Factor xi deficiency. Medical search. Frequent questions

unlike the soft tissue bleeds and hemarthroses that characterize hemophilia A and B, abnormal bleeding in FXI deficiency typically involves mucosal tissues, which are rich in fibrinolytic activity (eg, the oral and nasal cavities and urinary tract). (medscape.com)
The coagulation defect in plasma from these patients was corrected on mixing with plasma from patients with hemophilia, indicating that these patients lacked a factor different from those involved in hemophilia. (medscape.com)
[ 1 ] This disorder was found in both sexes and was understood to be inherited but was identified as being a less severe abnormality than that observed with hemophilia A and B. Hence, older terms for this disorder included Rosenthal syndrome, PTA deficiency, and hemophilia C. (medscape.com)
Other terms for this disorder include plasma thromboplastin antecedent (PTA) deficiency, Rosenthal syndrome, and hemophilia C (see image below). (medscape.com)
BACKGROUND Factor XI deficiency, also known as hemophilia C, is a rare inherited bleeding disorder that may leave routine coagulation parameters within normal range. (uniroma1.it)
[ 10 ] which, though significant, are not as severe as those seen in hemophilia A or hemophilia B . This finding reflects the important role factor XI plays in hemostasis. (medscape.com)
Coagulation disorders include Hemophilia A and B (which are inherited disorders), and Hemophilia C (which is due to a deficiency of factor XI). (differencebetween.net)
Hemophilia Hemophilias are common hereditary bleeding disorders caused by deficiencies of either clotting factor VIII or IX. (msdmanuals.com)
Factor XI deficiency Most hereditary coagulation disorders other than hemophilia are rare autosomal recessive conditions that cause excessive bleeding only in people homozygous for the recessive gene mutation. (msdmanuals.com)
1. Menegatti M, Peyvandi F . Treatment of rare factor deficiencies other than hemophilia. (msdmanuals.com)
Somewhere between the prep and the injection we all realized history was being made: this was the first - repeat, the FIRST - Tanzanian with hemophilia ever to get an infusion of factor VIII within Tanzania. (kelleycom.com)
The X-linked hereditary bleeding lifelong disorder known as hemophilia (in which the blood does not clot properly) is characterised by factor VIII (hemophilia A) or factor IX (hemophilia B or Christmas disease) deficiency. (novumprs.com)
Acquired hemophilia is a variety of the condition that occurs when a person's immune system attacks clotting factor VIII or IX in the blood. (novumprs.com)
Depending on your level of clotting factors, hemophilia can manifest itself in a variety of ways. (novumprs.com)
Bispecific antibody therapy (hemophilia A only).Emicizumab (Hemlibra) is a newer drug that doesn't include clotting factors. (novumprs.com)
This hormone may encourage the body to release more clotting factor in some mild hemophilia types. (novumprs.com)
A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia. (nih.gov)
26 May 2018 Factor XI Deficiency is a genetically inherited disease that's a form of hemophilia. (firebaseapp.com)
Recombinant factor VIIa (rFVIIa) has become available for treating people with hemophilia with inhibitors who experience bleeding or require surgery. (medscape.com)
Originally, rFVIIa was developed for the treatment of bleeding complications in patients with hemophilia with alloantibodies (inhibitors) against exogenous factor VIII or IX. (medscape.com)
We describe the uses of rFVIIa in conditions unrelated to hemophilia and the treatment of acquired inhibitors of factors VIII and IX. (medscape.com)
In hemophilia A, the missing substance is factor VIII. (en-academic.com)
Hemophilia B - Hemophilia due to deficiency of coagulation factor IX in the blood which results in prolonged oozing after minor and major injuries, tooth extractions, or surgery. (en-academic.com)
BACKGROUND: Hemophilia B (HB) is a bleeding disorder characterized by coagulation factor (F) IX (FIX) deficiency. (bvsalud.org)
Extended half-life recombinant FIX (rFIX) molecules have been generated to reduce the dosing burden and increase the protection of patients with hemophilia B. Clinical pharmacology studies with recombinant factor IX Fc fusion protein (rFIXFc) report a similar initial peak plasma recovery to that of rFIX, but with a larger volume of distribution. (bvsalud.org)

