• Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. (sigmaaldrich.com)
  • It was observed that tumor cells strongly accelerate plasma coagulation as a result of: i) expression of the blood clotting initiator protein, a tissue factor, as shown by flow cytometry and functional assays (factor Xa formation in the presence of cells and factor VIIa), and ii) direct activation of prothrombin to thrombin by cells, as evidenced by hydrolysis of the synthetic substrate, S-2238, and the natural substrate, fibrinogen. (scielo.br)
  • The prothrombinase complex is the enzymatic complex responsible for timely thrombin formation at the place of vascular injury and is composed of the enzyme, factor Xa (fXa), the non-enzymatic cofactor factor Va (fVa), and the substrate prothrombin assembled on a lipid membrane in the presence of divalent metal ions. (csuohio.edu)
  • The heparin-antithrombin complex then inactivates thrombin, activated factor X (fXa), and other activated clotting factors. (acponline.org)
  • The ability of factor VIIa to cleave other clotting factors depends on binding to its cofactor tissue factor (TF), which is expressed on the surface of endothelial cells and monocytes in response to injury or inflammation. (medscape.com)
  • With formation of the TF/VIIa complex, factor VIIa rapidly activates clotting factors VII, IX, and X, initiating the coagulation cascade. (medscape.com)
  • Five identified allelic polymorphisms also affect plasma levels of factor VII and factor VIIa, with variations of as much as 25-30% in levels of activity and antigen. (medscape.com)
  • Tissue factor (TF) is a 47-kDa membrane-bound protein that serves as a receptor and co-factor for the enzyme factor VIIa (FVIIa), with subsequent formation of the extrinsic tenase complex that converts factor X (FX) to FXa (2). (scielo.br)
  • An important natural anticoagulant, APC inactivates factors Va and VIIa. (medscape.com)
  • The United States has compensated military veterans for service-related injuries since the Revolutionary War, with the current indemnity model established near the end of World War I. The Department of Veterans Affairs (VA) began to provide disability benefits for post-traumatic stress disorder (PTSD) in the 1980s after the diagnosis became part of official psychiatric nosology. (wikipedia.org)
  • The Veterans Benefits Administration (VBA), a component of the Department of Veterans Affairs, processes disability claims and administers all aspects of the VA disability program. (wikipedia.org)
  • The United States Department of Veterans Affairs (VA) provides benefits to veterans whom the VA has determined have PTSD that developed during, or as a result of, their military service. (wikipedia.org)
  • Today, Representatives Gerry Connolly (D-VA) and Nancy Mace (R-SC), the Ranking Member and Chairwoman of the Subcommittee on Cybersecurity, Information Technology, and Government Innovation, introduced the Not Just a Number Act, bipartisan legislation to require the Department of Veterans Affairs (VA) to take a more comprehensive look at the factors that best prevent veteran suicide. (house.gov)
  • We examined the prevalence of nicotine dependence and its associated risk factors among veterans who used health services in the US Department of Veterans Affairs (VA) system. (cdc.gov)
  • 2015). Additional work extended the validation to include a sample of Department of Veterans Affairs (VA) administrative parents (collection of all the points of service that a VA leadership group manage, N=140), testing the dimensionality of the instrument in both samples (J. A. Williams et al. (cdc.gov)
  • Influencing Factors Associated with Implementation of INTERACT (Interventions to Reduce Acute Care Transfers) in VA Community Living Centers (CLCs) Using the Consolidated Framework. (bvsalud.org)
  • The Consolidated Framework was used to evaluate implementation data from eight VA Community Living Centers. (bvsalud.org)
  • Limitations The sample included only veterans who had surgeries at VA Medical Centers and cannot be generalized to veterans with surgeries outside the VA or to nonveteran patients and settings. (highwire.org)
  • It's one of the more disturbing revelations to arise from an investigation into fatal delays in care at Veterans Affairs medical centers: Employee bonuses appear to be one factor behind the manipulation of patient wait times in at least one hospital. (cnn.com)
