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  • small-cell l
  • PURPOSE: This phase II trial is studying how well giving cisplatin, etoposide, and cyclophosphamide together works in treating patients with extensive-stage small cell lung cancer. (clinicaltrials.gov)
  • VePesid
  • four of them, including etoposide (Vepesid), were later marketed. (wikipedia.org)
  • Further chemical modifications led to the well-known thenylidene derivative VM-26 (teniposide, Vumon, discovered in October 1965, commercialized by Sandoz in 1976) and to the ethylidene derivative VP-16-213 (etoposide, Vepesid, discovered on October 21, 1966), which remains very clinically successful. (wikipedia.org)
  • tumors
  • Etoposide concentrations are higher in normal lung than in lung metastases and are similar in primary tumors and normal tissues of the myometrium. (drugs.com)
  • PRECAUTIONS
  • Data have suggested a significant inverse correlation between serum albumin concentration and free fraction of etoposide (see PRECAUTIONS ). (drugs.com)
  • treatment
  • The injectable form of etoposide will be stored at the hospital or clinic where you receive treatment. (pharmasave.com)
  • Etoposide is still considered a potent, well-tolerated combination partner in innumerable hematologic and solid tumor treatment schedules, including those for malignant lymphomas and lung cancer. (wikipedia.org)
  • determine
  • However, how much you have used and whether you took etoposide with other substances would determine the specific effects. (emedtv.com)
  • given
  • The amount of etoposide that you will receive and the method it is given depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. (chemocare.com)
  • This form of etoposide is always given under the direct supervision of a doctor. (pharmasave.com)
  • supervision
  • Etoposide should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (drugs.com)
  • free
  • The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA topoisomerase II or the formation of free radicals. (drugs.com)
  • found
  • An inverse relationship between plasma albumin levels and etoposide renal clearance is found in children. (drugs.com)