Orphanet : 329] The disease is also called plasma thromboplastin antecedent (PTA) deficiency, haemophilia C, or Rosenthal syndrome. (omia.org)
Join us to meet others with haemophilia, von Willebrand disorder (VWD), factor XI deficiency, Glanzmann Thrombasthenia and other rare genetic bleeding disorders. (haemophilia.org.uk)
Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, present in about 1 in 5,000-10,000 male births. (rarediseaseday.org)
2] Haemophilia B (factor IX deficiency) occurs in around 1 in about 20,000-34,000 male births. (rarediseaseday.org)
Although it is not impossible for a female to have haemophilia, it is unusual: a female with haemophilia A or B would have to be the daughter of both a male haemophiliac and a female carrier, while the non-sex-linked haemophilia C due to coagulant factor XI deficiency, which can affect either sex, is more common in Jews of Ashkenazi (east European) descent[3] but rare in other population groups. (rarediseaseday.org)
Haemophilia patients have lower clotting factor level of blood plasma or impaired activity of the coagulation factors needed for a normal clotting process. (rarediseaseday.org)
Prof. Hermans discusses the differences between clotting factor VIII and factor IX deficiencies in female carriers of haemophilia, referred to as women and girls with haemophilia, and their underlying mechanisms. (roche.com)
Haemophilia A and B are both rare X-linked, hereditary bleeding disorders, caused by mutations in the genes encoding clotting factor VIII and factor IX, respectively, with the varying disease severity classified according to the level of factor activity. (roche.com)

2018-11-01. (epfl.ch)
2018 Feb. 40 (1):3-11. (medscape.com)

TT virus contaminates first-generation recombinant factor VIII concentrates. (medscape.com)
Results: Non-bleeders and bleeders had similarly low FXI levels, normal prothrombin times, normal levels of fibrinogen, factor VIII, von Willebrand factor and factor XIII, and normal platelet number and function. (tau.ac.il)
Antithrombin lowers the level of activated factor X. In addition, protein C and S and also responsible to stop over-clotting and do so by preventing the activation of factor V and VIII. (differencebetween.net)
When protein C and S deficiencies are present, disorders that lead to over clotting can occur and leave the body in a state where it is unable to stop factor V and VIII. (differencebetween.net)
This increase in the thrombin burst occurs after direct rFVIIa activation of factors IX and X on the surface of activated platelets (even in the absence of factor VIII or IX). (medscape.com)
Prof. Tiede discusses the history of discrepancies between assays of clotting factor VIII activity, including the introduction of recombinant concentrates, and provides an overview of the mechanisms for these discrepancies. (roche.com)

Employing data related to genetic variants that alter factor XI levels, the investigators found that in these individuals, the odds ratios (ORs) for venous thrombosis and ischemic stroke were 0.1 and 0.47, respectively, with the OR for major bleeding being 0.7. (medscape.com)
There are many things other than genetic variants that can contribute to the development of these diseases or conditions, including environmental or lifestyle factors. (latimes.com)
All data to date have been consistent with the hypothesis that hereditary factor XI deficiency represents a genetic disorder resulting from the absence of factor XI molecule. (ashpublications.org)
Many conditions need both genetic and environmental or lifestyle factors to develop. (medicalnewstoday.com)
Impact of genetic structural variants in factor XI deficiency: identification, accurate characterization, and inferred mechanism by long-read sequencing. (nih.gov)
This correlates with epidemiologic data suggesting that patients with a genetic factor XI deficiency have low rates of stroke and MI but don't appear to bleed spontaneously, Patel notes. (medscape.com)
Factor V Leiden is a disorder caused by a genetic mutation which results in a defect of factor V to the extent that protein C is unable to activate is. (differencebetween.net)
Genetic analysis of these two mutations may help characterize the bleeding tendency and confirm congenital FX deficiency. (karger.com)
A large variety of factors exist that influence disease progression, including social and behavioral factors, systemic factors, genetic factors, tooth factors and microbial composition of the dental biofilm. (bvsalud.org)

Rosenthal and colleagues first described factor XI deficiency in 1953. (medscape.com)
Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. (nih.gov)