  • The VA secretary's audit of a number of medical centers that concluded "some front-line, middle, and senior managers felt compelled to manipulate" the scheduling process to meet performance goals established by the agency. (cnn.com)
  • The coagulation system leans on a delicate balance between coagulant and anticoagulant factors. (csuohio.edu)
  • Computations include phase angle, apparent and reactive power, consumption and cost, and power factor correction. (goodmart.com)
  • Specific factor VII assays are required for diagnosis. (medscape.com)
  • Factor assays in family members are indicated to identify other affected individuals. (medscape.com)
  • Heterozygous carriers of factor V Leiden typically have APCR ratios in the range of 1.5 -1.8. (medscape.com)
  • The assay is highly sensitive and specific for factor V Leiden, with excellent discrimination between normal individuals and factor V Leiden heterozygous carriers. (medscape.com)
  • The risk of recurrent venous thromboembolism in heterozygous carriers of factor V Leiden and a first spontaneous venous thromboembolism. (msdmanuals.com)
  • Using VA data, investigators identified 43,257 Veterans who were offered lung cancer screening by a VA physician between 2013 and 2021 at any of 30 VA facilities. (va.gov)
  • Núñez E, Caverly T, Zhang S, Glickman M, Qian S, Boudreau J, Miller D, Slatore C, and Wiener R. Factors Associated with Declining Lung Cancer Screening after Discussion with a Physician in a Cohort of US Veterans. (va.gov)
  • Given the high level of need of these returning Veterans and possible barriers to care, it is important to understand correlates of overall mental health service use, as well as use of VA versus community mental health services. (va.gov)
  • These data will inform both VA and community systems who are attempting to treat Veterans in need. (va.gov)
  • The Veterans Choice Program is expected to expand healthcare access to thousands of Veterans by alowing them to receive care from non-VA healthcare providers. (va.gov)
  • Some research suggests that VA disability benefits achieve their goal of helping veterans who have PTSD. (wikipedia.org)
  • Veterans who file a disability claim due to PTSD almost always receive a compensation and pension examination (C&P exam) by VA-employed or VA-contracted psychologists or psychiatrists. (wikipedia.org)
  • By manipulating doctor's appointments for the veterans, the wait time to see a doctor appeared to be shorter, a factor considered in VA employee bonuses and raises, according to a VA inspector general report said. (cnn.com)
  • The House Committee on Veterans Affairs also asked the question during a combative hearing this week, where Rep. Dan Benishek, R-Michigan, inquired whether there was a financial motivation to manipulate appointment schedules at the Phoenix VA. (cnn.com)
  • The issue of patient wait times is not an overall performance factor ordered by the VA, Lynch recently told the House Committee on Veterans Affairs. (cnn.com)
  • As a result of the audit, the VA suspended financial incentives - bonuses and salary increases - for all Veterans Health Administration executives for the 2014 fiscal year. (cnn.com)
  • Major risk and protective factors within the subgroups of homeless veterans and veterans who served in Iraq and Afghanistan were broadly similar to those in the general VA population. (cdc.gov)
  • Given that other studies have found higher rates of nicotine dependence among veterans, this risk behavior may be underdiagnosed in VA medical records. (cdc.gov)
  • However, most veterans who smoke and use VA health services report they do not receive tobacco cessation treatment (7). (cdc.gov)
  • Research is inadequate on nicotine dependence in 2 groups of particular interest to the VA health system: homeless veterans and veterans who served in Iraq and Afghanistan in Operation Iraqi Freedom and Operation Enduring Freedom (OIF/OEF). (cdc.gov)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
  • Although no single laboratory test is diagnostic of RA, the presence of both anti-cyclic citrullinated protein antibody (ACPA) and rheumatoid factor (RF) positivity is highly specific for this condition. (medscape.com)
