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  • Erythromycin is a white to off-white powder, slightly soluble in water, and soluble in alcohol, chloroform, and ether. (nih.gov)
  • ERY-TAB ® tablets for oral administration are available in three dosage strengths, each white oval tablet containing either 250 mg, 333 mg, or 500 mg of erythromycin as the free base. (nih.gov)
  • The activity of the CYP3A enzymes can be induced or inhibited by certain drugs (e.g., dexamethasone), which can cause it to affect the metabolism of many different drugs, including erythromycin. (wikipedia.org)
  • If other CYP3A substrates - drugs that are broken down by CYP3A - such as simvastatin (Zocor), lovastatin (Mevacor), or atorvastatin (Lipitor)-are taken concomitantly with erythromycin, levels of the substrates increase, often causing adverse effects. (wikipedia.org)
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  • HPTLC separation of the two drugs followed by densitometric measurement of their spots at 340 nm for Isotretinoin before derivatization and 410 nm for Erythromycin after derivatization with 10% H2SO4 and heating at 100°C for 15 min. (scirp.org)
  • The drugs were satisfactorily resolved with RF values of 0.38 ± 0.02 and 0.55 ± 0.02 for Isotretinoin and Erythromycin, respectively. (scirp.org)
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  • We have prepared derivatives of erythromycin B as putative paediatric prodrugs, taking advantage of the much improved acid stability of erythromycin B relative to erythromycin A. Thus, erythromycin B enol ether ethyl succinate is very poorly soluble in water, and its hydrolysis is undetectable in conditions resembling the medicine bottle. (nih.gov)
  • Pseudomembranous colitis has been reported with nearly all antibacterial agents, including erythromycin, and may range in severity from mild to life-threatening. (recallguide.org)
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  • Erythromycin Topical Solution USP, 2% is a prescription medicine used in the topical treatment of acne vulgaris. (mediply.com)
  • the effect of hepatic dysfunction on biliary excretion of erythromycin is not known. (nih.gov)
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  • Erythromycin is metabolized by enzymes of the cytochrome P450 system, in particular, by isozymes of the CYP3A superfamily. (wikipedia.org)
  • Scholars@Duke publication: Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol. (duke.edu)
  • The N-demethylation of erythromycin and 6 beta-hydroxylation of cortisol are both functions of the glucocorticoid-inducible CYP3A in human liver microsomes. (duke.edu)
  • To determine whether 6 beta-hydroxylation and erythromycin N-demethylation are catalyzed by similar or distinct CYP3A isoforms, erythromycin N-demethylase activity, as reflected by the recently described 14[C]-erythromycin breath test, was compared with urinary 6 beta-hydroxycortisol/cortisol ratios, a measure of cortisol 6 beta-hydroxylase activity, in nine patients. (duke.edu)
  • New noninvasive tests of CYP3A strongly suggest cortisol 6 beta-hydroxylation and erythromycin N-demethylation are performed by distinct CYP3A isoforms. (duke.edu)
  • Chemically, erythromycin is (C 37 H 67 NO 13 ). (rxlist.com)
  • 5% to erythromycin and other macrolides, and to clindamycin complicates the treatment of both strep throat and severe c ent of R er invasive infections. (cdc.gov)
  • Erythromycin enhances fasting and postprandial proximal gastric tone in humans by a mechanism that does not seem to involve endogenous motilin release or a cholinergic pathway. (nih.gov)
  • More than one in five invasive GAS infections are caused by throat--imagine if it were erythromycin- and clindamycin-resistant strains, limiting the untreatable. (cdc.gov)
  • After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (US), from 1999 to 2001, which was partially attributed to strains related to the mef E-carrying England 14 -9 clone. (cdc.gov)
  • In this study, we calculated the rates of invasive erythromycin-nonsusceptible S. pneumoniae disease, mef E-associated disease, and disease due to mef E-carrying clones in the Baltimore metropolitan area in 1995, 1999, and 2001. (cdc.gov)
  • Cases of invasive pneumococcal disease with an erythromycin MIC ≥0.5 μg/mL isolated from January 1,1995, to December 31, 2001, were included. (cdc.gov)