• Epithelial and mesenchymal cells differ in phenotype as well as function, though both share inherent plasticity. (wikipedia.org)
  • However, on the other hand, p53, a well-known tumor suppressor, represses EMT by activating the expression of various microRNAs - miR-200 and miR-34 that inhibit the production of protein ZEB and SNAIL, and thus maintain the epithelial phenotype. (wikipedia.org)
  • These findings support the development of a potentially relevant therapeutic strategy to undermine the progression of normal cells to the mesenchymal phenotype in the naturally hypoxic lens without subverting cell viability. (molvis.org)
  • Recently, AGR2 was identified as a crucial component of the cellular machinery responsible for maintaining the epithelial phenotype, thereby interfering with the induction of mesenchymal phenotype cells by TGF-ß effects in cancer. (muni.cz)
  • EMT is the conversion of epithelial cells into cells with a mesenchymal phenotype, which is accompanied by a decrease in cell-cell cohesion and fundamental reorganization of the cytoskeleton. (biomedcentral.com)
  • Loss of epithelial and gain of dedifferentiated mesenchyme-like phenotype enable CRC cells to develop invasive and metastatic growth characteristics [ 22 ]. (biomedcentral.com)
  • Epithelial-Mesenchymal Transition Phenotype and Immune System" Encyclopedia , https://encyclopedia.pub/entry/22115 (accessed November 30, 2023). (encyclopedia.pub)
  • Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). (encyclopedia.pub)
  • Epithelial-mesenchymal transition (EMT) is a malignant cancer phenotype characterized by aggressive invasion and metastasis, and resistance to apoptosis. (irb.hr)
  • Epithelial-mesenchymal transition (EMT) refers to the process by which epithelial cells transform into a mesenchymal phenotype, which has been hypothesized to be a key event in promoting tumor invasion and metastasis [ 9 , 10 ]. (biomedcentral.com)
  • Epithelial-mesenchymal transition (EMT) is a process where polarised epithelial cells undergo molecular changes allowing them to gain a mesenchymal phenotype, with a subsequent enhanced ability to produce ECM components and increased migration and/or invasion. (lungdiseasesjournal.com)
  • Figure 2 Wt1 expression is necessary to keep up a mesenchymal phenotype in immortalised epicardial cells. (hiv-proteases.com)
  • Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells gain a mesenchymal phenotype, leading to increased motility. (yonsei.ac.kr)
  • The Rho-GTPase CDC42 is one of the specific targets of UBA6-initiated ubiquitination and plays a key role in the function of UBA6 in controlling epithelial homeostasis, since a CDC42 inhibitor, ML141, rescues UBA6-deficient cells from the EMT phenotype. (northwestern.edu)
  • These types of findings posture ShcA being a determinant of this epithelial phenotype by repressing TGF-β-induced Smad activation through differential dividing of radio complexes on the cell surface area. (biongenex.com)
  • In EMT Smad complexes start the expression of EMT "master" transcription elements and work with these types of to stifle the epithelial phenotype and activate mesenchymal gene phrase. (biongenex.com)
  • Therefore decreased ShcA expression improved TGF-β radio localization in clathrin spaces and autocrine Smad2/3 signaling repressed the epithelial phenotype and marketed EMT. (biongenex.com)
  • These findings position ShcA as a determinant of the epithelial phenotype by repressing TGF-β-induced Smad activation through differential partitioning of receptor complexes at the cell surface. (biongenex.com)
  • This transition was accompanied by typical N- to E- cadherin transition, stabilization of ß- catenin , and the downregulation of transcription factors responsible for maintenance of mesenchymal phenotype ( Snail , Slug , and Zeb1). (bvsalud.org)
  • Conversely, induction of AGR2 caused reversion of the mesenchymal phenotype back to the epithelial phenotype and re-acquisition of epithelial markers. (ox.ac.uk)
  • Taken together our results highlight a crucial role for AGR2 in maintaining the epithelial phenotype by preventing the activation of key factors involved in the process of EMT. (ox.ac.uk)
  • Here we show that the T-box transcription factor Brachyury induces in tumor cells epithelial-mesenchymal transition (EMT), an important step in the progression of primary tumors toward metastasis. (jci.org)
  • The formation of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. (ku.edu)