Factor XI (FXI) deficiency is a rare autosomal disorder that may be associated with bleeding. (medscape.com)
FXI deficiency can manifest first as a bleeding disorder or as an incidental laboratory abnormality. (medscape.com)
Factor XI (FXI) deficiency is an autosomal bleeding disorder, usually posttrauma or postsurgery, characterized by reduced levels of coagulation FXI in plasma. (hunimed.eu)
An hereditary deficiency in Factor XI can result in a lifelong bleeding disorder or go undetected. (medicalalgorithms.com)
1a) A patient with a minor factor deficiency may have a minor bleeding disorder. (medicalalgorithms.com)
Congenital factor XI deficiency / F11 deficiency is an inherited bleeding disorder characterized by reduced levels and activity of factor XI (FXI) resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. (omia.org)
Background: Factor XI (FXI) deficiency is a rare autosomal recessive disorder. (tau.ac.il)
2011-08-16 · Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. (firebaseapp.com)
Factor XIII deficiency is a congenital disorder that is inherited as an autosomal recessive trait and is associated with a variable bleeding tendency Acquired factor XIII deficiency is associated with liver failure, inflammatory bowel disease, leukemia, disseminated intravascular coagulation, Henoch-Schonlein purpura, systemic lupus erythematosus and exposure to certain drugs (phenytoin People with congenital (or inherited) factor XIII deficiency are born with low levels of factor XIII in the blood. (firebaseapp.com)
Factor XIII deficiency is a rare bleeding disorder. (firebaseapp.com)
Hereditary bleeding disorder caused by deficiency of a coagulation factor. (en-academic.com)
hereditary bleeding disorder caused by a deficiency of a substance necessary for blood clotting ( coagulation ). (en-academic.com)

This results in no measurable FXI in the homozygous state and a measurable factor XI level that is lower than the expected 50% in the heterozygous state. (medscape.com)
The antiserum was used in a neutralization-inhibition assay to study the relation between factor XI clotting activity and factor XI antigen in plasma from ten unrelated patients with homozygous factor XI deficiency and from 12 heterozygous family members of these patients. (ashpublications.org)
A 78-year-old man with homozygous factor XI deficiency and an extensive medical history, including coronary artery disease, congestive heart failure, diabetes, and chronic kidney disease, was admitted in April 2017 for transurethral resection of the bladder as the result of a urologic malignancy. (cdc.gov)

Todd T, J Perry D. A review of long-term prophylaxis in the rare inherited coagulation factor deficiencies. (medscape.com)

A family with hereditary FⅪ deficiency caused by compound heterozygous mutation]. (nih.gov)
The heterozygous variants p.Ser362Asn or p.Tyr384Ter indicate mild FX deficiency, but the compound heterozygous mutation of the two causes severe congenital FX deficiency and bleeding. (karger.com)

FXI deficiency can manifest as an incidental laboratory abnormality-for example, when a preoperative workup for elective surgery reveals an unexpected prolongation of the activated partial thromboplastin time (aPTT). (medscape.com)
[ 3 ] They identified the abnormality as a deficiency in a clotting factor, which they termed plasma thromboplastin antecedent (PTA). (medscape.com)
He identified the abnormality as a factor deficiency, which he termed PTA, that was distinct from the already identified antihemophilic globulin. (medscape.com)

Like many other coagulation factors, it is a serine protease. (wikipedia.org)
Recent findings from our group and others demonstrate the involvement of coagulation factors in both atherosclerosis ( 27 , 28 ) and AD ( 29 , 30 ). (spandidos-publications.com)
Thus when a blood vessel is injured, a temporary scab does form, but the missing coagulation factors prevent fibrin formation, which is necessary to maintain the blood clot. (rarediseaseday.org)
Unmet needs remain regarding the development of non-invasive administration routes for coagulation factors. (bvsalud.org)

