Erythroid specific dna binding factors. Medical search. Frequent questions

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. (wikipedia.org)
Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated with promoting the progression of myelofibrosis, i.e. a malignant disease that involves the replacement of bone marrow cells by fibrous tissue and extramedullary hematopoiesis, i.e. the extension of blood cell-forming cells to sites outside of the bone marrow. (wikipedia.org)
N-terminus zinc fingers) interacts with an essential transcription factor-regulating nuclear protein, FOG1. (wikipedia.org)
Using human K562 erythroleukemia cells capable of differentiating along erythroid and megakaryocytic lineages, we explore the differentiation-related role of heat shock transcription factor 2 (HSF2), which belongs to a family of transcription factors generally known to regulate heat shock gene expression. (abo.fi)
Taken together, our data suggest that HSF2 could function as a lineage-restricted transcription factor during differentiation of K562 cells along either the erythroid or the megakaryocytic pathway. (abo.fi)
DNA sequence motifs and epigenetic modifications contribute to specific binding by a transcription factor, but the extent to which each feature determines occupancy in vivo is poorly understood. (jamestaylor.org)
Acquired mutations in megakaryocyte transcription factor GATA1 have recently been reported in Down syndrome (DS), transient myeloproliferative disorder (TMD), and acute megakaryoblastic leukemia (AMKL). (ox.ac.uk)
BACKGROUND: Kruppel-like factor 13 (KLF13) is a transcription factor and plays an important role in carcinogenesis. (bvsalud.org)
Subsequently, T cells receiving PD-1 signals displayed impaired Cdk2 activation and failed to phosphorylate two critical Cdk2 substrates, the retinoblastoma gene product (Rb) and the TGFβ-specific transcription factor Smad3 , leading to suppression of E2F target genes but enhanced Smad3 transactivation (Figure 3). (shu.edu)
Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family member, acts as an oncogenic driver in hematological malignancies and promotes tumor growth in solid tumors. (biomedcentral.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Human ELF-1, a transcription factor that appears to be required for the T- cell-receptor-mediated trans activation of HIV-2 genes. (expasy.org)
Spi-B, a transcription factor that binds the PU-box. (expasy.org)
GAPB is a transcription factor capable of interacting with purine-rich repeats (GA repeats). (expasy.org)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
Pharmacological disruption of the Notch transcription factor complex. (harvard.edu)
Electrophoretic mobility shift analysis using nuclear extracts obtained from RAW264 cells and from the promonocytic cell line U-937 revealed the formation of at least three distinct protein-DNA complexes at each of these sites, one of which was found to contain the transcription factor Sp1. (uni-frankfurt.de)
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. (nature.com)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
Otherwise, carnosic acid is a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf2) protein, a transcription factor found in an inactive form in the cytosol bound to Kelch-like ECH-associated protein 1 (Keap1). (databasefootball.com)
At low concentrations, carnosic acid is detected by the cells as a xenobiotic and the Nrf2 transcription factor is activated, leading to an increase in the expression of proteins involved in cytoprotection, as mentioned above. (databasefootball.com)

Differentiation of multipotential hematopoietic cells into lineage-committed precursors involves the selection and maintenance of appropriate programs of gene expression, regulated by specific transcription factors. (abo.fi)
Our results reveal a multistep regulatory process of HSF2 gene expression, In K562 cells undergoing hemin-mediated erythroid differentiation, the increase in HSF2 protein levels is preceded by transcriptional induction of the HSF2 gene, accompanied by increased HSF2 mRNA stability. (abo.fi)
They play important roles in liver-specific transcription and are critical for CELL DIFFERENTIATION and METABOLISM. (umassmed.edu)
Based on these findings, we suggest a model for the different roles of GATA-1 in erythroid differentiation. (ox.ac.uk)
Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. (molcells.org)
In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. (molcells.org)
Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation. (molcells.org)
The up-regulation of miR-199b-5p during erythroid differentiation was dependent on the binding of GATA-1 and NF-E2 to its gene locus, which activated its transcription and maintained its high expression level in mature erythroid cells. (molcells.org)
Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation. (rochester.edu)
Abstract: A network of lineage-specific transcription factors and microRNAs tightly regulates differentiation of hematopoietic stem cells along the distinct lineages. (uni-frankfurt.de)
We found that the hematopoietic master regulator RUNX1 controls the expression of certain microRNAs, of importance during erythroid/megakaryocytic differentiation. (uni-frankfurt.de)
RUNX1 thus emerges as a key regulator of a microRNA network, driving differentiation at the megakaryocytic/erythroid branching point. (uni-frankfurt.de)