  • Snail-mediated epithelial-mesenchymal transition (EMT) process plays a fundamental role in facilitating pancreatic ductal adenocarcinoma (PDAC) stemness and metastasis. (jcancer.org)
  • One of the key processes in tumor progression and metastasis is epithelial to mesenchymal transition (EMT), in which TGF-ß signaling plays important roles. (muni.cz)
  • Epithelial-mesenchymal transition (EMT) and its reverse process, mesenchymal-epithelial transition MET, are crucial in several stages of cancer metastasis. (elsevierpure.com)
  • Epithelial-to-mesenchymal transition (EMT) is certainly a essential process in cancer progression and metastasis, requiring cooperation of the skin growth factor/Ras with the transforming growth factor- (TGF-) signaling pathway in a multistep process. (technologybooksindustrialprojectreports.com)
  • Epithelial cells express high levels of E-cadherin, whereas mesenchymal cells express those of N-cadherin, fibronectin and vimentin. (wikipedia.org)
  • Activation of Wnt pathway in breast cancer cells induces the EMT regulator SNAIL and upregulates the mesenchymal marker, vimentin. (wikipedia.org)
  • Consistently, knockdown of HuR led to the inhibition of EMT by upregulating epithelium marker Claudin-1 and downregulating mesenchymal marker Vimentin and Snail. (ku.edu)
  • After co-culture with tumour-associated pancreatic stellate cells (TPSCs), pancreatic cancer cells displayed up to 8-fold reduction in levels of epithelial-mesenchymal transition (EMT) markers E-cadherin and ZO-1, while β-catenin and vimentin levels were increased. (lu.se)
  • Up-regulated genes consist of those encoding protein advertising cell migration and invasion like the mesenchymal cell-cell adhesion proteins N-cadherin the intermediate filament proteins vimentin as well as the extracellular matrix protein fibronectin Gimeracil and collagen. (bioskinrevive.com)
  • Radiation induced EMT in lung cancer cells and xenografts, as evidenced by increased expression of the mesenchymal markers N-cadherin and Vimentin, and reduced expression of the epithelial markers E-cadherin and Cytokeratin. (oncotarget.com)
  • Throughout this process, the mesenchymal markers vimentin and N-cadherin are up-regulated, whilst the epithelial marker E-cadherin is down-regulated. (biomedcentral.com)
  • During EMT, epithelial cells lose apical-basal polarity, tight and adherens junctions in favour of front-back polarity, N-cadherin junctions and vimentin stress fibres 4,5 . (lungdiseasesjournal.com)
  • These promote the repression of epithelial features by suppressing E-cadherin expression, and induction of mesenchymal features, in part, through the activation of mesenchymal genes N-cadherin, vimentin and fibronectin, which are responsible for cell-cell adhesion, cell motility, and migration 6-11 . (lungdiseasesjournal.com)
  • Conversely the expression of mesenchymal markers Snail Lersivirine (UK-453061) (Fig. 1i j) and Vimentin was reduced Lersivirine (UK-453061) (Fig. 1m n). (hiv-proteases.com)
  • Methods: Esophageal biopsy specimens from 60 children were immunostained for epithelial (cytokeratin) and mesenchymal (vimentin) EMT biomarkers, and EMT was quantified. (elsevierpure.com)
  • Results: TGF-β1 treatment of esophageal epithelial cells in vitro for 24 hours induced upregulation of mesenchymal genes characteristic of EMT, including N-cadherin (3.3-fold), vimentin (2.1-fold), and fibronectin (7.5-fold). (elsevierpure.com)
  • The expression of mesenchymal markers Slug, Twist, and vimentin was increased while the expression of the epithelial marker E-cadherin was decreased by treatment with 0.1, 1, 10, 100 nM estrogen for 48 h. (yonsei.ac.kr)
  • Epithelial mesenchymal transition was assessed by analyzing the expression of Vimentin and E-Cadherin. (unicatt.it)
  • Induction of EMT was associated with decreased AGR2 along with changes in cellular morphology, actin reorganization, inhibition of E-cadherin and induction of the mesenchymal markers vimentin and N-cadherin in various cancer cell lines. (ox.ac.uk)
  • mobile assays [1 20 21 using human being mammary gland epithelial cells (HMLE) a vintage EMT experimental model [13 14 22 In keeping with outcomes from the luciferase reporter assay inside our cDNA displays many under-studied kinase applicants and positive settings (FYN and MET) significantly up-regulated the manifestation of mesenchymal markers including vimentin fibronectin and N-cadherin in HMLE cells (Fig. (healthcarecoremeasures.com)