FXI is a zymogen, and when activated by factor XIIa or thrombin or when it is autoactivated, FXI becomes a trypsinlike serine protease. (medscape.com)
Polyphosphate is a cofactor for the activation of factor XI by thrombin. (medscape.com)
Rugeri L, Quélin F, Chatard B, De Mazancourt P, Negrier C, Dargaud Y. Thrombin generation in patients with factor XI deficiency and clinical bleeding risk. (medscape.com)
One contains a binding site for thrombin, another for high molecular weight kininogen, a third one for factor IX, heparin and glycoprotein Ib and the fourth is implicated in forming the factor XI homodimer, including a cysteine residue that creates a disulfide bond. (wikipedia.org)
Activation by thrombin or factor XIIa is achieved by cleavage of Arg369-Ile370 peptide bonds on both subunits of the dimer. (wikipedia.org)
[ 1 ] Factor XI enhances generation of thrombin at the platelet surface. (medscape.com)
Activation of factor XIII (FXIII) by thrombin and calcium is a 2-step process. (medscape.com)
Factor XIII Deficiency Factor XIII (FXIII) is a tetrameric zymogen (FXIII-A (2)B (2)) that is converted into an active transglutaminase (FXIIIa) by thrombin and Ca (2+) in the terminal phase of the clotting cascade. (firebaseapp.com)
The decrease in fibrinolysis might be due to an increase in thrombin-activatable fibrinolysis inhibitor and an increase in factor XIIIa. (medscape.com)
rFVIIa is able to activate factor X on phospholipid vesicles, activated platelets, or monocytes independent of TF, although the TF-independent generation of thrombin is much less efficient than the TF-dependent thrombin generation by rFVIIa. (medscape.com)

Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency. (medscape.com)
A common ancestral mutation (C128X) occurring in 11 non-Jewish families from the UK with factor XI deficiency. (medscape.com)
This third group is thought to explain the dominant mutation patterns that are seen in some families with FXI deficiency. (medscape.com)

Pharmacological inhibitors of factor XI that are under clinical development but not yet approved for treatment as of May 2022[update] include the oral factor XIa inhibitors Asundexian (BAY 2433334) and Milvexian as well as the monoclonal anti-factor XI antibody Abelacimab (MAA868). (wikipedia.org)
2022-01-11. (epfl.ch)

Activated factor XI can be inactivated by antithrombin III, alpha1-protease inhibitor, C1 inhibitor, and alpha2-antiplasmin. (medscape.com)
Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor XIa include protein Z-dependent protease inhibitor (ZPI, a member of the serine protease inhibitor/serpin class of proteins), which is independent of protein Z (its action on factor X, however, is protein Z-dependent, hence its name). (wikipedia.org)
This article reports the rare occurrence and investigation of a specific anti-factor XI inhibitor that arose after fresh-frozen plasma infusion into a patient with previously unrecognized Factor XI deficiency. (mcmaster.ca)
Topline results from the largest study so far of a factor XI inhibitor ― released last week ― are indeed very encouraging. (medscape.com)
The phase 2 AZALEA-TIMI 71 study was stopped early because of an "overwhelming" reduction in major and clinically relevant nonmajor bleeding shown with the factor XI inhibitor abelacimab (Anthos) compared to rivaroxaban for patients with atrial fibrillation (AF). (medscape.com)
Severe deficiency of alpha 2-antiplasmin (levels 1 to 3% of normal), the major physiologic inhibitor of plasmin, can also cause bleeding as a result of poor control of plasmin-mediated proteolysis of fibrin polymers. (msdmanuals.com)

Affected dogs have significantly decreased Factor XI activity levels (less than 10%), heterozygous/carrier dogs have decreased Factor XI activity levels, (25-50%) but appear to be asymptomatic (Fogh and Fogh, 1988). (omia.org)

Congenital Factor XI deficiency is characterised by abnormal haemostasis and excessive bleeding, usually following trauma or surgery. (omia.org)
Inbal A, Oldenburg J, Carcao M, Rosholm A, Tehranchi R, Nugent D. Recombinant factor XIII: a safe and novel treatment for congenital factor XIII deficiency. (medscape.com)
New developments in the management of congenital Factor XIII deficiency. (medscape.com)
Congenital factor XIII deficiency is very rare, affecting only 1 in 2 million people - about 100-125 people in the US. (firebaseapp.com)