FOG1 powerfully promotes or suppresses the actions that the two transcription factors have on most of their target genes. (wikipedia.org)
The HS-40 enhancer is the major cis-acting regulatory element responsible for the developmental stage- and erythroid lineage-specific expression of the human α-like globin genes, the embryonic ζ and the adult α2/α/1. (tmu.edu.tw)
It acts as an activator and repressor of different target genes, for example, in erythroid cells it represses cell proliferation and early hematopoietic genes while activating erythroid genes, yet it is not clear how both of these functions are mediated. (ox.ac.uk)
With the GST gene sequences in hand, the researchers could home in on surrounding DNA regions that regulate the expression of the genes and identify the regulatory motifs in their promoters . (asbmb.org)
Their work made it clear that antioxidant genes such as GST have multiple regulatory elements in their promoters that are responsive to specific cellular stressors. (asbmb.org)
Subsequent work by Pickett's lab and others helped identify the transcription factors that recognize the ARE and activate the transcription of GST and other oxidative stress response genes. (asbmb.org)
The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. (umassmed.edu)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Cellular DNA-binding proteins encoded by the sis gene ( GENES, SIS ). (nih.gov)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)
We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. (lu.se)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
However, it is now recognised that CGIs are also found in about half the promoters of developmentally regulated/tissue-specific genes [ 4 ]. (biomedcentral.com)
Mouse α-globin genes, which lack an annotated CGI, exhibit tightly regulated tissue and developmental stage-specific regulation similar to that observed for the human α-globin genes, which contain a CGI and are regulated by PcG [ 9 ]. (biomedcentral.com)

A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. (childrensmercy.org)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
A DNA-binding protein that mediates DNA REPAIR of double strand breaks, and HOMOLOGOUS RECOMBINATION . (nih.gov)
A highly abundant DNA binding protein whose expression is strongly correlated with the growth phase of bacteria. (childrensmercy.org)
The protein plays a role in regulating DNA topology and activation of RIBOSOMAL RNA transcription. (childrensmercy.org)
Mammalian ELK-1, ELK-3 (also known as Net or SAP-2) and ELK-4 (also known as SRF accessory protein 1 (SAP-1)), which all form a ternary complex with the serum response factor (SRF). (expasy.org)
Adenovirus E1A enhancer-binding protein (E1A-F) (ETV4) (PEA3). (expasy.org)
PU.1 (also known as Spi-1), a protein that binds to a purine-rich sequence, the PU-box, that can act as a lymphoid-specific enhancer. (expasy.org)
GA binding protein (GAPB) α subunit. (expasy.org)
Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)
Helianthus annuus (Common sunflower) pollen specific protein SF3. (embl.de)
This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
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With a name reminiscent of a red TV puppet, the Goat Anti-Human ELMO1 Antibody binds to human ELMO1 (engulfment and cell motility protein 1). (bio-rad-antibodies.com)
It may sound like it recognizes little blue people, but in this case our Rabbit Anti-Human SMURF1 Antibody binds to the E3 ubiquitin-protein ligase SMURF1 (SMAD ubiquitination regulatory factor). (bio-rad-antibodies.com)
Both proteins are known to negatively control the bone morphogenetic protein (BMP) and the transforming growth factor beta ( TGF-β ) signaling pathways. (bio-rad-antibodies.com)
If you have dreamed about having dinosaur DNA or molecules in your body, you will have to continue imagining it because Mouse Anti-Human RAPTOR Antibody recognizes RAPTOR (regulatory-associated protein of mTOR), which has nothing to do with dinosaurs. (bio-rad-antibodies.com)

