprehensive patient support program for patients with hemophilia A, hemophilia A or B with inhibitors, factor VII deficiency, acquired hemophilia, Glanzmann's thrombasthenia, or factor XIII deficiency, regardless of product choice. (kelleycom.com)
On September 5, 1995, a 13-year-old boy with mild hemophilia A (factor VIII deficiency) became acutely ill with nausea and vomiting after a 2-week period of fatigue, poor appetite, and low-grade fever. (cdc.gov)
In response to this bulletin, two brothers with hemophilia A (aged 6 and 7 years) who had received this clotting factor concentrate were identified and tested for anti-HAV on November 17. (cdc.gov)

Prophylaxis in rare coagulation disorders -- factor XIII deficiency. (medscape.com)
Inadequate dietary intake is associated with cognitive impairment , infertility , growth retardation and iodine deficiency disorders in affected populations . (bvsalud.org)
Platelet disorders lead to defects in primary hemostasis and produce signs and symptoms different from coagulation factor deficiencies (disorders of secondary hemostasis). (medscape.com)
Hematological disorders are reported to be the major risk factor in 10% to 30% of the hemorrhagic strokes in most studies. (hindawi.com)
In addition, acquired disorders such as coagulation factor inhibitors affect adults more often than children. (medscape.com)
To improve rates of exclusive breastfeeding.4.6 Goal: To minimize the extent and magnitude of iron, iodine and vitamin A deficiency on pregnancy performance and outcome, the growth and development of young children and the productivity and efficiency of adults.Objectives1.Eliminate iodine deficiency disorders amongst the general population.2. (who.int)

As Factor XIII is composed of two subunit protein, A and B, for which the genes are located on different chromosomes, administration of recombinant A subunit improves clot stability and is becoming a therapeutic option for patients with this condition. (wikipedia.org)
Although it is a recombinant protein, rFXIII subunit A is identical in structure and function to the A subunit of factor XIII naturally produced in the body by healthy individuals. (wikipedia.org)
These genes provide instructions for making the two parts (subunits) of a protein called factor XIII. (medlineplus.gov)
Acquired factor XIII deficiency can also be caused by abnormal activation of the immune system, which produces specialized proteins called autoantibodies that attack and disable the factor XIII protein. (medlineplus.gov)
These studies demonstrate that a Cys430-Phe mutation does not prevent the de novo synthesis of the b subunit, but alters the conformation of the mutant protein sufficiently to impair its intracellular transport, resulting in its deficiency in this patient. (embl.de)
In each case of detecting a- or hypofibrinogenemia, the doctor should first of all think not about the genetically determined deficiency of this protein, but about the more frequently acquired forms of the indicated pathology in clinical practice, caused either by DIC or hepatic dystrophy. (treatment-diabetes-info.com)

Inherited factor XIII deficiency results from mutations in the F13A1 gene or, less commonly, the F13B gene. (medlineplus.gov)
Mutations in the F13A1 or F13B gene significantly reduce the amount of functional factor XIII available to participate in blood clotting. (medlineplus.gov)
Inherited factor XIII deficiency is usually due to mutations in the gene encoding the catalytic A subunit, located on chromosome 6. (medscape.com)
3 Fifty percent of the molecular defects responsible for A-subunit deficiency are missense mutations. (ashpublications.org)
Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
Therefore, identifying mutations in F10 is important for diagnosing congenital FX deficiency. (karger.com)
Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)
Factor XIII deficiency : complete phenotypic characterization of two cases with novel causative mutations / É. (unideb.hu)

A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. (embl.de)

Factor XIII deficiency is a rare bleeding disorder. (medlineplus.gov)
2011-08-16 · Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. (firebaseapp.com)
Factor XIII deficiency is a congenital disorder that is inherited as an autosomal recessive trait and is associated with a variable bleeding tendency Acquired factor XIII deficiency is associated with liver failure, inflammatory bowel disease, leukemia, disseminated intravascular coagulation, Henoch-Schonlein purpura, systemic lupus erythematosus and exposure to certain drugs (phenytoin People with congenital (or inherited) factor XIII deficiency are born with low levels of factor XIII in the blood. (firebaseapp.com)
Therefore, it is necessary to test factor XIII activity or clot solubility test for diagnosing this disorder. (biomedcentral.com)
A thirteen-year-old junior tennis player, who had had no past history of disorder and played several hours a day since 6 years old, visited our hospital with the chief complaint of left knee pain after tennis games for two years. (biomedcentral.com)
Catridecacog is a prescription medication used to prevent bleeding in people with a rare blood clotting disorder known as congenital Factor XIII A-subunit deficiency. (rxwiki.com)

citation needed] Two commercially produced factor XIII concentrates are currently available in Europe, one manufactured by Bio Products Laboratory (BPL) and only available in the United Kingdom. (wikipedia.org)

