• granulocytes
  • Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments. (wikipedia.org)
  • chemokines
  • Clinical studies have demonstrated a link between the eosinophil-selective chemokines, eotaxins (eotaxin-1/CCL11 and eotaxin-2/CCL24), eosinophils, and the inflammatory bowel diseases, Crohn's disease and ulcerative colitis (UC). (jimmunol.org)
  • This finding contributes to an understanding of CC chemokines in eosinophil biology and to the development of novel therapies for the treatment of eosinophilic disorders. (springer.com)
  • After maturation, eosinophils circulate in blood and migrate to inflammatory sites in tissues, or to sites of helminth infection in response to chemokines like CCL11 (eotaxin-1), CCL24 (eotaxin-2), CCL5 (RANTES), 5-hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid, and certain leukotrienes like leukotriene B4 (LTB4) and MCP1/4. (wikipedia.org)
  • inflammatory
  • Once considered a cell involved in host protection of parasitic infection, eosinophils multiple functions as leukocytes involved in the initiation and propagation of diverse inflammatory responses is being investigated. (creativebiomart.net)
  • Eosinophils are multifunctional leukocytes involved in the initiation and propagation of inflammatory reactions and the modulation of innate and adaptive immunity and can serve as a major effector cell, inducing tissue damage and dysfunction ( 5 ). (jimmunol.org)
  • These findings indicate a mechanism by which two inflammatory cells, the eosinophil and neutrophil, may interact to enhance the destruction of a target organism. (ajtmh.org)
  • These results suggest that under inflammatory conditions associated with asthma, phenolic β 2 -agonists may be subject to peroxidase-catalyzed nitration that could potentially diminish their therapeutic efficacy. (aspetjournals.org)
  • chloride
  • Other than its role in collagen IV production and its facultative use in eosinophils by the body, bromide is not known in other cases necessary for animal life, as its functions may generally be replaced (though in some cases not as well) by chloride. (wikipedia.org)
  • Inflammation
  • In these mice, the response to SEA, OVA, and CRA showed impaired Th2 cytokine production that was associated with aberrant type 2 inflammation displaying a 50 to 80% reduction in eosinophils. (rupress.org)
  • mast cells
  • The recruited T-cells are typically of the Th2 variety and the cytokines they produce lead to further recruitment of mast cells and eosinophils, and in plasma cell isotype switching to IgE which will bind to the mast cell FcεRI receptors and prime the individual for further allergic responses. (wikipedia.org)
  • Eosinophils, along with basophils and mast cells, are important mediators of allergic responses and asthma pathogenesis and are associated with disease severity. (wikipedia.org)
  • eosinophilic
  • These data demonstrate that intestinal macrophage and epithelial cell-derived eotaxin-1 plays a critical role in the regulation of eosinophil recruitment in colonic eosinophilic disease such as pediatric UC and provides a basis for targeting the eosinophil/eotaxin-1 axis in UC. (jimmunol.org)
  • marine algae
  • This enzyme catalyses the following chemical reaction RH + HBr + H2O2 ⇌ {\displaystyle \rightleftharpoons } RBr + 2 H2O Bromo peroxidases of red and brown marine algae (Rhodophyta and Phaeophyta) contain vanadate. (wikipedia.org)
  • oxidation
  • In general, diatomic gases only bind to the reduced heme, as ferrous Fe(II) while most peroxidases cycle between Fe(III) and Fe(IV) and hemeproteins involved in mitochondrial redox, oxidation-reduction, cycle between Fe(II) and Fe(III). (wikipedia.org)
  • recruitment
  • DSS treatment of eotaxin-2 −/− and eotaxin-1/2 −/− mice demonstrated that eosinophil recruitment was dependent on eotaxin-1. (jimmunol.org)
  • Mechanistic analyses indicated that Th2 cells developed normally and that the reduction in eosinophil recruitment was likely due to systemic reduction in interleukin 5. (rupress.org)
  • These studies revealed impaired Th2 cytokine production and eosinophil recruitment during Th2-mediated responses, with no abrogation of the Th1 response. (rupress.org)
  • asthmatic
  • Because peroxidase activity and nitrogen oxides are increased in the asthmatic airway, we examined whether salbutamol, a clinically important β 2 -agonist, is subject to potentially inactivating nitration. (aspetjournals.org)
  • found
  • Hemes are most commonly recognized as components of hemoglobin, the red pigment in blood, but are also found in a number of other biologically important hemoproteins such as myoglobin, cytochromes, catalases, heme peroxidase, and endothelial nitric oxide synthase. (wikipedia.org)
  • Although
  • Although eosinophils usually represent only a small percentage of the infiltrating leukocytes ( 2 , 3 ), their level has been proposed to be a negative prognostic indicator ( 3 , 4 ). (jimmunol.org)
  • Although eosinophils express both receptors, the role of Lkn-1 in immature eosinophils remains to be elucidated. (springer.com)