• Estrogen mediates its effects in target tissues through the activation of estrogen receptor subtypes: ERα and ERβ. (umassmed.edu)
  • To investigate the molecular bases of such differences, we performed a comparative computational analysis of the nuclear interactomes of the two ER subtypes, exploiting two datasets of receptor interacting proteins identified in breast cancer cell nuclei by Tandem Affinity Purification for their ability to associate in vivo with ligand- activated ER-a and/or ER-b. (unica.it)
  • These datasets comprise 498 proteins, of which only 70 are common to both ERs, suggesting that differences in the nature of the two ER interactomes are likely to sustain the distinct roles of the two receptor subtypes. (unica.it)
  • Thus, it is reasonable to suggest that a dysregulation of the two estrogen receptor subtypes may induce breast cancer development. (unical.it)
  • Because estrogen may be involved in maternal recognition of pregnancy and embryonic migration in llamas, expression of estrogen receptor subtypes alpha (ERalpha) and beta (ERbeta) was evaluated in corpus luteum (CL), endometrium, and uterus using relative RT-PCR. (oregonstate.edu)
  • As expected, 17β-estradiol or selective activation of ERα with pyrazole triol (PPT) induced the expression of estrogen-response genes including progesterone receptor, amphiregulin and trefoil factor 1. (umassmed.edu)
  • HOXA10 as well as estrogen and progesterone receptor protein expression in the epithelium, stroma, and adjacent smooth muscle of rectosigmoid endometriosis. (usp.br)
  • Anti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. (nih.gov)
  • To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
  • The study questions whether reliance on insufficiently-validated antibodies has led science down a dead-end path since the discovery of estrogen receptor beta (ESR2) in the 1990s. (sciencedaily.com)
  • However, the molecular mechanisms underlying the potential opposing roles played by the two estrogen receptors on tumor cell growth remain to be elucidated. (unical.it)
  • Upon binding to 17-β-estradiol, estriol or related ligands, the encoded protein forms homo-dimers or hetero-dimers with estrogen receptor α that interact with specific DNA sequences to activate transcription. (wikipedia.org)
  • Estrogen (17β-estradiol) has paradoxical effects in both promoting and preventing breast cancer as estrogen activates proliferation, but also promotes p53-mediated surveillance pathways. (umassmed.edu)
  • To examine the capability of these receptors in mediating surveillance as opposed to proliferation, selective estrogen receptor agonists were compared with 17β-estradiol for induction of proliferation and radiation induced apoptosis in vivo. (umassmed.edu)
  • The purpose of this study was to test the hypothesis that there is a sex difference in 17 beta-estradiol regulation of Akt signaling with Estrogen Receptor Alpha activation in prenatal neurons. (wisconsin.edu)
  • Although many studies have been performed in this area, most of them have only addressed the effects of 17 beta-estradiol (E2) and tamoxifen (TAM) on MCF7 cells. (urosario.edu.co)
  • In addition, some pathways that are typically altered during cardiac aging-induced damage, including the generation of radical oxidative species, the mitochondrial metabolic activity, the modulation of the mitochondrial calcium buffering capacity, and the regulation of estradiol and estrogen-regulated gene expression, were investigated [ 20 - 22 ]. (hindawi.com)
  • Also of interest, the addition of the native estrogen, 17beta-estradiol, or the antiandrogens, cyproterone acetate (1-1000 nM) or hydroxyflutamide (1-1000 nM), had no effect on basal or hCG-stimulated T following exposure for 24 h, suggesting that the actions of HPTE are not due to its estrogenic or antiandrogenic properties. (cdc.gov)
  • I would like to talk about the Early vs. Late Intervention Trial with Estradiol (ELITE), which directly tested the timing hypothesis for estrogen in cardiovascular disease. (medscape.com)
  • The ELITE trial tested oral estradiol , using 17 beta-estradiol at a dose of 1 mg/day. (medscape.com)
  • Epidemiological studies indicate a role for estrogen in protecting against colorectal cancer. (tdl.org)
  • Estrogen receptors and inflammation in colorectal cancer. (lu.se)
  • The I3V mutation displayed no differences with regard to transcriptional activity in a reporter assay, as compared with the wildtype receptor. (houstonmethodist.org)
  • The transcriptional activity of the estrogen receptor (ER) may be modified by small-ubiquitin related modifier (SUMO1). (nel.edu)
  • We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. (rcsb.org)
  • 7th Space Interactive July 23, 2011 Estrogens exert anti-inflammatory and neuroprotective effects in the brain mainly via estrogen receptors alpha (ERalpha) and beta (ERbeta). (sanevax.org)
