PlateletSedimentation rateViscosityPlateletsReversibleAggregateDeformabilityMicrocirculationHematocritVenousFibrinogenLymphocytesIndicesPhysiologicalShearParametersClinicalVivoConcentrationsCharacterizationInfluenceAffectsRouleauxRatsCellularDiseaseObservationsProteinAcuteAntigensPatientsCellHealthyMechanismHumanExamineMeasureWhole-bloodProcessGroup
Platelet5
- 1. S-Nitrosothiols are nitric oxide (NO) donor drugs that have been shown to inhibit platelet aggregation in platelet rich plasma (PRP) in vitro and to inhibit platelet activation in vivo. (uhi.ac.uk)
- The aim of this study was to compare the platelet effects of a novel S-nitrosated glyco-amino acid, RIG200, with an established S-nitrosothiol, S-nitrosoglutathione (GSNO) in PRP, and to investigate the effects of cell-free haemoglobin and red blood cells on S-nitrosothiol-mediated inhibition of platelet aggregation. (uhi.ac.uk)
- 2. The effects of GSNO and RIG200 in collagen (2.5 microg ml(-1))-induced platelet aggregation in PRP and whole blood were investigated in vitro. (uhi.ac.uk)
- Human pharmacological data show increased EEG alertness in geriatric subjects, reduction in blood viscosity and improved cerebral perfusion in specific areas in healthy men (60-70 years), and reduction in platelet aggregation. (qidosha.com)
- Effect of acute zinc deprivation on plasma zinc and platelet aggregation in adult males. (reading.ac.uk)
Sedimentation rate4
- Rouleaux formation also determines Erythrocyte sedimentation rate which is a non-specific indicator of the presence of disease. (wikipedia.org)
- Erythrocyte sedimentation rate closely reflects the extent of aggregation, therefore can be used as a measure of aggregation. (wikipedia.org)
- Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. (jabfm.org)
- Serum or plasma C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are employed in routine clinical practice as laboratory markers of systemic inflammation. (jabfm.org)
Viscosity2
- Erythrocyte aggregation is the main determinant of blood viscosity at low shear rate. (wikipedia.org)
- In laboratory experiments, the addition of nattokinase to whole human blood resulted in a dose-dependent decrease of erythrocyte aggregation and viscosity. (drhoffman.com)
Platelets3
- Platelets often have functional abnormalities, shown by a defect in the aggregation response to agonists. (orpha.net)
- Peripheral blood smear shows abnormal erythrocyte size and shape as well as paucity of platelets. (orpha.net)
- Low zinc status in rats impairs calcium uptake and aggregation of platelets stimulated by fluoride. (reading.ac.uk)
Reversible2
- Erythrocyte aggregation is the reversible clumping of red blood cells (RBCs) under low shear forces or at stasis. (wikipedia.org)
- A method based on transient shear flow dynamics of red cell aggregates was developed to investigate reversible re-aggregation processes with decreasing shear flow. (korea.ac.kr)
Aggregate2
- Erythrocytes aggregate in a special way, forming rouleaux. (wikipedia.org)
- The analysed data is represented by aggregation parameters-aggregate size index, aggregate sedimentation time index, total number of fluctuations, time required for completion of process, effective number of cells and effective cellular sedimentation duration. (iospress.com)
Deformability7
- The hemorheological parameters, erythrocyte aggregation and deformability are determined in jaundice patients and are compared with that of healthy subjects. (iospress.com)
- The erythrocyte deformability is determined by measurement of passage time (reciprocal of deformability) of erythrocyte suspension in phosphate buffered saline at hematocrit 6% through cellulose … membranes. (iospress.com)
- As a first step, we correlated a number of deformability and aggregation parameters in red blood cells from healthy donors, which we obtained in the course of our studies on red blood cell homeostasis in health and disease. (frontiersin.org)
- The observations suggest that deformability and aggregation share at least one common, membrane-related molecular mechanism. (frontiersin.org)
- Together with data obtained after treatment with various agents known to affect membrane organization in vitro , our findings suggest that a phosphorylation-controlled interaction between the cytoskeleton and the integral membrane protein band 3 is part of the membrane-centered mechanism that plays a role in deformability as well as aggregation. (frontiersin.org)