  • Blood coagulation involves a series of zymogen acti-vation reactions that are mainly performed by enzyma- tic complexes consisting of a serine protease, a protein co-factor and membranes containing anionic phospholipids (1). (scielo.br)
  • Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
  • The activated protein C resistance assay is a screening test for the presence of factor V Leiden. (msdmanuals.com)
  • In patients with homozygous or heterozygous factor V Leiden resistance , the prolongation of the clotting time is significantly reduced because their factor V is resistant to cleavage by activated protein C. (msdmanuals.com)
  • Dr. William Ershler, MD is a Hematology Specialist in Fairfax, VA. (sharecare.com)
  • Dr. William Ershler, MD is a Hematology Specialist in Fairfax, VA and has 45 years experience. (sharecare.com)
  • Heparin resistance can also occur with increased clearance of heparin or an increase in acute phase reactant proteins such as factor VIII, which can bind to and neutralize heparin. (acponline.org)
  • The APCR assay uses snake venoms to activate factor V and prothrombin, thus triggering the lower portion of the clotting pathway and eliminating interference by factor VIII and by lupus anticoagulants (in the absence of phospholipid complexes). (medscape.com)
  • Inherited factor VII (FVII) deficiency is a rare autosomal recessive hemorrhagic disorder. (medscape.com)
  • Inherited factor VII deficiency can be classified as type 1 or type 2, depending on the absence or presence of factor VII antigen in plasma. (medscape.com)
  • Although individuals with the lowest factor VII levels are most likely to be symptomatic, patients with identical mutations may have marked differences in clinical bleeding, suggesting that other factors may contribute to the clinical manifestations of factor VII deficiency. (medscape.com)
  • This ability was highly potentiated by the addition of exogenous factor Va, which functions as a co-factor for the enzyme factor Xa. (scielo.br)
  • In contrast, prothrombin activation was not observed when cells were previously incubated with DEGR-factor Xa, an inactive derivative of the enzyme. (scielo.br)
  • We have identified the molecular defect in factor V Leiden and we have delineated specific amino acid regions on the factor V/Va molecule that are crucial for their functions. (csuohio.edu)
  • Homozygotes for factor V Leiden usually have APRC ratios of less than 1.5. (medscape.com)
  • In the vast majority of cases, the patient with APCR carries the Leiden variant of factor V, in which the APC cleavage site on factor V is altered. (medscape.com)
  • The factor V Leiden mutation is not uncommon, with the heterozygous carrier state occurring in up to 5% of the US population. (medscape.com)
  • Factor V Leiden is found in 30-50% of patients with recurrent venous thromboembolism (VTE) and is the most common hereditary cause of thrombosis. (medscape.com)
  • Patients with abnormal APCR ratios should have genetic testing to confirm factor V Leiden mutation status. (medscape.com)
  • Karmacharya P, Aryal MR, Donato A. Mesenteric vein thrombosis in a patient heterozygous for factor V Leiden and G20210A prothrombin genotypes. (medscape.com)
  • Factor V Leiden is the most common of these mutations. (msdmanuals.com)
  • Ethnic distribution of factor V Leiden in 4047 men and women. (msdmanuals.com)
  • Confirmation of factor V Leiden is then done by DNA-based testing for the mutation. (msdmanuals.com)
  • More than 100 mutations, mostly missense mutations, have been identified in the factor VII gene located on chromosome 13. (medscape.com)
  • Any of several mutations to factor V make it resistant to inactivation by APC, increasing the tendency for thrombosis. (msdmanuals.com)
  • Although sustained VA can occur in apparently normal hearts, approximately 50% of patients have either CHD or myopathy. (medscape.com)
  • Patients with VA and their families must know how to perform cardiopulmonary resuscitation (CPR) and how to contact local emergency medical services (EMS) to promptly begin therapy or prevent excessive therapy, as warranted. (medscape.com)
  • Little is known about how frequently patients decline LCS when it is offered, or factors associated with their decision. (va.gov)
  • This retrospective cohort study sought to determine how frequently patients decline LCS when it is offered by a physician - and to define patient and facility-level factors associated with their decision. (va.gov)
