E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. (icr.ac.uk)
Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). (icr.ac.uk)
Proteins4
These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
E2F2 effects the cell cycle, tumor suppressor proteins, and can also be transformed by proteins of small DNA tumor viruses. (journalsmededu.pl)
opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
These particular genes code for several proteins including heat shock proteins, chaperonins, neurotrophic growth factors, transcriptional growth promoters and proteinases. (emerging-researchers.org)
Protein6
Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene. (wikipedia.org)
E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. (idrblab.net)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Interestingly, real-time PCR and translation inhibition studies revealed that survivin was over-expressed partially through the up-regulation of protein translation instead of gene transcription in A549 cancer cells. (biomedcentral.com)
Tumor5
TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
Pathways4
The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
Numerous studies have demonstrated a role for E2F2 in various signaling pathways. (journalsmededu.pl)
Further investigations of E2F2 pathways are warranted for a clearer understanding of neoplastic processes and to identify novel pharmacological treatments. (journalsmededu.pl)
Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
Promotes2
E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
The lncRNA TMPO-AS1 promotes cell proliferation, migration, invasion and epithelial-to-mesenchymal transition by regulating the miR-1179/E2F2 axis [ 13 ]. (biomedcentral.com)
Although more highly transcribed genes acquire methylation earlier, the major transitions in the oocyte transcriptome occur well before the de novo methylation phase, indicating that transcription is generally not rate limiting in conferring permissiveness to DNA methylation. (biomedcentral.com)
To further explore the molecular function of Rasd1, we performed a yeast two-hybrid screen and identified Ear2, a negative regulator of renin transcription, as an interaction partner of Rasd1. (biomedcentral.com)
RYBP1
E2F2 has been shown to interact with: BRD2, RYBP, and RB1. (wikipedia.org)
Encodes1
The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
E2Fs1
Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
Prognostic1
E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
Promoters1
The E2F transcription factor family regulates the expression of various cellular promoters, particularly those involved in the cell cycle. (avivasysbio.com)
Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. (idrblab.net)
Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. (icr.ac.uk)
Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
Role1
Given the predominant role of transcription, we sought to investigate whether transcription timing is rate limiting for de novo methylation and determines the asynchrony of methylation events. (biomedcentral.com)
Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
Important2
Cardiac hypertrophy is an important and independent risk factor for the development of cardiac myopathy that may lead to heart failure. (mdpi.com)
Abnormal bite force is an important risk factor for oral and maxillofacial disorders, which is a critical dilemma that dentists face every day without effective solutions. (bvsalud.org)
Description4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Myogenic Factor 5 (MYF5) in Tissue homogenates and other biological fluids. (1elisakits.com)
Description: A sandwich ELISA kit for detection of Myogenic Factor 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Description: Quantitative sandwich ELISA for measuring Human Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Description: Quantitative sandwich ELISA for measuring Mouse Myogenic factor 5 (MYF5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (1elisakits.com)
Human1
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). (idrblab.net)
Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
Growth1
We also identified differential enrichment of transcription factor binding motifs in CGIs acquiring methylation early or late in oocyte growth. (biomedcentral.com)