• The structure reveals an RNA-engaged helicase atop the non-catalytic core, with RNA captured within the central channel and DIS3 exoribonuclease active site. (rcsb.org)
  • Schizosaccharomyces pombe 5'-3' exoribonuclease Dhp1 (dhp1), mRNA. (genscript.com)
  • An 3'-5'-exoribonuclease that specifically recognizes RNAs. (expasy.org)
  • Exoribonuclease Nibbler was identified to module Piwi-interacting RNAs (piRNAs). (zymoresearch.com)
  • Our data support the wide distribution of previously experimentally characterized exoribonuclease resistant RNAs (xrRNAs) within tick-borne and no-known-vector flaviviruses and provide evidence for the existence of a cascade of duplicated RNA structures within insect-specific flaviviruses. (nih.gov)
  • The nidovirus 3'-5' exoribonuclease (ExoN) domain may enhance the fidelity of RNA synthesis by correcting nucleotide incorporation errors made by the RNA-dependent RNA polymerase. (expasy.org)
  • Subtle structural differences of nucleotide analogs may impact SARS-CoV-2 RNA-dependent RNA polymerase and exoribonuclease activity. (cdc.gov)
  • Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR. (nih.gov)
  • Identification of phlebovirus and arenavirus RNA sequences that stall and repress the exoribonuclease XRN1. (nih.gov)
  • Exoribonucleases are involved in the degradation of many different RNA species, including messenger RNA, transfer RNA, ribosomal RNA and miRNA. (wikipedia.org)
  • Exoribonucleases can be single proteins (such as RNase D or RNase PH) but also can be complexes of multiple proteins, such as the exosome complex (in which four of the major exoribonuclease families are represented). (wikipedia.org)
  • Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (thermofisher.com)
  • This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. (novusbio.com)
  • An exoribonuclease is an exonuclease ribonuclease, which are enzymes that degrade RNA by removing terminal nucleotides from either the 5' end or the 3' end of the RNA molecule. (wikipedia.org)
  • Exoribonucleases can use either water to cleave the nucleotide-nucleotide bond (which is called hydrolytic activity) or inorganic phosphate (which is called phosphorolytic activity). (wikipedia.org)
  • Hydrolytic exoribonucleases are classified under EC number 3.1 and phosphorolytic exoribonucleases under EC number 2.7.7. (wikipedia.org)
  • Canis lupus familiaris 5'-3' exoribonuclease 2 (XRN2), mRNA. (genscript.com)
  • Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. (figshare.com)
  • With the aim to identify novel SARS-CoV-2 antivirals, we have purified the exoribonuclease/methyltransferase (nsp14) and its cofactor (nsp10) and developed biochemical assays compatible with high-throughput approaches to screen for exoribonuclease inhibitors. (figshare.com)
  • We have screened a library of over 5000 commercial compounds and identified patulin and aurintricarboxylic acid (ATA) as inhibitors of nsp14 exoribonuclease in vitro. (figshare.com)
  • 2022. Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors. (nih.gov)
  • Non-structural protein 10 (nsp10) is a conserved stimulator of two enzymes crucial for viral replication, nsp14 and nsp16, exhibiting exoribonuclease and methyltransferase activities. (rcsb.org)
  • An exoribonuclease is an exonuclease ribonuclease, which are enzymes that degrade RNA by removing terminal nucleotides from either the 5' end or the 3' end of the RNA molecule. (wikipedia.org)
  • Enzymes that remove nucleotides from the 5' end are called 5'-3' exoribonucleases, and enzymes that remove nucleotides from the 3' end are called 3'-5' exoribonucleases. (wikipedia.org)
  • In mammals, uridylated pre-let-7 miRNAs and mRNAs are targeted by the 3' to 5' exoribonuclease DIS3L2. (nih.gov)
  • The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. (waw.pl)
  • RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. (kegg.jp)
  • Abstract Polynucleotide phosphorylase (PNPase) can be an important mitochondria-localized exoribonuclease implicated in multiple natural processes and individual disorders. (bioskinrevive.com)
  • Results suggest that the RNase D family, which includes Werner syndrome protein and the 100 kDa antigenic component of the human polymyositis scleroderma (PMSCL) autoantigen, is a 3'-->5' exoribonuclease structurally and functionally related to the 3'-->5' exodeoxyribonuclease domain of DNA polymerases. (embl.de)
  • Exoribonucleases can be single proteins (such as RNase D or RNase PH) but also can be complexes of multiple proteins, such as the exosome complex (in which four of the major exoribonuclease families are represented). (wikipedia.org)
  • RNase R is an E. coli exoribonuclease which exhibits 3' to 5' exonuclease activity, efficiently digesting nearly all linear RNA species. (mclab.com)
  • Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. (expasy.org)
  • Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA. (expasy.org)
  • Exoribonucleases are involved in the degradation of many different RNA species, including messenger RNA, transfer RNA, ribosomal RNA and miRNA. (wikipedia.org)
  • With the recent discovery of roles for microRNAs in gene expression, it was reported that the HCV RNA genome subverts liver-specific microRNA miR-122 to protect its 5' end from degradation by host cell exoribonucleases. (medscape.com)
  • Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (thermofisher.com)
  • 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (nih.gov)
  • The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. (gzsys.org.cn)
  • Molecular function: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends. (expasy.org)
  • Enables 3'-5'-exoribonuclease activity. (nih.gov)
  • 2019). Whether such a specific activity exists in organisms that lack Orn-type exoribonucleases remained unclear. (cornell.edu)
  • The structures, together with comparative genomic analyses of the phylogeny of DEDD-type exoribonucleases, indicate convergent evolution as the mechanism of how dinucleotidase activity emerged repeatedly in various organisms. (cornell.edu)
  • Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast ( Saccharomyces cerevisiae ) exosome, which is an RNA-processing complex consisting of 11 3' → 5' exoribonucleases. (biomedcentral.com)