  • Design A cross-sectional study of 12,599 patients, who underwent major surgical amputation of the lower limb at a VA medical center from January 1, 2005, to December 31, 2010, was conducted. (highwire.org)
  • Since 1988 VA disability claim decisions have been subject to federal court review. (wikipedia.org)
  • Investigations to determine the contribution by factor VII polymorphisms, other hemostatic proteins, and environmental factors have not yielded specific predictors of bleeding risk. (medscape.com)
  • Independent risk and protective factors associated with receiving a nicotine dependence diagnosis were identified using logistic regression analysis. (cdc.gov)
  • This chapter focuses on the epidemiological, mechanistic, and treatment aspects of EVA and what can be learned about protective factors associated with SUPERNOVA. (lu.se)
  • Risk Factor™ is a free tool created by the nonprofit First Street Foundation® to make it easy to understand risks from a changing environment. (riskfactor.com)
  • Get notified when something new launches on Risk Factor! (riskfactor.com)
  • Wind Factor® risk based on the projected likelihood and speed of hurricane, tornado, or severe storm winds impacting it. (redfin.com)
  • At present, classification based on clinical history (age and type of presentation) rather than on factor VII activity levels has proved to be more useful in predicting future risk of bleeding. (medscape.com)
  • on behalf of the Diabetes Control and Complications Trial/Epidemi-ology of Diabetes Interventions and Complications (DCCT/EDIC) studies, assessed the effects of prior intensive insulin treatment and risk factors on patient-reported visual function in this DCCT/EDIC cohort. (aao.org)
  • Substance abuse, other mental health diagnoses, and homelessness were identified as major risk factors. (cdc.gov)
  • In some individuals, this process is taking a more rapid course, so called early vascular aging (EVA), with increased aortic PWV, even adjusted for other age, sex, and other hemodynamic variables as well as cardiovascular risk factors. (lu.se)
  • However, in other more fortunate individuals, the vascular tree seems to be remarkably protected from such aging phenomena, even under the same risk factor burden-a variant of more healthy VA or even supernormal vascular aging (SUPERNOVA). (lu.se)
  • The popularity of account receivable factoring in Richmond VA is on the rise, and for good reason. (neebocapital.com)
  • With account receivable factoring in Richmond VA, you can receive reliable credit investigation for all prospective customers so that you can identify the ones who are likely to cause problems. (neebocapital.com)
  • Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma. (sigmaaldrich.com)
  • on behalf of the Diabetic Retinopathy Clinical Research Net-work, reported additional outcomes from a randomized trial comparing aflibercept, bevacizumab, and ranibi-zumab for diabetic macular edema (DME) within subgroups based on baseline visual acuity (VA) and central subfield thickness (CST). (aao.org)
  • Prespecified subgroups were established according to baseline VA and CST. (aao.org)
  • It is recommended to hire a professional basement renovation Alexandria VA contractor is recommended when you're looking to DIY. (thedailycryptocurrencynews.com)
  • Alexandria, VA: Army Research Institute. (bvsalud.org)
  • and feeding on protection against obesity, postpartum factors (infant admitted to type 2 diabetes, acute leukaemia and Methods the neonatal care unit, when infant was colic [1-3]. (who.int)
  • Investigators also assessed patient demographics, VA priority status, and comorbidities. (va.gov)
  • Factor VII is one of the vitamin K-dependent coagulation factors synthesized in the liver. (medscape.com)
  • Activation of factor VII is the initiating event of in vivo coagulation. (medscape.com)
  • Our objective was to identify the influencing factors associated with the implementation of the INTERACT (Interventions to Reduce Acute Care Transfers) Quality Improvement program within a national healthcare system . (bvsalud.org)
  • Qualitative implementation data suggest two influencing Consolidated Framework domains had a strong influence 1) key attributes of the intervention (e.g., adaptability or complexity) and 2) internal organizational factors (e.g., culture or compatibility). (bvsalud.org)