These patients need exogenous subunit A of factor XIII since they have a mutation which prevents production of the A subunit. (wikipedia.org)
These mutation carriers have a reduced amount of factor XIII in their bloodstream (20 to 60 percent of normal), and they may experience abnormal bleeding after surgery, dental work, or major trauma. (medlineplus.gov)
Molecular and cellular basis of deficiency of the b subunit for factor XIII secondary to a Cys430-Phe mutation in the seventh Sushi domain. (embl.de)
Prevalence of factor V Leiden and prothrombin G20210A gene mutation. (medscape.com)
Matched case-control study on factor V Leiden and the prothrombin G20210A mutation in patients with ischemic stroke/transient ischemic attack up to the age of 60 years. (medscape.com)
The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)

Recombinant factor XIII (rFXIII) is the only drug alternative to receiving blood transfusions, the traditional treatment for factor XIII deficiency. (wikipedia.org)
Recombinant factor XIII-A 2 (Tretten) was approved by the US Food and Drug Administration (FDA) in December 2013 and presents an alternative in the treatment of congenital factor XIII A-subunit deficiency. (medscape.com)
143-146 Supplementation with human or recombinant factor XIII has been demonstrated to reduce bleeding after adult heart surgery, although possibly only in the presence of factor deficiency. (firebaseapp.com)

The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
New FDA Orphan Drugs: Cethromycin, Maribavir, rhPDGF-BB The FDA has granted orphan drug designation for cethromycin, maribavir, and recombinant human platelet-derived growth factor (rhPDGF-BB). (medscape.com)
Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. (antibodies-online.com)
Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. (antibodies-online.com)

As factor XIII level was 54% preoperatively, we diagnosed that this condition was caused by low activity level of the factor and administered factor XIII concentrates. (biomedcentral.com)

Some people, including parents of individuals with factor XIII deficiency, carry a single mutated copy of the F13A1 or F13B gene in each cell. (medlineplus.gov)

Nutrients;14(13)2022 Jun 21. (bvsalud.org)
13 1-12, 2022. (unideb.hu)

Signs and symptoms of inherited factor XIII deficiency begin soon after birth, usually with abnormal bleeding from the umbilical cord stump. (medlineplus.gov)
Other signs and symptoms of inherited factor XIII deficiency include nosebleeds, bleeding of the gums, easy bruising, problems with wound healing, bleeding after surgery, and abnormal scar formation. (medlineplus.gov)
Signs and symptoms occur as the result of a deficiency in the blood clotting factor 13, which is responsible for stabilizing the formation of a blood clot. (firebaseapp.com)
mia and G6PD deficiency, signs and and haemolytic anaemia and is the symptoms of iron-deficiency anaemia result of a decrease in haemoglobin Sample and anaemia, such as pica, agitation, (Hb)F synthesis during the first year This cross-sectional study was conduct- anorexia and pale conjunctiva, and of life ( 3 ). (who.int)

ous attempt to detect and remedy their difficulties or their deficiencies if these Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII. (firebaseapp.com)
Factor XI inhibitors in adjunct to antiplatelet therapy: the ultimate dual-pathway inhibition? (btvb.org)
FFP is ineffective in managing bleeding due to direct factor Xa inhibitors. (msdmanuals.com)
A mixing study was performed to eliminate the presence of coagulation factor inhibitors and lupus anticoagulant. (karger.com)

12 (6), 1-13, 2023. (unideb.hu)
13 (11), 1-8, 2023. (unideb.hu)

Inherited factor XIII deficiency also increases the risk of spontaneous bleeding inside the skull (intracranial hemorrhage), which is the leading cause of death in people with this condition. (medlineplus.gov)

Dickneite G, Herwald H, Korte W, Allanore Y, Denton CP, Matucci Cerinic M. Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions. (medscape.com)
Factor XIII is a plasma transglutaminase that catalyzes the final step in the coagulation cascade, cross-linking the loose fibrin polymer into a highly organized structure. (medscape.com)
The two methods used to measure the enzymatic activity of factor XIII include measurement of synthetic amine incorporation into a fibrin clot, and measurement of ammonium ion release during the transglutaminase reaction. (medscape.com)

Atasay B, Arsan S, Gunlemez A, Kemahli S, Akar N. Factor V Leiden and prothrombin gene 20210A variant in neonatal thromboembolism and in healthy neonates and adults: a study in a single center. (medscape.com)
This gene encodes the coagulation factor XIII A subunit. (antibodies-online.com)

The production of autoantibodies against factor XIII is sometimes associated with immune system diseases such as systemic lupus erythematosus and rheumatoid arthritis . (medlineplus.gov)
The development of autoantibodies to factor XIII has been reported. (medscape.com)

rFXIII acts by inhibiting fibrinolysis factors which enzymatically cleave the fibrin matrix, leading to the ultimate formation of clots. (wikipedia.org)
Excessive fibrinolysis may also occur with dysfibrinogenemia, factor XIII deficiency, decreased PAI-1 levels or decreased alpha -2- antiplasmin activity. (clevelandcliniclabs.com)