  • It has additionally been proven to take part in learning and storage in mice [28 30 Since HMLE cells include some Compact disc44high/Compact disc24low mesenchymal cells and exhibit measureable degrees of mesenchymal markers vimentin and N-cadherin we following examined if the detectable mesenchymal phenotypes could possibly be weakened through shRNA-mediated down-regulation of CDKL2 gene. (healthcarecoremeasures.com)
  • Indeed prostate malignancy epithelial cell collection PC3 and pancreatic malignancy epithelial cell collection Mubritinib SU86.86 showed increased vimentin expression and enhanced migration ability with CDKL2 ectopic expression (Fig. (healthcarecoremeasures.com)
  • INTRODUCTION Epithelial-mesenchymal transition (EMT) is a transcriptional and morphological program that occurs during normal development and tissue remodeling and in the progression of diseases such as fibrosis and metastatic cancers. (bioskinrevive.com)
  • The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
  • Epithelial-mesenchymal transition and its implications for fibrosis. (bioseek.eu)
  • Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaemp-ferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice[J]. Lab Invest, 2014, 94: 297-308. (magtechjournal.com)
  • Epithelial-mesenchymal transition (EMT) is a usual cell difference event during development and contributes pathologically to cáncer and fibrosis progression. (biongenex.com)
  • Role of epithelial-mesenchymal transition (EMT) and fibroblast function in cerium oxide nanoparticle s-induced lung fibrosis. (cdc.gov)
  • The objective of the present study was to investigate the modification of fibroblast function and the role of epithelial-mesenchymal transition (EMT) in CeO2-induced fibrosis. (cdc.gov)
  • Oxidant stress from smoking may damage alveolar epithelial cells and contribute to the pathogenesis of idiopathic pulmonary fibrosis. (medscape.com)
  • Epithelial cells are closely connected to each other by tight junctions, gap junctions and adherens junctions, have an apico-basal polarity, polarization of the actin cytoskeleton and are bound by a basal lamina at their basal surface. (wikipedia.org)
  • Mesenchymal cells, on the other hand, lack this polarization, have a spindle-shaped morphology and interact with each other only through focal points. (wikipedia.org)
  • On the other hand, transcription factors such as grainyhead-like protein 2 homologue (GRHL2), and ETS-related transcription factors ELF3 and ELF5 are downregulated during EMT and are found to actively drive MET when overexpressed in mesenchymal cells. (wikipedia.org)
  • Overexpression of Brachyury in human carcinoma cells induced changes characteristic of EMT, including upregulation of mesenchymal markers, downregulation of epithelial markers, and an increase in cell migration and invasion. (jci.org)
  • Conversely, inhibition of Brachyury resulted in downregulation of mesenchymal markers and loss of cell migration and invasion and diminished the ability of human tumor cells to form lung metastases in a xenograft model. (jci.org)
  • The purpose of this study was to identify potential therapeutic strategies to slow down or prevent the expression of early-onset epithelial to mesenchymal transition (EMT) marker proteins (fibronectin and alpha smooth muscle actin, α-SMA) without sacrificing the synthesis and accumulation of the prosurvival protein vascular endothelial growth factor (VEGF) in cultured virally transformed human lens epithelial (HLE) cells. (molvis.org)
  • The ocular lens and its complement of epithelial cells are adapted to exist under hypoxic conditions that would otherwise injure most types of cell. (molvis.org)
  • Human lens epithelial (HLE) cells survive under hypoxia through complex and interactive signal transduction pathways whose mechanisms of action are not well understood. (molvis.org)
  • Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. (whiterose.ac.uk)
  • Actin filaments in epithelial cells are structured in cortical slim bundles. (bioskinrevive.com)
  • On the other hand actin filaments in transdifferentiated mesenchymal cells are bundled Gimeracil into heavy contractile stress materials in the ventral cell surface area. (bioskinrevive.com)
  • Disappearance of Cav1 enables cells to undergo epithelial-mesenchymal transition (EMT). (cipsm.de)
  • Epithelial to mesenchymal transition (EMT) of cancer cells involves loss of epithelial polarity and adhesiveness, and gain of invasive and migratory mesenchymal behaviours. (ox.ac.uk)
