A problem in endocardial cushion development or remodeling is thought to be associated with atrioventricular septal defect. (wikipedia.org)
Endocardial cushion defect (ECD) is an abnormal heart condition. (medlineplus.gov)
In the past, this anomaly has been called by different names, such as AV canal defect or endocardial cushion defect. (msdmanuals.com)
A 2.5 kilogram female with trisomy 21, TEF and endocardial cushion defect was scheduled for TEF repair. (ispub.com)
This defect - also known as endocardial cushion defect or atrioventricular septal defect - is caused by a poorly formed central area of the heart. (kidshealth.org)
37. Anesthetic management of pheochromocytoma resection in a patient with F4 and a complete endocardial cushion defect. (nih.gov)
Sometimes called an endocardial cushion defect or atrioventricular septal defect, an atrioventricular canal defect is present at birth (congenital). (noseplasticsurgery.in)
Septal Defects1
Mice lacking endocardial Jag1, Notch1, or RBPJ displayed enlarged valve cusps, bicuspid aortic valve, and septal defects, indicating that endocardial Jag1 to Notch1 signaling is required for post-epithelial-mesenchymal transition valvulogenesis. (elsevierpure.com)
Ventricular3
Cardiomyocyte-specific inhibition of sox9b function resulted in a decrease in ventricular cardiomyocytes, an increase in atrial cardiomyocytes, hypoplastic endothelial cushions, and impaired epicardial development, ultimately culminating in heart failure. (nature.com)
and (3) the removal/remodeling of CJ during advanced heart looping stages, which leads to the formation of ventricular trabeculations and endocardial cushions. (bvsalud.org)
It has been experimentally determined that the effect of cadmium citrate at a given dose results in the reduced endocardial cushions volume of the atrial-ventricular channel and the reduced cardiofetal index in rat embryos. (dp.ua)
Septum primum2
Ostium primum ASD: These defects are caused by incomplete fusion of septum primum with the endocardial cushion. (medscape.com)
The opening between the Septum Primum and endocardial cushions is foramen primum (ostium primum) , which serves as a shunt. (medicosnotes.com)
Cardiac5
The endocardial cushions are thought to arise from a subset of endothelial cells that undergo epithelial-mesenchymal transition, a process whereby these cells break cell-to-cell contacts and migrate into the cardiac jelly (towards the interior of the heart tube). (wikipedia.org)
Cell biology of cardiac cushion development. (medscape.com)
Endocardial cushion defects (ECDs) of the cardiac outflow tract are among the most common congenital heart disease phenotypes. (nih.gov)
Methods and Results: Using cardiac-specific conditional targeted mutant mice, we find that endothelial/endocardial deletion of Mib1-Dll4-Notch1 signaling, possibly favored by Manic-Fringe, is specifically required for cardiac epithelial-mesenchymal transition. (elsevierpure.com)
Conclusions: During cardiac valve formation, Dll4-Notch1 signaling leads to epithelial-mesenchymal transition and cushion formation. (elsevierpure.com)
Posterior1
Of the 2 intercalated endocardial cushions, the right cushion eventually forms the posterior aortic valve cusp, whereas the left forms the anterior pulmonic valve leaflet. (medscape.com)
Mesenchymal2
A key step in valve formation during heart development is the epithelial-mesenchymal transformation (EMT) of a subpopulation of endocardial cells in the atrioventricular cushion (AVC). (wustl.edu)
The type III transforming growth factor-β receptor (TGFβR3) regulates AVC endocardial cell EMT in vitro and mesenchymal cell differentiation in vivo. (wustl.edu)
Pulmonary1
The endocardial cushions of the vertebral artery and pulmonary edema. (lowerbricktown.com)
Atrial1
Upon sectioning of the heart the atrioventricular endocardial cushions can be observed in the lumen of the atrial canal as two thickenings, one on its dorsal and another on its ventral wall. (wikipedia.org)
Fuse1
The dextrosuperior and sinistroinferior cushions fuse and, in doing so, form the truncal septum. (medscape.com)
Notch1
Hbegf expression in embryonic endocardial cells could be readily activated through a RBPJ-binding site, identifying Hbegf as an endocardial Notch target. (elsevierpure.com)
Fetal2
Estructuras del corazón fetal que son áreas que protruyen en el tabique situado entre las ATRIOS CARDIACOS y los VENTRÍCULOS CARDIACOS. (bvsalud.org)
The fourfold repeated domain of OSF-2 shows homology with the insect protein fasciclin Periostin mRNA is expressed in the developing mouse embryonic and fetal heart, and that it is localized to the endocardial cushions that ultimately divide the primitive heart tube into a four-chambered heart. (biovendor.com)
BICUSPID VALVE1
During development, growth and fusion of endocardial cushions at midline forms the two atrioventricular canals, the sites for future TRICUSPID VALVE and BICUSPID VALVE . (nih.gov)
Valves2
The endocardial cushions are a subset of cells found in the developing heart tube that will give rise to the heart's primitive valves and septa, critical to the proper formation of a four-chambered heart. (wikipedia.org)
The improper fusion or the incomplete dedifferentiation of the previously mentioned endocardial cushions is thought to be responsible for the formation of anatomically and structurally congenitally abnormal aortic valves. (medscape.com)
Heart4
Endocardial cushions, or atrioventricular cushions, refer to a subset of cells in the development of the heart that play a vital role in the proper formation of the heart septa. (wikipedia.org)
These migrated cells form the "swellings" called the endocardial cushions seen in the heart tube. (wikipedia.org)
Endocardial tubes Heart development Mesenchyme This article incorporates text in the public domain from page 512 of the 20th edition of Gray's Anatomy (1918) Maschhoff KL, Baldwin HS (2000). (wikipedia.org)
The endocardial cushions are two thicker areas that develop into the walls (septum) that divide the four chambers of the heart. (medlineplus.gov)
Leaflets1
During this time, the endocardial cushions also undergo dedifferentiation from a myosin-heavy chain to an alpha-smooth muscle actin phenotype, resulting in mature arterial valvular leaflets. (medscape.com)
Formation1
VEGF is essential for endocardial cushion formation and derangements in VEGF synthesis lead to ECD. (nih.gov)
Tube1
Non-uniform spatial distribution of CJ generates non-circular cross sections of the opened endocardial tube (initially elliptic, later deltoid), which seem to be advantageous for valveless pumping. (bvsalud.org)
Data1
Taken together, our data demonstrate that TGFβR3-dependent endocardial cell EMT stimulated by either TGFβ2 or BMP-2 requires Smad4 and the activation of the Par6/Smurf1 pathway. (wustl.edu)