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  • AMPA
  • α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonists are of potential interest for the treatment of certain acute and chronic neurodegenerative diseases, including amyotrophic lateral sclerosis. (aspetjournals.org)
  • axon
  • Propagation of an action potential on the membrane of an axon. (brainscape.com)
  • Refers to the state of an axon in the repolarizing period during which a new action potential cannot be elicited (with some exceptions), because gate 2 of sodium channels, which is not voltage sensitive, is closed. (brainscape.com)
  • Play media In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise. (wikipedia.org)
  • If the sum of the input signals into one neuron surpasses a certain threshold, the neuron sends an action potential (AP) at the axon hillock and transmits this electrical signal along the axon. (wikipedia.org)
  • Backpropagating action potentials cannot occur because after an action potential travels down a given segment of the axon, the voltage gated sodium channels' (Na+ channels) m gate becomes closed, thus blocking any transient opening of the h gate from causing a change in the intracellular [Na+], and preventing the generation of an action potential back towards the cell body. (wikipedia.org)
  • neuronal
  • Kainic acid is utilised in primary neuronal cell cultures and acute brain slice preparations to study of the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics. (wikipedia.org)
  • AMPAR
  • This is because they lack surface AMPAR to pass current at hyperpolarized potentials, but do possess NMDARs that will pass current at more positive potentials (because of relief of magnesium block). (wikipedia.org)
  • stimuli
  • For example, repetitive presentation of sound stimuli can lead to a long-lasting increase in the auditory-evoked potential in human and mouse cortex as assessed, respectively, with surface electrodes and transcranial fluorescence imaging ( 20 , 21 ). (pnas.org)
  • response
  • The Bienenstock, Cooper and Munro model (BCM model) proposes that a certain threshold exists such that a level of postsynaptic response below the threshold leads to LTD and above it leads to LTP. (wikipedia.org)
  • receptor
  • Interictal and ictal epileptiform discharges restricted to the temporal region were induced by a brief (3,5 min) arterial perfusion of the GABAA receptor antagonist, bicuculline methiodide (50 ,M). Current source density analysis of laminar field profiles performed with the silicon probes was carried out at different sites to establish network interactions responsible for the generation of epileptiform potentials. (academicconcepts.net)
  • amino
  • The mGluRs in group I, including mGluR1 and mGluR5, are stimulated most strongly by the excitatory amino acid analog L-quisqualic acid. (wikipedia.org)
  • Results from both in vitro and in vivo experiments confirm that the pharmacological activity profiles of the two losigamone enantiomers are not identical and suggest further that excitatory amino acid-mediated processes are involved in the mode of action of (+)-losigamone (the compound shown in the image) whereas (-)-losigamone does not possess such properties. (wikipedia.org)
  • current
  • The term driving force is related to equilibrium potential, and is likewise useful in understanding the current in biological membranes. (wikipedia.org)
  • biological
  • Substance P is a key first responder to most noxious/extreme stimuli (stressors), i.e., those with a potential to compromise biological integrity. (wikipedia.org)
  • shown
  • It has been shown that patients treated for depression with transmucosal ketamine show no adverse side effects, though potential interactions with other drugs may cause adverse effects. (wikipedia.org)
  • animal
  • Epidemiological and animal studies have raised concern for their potential to induce developmental neurotoxicity (DNT). (springer.com)