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  • viral
  • The utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 was able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication. (mdpi.com)
  • Methods The changes in global gene expression and secreted cytokine profiles induced by lytic or benign enterovirus infections were studied in primary human pancreatic islet using DNA microarrays and viral strains either isolated at the clinical onset of type 1 diabetes or capable of causing a diabetes-like condition in mice. (diva-portal.org)
  • Presence of viral particles in fecal matter and in epithelial intestinal cells indicate that the virus replicates in the gastrointestinal tract of humans. (wikipedia.org)
  • Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. (wikipedia.org)
  • genome
  • Analysis of human enterovirus 71 (EV-71) subgenotype B3 genome sequences revealed that the 3D RNA polymerase and domain Z of the 3'-untranslating region RNA secondary structure had high similarity to CV-A16. (biomedcentral.com)
  • All enteroviruses contain a genome of approximately 7,500 bases and are known to have a high mutation rate due to low-fidelity replication and frequent recombination. (wikipedia.org)
  • protein
  • In each cluster, HEV68 was diagnosed by reverse transcription--polymerase chain reaction (RT-PCR) testing targeting the 5'-nontranslated region, followed by partial sequencing of the structural protein genes, VP4-VP2, VP1, or both, to give definitive, enterovirus type-specific information. (cdc.gov)
  • Mouse monoclonal antibody prepared against a recombinant form of the human interferon beta protein was purified from clone A7 hybridoma supernatant by protein G affinity chromatography. (atcc.org)
  • Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. (wikipedia.org)
  • specimens
  • Development of a transcription-reverse transcription concerted reaction method for specific detection of human enterovirus 71 from clinical specimens. (nih.gov)
  • Specimens submitted for detection of enterovirus (n = 17,349) and proportions with positive results. (cdc.gov)
  • respiratory
  • In the past 2 years, CDC has learned of several clusters of respiratory illness associated with human enterovirus 68 (HEV68), including severe disease. (cdc.gov)
  • Enteroviruses affect millions of people worldwide each year, and are often found in the respiratory secretions (e.g., saliva, sputum, or nasal mucus) and stool of an infected person. (wikipedia.org)
  • proteins
  • Western blotting, two-dimensional gel electrophoresis, and mass spectrometry were used to identify human islet proteins bound by the clone 5-D8/1. (diva-portal.org)
  • strain
  • The first oncolytic virus approved by a national regulatory agency is genetically not modified ECHO-7 strain enterovirus RIGVIR, approved in Latvia in 2004 for treatment of skin melanoma. (wikipedia.org)
  • receptor
  • 2009. The cellular attachment and entry of human enterovirus 71: the role of glycosaminoglycans and evidence for a second receptor, in American Society for Virology 25th Annual Meeting, Jul 15 2009. (edu.au)
  • symptoms
  • Experts estimate that the majority of the population has, in fact, been exposed to the enterovirus, but that no symptoms are exhibited in healthy adults. (wikipedia.org)
  • These mice exhibited all symptoms and pathology of poliomyelitis observed in humans including flaccid paralysis and spinal cord lesions. (wikipedia.org)
  • virus
  • Astrovirus is a type of virus that was first discovered in 1975 using electron microscopes following an outbreak of diarrhea in humans. (wikipedia.org)
  • cause
  • Like all enteroviruses, it can cause variable skin rashes, abdominal pain and soft stools. (wikipedia.org)
  • Human astroviruses have been shown in numerous studies to be an important cause of gastroenteritis in young children worldwide. (wikipedia.org)
  • results
  • RESULTS The frequency of human enterovirus RNA in stool samples from case subjects before seroconversion (43 of 339, 12.7%) did not differ from the frequency in control subjects (94 of 692, 13.6%) ( P = 0.97). (diabetesjournals.org)
  • In view of these conflicting results, we aimed to test whether the presence of human enterovirus in monthly fecal samples predicted development of repeated positivity for two or more diabetes-associated islet autoantibodies in children with the HLA genotype conferring the highest risk for type 1 diabetes. (diabetesjournals.org)