First, human erythroid K562 cells stably integrated with various HS-40 mutants cis linked to a human α-globin promoter-growth hormone hybrid gene were analyzed by genomic footprinting and expression analysis. (tmu.edu.tw)
Second, a specific 1- bp, GC→TA mutation in the 3'-NA motif of HS-40, 3'-NA(II), has been shown previously to cause significant derepression of the embryonic ζ-globin promoter activity in erythroid cells. (tmu.edu.tw)
Finally, we show by chromatin immunoprecipitation experiments that only binding of NF- E2, not AP1, could be detected in vivo in K562 cells around the HS-40 region. (tmu.edu.tw)
These data exclude a role for AP1 in the developmental regulation of the human α-globin locus via the 3'-NA motif of HS-40 in embryonic/fetal erythroid cells. (tmu.edu.tw)
When it feels your body enters into oxidative stress (when free radicals skyrocket), it binds itself with your DNA and signals your cells to shield themselves from future stress. (susansmithjones.com)
We demonstrate that enhanced HSF2 expression and the acquisition of HSF2 DNA binding activity are strictly specific for erythroid characteristics of K562 cells. (abo.fi)
GATA-1 forms distinct activating and repressive complexes in erythroid cells. (ox.ac.uk)
Using a biotinylation tagging/proteomics approach in erythroid cells, we describe distinct GATA-1 interactions with the essential hematopoietic factor Gfi-1b, the repressive MeCP1 complex and the chromatin remodeling ACF/WCRF complex, in addition to the known GATA-1/FOG-1 and GATA-1/TAL-1 complexes. (ox.ac.uk)
We addressed this question in erythroid cells by identifying DNA segments occupied by GATA1 and measuring the level of trimethylation of histone H3 lysine 27 (H3K27me3) and monomethylation of H3 lysine 4 (H3K4me1) along a 66 Mb region of mouse chromosome 7. (jamestaylor.org)
Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. (molcells.org)
Forced expression of miRNA-199b-5p in K562 cells affected erythroid cell proliferation and maturation. (molcells.org)
Moreover, we identified c-Kit as a direct target of miR-199b-5p in erythroid cells. (molcells.org)
RESULTS: Hypoxic environment promoted the secretion of small extracellular vesicles, and reduced the apoptosis and DNA damage caused by radiation, accompanied by increased expression of small extracellular vesicles miR-152-3p from hypoxic cervical cancer cells. (bvsalud.org)
Anti-PD-1 antibodies (dark green) or anti-PD-L1 antibodies (light green) can prevent the tumor cell from binding PD-1 and thus allow T cells to remain active. (shu.edu)
In embryonic stem cells, SMAD2/3-TIF1γ recognizes specific chromatin marks, promoting access of SMAD2/3-SMAD4 to otherwise repressed targets. (shu.edu)
Using this CasIP assay, we identified FECR1, a FLI1 exonic circular RNA that binds to the FLI1 promoter and epigenetically activates FLI1 in breast cancer cells. (biomedcentral.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. (hindawi.com)
Codanin-1 Mutations Engineered in Human Erythroid Cells Demonstrate Role of CDAN1 in Terminal Erythroid Maturation. (rochester.edu)
Expression of a reporter gene linked to the −101HCK promoter region was up-regulated by Sp1, but not by other members of the Sp1 family of transcription factors, in Drosophila Schneider cells. (uni-frankfurt.de)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
When administrated to some mammalian cells at the concentration of 1 µM, carnosic acid protects the cellular components ( i.e. lipids, proteins, DNA, RNA) against chemical stressors such as hydrogen peroxide (H 2 O 2 ), paraquat (an agrochemical), 6-hydroxydopamine (which is used to induce Parkinson's like disease experimentally), among other toxicants. (databasefootball.com)
Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)

GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell lineages. (ox.ac.uk)
GATA-1 and PU.1 then initiate the presumed cascade of It governs the erythroid - myeloid lineages and demonstrates both transcriptional changes that culminate in the specification of the commitment as well as priming features [6,7]. (lu.se)

Megaloblastic maturation of erythroid precursors is shown. (medscape.com)
The Steiner laboratory utilizes genomics techniques to study the molecular mechanisms underlying erythroid maturation and development. (rochester.edu)
Regulation of RNA Polymerase II Activity is Essential for Terminal Erythroid Maturation. (rochester.edu)

