• EV71
  • Enterovirus 71 (EV71) is a common cause of Hand, foot, and mouth disease (HFMD) and may also cause severe neurological diseases, such as encephalitis and poliomyelitis-like paralysis. (virosin.org)
  • Basing on the previous studies of elicited protection in mice and rhesus monkeys, a formalin-inactivated EV71 vaccine (Human Diploid cell, KMB-17 Cell) has been licensed by SFDA in China, Dec. 2010. (clinicaltrials.gov)
  • The basic reproductive number (R0) for enterovirus 71 (EV71) was estimated to a median of 5.48 with an interquartile range of 4.20 to 6.51. (wikipedia.org)
  • Enterovirus 71 (EV71), one of the major causative agents for hand, foot and mouth disease (HFMD), is sometimes associated with severe central nervous system diseases. (wikipedia.org)
  • viral
  • The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. (mdpi.com)
  • In a hospital setting, you can do a viral study to find out if a child has an enterovirus. (parentmap.com)
  • Presence of viral particles in fecal matter and in epithelial intestinal cells indicate that the virus replicates in the gastrointestinal tract of humans. (wikipedia.org)
  • Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. (wikipedia.org)
  • genome
  • Analysis of human enterovirus 71 (EV-71) subgenotype B3 genome sequences revealed that the 3D RNA polymerase and domain Z of the 3'-untranslating region RNA secondary structure had high similarity to CV-A16. (biomedcentral.com)
  • All enteroviruses contain a genome of approximately 7,500 bases and are known to have a high mutation rate due to low-fidelity replication and frequent recombination. (wikipedia.org)
  • vaccine
  • While there is no preventive vaccine or medicine to treat enteroviruses directly, medical attention is needed if there is difficulty breathing or if there are significant changes in condition , such as if a child initially only shows mild cold symptoms then suddenly begins wheezing or coughing in an alarming way. (parentmap.com)
  • protein
  • In each cluster, HEV68 was diagnosed by reverse transcription--polymerase chain reaction (RT-PCR) testing targeting the 5'-nontranslated region, followed by partial sequencing of the structural protein genes, VP4-VP2, VP1, or both, to give definitive, enterovirus type-specific information. (cdc.gov)
  • Mouse monoclonal antibody prepared against a recombinant form of the human interferon beta protein was purified from clone A7 hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. (wikipedia.org)
  • proteins
  • Western blotting, two-dimensional gel electrophoresis, and mass spectrometry were used to identify human islet proteins bound by the clone 5-D8/1. (diva-portal.org)
  • strain
  • The first oncolytic virus approved by a national regulatory agency is genetically not modified ECHO-7 strain enterovirus RIGVIR, approved in Latvia in 2004 for treatment of skin melanoma. (wikipedia.org)
  • receptor
  • 2009. The cellular attachment and entry of human enterovirus 71: the role of glycosaminoglycans and evidence for a second receptor, in American Society for Virology 25th Annual Meeting, Jul 15 2009. (edu.au)
  • Healthy
  • Experts estimate that the majority of the population has, in fact, been exposed to the enterovirus, but that no symptoms are exhibited in healthy adults. (wikipedia.org)
  • virus
  • Astrovirus is a type of virus that was first discovered in 1975 using electron microscopes following an outbreak of diarrhea in humans. (wikipedia.org)
  • cause
  • Like all enteroviruses, it can cause variable skin rashes, abdominal pain and soft stools. (wikipedia.org)
  • Human astroviruses have been shown in numerous studies to be an important cause of gastroenteritis in young children worldwide. (wikipedia.org)
  • type
  • In view of these conflicting results, we aimed to test whether the presence of human enterovirus in monthly fecal samples predicted development of repeated positivity for two or more diabetes-associated islet autoantibodies in children with the HLA genotype conferring the highest risk for type 1 diabetes. (diabetesjournals.org)
  • results
  • RESULTS The frequency of human enterovirus RNA in stool samples from case subjects before seroconversion (43 of 339, 12.7%) did not differ from the frequency in control subjects (94 of 692, 13.6%) ( P = 0.97). (diabetesjournals.org)
  • Specimens submitted for detection of enterovirus (n = 17,349) and proportions with positive results. (cdc.gov)
  • occur
  • Cases have been described to occur late in the enterovirus season (roughly the period of time between the spring equinox and autumn equinox), which is typically during August and September in the Northern Hemisphere. (wikipedia.org)
  • Cases
  • As of October 2014, the CDC was investigating 10 cases of paralysis and/or cranial dysfunction in Colorado and other reports around the country, coinciding with the increase in enterovirus D68 activity. (wikipedia.org)
  • disease
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • He is an expert on Japanese encephalitis, an emerging infectious disease that is a zoonosis spread from animals to humans by mosquitoes. (wikipedia.org)
  • detect
  • A method using real-time RT-PCR, which can detect all human astrovirus genotypes, has been reported. (wikipedia.org)