  • We used immunohistochemistry to evaluate differences in apoptosis (quantified by the expression of cleaved caspase-3) and cell proliferation (quantified by the expression of Ki-67) in 56 advanced serous ovarian cancer cases, stratified according to the absence or presence of estrogen receptor β2 (ERβ2) protein in the cytoplasmic compartment (31 cERβ2- and 25 cERβ2+ cases, respectively). (unicatt.it)
  • In the present study, we have demonstrated that ER beta overexpression in breast cancer cells decreases cell proliferation and down-regulates ER alpha mRNA and protein content, along with a concomitant repression of estrogen-regulated genes. (unical.it)
  • Silencing of NCoR gene expression by RNA interference reversed the down-regulatory effects of ER beta on ER alpha gene expression and cell proliferation. (unical.it)
  • We have shown previously that extracellular psoriasin binds to the receptor for advanced glycation end products (RAGE), promoting endothelial cell proliferation (8). (medicaljournals.se)
  • Mediated by androgen receptors, because they while there are many the medical outsourcing space focused on all aspects of revenue cycle management. (tattoorockparlour.com)
  • Moreover, we found that aromatase, an enzyme critical for estrogen production, is present at presynaptic termini, supporting a role for brain-synthesized estrogen as a neuromodulator in the cortex. (jneurosci.org)
  • To aid in the examination of this phenomenon, the cDNA sequences encoding estrogen receptor-alpha (esr1), estrogen receptor-beta-a (esr2a) and ovarian aromatase (cyp19a1a) for the yellow perch were obtained. (usda.gov)
  • It also raised hopes for a new endocrine treatment to complement the success of estrogen-blocking drugs such as Tamoxifen. (sciencedaily.com)
  • However, the effect of rapid signaling via ERβ on dendritic spines and the signaling pathways initiated by this receptor in cortical neurons are unknown. (jneurosci.org)
  • Furthermore, environmental estrogens, such as Bisphenol A, activate MCs in preclinical models but their impact on pain pathways or migraine is understudied. (frontiersin.org)
  • The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)
  • We previously showed an unfavorable prognostic role of the cytoplasmic estrogen receptor β2 (cERβ2) in serous ovarian cancer. (unicatt.it)
  • These therapies target estrogen receptor alpha (ESR1), which was the first and most important biomarker in breast cancer, and can predict which patients respond to anti-estrogen treatment. (sciencedaily.com)
  • Altogether, these data provide new insights on the protein-protein interaction networks controlled by ER-a and -b that mediate their ability to transduce estrogen signaling in breast cancer cells. (unica.it)
  • Furthermore, site-directed mutagenesis and deletion analysis revealed that the proximal GC-rich motifs at -223 and -214 are critical for the ER beta-induced ER alpha down-regulation in breast cancer cells. (unical.it)
  • The vasopressin (VP) magnocellular neurosecretory cells (MNCs) in the supraoptic and paraventricular (PVN) nuclei are regulated by estrogen and exhibit robust expression of estrogen receptor (ER)-β. (jneurosci.org)
  • Because of the eminent role of receptors for mediating the biological effects of steroid hormones, changes in receptor expression could alter responsiveness of the target cells and determine the physiological circumstances in which gonadal steroids become important regulators of cell function. (jneurosci.org)
  • In type 2 diabetes (late stage), beta cells fail to secrete insulin for maintaining the blood glucose level, owing to insulin resistance and genetic defect. (medscape.com)
  • ERβ is a member of the family of estrogen receptors and the superfamily of nuclear receptor transcription factors. (wikipedia.org)
  • These receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors. (sanevax.org)
  • Transcriptional regulation of estrogen-responsive genes was also compared in mouse mammary epithelium in vivo and in the human mammary MCF7 cell line transduced with a repressible ERβ. (umassmed.edu)
  • Interestingly, the ERβ agonist DPN selectively induced the expression of genes that repress proliferation including TGFβ2 while inhibiting proliferative canonical wnt signaling via beta-catenin by inducing WNT5a and AXIN2. (umassmed.edu)
  • This study aimed to determine the effect of low doses of E2 and TAM on the expression levels of 84 key genes, which are commonly involved in breast carcinogenesis, in four BC cell lines differentially expressing estrogen receptor (ER) alpha and HER2 (MCF7, T47D, BT474, and SKBR3). (urosario.edu.co)
  • Its expression is under the control of various steroid hormones, such as estrogens. (nel.edu)
  • Estrogen receptor beta (ERβ) also known as NR3A2 (nuclear receptor subfamily 3, group A, member 2) is one of two main types of estrogen receptor-a nuclear receptor which is activated by the sex hormone estrogen. (wikipedia.org)
  • Estrogen Receptor alpha and beta (ER-a and -b) are members of the nuclear receptor family of transcriptional regulators with distinct roles in mediating estrogen dependent breast cancer cell growth and differentiation. (unica.it)