- Tissue oxygenation depends on hemoglobin as much as on red blood cell (RBC) characteristics such as metabolism, communication with the immune system, deformability and aggregation behavior. (frontiersin.org)
- The influence of methodical parameters (like geometry of the glass capillary, sucking pressure) as well as results concerning experimentally altered RBC by heat treatment are briefly described and give evidence that the … parameters entry time te , passage time tp and amplitude A, derived from impulse-like changes of conductivity describe the deformability of an individual erythrocyte. (semcs.net)
Microcirculation2
- Erythrocyte aggregation also affects hemodynamic mechanisms in microcirculation and vascular control mechanisms. (wikipedia.org)
- In addition, treatment with WSJPR could strongly reduce blood flow, erythrocyte aggregation index, and ameliorate microcirculation. (biomedcentral.com)
Hematocrit1
- Hematocrit distribution and red blood cell aggregation are the major determinants of blood flow in narrow tubes at low flow rates. (johnshopkins.edu)
Venous2
- Enhanced aggregation affects venous hemodynamics. (wikipedia.org)
- Spontaneous aggregation of erythrocytes of venous blood was quantitatively evaluated by a special system of criteria for microphotographs of aggregates: the 1st group - before and after 10 days of phototherapy, while the 2nd and control groups - once. (ersjournals.com)
Fibrinogen2
- The presence or increased concentrations of acute phase proteins, particularly fibrinogen, results in enhanced erythrocyte aggregation. (wikipedia.org)
- In the present study, these newly proposed indices were also validated by differentiating the effect of fibrinogen on RBC aggregation and then these indices were compared to the conventional indices that were measured by a rotational aggregometer. (korea.ac.kr)
Lymphocytes2
- Rosetting of activated human T lymphocytes with autologous erythrocytes. (ox.ac.uk)
- Zinc in plasma, neutrophils, lymphocytes, and erythrocytes as determined by flameless atomic absorption spectrophotometry. (reading.ac.uk)
Indices1
- Critical-time and critical-shear stress corresponding to the peak point were examined by varying the initial pressure-differential and the microchannel depth, and these results showed good potential for being used as new aggregation indices. (korea.ac.kr)
Physiological2
- Erythrocyte aggregation is a physiological phenomenon that takes places in normal blood under low-flow conditions or at stasis. (wikipedia.org)
- To address the potential interdependence of these two parameters, we measured deformation and aggregation in a variety of physiological as well as pathological conditions. (frontiersin.org)
Shear1
- Erythrocytes must be able to rapidly deform while also maintaining membrane stability when exposed to varying shear stresses. (hemorheology.com)
Parameters1
- Our aim is to develop an ultrasound diagnostic tool allowing to measure quantitative parameters that reflect the red blood cell aggregation state in situ and in vivo . (cnrs-mrs.fr)
Clinical1
- Erythrocyte aggregation: basic aspects and clinical importance. (hemorheology.com)
Vivo1
- Influence of erythrocyte aggregation on in vivo blood flow is still a controversial issue. (wikipedia.org)
Concentrations3
- 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
- Moreover, the kinetic constraints imposed by such rapid erythrocyte invasion mean that extremely high concentrations of functional antibody are required to neutralize the parasite 6 . (nature.com)
- 3. Neither compound inhibited aggregation in whole blood, even at concentrations of 100 microM. (uhi.ac.uk)
Characterization2
- Laboratoire de Mécanique et d'Acoustique (LMA), Marseille, France Ph.D. Ultrasound characterization of erythrocyte aggregation 2012 - 2013 Specialization in Bio-engineering, Arts et Métiers Paristech, Paris - Bordeaux, France 2009 - 2013 Generalist engineer, Mechanical Engineering. (cnrs-mrs.fr)
- Isolation and characterization of a glycoprotein from human group O erythrocyte membrane. (wikidata.org)
Influence1
- Surface properties of erythrocytes, such as surface charge density strongly influence the extent and time course of aggregation. (wikipedia.org)
