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  • gene
  • Exons are predicted and reconstructed in the same run providing the complete gene structure for the protein query of interest. (biomedcentral.com)
  • WebScipio offers high quality gene structure figures with the clusters of mutually exclusive exons colour-coded, and several analysis tools for further manual inspection. (biomedcentral.com)
  • Mutation
  • The mechanism behind exon skipping is a mutation specific antisense oligonucleotide (AON). (wikipedia.org)
  • An antisense oligonucleotide is a synthesized short nucleic acid polymer, typically fifty or fewer base pairs in length that will bind to the mutation site in the pre-messenger RNA, to induce exon skipping. (wikipedia.org)
  • eukaryotes
  • Moreover, to define more precisely the time when exon shuffling became significant in eukaryotes, the evolutionary distribution of modular proteins that evolved through this mechanism were examined in different organisms (i.e. (wikipedia.org)
  • Evolution of eukaryotes is mediated by sexual recombination of parental genomes and since introns are longer than exons most of the crossovers occur in noncoding regions. (wikipedia.org)
  • Governor
  • Exon was Chair of the Nebraska Democratic Party in 1970 when he decided to run for Governor. (wikipedia.org)
  • Exon was re-elected in a landslide in 1974 and became the first Nebraska Governor to serve eight years in that position. (wikipedia.org)
  • 2017
  • The Korea Brain Research Institute (President Kyung-jin Kim) announced on Wednesday February 8, 2017 that an international collaborative research team including Senior Researcher Yun Ha Jeong succeeded in discovering a phenomenon that cryptic exons that are related to Lou Gehrig's Disease and Frontotemporal Dementia (FTD) are highly variable depending on the cell types. (eurekalert.org)
  • Tdp-43 Cryptic Exons are Highly Variable between Cell Types," Molecular Neurodegeneration 2017. (eurekalert.org)
  • Exon was recruited by Carlton as a rookie player before the 2017 season. (wikipedia.org)
  • On 25 May 2017, Exon was, along with Isabella Ayre, traded to Brisbane in a complex trade involving four teams, five players, and a draft pick. (wikipedia.org)
  • occurs
  • There are different mechanisms through which exon shuffling occurs: transposon mediated exon shuffling, crossover during sexual recombination of parental genomes and illegitimate recombination. (wikipedia.org)
  • Dystrophin can maintain a large degree of functionality so long as the essential terminal domains are unaffected, and exon skipping only occurs within the central rod domain. (wikipedia.org)
  • transcript
  • These changes affect some of the transcript cluster and exon cluster IDs. (affymetrix.com)
  • Corrected: There were some cases where the first exon of a transcript was incorrectly treated as a separate transcript. (affymetrix.com)
  • This field is set with the transcript_cluster_id, not exon level probe set id. (affymetrix.com)
  • Amendment
  • He helped sponsor the Exon-Florio Amendment, which prevented takeovers or mergers by foreign companies of U.S. companies, if said merger was found to be a threat to national security. (wikipedia.org)
  • The Exon-Florio Amendment 50 U.S.C. app 2170 is a law that was enacted by the United States Congress in 1988 to review foreign investment within the United States. (wikipedia.org)
  • Site
  • le classique o on enl ve un exon de mani re alternative un site donneur alternatif un site accepteur alternatif les exons mutuellement exclusifs et la r tention d'introns. (futura-sciences.com)
  • found
  • however, whether they are also found in exons, the coding regions of DNA, is unclear. (sciencemag.org)
  • analyzed 25 mouse and human enhancer-associated ChIP-seq data sets in order to identify enhancer peaks that overlap exons and found regulatory transcription factor binding to exonic regions. (sciencemag.org)
  • regions
  • In this paper we concentrate on short initial exons and present a method to improve the detection of these short coding regions. (springer.com)
  • The term exon derives from the expressed region and was coined by American biochemist Walter Gilbert in 1978: "The notion of the cistron… must be replaced by that of a transcription unit containing regions which will be lost from the mature messenger - which I suggest we call introns (for intragenic regions) - alternating with regions which will be expressed - exons. (wikipedia.org)
  • The introns are later removed before the protein is made, leaving only the coding exon regions. (wikipedia.org)
  • It is known that these mutations cluster in areas known as the 'hot spot' regions - primarily in exons 45-53 and to a lesser extent exons 2-20. (wikipedia.org)
  • As the majority of DMD mutations occur in these 'hot spot' regions, a treatment which causes these exons to be skipped could be used to treat up to 50% of DMD patients. (wikipedia.org)
  • normally
  • Due to his ability to control expenditures and his reluctance to raise taxes, Exon won the support of many Nebraskans who normally voted Republican. (wikipedia.org)
  • functional
  • Absence of an exon-encoded enhancer, however, did have functional consequences. (sciencemag.org)
  • Successful treatment by way of exon skipping could lead to a mostly functional dystrophin protein, and create a phenotype similar to the less severe Becker muscular dystrophy (BMD). (wikipedia.org)
  • Thus
  • Given these parameters, exon skipping can be used to restore an open reading frame by inducing a deletion of one or several exons within the central rod domain, and thus converting a DMD phenotype into a BMD phenotype. (wikipedia.org)
  • role
  • Therefore, exon shuffling became a major role in the construction of younger proteins. (wikipedia.org)
  • In the report, Exon warned of the dangers if such weapons fell into the hands of terrorists and recommended the formation of an agency with a similar role to the Department of Homeland Security. (wikipedia.org)
  • specific
  • Senior Researcher Yun Ha Jeong from the Korea Brain Research Institute said, "This study suggests that Tdp-43 proteinopathy and specific cryptic exons are involved in the process of degenerative brain and muscle disorders in a unique way. (eurekalert.org)
  • different
  • Additionally exons can be classified into nine different groups based on the phase of the flanking introns (symmetrical: 0-0, 1-1, 2-2 and asymmetrical: 0-1, 0-2, 1-0, 1-2, etc. (wikipedia.org)
  • another
  • Some mutations require exon skipping at multiple sites, sometimes adjacent to one another, in order to restore the reading frame. (wikipedia.org)
  • data
  • To do this, I'd like to combine expression data (RNA-seq or Microarray) and exons data (UCSC track). (mail-archive.com)
  • I've started learning Galaxy and was able to import BED files for UCSC exons (as in the Galaxy 101 tutorial) and a BED file for Affy microarray expression data. (mail-archive.com)
  • common
  • a) While some cryptic exons are common between cell types, many cryptic exons are unique to neurons (58), muscle (79) and stem cells . (eurekalert.org)