  • This occurred through ER beta-Sp1 protein-protein interactions within the ER alpha promoter region and the recruitment of a corepressor complex containing the nuclear receptor corepressor NCoR, accompanied by hypoacetylation of histone H4 and displacement of RNA-polymerase II. (unical.it)
  • In this study, we identified five novel polymorphisms in the estrogen receptor beta (ERP) gene in an African population. (houstonmethodist.org)
  • Comparison of the polymorphisms of androgen receptor gene and estrogen alpha and beta gene between adolescent females with first-onset major depressive disorder and controls. (bvsalud.org)
  • Human estrogen receptors alpha and beta are crucially involved in the regulation of mammary growth and development. (unical.it)
  • suggesting the potential for direct regulation of MNCs by estrogen. (jneurosci.org)
  • Here, we explored the mechanistic role of RIP140 in breast cancer and its involvement in estrogen receptor α (ERα) transcriptional regulation of gene expression. (aacrjournals.org)
  • Although it is biologically plausible that estrogen would reduce progression of atherosclerosis in early but not later menopause, we know that the estrogen receptors are more functional in early menopause. (medscape.com)
  • MCs express receptors for both estrogen and progesterone that induce degranulation upon binding. (frontiersin.org)
  • Some isoforms dominantly inhibit the activity of other estrogen receptor family members. (wikipedia.org)
  • The Sweden-based research team says their study invalidates all but one of the antibodies used to detect estrogen receptor beta. (sciencedaily.com)
  • Our study contributes to improved reproducibility within research using biologics, or antibodies, and it clarifies earlier controversies within the field of estrogen and breast cancer, thus helping move the field forward. (sciencedaily.com)
  • Normal breast tissues display a relative higher expression of ER beta than ER alpha, which drastically changes during breast tumorogenesis. (unical.it)
  • Also estrogen research relating to multiple other tissues and diseases are impacted by this study. (sciencedaily.com)
  • This is also the period when females normally begin to outgrow males and a female-biased SSD begins to be manifested, pointing towards an upregulation of E2 receptors (ERs) on target tissues (ovary, liver or pituitary) and a coinciding increase in tissue expression of growth-regulatory factors. (usda.gov)
  • Mammary proliferation and estrogen sensitivity is higher in young female mice than in old or parous female mice, particularly during pubertal mammary gland development. (wikipedia.org)
  • Transient transfection experiments, using a vector containing the human ER alpha promoter region, showed that elevated levels of ER beta down-regulated basal ER alpha promoter activity. (unical.it)
  • MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
  • Our results provide evidence for a novel mechanism by which overexpression of ER beta through NCoR is able to down regulate ER alpha gene expression, thus blocking ER alpha's driving role on breast cancer cell growth. (unical.it)
  • Expression of estrogen receptors alpha and beta in the corpus luteum and uterus from non-pregnant and pregnant llamas. (oregonstate.edu)
  • Exposure of neonatal rats to the endocrine disrupter Bisphenol A affects ontogenic expression pattern of testicular steroid receptors and their coregulators. (greenmedinfo.com)
  • They also searched large databases of gene expression, including The Cancer Genome Atlas, The Genotype-Tissue Expression, and the Human Protein Atlas, and pin-pointed a universal lack of estrogen receptor beta messenger RNA in breast tissue. (sciencedaily.com)
  • Since the cloning of estrogen receptor (ER)-β, many studies have demonstrated ER-β expression in MNCs (Shughrue et al. (jneurosci.org)
  • Insulin is an anabolic hormone that promotes glucose uptake, glycogenesis, lipogenesis, and protein synthesis of skeletal muscle and fat tissue through the tyrosine kinase receptor pathway. (medscape.com)
  • DHEA is a hormone that can affect how estrogen works in the body. (medlineplus.gov)
  • However, this trial does provide further reassurance about the use of estrogen for the treatment of moderate to severe hot flashes, night sweats, and other menopausal symptoms in early menopause, as well as further evidence that concerns about coronary risk should not be used as a reason for denying hormone therapy treatment to women in early menopause who have these symptoms and are otherwise appropriate candidat es for treatment. (medscape.com)
  • The concomitant inclusion of the pure estrogen antagonist, ICI 182, 780, did not alter the inhibitive effects of HPTE, suggesting that the actions of HPTE are not mediated by binding to estrogen receptor alpha or beta. (cdc.gov)
  • Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. (tcd.ie)
