• PMID
  • PMID 26124166 Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. 2'-C-methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. (wikipedia.org)
  • Lyme
  • The phenomenon of nonviraemic or nonsystemic transmission turns out to be widespread - it has been subsequently observed with many other viruses transmitted by ticks, black flies and mosquitos, including major human pathogens such as West Nile virus, as well as other pathogens, including the spirochaete Borrelia burgdorferi, which causes Lyme disease. (wikipedia.org)
  • phylogenetic
  • Additionally, novel phylogenetic conserved structures were identified in the variable part of the 3'-untranslated region, and their sequence and structure similarity when compared with earlier identified structures suggests an enhancing function on virus replication and translation. (diva-portal.org)
  • Russia
  • Even though lineage II has been predominant in POWV positive tick pools, both lineages have had confirmed cases of human disease in North America and Russia The lineages share 84% nucleotide sequences and 94% amino acid sequence identity. (wikipedia.org)
  • molecular
  • His work has revealed the origin, evolution and molecular epidemiology of important human pathogens including Hepatitis C, influenza, HIV and dengue, and enabled more accurate assessments of what types of virus are most likely to emerge in human populations and whether they will evolve human-to-human transmission. (wikipedia.org)
  • transmit
  • It has been found that the yellow-necked mouse can transmit the virus causing tick-borne encephalitis while being immune to the virus itself. (wikipedia.org)
  • The cattle tick can transmit an animal disease called Theileriosis to cattle, which can cause considerable blood loss and occasional death of calves, but mainly is important to dairy farmers because of decreased milk production and sheep farmers because of decreased wool quantity and quality. (wikipedia.org)
  • POWV
  • scapularis is an important vector for the Deer Tick Virus, which plays a vital role in maintaining the POWV. (wikipedia.org)
  • About 10% of POWV encephalitis cases are fatal and half the survivors have permanent symptoms that affect their brain. (wikipedia.org)
  • Arthropods
  • During this research, Nuttall visited sea-bird colonies and became interested in ticks, arthropods that often infest sea birds as well as other vertebrates, and can act as vectors for disease. (wikipedia.org)
  • 2017
  • The tick was not known to be present on the mainland U.S. until November 9 2017, when it was first discovered on a farm in Hunterdon County, New Jersey, though it had been collected in US ports on import animals and materials at least a dozen times prior. (wikipedia.org)
  • strains
  • Finally, we were able to detect variations that help in the understanding of virus adaptations to varied environmental temperatures and mammalian hosts through a comparative approach that compares RNA folding dynamics between strains with different mammalian cell passage histories. (diva-portal.org)
  • Symptoms
  • WNE presents with similar symptoms to other viral encephalitis with fever, headaches, and altered mental status. (wikipedia.org)
  • A prominent finding in WNE is muscular weakness (30 to 50 percent of patients with encephalitis), often with lower motor neuron symptoms, flaccid paralysis, and hyporeflexia with no sensory abnormalities. (wikipedia.org)
  • Typically, people infected with dengue virus are asymptomatic (80%) or have only mild symptoms such as an uncomplicated fever. (wikipedia.org)
  • bites
  • Besides transmission through tick bites, the virus can also be passed on by ingestion of unpasteurized dairy products such as milk and cheese from infected goats, sheep, or cows. (zoologix.com)
  • Prevention of tick bites is the best precaution. (wikipedia.org)
  • bite
  • The transmission mainly occurs by the bite of an infected tick. (hu-berlin.de)
  • Prevention includes non-specific (tick-bite prevention, tick checks) and specific prophylaxis in the form of a vaccination. (wikipedia.org)
  • birds
  • The cattle tick lives on mammals and birds. (wikipedia.org)
  • Natural infestations have been found on wild animals like bear, deer, foxes, hares, small mammals like rats, ferrets and birds, the latter hosting the ticks larvae. (wikipedia.org)
  • viremia
  • Such an unusual clinical case offers the unique chance of detecting persistent viremia associated to the erythrocyte fraction and shedding of the virus in the urine for more than six weeks. (units.it)
  • pathogens
  • Nuttall's recent work has focused on discovering the function of tick saliva's many constituents, as well as the mechanisms by which tick-transmitted pathogens use them to enhance their transmission. (wikipedia.org)
  • antiviral
  • With Norbert Fuchsberger, Valeria Hajnicka and others, Nuttall has shown that tick saliva suppresses the host's antiviral immune responses, including natural killer cell activity and the induction of type I interferon and cytokines involved in inflammation. (wikipedia.org)
  • Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. (wikipedia.org)
  • Sustained viral response in a hepatitis C virus-infected chimpanzee via a combination of direct-acting antiviral agents. (wikipedia.org)