• release
  • Here we present a protocol for evaluating Evans Blue extravasation in rodents with the aid of local application of capsaicin to initiate a neurogenic response exciting the local nociceptors, causing pain, axon reflex vasodilatation and plasma extravasation due to local release of inflammatory mediators. (scienceexchange.com)
  • active
  • Evans blue is pharmacologically active, acting as a negative allosteric modulator of the AMPA and kainate receptors and as an inhibitor of vesicular glutamate transporters. (wikipedia.org)
  • areas
  • Time-dependent studies showed gradual increases in the diameter and number of these heterogeneously sized leaky spots, which finally fused to sizes corresponding to the "blue areas" for EBA or "brown areas" for HRP. (ahajournals.org)
  • levels
  • The intensity of Evans Blue was decreased, and expression levels of zonula occluden-1 and claudin-5 were increased in the EPC group. (frontiersin.org)
  • model
  • In contrast, mdx mice, a dystrophin-deficient animal model for Duchenne muscular dystrophy, showed significant Evans blue accumulation in skeletal muscle fibers. (rupress.org)