Based primarily on mouse studies, it is proposed that the GATA1-FOG1 complex promotes human erythropoiesis by recruiting and binding with at least two gene expression-regulating complexes, Mi-2/NuRD complex (a chromatin remodeler) and CTBP1 (a histone deacetylase) and three gene expression-regulating proteins, SET8 (a GATA1-inhibiting histone methyltransferase), BRG1 (a transcription activator), and Mediator (a transcription co-activator). (wikipedia.org)
They also modify transcription factors and CHROMATIN through ACETYLATION. (childrensmercy.org)
The laboratory is particularly interested in studying how specific DNA sequences, DNA binding proteins, and chromatin. (rochester.edu)
These regions are known as CpG islands (CGIs) and consist of short (~ 1000 bp) interspersed CpG-rich and predominantly unmethylated DNA sequences [ 1 ], which are associated with transcriptionally permissive chromatin state [ 2 ]. (biomedcentral.com)

This derepression was hypothesized to be regulated through competitive binding of different nuclear factors, in particular AP1 and NF-E2, to the 3'-NA motif. (tmu.edu.tw)
Also known as Nuclear Factor Erythroid 2-related factor , your NRF2 is your system's bodyguard. (susansmithjones.com)
Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
This graph shows the total number of publications written about "Hepatocyte Nuclear Factors" by people in this website by year, and whether "Hepatocyte Nuclear Factors" was a major or minor topic of these publications. (umassmed.edu)
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Megaloblastic anemia is an aregenerative macrocytic anemia with nuclear dysmaturity, where the nucleus appears immature relative to the cytoplasm because of impaired DNA synthesis (see the image below). (medscape.com)
Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified. (nih.gov)
The Arabidopsis type-IV zinc-finger proteins may represent the previously defined family of nuclear GATA-binding proteins implicated in light-responsive transcription. (gao-lab.org)
One of these transcriptional regulators is nuclear factor erythroid 2-related factor 2, or NRF2, identified in 1994 by another research group. (asbmb.org)
Nuclear Factor 90 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
In addition to binding to RNA, nuclear factor 90 proteins form heterodimeric complexes that regulate GENETIC TRANSCRIPTION and may play a role in T-CELL activation. (ouhsc.edu)
V-ets and c-ets-1, its cellular progenitor, have been shown [ 1 ] to be nuclear DNA-binding proteins. (expasy.org)
This nuclear enzyme has 3'-5' exonuclease activity that proofreads human DNA polymerase activity. (bio-rad-antibodies.com)

C-terminus zinc finger) binds to DNA-specific nucleic acid sequences sites viz. (wikipedia.org)
The researchers used GST-specific antibodies from Barbara Hales ' laboratory at McGill University in Montreal to detect and isolate mRNA-ribosome complexes called polysomes that contained GST-encoding mRNA sequences. (asbmb.org)
In conclution, DNA amplification is a rapid, reliable and accurate method with a high degree of sensitivity and specificity for the detection of Mycobacterium tuberculosis DNA sequences and it can replace the conventional culture method in the diagnosis of extra pulmonary tuberculosis and tuberculosis meningitis except in the situation when antibiotic sensitivity results are required. (who.int)

Human ERF, a potent transcriptional repressor that binds to the HI element of the Ets-2 promoter. (expasy.org)
A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)

A family of transcription factors found primarily in PLANTS that bind to the G-box DNA sequence CACGTG or to a consensus sequence CANNTG. (ucdenver.edu)
The SMAD proteins are a family of transcription factors consisting of 8 members, SMAD1-8, which are further subdivided into 3 classes based on structural and functional properties. (shu.edu)
Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)

Because NRF2 binds ARE, suggesting it helps regulate oxidative stress responses, Pickett and his team focused on it next and helped uncover key aspects of how NRF2 itself is regulated. (asbmb.org)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)