Low levels of factor XI also occur in many other disease states, including Noonan syndrome. (wikipedia.org)
New information cerebellar abiotrophy of Arabians, Severe Combined Immunodeficieincy (SCID) of Arabians, Lavender foal syndrome of Arabians, Lethal White Syndrome of overo Paints, Glycogen Branching Enzyme Deficiency (GBED) of Quarter Horses, hemophila and thrombobasthenia will be discussed. (dvm360.com)

Options include factor replacement with fresh frozen plasma, antifibrinolytic therapy with tranexamic acid, and fibrin glue. (medscape.com)

FXI deficiency can result from mutations that impair either the synthesis of the FXI molecule or the secretion of the FXI molecule from the producing cell. (medscape.com)
Two predominant mutations, type II and III (using an older classification system) cause the FXI deficiency in patients of Ashkenazi Jewish descent. (medscape.com)
Mutations in the F10 -coding gene can cause factor X (FX) deficiency, leading to abnormal coagulation activity and severe tendency for hemorrhage. (karger.com)
Therefore, identifying mutations in F10 is important for diagnosing congenital FX deficiency. (karger.com)

Biological determinants of bleeding in patients with heterozygous factor XI deficiency. (medscape.com)
Castaman G, Ruggeri M, Rodeghiero F. Clinical usefulness of desmopressin for prevention of surgical bleeding in patients with symptomatic heterozygous factor XI deficiency. (medscape.com)

21(11): 3117-3123, 2023 11. (bvsalud.org)

The administration of 4-factor prothrombin complex concentrate (4F-PCC) has expanded beyond its Food and Drug Administration (FDA)-approved indication for the emergent reversal of vitamin K antagonists (VKAs). (bvsalud.org)
BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. (lu.se)
METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in the PROC (protein C), PROS1 (protein S), and SERPINC1 (antithrombin) anticoagulant genes were determined in 29 387 subjects (born 1923-1950, 60% women) who participated in the Malmö Diet and Cancer study (1991-1996). (lu.se)

Mangla A, Hamad H, Kumar A. Factor XIII Deficiency. (medscape.com)
Delayed umbilical bleeding--a presenting feature for factor XIII deficiency: clinical features, genetics, and management. (medscape.com)
Karimi M, Peyvandi F, Naderi M, Shapiro A. Factor XIII deficiency diagnosis: challenges and tools. (medscape.com)
Central nervous system bleeding in pediatric patients with factor XIII deficiency: a study on 23 new cases. (medscape.com)
Gynecological and obstetric outcome in the French cohort of women with factor XIII deficiency. (medscape.com)
Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. (firebaseapp.com)

The IgG fraction of the patient's plasma that contained anti-Factor XI antibody was isolated by chromatography on DEAE-Affigel and concentrated. (mcmaster.ca)

143-146 Supplementation with human or recombinant factor XIII has been demonstrated to reduce bleeding after adult heart surgery, although possibly only in the presence of factor deficiency. (firebaseapp.com)
This has become the case for treatment of hemorrhage with recombinant factor VIIa (rFVIIa). (medscape.com)

A proposed classification system for factor XI deficiency is based on the patterns of protein production or dimerization of the FXI molecule. (medscape.com)
The unknown functions of a known protein: the case of coagulation factor XI. (nih.gov)
Type I deficiency is a quantitative defect resulting from decreased synthesis of the protein, whereas type II deficiency is characterized by a normal or near‐normal concentration of functionally defective FXIII‐A. Untreated, severe congenital FXIII‐A deficiency causes severe bleeding events in the majority of cases, with intracranial hemorrhage being the major cause of death. (firebaseapp.com)

Factor XI deficiency acquired by liver transplantation. (medscape.com)
Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form. (wikipedia.org)
Factor XI is synthesized in the liver and megakaryocytes and is an 80-kd zymogen precursor of a serine protease. (medscape.com)
Acquired factor XIII (FXIII) deficiency can be caused by liver disease, inflammatory bowel disease , and disseminated intravascular coagulation , although controversy surrounds whether the low plasma levels in these conditions actually contribute to clinical bleeding. (medscape.com)