  • SUMO1 enhances 17-beta estradiol's effect on CRH promoter activation through estrogen receptors. (nel.edu)
  • Zhu H, Zhou J. SUMO1 enhances 17-beta estradiol's effect on CRH promoter activation through estrogen receptors. (nel.edu)
  • Estrogen receptor β (ERβ) has been found to be the main ER in the colon. (tdl.org)
  • Background The oestrogen receptor beta (ERβ) is the predominant oestrogen receptor in the normal colon mucosa and has been reported to exert anti-proliferative and pro-apoptotic effects. (lu.se)
  • 9: Determine if toll-like receptor/early response protein-1 signaling is mediating embryonic/placental inflammation and epigenetic dysregulation in offspring due to maternal obesity in rodent models/human subjects. (usda.gov)
  • However, the molecular mechanisms underlying the rapid effects of estrogen on the dendritic spines of cortical neurons are not clear. (jneurosci.org)
  • Estrogen receptor β (ERβ) is expressed in cortical neurons, and ERβ knock-out mice display impaired performance in cortically mediated processes, suggesting that signaling via this receptor has profound effects on cortical neuron function. (jneurosci.org)
  • However, the effect of rapid signaling through estrogen receptor β (ERβ) in cortical neurons is not known. (jneurosci.org)
  • These data suggest that signaling through ERβ results in rapid modification of dendritic spines of cortical neurons, supporting the role of brain-synthesized estrogen as a postsynaptic morphogen. (jneurosci.org)
  • In supply-side analysis, we reach out to the Estrogen Receptor Beta Market players to collect information on their portfolio, revenue, target customers, and other insights. (datavagyanik.com)
  • For nearly two decades researchers have sought a way to target an estrogen receptor in the hope they could improve breast cancer survival, but a new article contends that the effort may never pan out. (sciencedaily.com)
  • The target receptor does not actually appear to be where they believe it to be. (sciencedaily.com)
  • Location analysis of estrogen receptor {alpha} target promoters reveals that FOXA1 defines a domain of the estrogen response. (hum-molgen.org)
  • Estrogen receptor beta gene variant is associated with vascular dementia in elderly women. (cdc.gov)
  • These sequences are valuable molecular tools that can be used in future studies investigating estrogen mechanisms and actions, such as SSD, in yellow perch. (usda.gov)
  • These results implicate ERβ signaling in controlling dendritic spine morphology, in part via a PAK/ERK1/2-dependent pathway, and provide mechanistic insight into the rapid cellular effects of estrogen on brain function. (jneurosci.org)
  • Moreover, because testosterone (T) can be aromatized into estrogen in the hypothalamus ( Lephart, 1996 ) and because the androgen receptor is not expressed in MNCs, it is conceivable that effects of T could also be mediated through ER-β. (jneurosci.org)
  • examine role of G-coupled receptor protein GPR109A as potential mediator of PA effects on bone. (usda.gov)
  • Hart GJ , Orr DC , Penn CR , Figueiredo HT , Gray NM , Boehme RE , Effects of (-)-2'-deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma. (cdc.gov)
  • ER-alfa) e beta (ER-beta) dos receptores de estrogênio, e do receptor de progesterona AB (PR-AB) e sua isoforma B (PR-B) na lesão (LES) e no tecido muscular liso perilesional (TMLP) de ERS de pacientes inférteis, durante as fases proliferativa e secretora do ciclo menstrual. (usp.br)
  • PR-B foi mais expresso durante a fase secretora, independentemente do local de expressão, segundo a AM. A expressão de HOXA10 correlacionou-se diretamente com PR-AB e PR-B na ERS, segundo a AM. Não houve correlação entre ER-alfa e ER-beta com HOXA10, PR-AB ou PR-B em nenhuma fase do ciclo ou local de expressão de ERS. (usp.br)
  • Immunocytochemistry demonstrated that the decrease in ER-β mRNA was translated into depletion of receptor protein content in hyper-osmotic animals. (jneurosci.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Estrogen Receptor Beta (ERb) in tissue homogenates, cell lysates and other biological fluids. (taleffectors.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Estrogen Receptor Beta (ERb) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (taleffectors.com)
  • Description: A sandwich ELISA kit for detection of Estrogen Receptor Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (taleffectors.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Estrogen Receptor Beta (ERb) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (taleffectors.com)
  • Sex steroid receptors (SSRs), which are involved in BC etiology and progression, promote BCSC proliferation, dedifferentiation and migration. (wjgnet.com)
  • Yellow perch (Perca flavescens) exhibit an estrogen-stimulated sexual size dimorphism (SSD) wherein females grow faster and larger than males. (usda.gov)
  • In these four regions, all the countries have been covered in detail with information on Estrogen Receptor Beta Market size, trends, and forecast. (datavagyanik.com)