These motifs are critical for both transcription factors' gene-regulating actions. (wikipedia.org)
A model has been proposed in which competitive factor binding at one of the HS-40 motifs, 3'-NA, modulates the capability of HS-40 to activate the embryonic ζ-globin promoter. (tmu.edu.tw)
By the assay, we demonstrate that factors bound at different motifs of HS-40 indeed act in concert to build a fully functional enhanceosome. (tmu.edu.tw)
The specific motif variant AGATAA and occurrence of multiple WGATAR motifs are both strong discriminators. (jamestaylor.org)
Combining motifs to pair a WGATAR motif with a binding site motif for GATA1, EKLF or SP1 improves discriminative power. (jamestaylor.org)
R = G or A) motifs involved in erythroid-specific gene expressionin vertebrates. (gao-lab.org)
GATA factors are characterised by the presence of conserved, type-IV zinc-finger motifs Animal factors typically contain two C-x2-Cx17-C-x2-C zinc-finger domains. (gao-lab.org)
They consist of two zinc-binding motifs that resemble GATA-like Znf's, however the residues holding the zinc atom(s) are variable, involving Cys, His, Asp or Glu residues. (embl.de)
Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)
Finally, we found enrichment of CpG-containing DNA motifs in CFP1 peaks at CGI promoters. (biomedcentral.com)

a beta-cell-specific transcriptional enhancer found in the insulin gene. (embl.de)

Molecular and structural organization of the non-transcribed spacer (NTS) of ribosomal DNA of D. melanogaster. (cnr.it)

These data suggest that FECR1 circular RNA acts as an upstream regulator to control breast cancer tumor growth by coordinating the regulation of DNA methylating and demethylating enzymes. (biomedcentral.com)
TAp63a, a homolog of the p53 tumor suppressor, is a quality control factor in the female germline. (uni-frankfurt.de)

also called BTB) domain and carboxy-terminal Krüppel-type zinc fingers, which bind to the DNA. (bio-rad-antibodies.com)

Thus, modification of factor binding at a single motif could drastically change the configuration and function of the HS-40 enhanceosome. (tmu.edu.tw)
However, the 3'-NA(II) mutation causes an approximately twofold reduction of the binding affinity of NF-E2 factor to the 3'-NA motif. (tmu.edu.tw)
While 91% of the GATA1-occupied segments contain the consensus binding-site motif WGATAR, only ∼0.7% of DNA segments with such a motif are occupied. (jamestaylor.org)
Combining primary sequence and epigenetic determinants captures 52% of the GATA1-occupied DNA segments and substantially increases the specificity, to one out of seven segments with the required motif combination and epigenetic signals being bound. (jamestaylor.org)
The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. (expasy.org)
In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)

Primary sequence and epigenetic determinants of in vivo occupancy of genomic DNA by GATA1. (jamestaylor.org)
To provide novel insight into GATA1 mutations in DS, genomic DNA was assayed from 12 AMKL and 4 TMD cases (including neonatal, prediagnosis samples in 4 of 16), neonatal blood spots from 21 DS children without clinically evident TMD or AMKL, and 62 non-DS cord blood samples, using techniques not previously employed with such samples. (ox.ac.uk)

We also show that subsets of GATA-1 gene targets are bound in vivo by distinct complexes, thus linking specific GATA-1 partners to distinct aspects of its functions. (ox.ac.uk)
Activated complexes accumulate in the nucleus where they cooperate with DNA-binding cofactors to regulate target gene transcription. (shu.edu)
STAT5a/b/DNA complexes were immunoprecipitated using 5 µg Rabbit Anti-Human/Mouse STAT5a/b Pan Specific Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2168) or control antibody (Catalog # AB-105-C ) for 15 minutes in an ultrasonic bath, followed by Biotinylated Anti-Rabbit IgG Secondary Antibody (Catalog # BAF008 ). (rndsystems.com)

Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins or DNA. (asbmb.org)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Oxidative stress produces DNA damage and also induces responses, which could help the cell to restore the initial equilibrium. (hindawi.com)

Phenotypic and proteomic characterization of the human erythroid progenitor continuum reveal dynamic changes in cell cycle and in metabolic pathways. (rochester.edu)

In the present study, we identified miR-199b-5p as a positive erythroid regulator, that was regulated by the key erythroid transcription factors GATA-1 and NF-E2. (molcells.org)
Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. (umassmed.edu)

They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. (childrensmercy.org)

Avian leukemia virus E26 is a replication defective retrovirus that induces a mixed erythroid/myeloid leukemia in chickens. (expasy.org)