The presence or absence of some of these variants is associated with an increased risk for developing any one of the following diseases or conditions: Parkinson's disease, late-onset Alzheimer's disease, celiac disease, alpha-1 antitrypsin deficiency, early-onset primary dystonia, factor XI deficiency, Gaucher disease type 1, glucose-6-phosphate dehydrogenase deficiency, hereditary hemochromatosis, and hereditary thrombophilia. (aacc.org)

In humans, Factor XI is encoded by the F11 gene. (wikipedia.org)
The gene for factor XI is located on chromosome 4. (medscape.com)
In mice, knockout of the gene for factor XI does not lead to death in utero. (medscape.com)
This gene encodes coagulation factor XI of the blood coagulation cascade. (nih.gov)
Bleeding typically occurs after trauma or surgery in people who are homozygotes or compound heterozygotes for factor XI gene abnormalities. (msdmanuals.com)

Severity of bleeding in factor XI deficiency could not be correlated with the level of factor XI activity or factor XI antigen. (ashpublications.org)
The extent of factor deficiency determines the probability and severity of bleeding. (msdmanuals.com)
In patients with a deficiency of factor XI, there is no clear association between factor XI plasma levels and the severity of bleeding, indicating that the molecular action of factor XI in normal hemostasis is not precisely understood. (msdmanuals.com)
There is no precise relationship between the plasma factor XI level and severity of bleeding. (msdmanuals.com)

The so-called contact factors include factor XI, factor XII, high-molecular-weight kininogen (HK), and prekallikrein (PK). (medscape.com)

4) The assay for Factor XI may be falsely elevated if the blood sample is exposed to glass or if it has been frozen (false negative). (medicalalgorithms.com)
It was shown to exert inhibitory effect on purified Factor XI and XIa both in the activated and nonactivated partial thromboplastin time assay. (mcmaster.ca)
He also discusses the significance and relevance of assay discrepancies in contemporary factor concentrates, including longer-acting molecules and provide guidance for practical solutions within clinical laboratories. (roche.com)

Definition of the bleeding tendency in factor XI-deficient kindreds--a clinical and laboratory study. (medscape.com)
The pharmaceutical industry is on the case with several factor XI inhibitors now in clinical development. (medscape.com)
Dickneite G, Herwald H, Korte W, Allanore Y, Denton CP, Matucci Cerinic M. Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions. (medscape.com)

FXI remains on the surface and activates factor IX in plasma. (medscape.com)
Plasma is the fluid compartment of blood containing the soluble clotting factors. (medscape.com)
Dental surgery in patients with severe factor XI deficiency without plasma replacement. (medscape.com)
Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. (wikipedia.org)
Binding of factor XIa to activated platelets localizes it to the site of clot formation and protects it from plasma protease inhibitors. (medscape.com)
This antiserum, after concentration, neutralized 50% of the factor XI clotting activity of a standard normal plasma at an antiserum dilution of 1/900. (ashpublications.org)
During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. (nih.gov)
This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. (nih.gov)
The patient also received 14 plasma transfusions to keep his factor XI levels above the hemostatic threshold. (cdc.gov)

Use of desmopressin for prophylaxis of surgical bleeding in factor XI- deficient patients. (medscape.com)
A study by Kyrle et al reported that in patients who had experienced an unprovoked venous thromboembolism (VTE), the 10-year probability of VTE recurrence was 31% in individuals below the 34th percentile for factor XIa, compared with 43% for those between the 34th and 67th percentiles, and 41% for patients in a higher percentile. (medscape.com)
Moreover, the results indicated that among patients with lower factor XI levels, the absolute risk reductions are greater in individuals at high risk for thrombosis, including those with atrial fibrillation or cancer. (medscape.com)
Phenotype and genotype analysis of patients with severe factor XI deficiency in Shaanxi Province, China. (nih.gov)
Naderi M, Eshghi P, Cohan N, Miri-Moghaddam E, Yaghmaee M, Karimi M. Successful delivery in patients with FXIII deficiency receiving prophylaxis: report of 17 cases in Iran. (medscape.com)
Here evidence implicating omega-3 (n-3) fatty acid deficiency in the pathoaetiology of CHD and MDD is reviewed, and the hypothesis that n-3 fatty acid deficiency is a preventable risk factor for CHD comorbidity in MDD patients is evaluated. (hindawi.com)
The expanded use of 4F-PCC was associated with a less robust reduction in the international normalized ratio (INR) (INR of -0.7 ± 1.3 vs INR of -1.6 ± 1.8, P = .002), and fewer patients in the nVKA group achieved a postadministration INR of less than1.5 (11% vs 79%, P = .001) than those in the VKA group. (bvsalud.org)