Affects1
- Aggregation of red blood cells affects the efficiency of blood flow and oxygen delivery to tissues. (ersjournals.com)
Rouleaux1
- Rouleaux are stacks of erythrocytes which form because of the unique discoid shape of the cells in vertebrate body. (wikipedia.org)
Rats3
- The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
- These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
- Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
Cellular2
- Erythrocyte aggregation is determined by both suspending phase (blood plasma) and cellular properties. (wikipedia.org)
- Protein aggregation is one of the major cellular hallmarks of neurodegenerative diseases (ND). (biomedcentral.com)
Disease2
- Blood-stage vaccines seek to induce antibodies against the merozoite form of the parasite that invades erythrocytes 2 , and could complement pre-erythrocytic immunity afforded by RTS,S/AS01, protect against disease severity and/or reduce transmission by accelerating the control and clearance of blood-stage parasitemia. (nature.com)
- Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy define alpha-synucleinopathies, a group of ND characterized by intracellular aggregation of alpha-synuclein (aSYN) protein [ 1 ]. (biomedcentral.com)
Observations1
- The observations show that the aggregation process in jaundice starts earlier, form compact structures which move faster initially and thus reducing the effective number of cells in the observation volume at all time intervals compared to that of normal suspensions. (iospress.com)
Protein3
- Importantly, we discovered that aSYN protein aggregation is modulated by patient brain cells' intracellular milieus at the primary nucleation phase. (biomedcentral.com)
- However, there is no data that indicates if and how patient-specific brain cells' intracellular milieus modulate protein aggregation. (biomedcentral.com)
- Here, we studied changes in intracellular environment of PD patients' brain cells and how they modulate aSYN protein aggregation, using human induced pluripotent stem cells (hiPSC) and biochemical methods combined with infrared spectroscopy technique. (biomedcentral.com)
Acute1
- We examined the effect of defibrinogenation with batroxobin on the erythrocyte aggregability (RBC-A) in 16 patients with cerebral infarction during the acute phase (less than 72 hours after onset). (elsevierpure.com)
Antigens1
- The development of an effective vaccine against the merozoite has proved exceptionally challenging, hindered by substantial levels of polymorphism in the most widely studied candidate antigens 4 and redundant erythrocyte invasion pathways 5 . (nature.com)
Patients2
- To study erythrocyte aggregation in patients with COPD during phototherapy with lamps with ceramic coating. (ersjournals.com)
- Erythrocyte aggregation increases in patients with COPD. (ersjournals.com)
Cell1
- The role of membrane organization is prominently reflected in red blood cell deformation and aggregation. (frontiersin.org)
Healthy1
- In both groups of COPD (after and without phototherapy), erythrocyte aggregation was higher than in healthy men (6,5±1,35). (ersjournals.com)
Mechanism1
- This mechanism is also known as "chemiosmotic hypothesis" for aggregation. (wikipedia.org)
Human1
- Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis. (wikidata.org)
Examine1
- Notably, we performed a Thioflavin T (ThT)-based fluorescence assay to examine the effect of patient genome-induced changes in brain cells intracellular milieu on aggregation of recombinant p.A53T aSYN monomers. (biomedcentral.com)
Measure1
- While routine blood tests for humans indirectly measure inflammation through RBC sedimentation induced by RBC aggregation, hemorheology is not commonly incorporated into veterinary medicine. (hemorheology.com)
Whole-blood1
- The RBC-A was examined using the whole-blood erythrocyte aggregometer developed by us (Am. J. Physiol. (elsevierpure.com)
Process2
- Erythrocyte aggregation can also be quantitated by monitoring optical properties of blood during the time course of aggregation process. (wikipedia.org)
- Erythrocytes have been used as a biological probe in exploring the aging process (Bernabucci et al . (scialert.net)
Group1
- In the 1st group before the start of phototherapy erythrocyte aggregation was 8,4±1,99. (ersjournals.com)