The IF-B-12 complex makes its way to the terminal ileum, where it binds to receptors on the enterocyte. (medscape.com)
TGF-β ligands bind type I and type II receptors at the cell surface. (shu.edu)
One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. (umassmed.edu)
SMURF1 is a ubiquitin ligase specific for SMAD proteins associated to receptors (R-SMADs). (bio-rad-antibodies.com)

other agents commonly ingested by the humans, such as drugs and food additives), the production of reactive species/free radicals may increase, leading to oxidative or nitrosative stress, depending on the specific reactive species are generated. (databasefootball.com)

A DNA fragment containing 101 base pairs of the 5′-flanking sequence showed strong promoter activity in the macrophage cell line RAW264 but was inactive in the non-monocytic cell lines HUT-78 and NIH-3T3. (uni-frankfurt.de)

In the nucleus it behaves as a DNA chaperone, sustains nucleosome dynamics and chromosomal stability, and contributes to telomere maintenance [ 10 ]. (hindawi.com)

This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. (umassmed.edu)

Importantly, we show that FOG-1 mediates GATA-1 interactions with the MeCP1 complex, thus providing an explanation for the overlapping functions of these two factors in erythropoiesis. (ox.ac.uk)
Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. (molcells.org)
The majority of known fungal GATA factors contain a single C-x2-C-x17-C-x2-C finger with greatest similarity to the carboxyl (C) terminal finger of animal GATA factors.Several examples of fungal GATA factors containing a variant C-x2-C-x18-C-x2-C DNA-binding domain are also known. (gao-lab.org)
Plant GATA factors typically contain a single zinc finger. (gao-lab.org)
Arabidopsis thaliana GATA factors: organisation, expression and DNA-binding characteristics. (gao-lab.org)

Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene. (expasy.org)
PVDF membrane was probed with 1 µg/mL of Rabbit Anti-Human/Mouse STAT5a/b Pan Specific Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2168) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # HAF008 ). (rndsystems.com)
A specific band was detected for STAT5a/b at approximately 91 kDa (as indicated) using 20 µg/mL of Rabbit Anti-Human/Mouse STAT5a/b Pan Specific Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2168). (rndsystems.com)
An integrated encyclopedia of DNA elements in the human genome. (nature.com)

FLI-1, a sequence specific transcriptional activator. (expasy.org)

FECR1 also binds to and downregulates in trans DNMT1, a methyltransferase that is essential for the maintenance of DNA methylation. (biomedcentral.com)

It is transported across the cell and enters the circulation bound to a transport molecule, TC II. (medscape.com)
When PD-1 binds to PD-L1 (yellow) on another cell, the T cell becomes deactivated. (shu.edu)
Below are the most recent publications written about "Host Cell Factor C1" by people in Profiles. (rush.edu)
Franco, H. L., Nagari, A. & Kraus, W. L. TNFα signaling exposes latent estrogen receptor binding sites to alter the breast cancer cell transcriptome. (nature.com)
They will modulate biotransformation of other xenobiotics present in the cell at that specific moment. (databasefootball.com)
Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to neutropenia), and increased bleeding and bruising (secondary to thrombocytopenia). (msdmanuals.com)

They also develop specific strategies to increase ROS resistance, which include deviation of the glycolytic flux into the pentose phosphate pathway (PPP) or changes in other enzymatic mechanisms enhancing ROS detoxification [ 3 , 4 ]. (hindawi.com)
DNA damage increases TP53 levels through an ATM-dependent pathway. (medscape.com)

We reveal that relief of inhibition leads to tetramer formation with ~20-fold higher DNA affinity. (uni-frankfurt.de)

G-Box Binding Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)

Anatomy28

Organisms10

Diseases7

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes77

Technology, Industry, Agriculture2

Information Science3

Health Care1

Transcription Factor22

Differentiation15

Genes17

Protein20

Cells24

Lineages2

Maturation3

Chromatin4

Nuclear14

Sequences3

Repressor2

Family of transcription factors3

NRF22

Motifs10

Enhancer1

Molecular1

Tumor2

Zinc fingers1

Motif6

GATA12

Complexes3

Oxidative stress3

Progenitor1

Regulator2

Basal1

Induces1

Receptors4

Humans1

Promoter activity1

Nucleus1

Gene expression1

GATA5

Human4

Sequence-specific1

Essential1

Cell6

Pathway2

Inhibition1

MeSH2