Menstrual bleeding, pregnancy and delivery present an intrinsic haemostatic challenge to women with bleeding disorders such as factor XI (FXI) deficiency. (rug.nl)

High levels of factor XI have been implicated in thrombosis, although it is uncertain what determines these levels and how serious the procoagulant state is. (wikipedia.org)
[ 7 ] In a mouse model, factor XI appears to play a greater role in thrombosis than in hemostasis. (medscape.com)
On the other hand, a study by Georgi et al indicated that in persons genetically disposed to lower concentrations of factor XI, the risk of venous thrombosis and ischemic stroke are reduced. (medscape.com)
The authors suggested that the risk of venous thrombosis and ischemic stroke may be significantly reduced by pharmacologic inhibition of factor XI, with no clear evidence demonstrating that this therapy would increase the risk for major bleeding. (medscape.com)
The hope that factor XI inhibitors will prevent pathologic thrombosis with a lower bleeding risk compared to other anticoagulants comes down to the role of factor XI in the coagulation cascade. (medscape.com)
Another doctor involved in the field, Manesh Patel, MD, chief of cardiology at Duke University Medical Center, added, "We think that factor XI inhibitors may prevent the pathologic formation of thrombosis while allowing formation of thrombus for natural hemostasis to prevent bleeding. (medscape.com)

It can be activated in vitro by activated factor XII (XIIa). (medscape.com)

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bbb complex (C3 convertase) and the (C3b)nbb complex (C5 convertase) in the alternative complement pathway. (lu.se)
This report summarizes two new recommendations approved by ACIP: 1) routine vaccination of adolescents, preferably at age 11 or 12 years, with a booster dose at age 16 years and 2) a 2-dose primary series administered 2 months apart for persons aged 2 through 54 years with persistent complement component deficiency (e.g. (cdc.gov)

Asakai R, Chung DW, Davie EW, Seligsohn U. Factor XI deficiency in Ashkenazi Jews in Israel. (medscape.com)

11. Why don't they tell the truth, that Vitamin D deficiency is a major risk factor for serious illness? (blogspot.com)
Vitamin B12 deficiency: a factor that induces depression? (bvsalud.org)
The deficiency of vitamin B12 creates a case of hyperhomocysteinemia and decline of S-adenosylmethionine, which is a risk factor for depression without adequate treatment. (bvsalud.org)
This project had as an objective to verify the relation between depression and the deficiency of vitamin B12, through literary revision. (bvsalud.org)

Bleeding associated with FXI deficiency is predictable neither within a patient nor within a family. (medscape.com)
In contrast to hemophilias A and B, bleeding manifestations in FXI deficiency often show little correlation with the FXI level. (medscape.com)
Aim: To provide a systematic overview of studies on gynaecological and obstetrical bleeding problems in women with FXI deficiency. (rug.nl)
Conclusion: Women with FXI deficiency have a clearly increased risk of HMB, and of bleeding complications after miscarriage, TOP and delivery. (rug.nl)
1) An affected patient may show a variable bleeding tendency that depends on the level of Factor XI present. (medicalalgorithms.com)
1b) A patient with a major factor deficiency may experience excessive bleeding. (medicalalgorithms.com)
3) The bleeding may be worse after aspirin or if other coagulation deficiencies are present. (medicalalgorithms.com)
Marked decreases in factor XI are indicative of a mild bleeding diathesis. (medscape.com)
The problem, therefore, with anticoagulants used to date that block one of these factors is that they prevent clotting but also cause bleeding. (medscape.com)
By repeatedly triggering bleeding into muscles and joints, deficiency produces hemophilic arthropathy and contractures. (novumprs.com)
The management of bleeding episodes includes infusions of clotting factor, which is derived from human blood or by recombinant DNA technology. (en-academic.com)
Severe deficiency can present with catastrophic bleeding in infancy. (roche.com)

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