  • A hallmark feature of EMT is the downregulation of E-cadherin, a cell-cell adhesion molecule localized on the surface of epithelial cells [ 17 ]. (biomedcentral.com)
  • During epithelial-to-mesenchymal transition (EMT), cells lining the tissue periphery break up their cohesion to migrate within the tissue. (pasteur.fr)
  • This dramatic reorganization involves a poorly characterized reorientation of the apicobasal polarity of static epithelial cells into the front-rear polarity of migrating mesenchymal cells. (pasteur.fr)
  • Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. (bioseek.eu)
  • In this mesenchymal subtype, a decreased number of CD8 + tumor-infiltrating lymphocytes (TILs) were detected, suggesting an association between EMT tumor cells and exclusion of these immune cells from the TME. (encyclopedia.pub)
  • An association between EMT tumor cells (mesenchymal and hybrid epithelial-mesenchymal phenotypes) and increased numbers of infiltrating PD-1 + cells was also observed in another study in patients with adenocarcinoma of the lung [ 6 ] . (encyclopedia.pub)
  • The expression of biomarkers of epithelial-mesenchymal transition (EMT) was higher in SACC cells treated with CAF EVs treated with CAF EVs than in the negative controls, and high levels of IL-6 were detected in CAF and their EVs. (researchsquare.com)
  • IPF is thought to be a result of a combination of genetic and environmental factors with repetitive micro-injuries to alveolar epithelial cells playing a central role. (lungdiseasesjournal.com)
  • However, lineage tracing in transgenic mice suggests the contribution of epithelial cells, which have undergone EMT, to the fibroblast population may be negligible. (lungdiseasesjournal.com)
  • Instead, recent findings suggest that alveolar epithelial type II (ATII) cells undergoing EMT promote a pro-fibrotic microenvironment through paracrine signalling activating local fibroblasts. (lungdiseasesjournal.com)
  • Epicardial epithelial-mesenchymal transition (EMT) is normally hypothesized to create cardiovascular progenitor cells that differentiate into several cell types including coronary even muscle and endothelial cells perivascular and cardiac interstitial fibroblasts and cardiomyocytes. (hiv-proteases.com)
  • We found that E-cadherin and Cytokeratin (CK) epithelial markers were upregulated in mutant epicardial cells in comparison with control hearts (Fig. 1k-n). (hiv-proteases.com)
  • Epithelial-mesenchymal transition allows cancer cells to move to proximal blood vessels for intravasation. (elsevierpure.com)
  • However, because EMT and MET processes are dynamic, mesenchymal cancer cells are likely to undergo MET transiently and subsequently re-undergo EMT to restart the metastatic process. (elsevierpure.com)
  • To elucidate such regulation, we chose HCC38, a human triple-negative breast cancer cell line, because HCC38 is composed of epithelial and mesenchymal populations at a fixed ratio even though mesenchymal cells proliferate significantly more slowly than epithelial cells. (elsevierpure.com)
  • We purified epithelial and mesenchymal cells from Venus-labeled and unlabeled HCC38 cells and mixed them at various ratios to follow EMT and MET. (elsevierpure.com)
  • Using this system, we found that the efficiency of EMT is approximately an order of magnitude higher than that of MET and that the two populations significantly enhance the transition of cells from the other population to their own. (elsevierpure.com)
  • LIPUS promoted the differentiation of colon cancer cells, affected epithelial-to-mesenchymal transition, promoted the closure of a wound as well as increased the release of EVs compared with untreated cells. (unicatt.it)
  • Mammary epithelial MCF-10A cells expressing shRNA against UBA6 fail in establishing cell cycle arrest in response to detachment from extracellular matrix, confluency with fully engaged cell-cell contact or growth factor deprivation. (northwestern.edu)
  • observed that ShcA protects the epithelial condition of nontransformed cells against EMT simply by repressing TGF-β-induced Smad-mediated gene expression. (biongenex.com)
  • Interestingly, a subpopulation of cells overexpressing SIRT7 exhibited an intermediate stage between mesenchymal and epithelial characters . (bvsalud.org)
  • Transformed epithelial cells showed a loss of heterochromatisation as evidenced by a loss of HP1α and H3K9 dimethylation staining . (bvsalud.org)
