• kinase
  • Walter moved from Rockefeller to start his own laboratory at the University of California, San Francisco, where he and his group identified an ER resident transmembrane kinase/endoribonuclease, Ire1, which is one of three known sensors of the folding capacity within the endoplasmic reticulum lumen responsible for initiating a signaling pathway known as the unfolded protein response. (wikipedia.org)
  • cytosolic
  • Seven out of ten (EMC1, EMC3, EMC4, MMMGT1, EMC6, EMC7, EMC10) subunts are predicted to contain at least one transmembrane domain (TMD), whereas EMC2, EMC8 and EMC9 do not contain any predicted transmembrane domains are herefore likely to interact with the rest of the EMC on the cytosolic face of the endoplasmic reticulum (ER). (wikipedia.org)

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  • Signal
  • A homologous system exists in eukaryotes, where the signal peptide directs the newly synthesized protein to the Sec61 channel, which shares structural and sequence homology with SecYEG, but is present in the endoplasmic reticulum. (wikipedia.org)