• AMPA
  • α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists are of potential interest for the treatment of certain acute and chronic neurodegenerative diseases, including amyotrophic lateral sclerosis. (aspetjournals.org)
  • occur
  • Graded potentials that occur at approximately the same time on a membrane are summed. (brainscape.com)
  • Backpropagating action potentials cannot occur because after an action potential travels down a given segment of the axon, the voltage gated sodium channels' (Na+ channels) m gate becomes closed, thus blocking any transient opening of the h gate from causing a change in the intracellular [Na+], and preventing the generation of an action potential back towards the cell body. (wikipedia.org)
  • Scaling has been found to occur when the strength of all of a neuron's excitatory inputs are scaled up or down. (wikipedia.org)
  • neuronal
  • Kainic acid is utilised in primary neuronal cell cultures and acute brain slice preparations to study of the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics. (wikipedia.org)
  • AMPAR
  • This is because they lack surface AMPAR to pass current at hyperpolarized potentials, but do possess NMDARs that will pass current at more positive potentials (because of relief of magnesium block). (wikipedia.org)
  • axon
  • Propagation of an action potential on the membrane of an axon. (brainscape.com)
  • Refers to the state of an axon in the repolarizing period during which a new action potential cannot be elicited (with some exceptions), because gate 2 of sodium channels, which is not voltage sensitive, is closed. (brainscape.com)
  • If the sum of the input signals into one neuron surpasses a certain threshold, the neuron sends an action potential (AP) at the axon hillock and transmits this electrical signal along the axon. (wikipedia.org)
  • occurs
  • We have recently discovered a phenomenon that may be related to intestinal hypersensitivity and hyper-reflexia, sustained slow postsynaptic excitation (SSPE), which occurs in intrinsic sensory neurones of the small intestine. (bmj.com)
  • response
  • The Bienenstock, Cooper and Munro model (BCM model) proposes that a certain threshold exists such that a level of postsynaptic response below the threshold leads to LTD and above it leads to LTP. (wikipedia.org)
  • current
  • The current is activated at around −60 mV, making it able to generate a low-threshold spike at or near the resting potential. (wikipedia.org)