- Ergoline is a chemical compound whose structural skeleton is contained in a variety of alkaloids, referred to as ergoline derivatives or ergoline alkaloids. (wikipedia.org)
- Ergoline alkaloids, one being ergine, were initially characterized in ergot. (wikipedia.org)
- Even so, many ergoline alkaloids have been found to be clinically useful. (wikipedia.org)
- Ergoline alkaloids are found in lower fungi and some species of flowering plants: the Mexican species Turbina corymbosa and Ipomoea tricolor of the Convolvulaceae (morning glory) family, the seeds of which were identified as the psychedelic plant drugs known as "ololiuhqui" and "tlitliltzin", respectively. (wikipedia.org)
- There may be a fungal origin of the ergoline alkaloids also in the Convolvulaceae. (wikipedia.org)
- Like the ergot alkaloids in some monocot plants, the ergoline alkaloids found in the plant Ipomoea asarifolia (Convolvulaceae) are produced by a seed-transmitted endophytic clavicipitaceous fungus. (wikipedia.org)
- Ergoline alkaloids were first isolated from ergot, a fungus that infects rye and causes ergotism or St. Anthony's fire. (wikipedia.org)
- Reports of the toxic effects due to ergoline alkaloids date back to the 12th century. (wikipedia.org)
- Attempts to characterize the activity of ergoline alkaloids began in 1907, with the isolation of ergotoxine by G. Barger and F. H. Carrin. (wikipedia.org)
- Following the determination of the basic chemical structure of the ergot alkaloids in 1930, an era of intensive exploration of synthetic derivatives began and industrial production of ergoline alkaloids exploded, with Sandoz continuing to be the leading company in their production worldwide, up until 1950 when other competitors arose. (wikipedia.org)
- Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth. (wikipedia.org)
- Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid also found in ergot. (wikipedia.org)
- Ergoline is a common name for the ring structure found in these alkaloids. (chemicalforums.com)
- A series of structurally-related alkaloids that contain the ergoline backbone structure. (reference.md)
- Ergoline is a chemical compound whose structural skeleton is contained in a diverse range of alkaloids and a few psychedelic drugs ( ololiuhqui , LSD ). (wikidoc.org)
- Ergoline alkaloids were first isolated from ergot , a fungus that infects grain and causes the disease ergotism . (wikidoc.org)
- With the isolation of ergotamine in 1918 by A. Stoll came the first therapeutic use of isolated ergoline alkaloids. (wikidoc.org)
- Chemical Forums: Ergotamine tartrate, Ergoline? (chemicalforums.com)
- Topic: Ergotamine tartrate, Ergoline? (chemicalforums.com)
- Ergoline derivitives are used clinically for the purpose of vasoconstriction (5-HT 1 Agonists - Ergotamine) and in the treatment of migraine (used with caffeine ) and Parkinson's disease , some are implicated in the disease ergotism . (wikidoc.org)
- They include compounds that are structurally related to ergoline (ERGOLINES) and ergotamine (ERGOTAMINES). (bvsalud.org)
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- The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. (wikipedia.org)
- There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. (wikipedia.org)
- Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. (wikipedia.org)
- While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding. (wikipedia.org)
- Ergoline derivatives, such as hydergine, a mixture of dihydroergotoxine mesylates or ergoline mesylates, have also been used in the treatment of dementia. (wikipedia.org)
- Template:Splitsection There are three main classes of ergoline derivatives, the water-soluble amides of lysergic acid , the water-insoluble ergopeptines (i.e., ergo peptides ), and the clavine group. (wikidoc.org)
- These compounds have a tri peptide structure attached to the basic ergoline ring, in the same location as the amide group of the lysergic acid derivatives. (wikidoc.org)
- Some synthetic ergoline derivatives do not fall easily into any of the above groups. (wikidoc.org)
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- A variety of modifications to the basic ergoline are seen in nature, for example agroclavine , elymoclavine , lysergol . (wikidoc.org)
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- There are a couple of different 'classes' of molecules that have this ergoline ring structure. (chemicalforums.com)
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