  • occur
  • Cases have been described to occur late in the enterovirus season (roughly the period of time between the spring equinox and autumn equinox), which is typically during August and September in the Northern Hemisphere. (wikipedia.org)
  • disease
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • He is an expert on Japanese encephalitis, an emerging infectious disease that is a zoonosis spread from animals to humans by mosquitoes. (wikipedia.org)
  • activity
  • As of October 2014, the CDC was investigating 10 cases of paralysis and/or cranial dysfunction in Colorado and other reports around the country, coinciding with the increase in enterovirus D68 activity. (wikipedia.org)
  • immunodeficiency virus
  • The emergence of antivirals is the product of a greatly expanded knowledge of the genetic and molecular function of organisms, allowing biomedical researchers to understand the structure and function of viruses, major advances in the techniques for finding new drugs, and the pressure placed on the medical profession to deal with the human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS). (wikipedia.org)
  • tissues
  • The majority of studies investigating type 1 diabetes have been performed in rodents due to the lack of availability of human tissues. (wikipedia.org)
  • nPOD grew out of a vision to bridge this gap of understanding by creating a biobank to collect and distribute diabetes-associated human tissues to researchers. (wikipedia.org)
  • cardiac
  • Out of 143 differentially-regulated genes, LIMP-2 was identified to be significantly upregulated in heart failure-prone rat cardiac muscle biopsies, which also proved true in human heart failure. (wikipedia.org)
  • type
  • The weight discrepancy between its theoretical (54.3 kDa) and observed (85 kDa) is due to the presence of 10 high mannose-type N-linked oligosaccharide chains in the human form of this protein, compared to 11 in mouse and rat. (wikipedia.org)
  • Astrovirus is a type of virus that was first discovered in 1975 using electron microscopes following an outbreak of diarrhea in humans. (wikipedia.org)
  • JDRF recognized this reality and took on the vision to create a biobank of human tissue for type 1 diabetes research, despite the notion of the time that it was an impossible feat. JDRF asked Mark Atkinson, PhD, at the University of Florida to drive this initiative. (wikipedia.org)
  • http://www.diabetesincontrol.com/articles/diabetes-news/15408-type-of-enterovirus-linked-to-type-1-diabetes) More recent research implicates strains B1, A4, A2 and A16 in the destruction of beta cells, with some suggestion that strains B3 and B6 may have protective effects via immunological cross-protection. (wikipedia.org)
  • virus
  • Other types of herpes virus that floating of bovine enterovirus by short chain fatty acids much talked about above are widely used and work well applied directly opposed are most meats and hinder healing by bringing blood to the hormonal imbalance. (zapcoldsoresaway.com)
  • biological
  • While these studies have allowed us to identify potential causes for T1D and have directed many researchers in the development of their methods, key biological differences between rodents and humans prevent their use to uncover the specifics of disease progression. (wikipedia.org)
  • several
  • Iraq officially acknowledged that it had worked with several species of bacterial pathogen, including Bacillus anthracis, Clostridium botulinum and Clostridium perfringens (gas gangrene) and several viruses (including enterovirus 17 [human conjunctivitis], rotavirus and camelpox). (wikipedia.org)
  • cells
  • from rat liver lysosomes, LIMP-2 was cloned in 1992 by two groups, one isolated LIMP-2 from human metastatic pancreatic islet tumor cells, and one from rat liver lysosomal membranes. (wikipedia.org)
  • cases
  • Because the human body begins to deteriorate with age, and because human population is living many years longer, there has been a growth in cases of myelomalacia. (wikipedia.org)
  • body
  • In animals and humans, poisons are often bound to sugar molecules as part of their elimination from the body. (medchemexpress.com)
  • When psychologically stressed, the human body produces stress hormones like cortisol, which are able to trigger interleukin-6 release into the circulation. (wikipedia.org)