The Prevalence and Risk Factors Associated with Iodine Deficiency in Canadian Adults. (bvsalud.org)
Herein, we examined the prevalence of iodine deficiency in adults (median age of 61 years) based on the analysis of 24 h urine samples collected from 800 participants in four clinical sites across Canada in the Prospective Urban and Rural Epidemiological (PURE) study. (bvsalud.org)
A high prevalence of -thalassaemia trait was the major potential risk factor in this population. (who.int)
Written consent marriage, illiteracy and certain cultural was taken from each student within the There are a number of different no- beliefs in different nomadic groups may legal age range and the remaining par- mad tribes of different ethnicities in produce variations in the prevalence ticipants signed the consent with their the Islamic Republic of Iran and the of thalassaemia, G6PD deficiency and parents signing as witnesses. (who.int)
The Data collection in the Islamic Republic of Iran ( 1 ) aim of this study was to investigate the The study was performed over a which drastically affects the family prevalence of iron-deficiency anaemia, 6-month period from March to July and personal life of sufferers and is a -thalassaemia, and G6PD deficiency 2012. (who.int)
Reduce the prevalence of vitamin A deficiency and iron deficiency anemia in women and children.3.To increase the consumption of foods rich in micronutrients.4.7 Goal: To reduce mortality due to acute malnutrition and its long term adverse effects on growth and development.Objectives1. (who.int)

This report Human Immuno Deficiency Virus / Acquired Immune Deficiency. (firebaseapp.com)

Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management. (medscape.com)

Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. (wikipedia.org)
Women with inherited factor XIII deficiency tend to have heavy or prolonged menstrual bleeding (menorrhagia) and may experience recurrent pregnancy losses (miscarriages). (medlineplus.gov)
Central nervous system bleeding in pediatric patients with factor XIII deficiency: a study on 23 new cases. (medscape.com)
Although acquired factor XIII deficiency has been described in association with chronic conditions such as hepatic failure, inflammatory bowel disease, and myeloid leukemia, the only significant cause for bleeding in children is an inherited deficiency. (medscape.com)
The U.S. Food and Drug Administration today approved Corifact, the first product intended to prevent bleeding in people with the rare genetic defect congenital Factor XIII deficiency. (medicineandtechnology.com)
The deficiency may lead to soft tissue bruising, mucosal bleeding and fatal intracranial bleeding. (medicineandtechnology.com)
Newborns with Factor XIII deficiency may have umbilical cord bleeding. (medicineandtechnology.com)
Historical Factors to Explore in Adults Presenting With Abnormal Bleeding. (medscape.com)

2018. 13 (7):e0199240. (medscape.com)

Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa. (ukw.de)

Factor XIII acts at the end of the cascade to strengthen and stabilize newly formed clots, preventing further blood loss. (medlineplus.gov)
Ichinose A, Asahina T, Kobayashi T. Congenital blood coagulation factor XIII deficiency and perinatal management. (medscape.com)
Patients with congenital Factor XIII deficiency don't make enough Factor XIII, a substance that circulates in the blood and is important for normal clotting. (medicineandtechnology.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
First, by how much they struggle: standard factor doesn't work to clot the blood, different treatment protocols sometimes fail, children are on prescription painkillers, with ports and surgeries. (kelleycom.com)
Whole blood can provide improved oxygen-carrying capacity, volume expansion, and replacement of clotting factors and was previously recommended for rapid massive blood loss. (msdmanuals.com)
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. (antibodies-online.com)

Thrombin, generated by reactions initiated by activated tissue factor VII/factor IX pathways, leads to clot formation. (medscape.com)
Activation of the zymogen to factor XIIIa depends on limited thrombin cleavage of the A subunits followed by calcium-dependent dissociation of the B subunits, exposing the A subunit active site (as shown in the image below). (medscape.com)

and type II deficiency, characterized by the lack of the A subunit alone. (antibodies-online.com)

citation needed] Fresh frozen plasma and cryoprecipitate are the mainstay of therapy for Factor XIII deficiency, but carry risk related to transfusion. (wikipedia.org)
Influence of factor XIII activity on post-operative transfusion in congenital cardiac surgery-A retrospective analysis. (medscape.com)

Todd T, J Perry D. A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies. (medscape.com)

Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. (medscape.com)

Factor XIII is known as fibrin stabilizing factor, which acts in the terminal phase of the coagulation cascade. (biomedcentral.com)

Diseases1

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

FXIII35

Diagnosis10

Treatment for congenital2

Hereditary factor XIII defic1

Willebrand4

Hemophilia4

Disorders6

Protein6

Mutations8

Subunit of factor1

Disorder6

Produced factor XIII concentrates1

Mutation6

Recombinant Factor XIII3

Platelet4

Concentrates1

F13A11

20222

Symptoms4

Inhibitors4

20232

Spontaneous1

Transglutaminase3

Gene2

Autoantibodies2

Fibrinolysis2

Prevalence6

Immune Deficiency1

Genetics1

Bleeding8

20181

Secondary1

Blood8

Thrombin2

Type II deficiency1

Transfusion2

Prophylaxis1

Fibrin clot1

Coagulation cascade1