  • Separate multivariate logistic regressions examined the impact of guideline implementation and identified factors associated with service receipt. (highwire.org)
  • To do so, 3 category of variables including 1- Human factors, 2- Biophysical factors and 3- Instrumental and logistic factors that contained altogether 26 variables are studied. (ac.ir)
  • Social scientists and others have expressed concern about the consistency and accuracy of PTSD C&P exam findings, although the VA generally rejects such concerns as unfounded or exaggerated. (wikipedia.org)
  • These post hoc secondary findings suggest that for eyes with better initial VA and thicker CST, some VA outcomes may be worse in the bevacizumab group than in the aflibercept and ranibizumab groups. (aao.org)
  • Moreover, a monoclonal antibody against bovine factor Xa reduced the prothrombin-converting activity of tumor cells. (scielo.br)
  • The aim of this study was to determine the prevalence of exclusive breastfeeding in Tehran, Islamic Republic of Iran in the first 6 months of life, and the factors that influence it. (who.int)
  • Using Afb and the previously determined branching ratio, q2 distribution, and D* polarization, we obtain the first measurement of the form-factor ratios that are used to describe this semileptonic decay. (ku.edu)
  • Objectives The purposes of this study were: (1) to describe the utilization of rehabilitative services in the acute care setting by people who underwent major lower limb amputation in the VA from 2005 to 2010, (2) to identify factors associated with receipt of rehabilitation services, and (3) to examine the impact of the guidelines on service receipt. (highwire.org)
  • Management of acute hemorrhage primarily consists of factor VII replacement therapy to treat bleeding. (medscape.com)
  • Vascular aging (VA) is a reflection of biological aging in general and subject to many influences during the life course. (lu.se)
  • Prior to 2014, VA C&P examiners determined if a veteran had PTSD based on DSM-IV diagnostic criteria for the disorder. (wikipedia.org)
  • Leidos seeks a Consulting Employee to support FHWA's Human Factors Onsite Support Services Contract for FHWA's Safety and Operations programs, and lead the research under this program. (leidos.com)
  • Click here to check amazing Va Voom Vintage content for Pakistan. (accessify.com)
  • Using a case-control design, we compared all VA health service users in fiscal year 2008-2009 (N = 5,031,381) who received a nicotine dependence diagnosis with those who did not. (cdc.gov)
  • Among all recent VA health service users, 15% (n = 749,353) received a diagnosis of nicotine dependence. (cdc.gov)
  • Let us help you preserve your integrity as a brand by increasing the security level in your organization with Multi-Factor Authentication Solutions. (m3tc.com)
  • Thus, Department of Veteran Affairs (VA) provides smoking cessation interventions and programs to its health system users (5,6). (cdc.gov)
  • Identifying veteran characteristics related to tobacco use can clarify who is most likely to benefit from smoking prevention and cessation interventions and may enhance VA efforts to reduce smoking and smoking-related illnesses. (cdc.gov)
  • APC resistance (APCR) is a hypercoagulability disorder in which factor V cannot be inactivated by APC. (medscape.com)
  • But as it stands now, the VA is limited in the data it can use to study and ultimately prevent veteran suicide. (house.gov)
  • Currently, when the VA analyzes veteran suicide data, they do not have access to whether a veteran utilized education opportunities, job training, housing, or full disbursement of benefits. (house.gov)
  • The Not Just a Number Act would require the VA to examine benefits usage in their annual suicide prevention report in order to evaluate the relationship between VA benefits and veteran suicide. (house.gov)
  • The bill would also have VA analyze which benefits have the greatest impact on preventing suicide, and require the Department to issue recommendations for expansion of those benefits in their fight to combat veteran suicides. (house.gov)
  • Today, God's Country: The New Zealand Factor launches. (peta.org)
  • 2015). Validation in the VA sample also showed the Indicators of Integration to be reliable (J. A. Williams et al. (cdc.gov)