  • In conclusion, we report a role of SIRT7 in mesenchymal cells , which may have implications for health and disease . (bvsalud.org)
  • The active, un-phosphorylated form of GSK3β maintains both (i) epithelial phenotypes by inhibiting the expression and stabilization of Snail and Slug and (ii) high E-cadherin expression ( Boble and Woodgett, 2007 ) in resting epithelial cells. (molcells.org)
  • During cancer progression, epithelial cancer cells can be reprogrammed into mesenchymal-like cells with increased migratory potential through the process of epithelial-mesenchymal transition (EMT), representing an essential step of tumor progression towards metastatic state. (ox.ac.uk)
  • Transforming growth factor β1 exposure of in vitro cultured primary clear cell renal cell carcinoma cells resulted in cells adopting a mesenchymal morphology similar to sarcomatoid clear cell renal cell carcinoma. (lu.se)
  • The posterior endoderm in Drosophila embryos undergoes an epithelial-mesenchymal transition (EMT), driving the collective migration of endoderm cells. (whiterose.ac.uk)
  • The epithelial-mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and continues to be closely from the acquisition of aggressive traits by epithelial cancer cells. (healthcarecoremeasures.com)
  • Besides changes in EMT marker expression HMLE cells expressing some kinases such as CDKL2 ZAK FYN and MET lost cell-cell contact Mubritinib and acquired a spindle fibroblast-like mesenchymal morphology (Fig. (healthcarecoremeasures.com)
  • Since EMT has also been found in epithelial cell of other tissue types we suspected that CDKL2 plays a Mubritinib similar role in other epithelial cells. (healthcarecoremeasures.com)
  • These results suggest that CDKL2's role on EMT regulation is not limited to HMLE mammary gland epithelial cells. (healthcarecoremeasures.com)
  • Mutant endometrial epithelial cells were transcriptome profiled and compared to control cells and ARID1A/PIK3CA mutant endometrium. (nih.gov)
  • The EMT program dissociates the cells within epithelial cell sheets into individual cells that exhibit multiple mesenchymal attributes. (medscape.com)
  • TGF-β drives epithelial-mesenchymal transdifferentiation (EMT) which allows cell immigration and breach. (biongenex.com)
  • Epithelial to mesenchymal transition (EMT) is the cellular transition process of epithelium-associated phenotypes and behaviors into mesenchymal phenotypes. (iiarjournals.org)
  • Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition. (pasteur.fr)
  • Here we demonstrate that ubiquitination pathways initiated specifically by UBA6 set a suppressive barrier against critical steps of mammary carcinogenesis such as loss of polarity, anoikis resistance and epithelialmesenchymal transition (EMT). (northwestern.edu)
  • Snail and Slug are known to regulate the expression of p63 isoforms, another transcription factor that is required for proper development of epithelial structures. (wikipedia.org)
  • [ 4 ] EMT programs are orchestrated by a set of pleiotropically acting transcription factors, including Slug, Snail, Twist, ZEB1, and ZEB2, which organize entrance into a mesenchymal state by suppressing expression of epithelial markers (E-cadherin) and inducing expression of other markers associated with the mesenchymal state. (medscape.com)
  • Overexpression of miR-30b led to reduced expression of mesenchymal marker N-cadherin and the upregulation of epithelial marker E-cadherin. (jcancer.org)
  • At the same time down-regulation of epithelial marker occludin [21] was observed for some kinases (Fig. (healthcarecoremeasures.com)
  • 2009 ). These transcription elements travel EMT by repressing manifestation of epithelial genes and activating manifestation of mesenchymal genes. (bioskinrevive.com)
  • Paradoxically, radiation can activate TGF-β1 signaling and induce the epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor progression. (oncotarget.com)
  • Epithelial-mesenchymal transition (EMT) is an essential process during embryonic development that also has a profound impact on cancer progression. (oncotarget.com)
  • Down-regulated genes consist of those encoding protein keeping epithelial cell-cell adhesions like the adherens junction proteins E-cadherin as well as the limited junctions protein claudins and occludin. (bioskinrevive.com)
  • Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer. (ox.ac.uk)
  • We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). (nih.gov)
  • Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. (whiterose.ac.uk)
  • Thus, a high expression of inhibitory immune checkpoint molecules such as PD-1, PD-L1, CTLA-4, OX40L, and PD-L2 was observed in tumors with the most mesenchymal EMT scores. (encyclopedia.pub)
  • Epithelial-mesenchymal transition (EMT) is a critical step in the acquisition of the migratory and invasive capabilities associated with metastatic competence. (molcells.org)
  • Approximately 8% of clear cell renal cell carcinoma cases contain regions of radically different morphology, demonstrating a mesenchymal appearance histologically resembling sarcomas. (lu.se)
  • Gene expression clustering studies in ovarian cancer have shown that the mesenchymal subtype, enriched in an EMT-related gene signature, has a worse prognosis and survival compared to other subtypes [ 1 ] . (encyclopedia.pub)
  • The relationships between B7-H4 expression, immune cell infiltration, epithelial-mesenchymal transition (EMT), clinicopathological features, and survival prognosis were determined through the TCGA database and verified in a large CRC cohort ( n = 1118). (biomedcentral.com)
  • Furthermore the sarcomatoid elements demonstrate an enhanced expression of epithelial-mesenchymal transition related mesenchymal markers as compared with the clear cell renal cell carcinoma counterparts. (lu.se)
  • TG2 expression correlated with tumour advancement and expression of markers of epithelial-mesenchymal transition (EMT). (oncotarget.com)
  • Notably CDKL2 is expressed significantly higher in mesenchymal human breast cancer cell lines than in epithelial lines and its over-expression/amplification in human breast cancers is associated with shorter disease-free survival. (healthcarecoremeasures.com)
  • In the context of either TP53 or ARID1A loss, PIK3CA mutant endometrium exhibited inflammatory pathway activation, but other gene expression programs differed based on TP53 or ARID1A status, such as epithelial-to-mesenchymal transition. (nih.gov)
  • While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. (whiterose.ac.uk)
  • SIRT7 overexpression in immortalized mouse fibroblasts (NIH3T3) induced epithelial transition. (bvsalud.org)
  • The p63 factor is involved in inhibiting EMT and reduction of certain p63 isoforms may be important in the development of epithelial cancers. (wikipedia.org)
  • EMT, and its reverse process, MET (mesenchymal-epithelial transition) are critical for development of many tissues and organs in the developing embryo, and numerous embryonic events such as gastrulation, neural crest formation, heart valve formation, secondary palate development, and myogenesis. (wikipedia.org)
  • Epithelial mesenchymal transition (EMT) process has been shown as highly relevant to cancer prognosis. (kobv.de)
  • Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
  • The epithelial-mesenchymal transition (EMT) is an essential process in multiple biochemical changes, including embryonic development, tissue remodeling and wound healing. (molcells.org)
  • In the present study we investigate whether the sarcomatoid conversion of clear cell renal cell carcinoma could be interpreted as linked to the process of epithelial-mesenchymal transition. (lu.se)
  • This is achieved via a process known as epithelial-to-mesenchymal transition (EMT). (medscape.com)
  • Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition. (lu.se)
  • We further selected a representative case, clinically demonstrating direct overgrowth of the sarcomatoid component into the liver and colon, for extended immunohistochemical characterization, resulting in a further set of positive and negative epithelial-mesenchymal transition markers as well as pronounced transforming growth factor β positivity, indicating that sarcomatoid clear cell renal cell carcinoma may be associated to epithelial-mesenchymal transition. (lu.se)
  • We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma. (lu.se)
  • Background: Epithelial to mesenchymal transition (EMT) is critical for human placental development, trophoblastic differentiation, and pregnancy-associated diseases. (impleomedical.com)
  • Epithelial-mesenchymal transition was first recognized as a feature of embryogenesis by Betty Hay in the 1980s. (wikipedia.org)
  • The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
  • by short hairpin RNA had fewer thinner and less stable actin bundles incomplete morphological transition and decreased invasive capacity. (bioskinrevive.com)