• E2F is a group of genes that encodes a family of transcription factors in higher eukaryotes. (fortunepublish.com)
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
  • Disease relevance of E 2 f 1 Transactivation of E2F- regulated genes by polyomavirus large T antigen: evidence for a two- step mechanism. (wikigenes.org)
  • We, in a dogma changing study demonstrated that key cell cycle genes are regulated by HCFC1 cofactor recruitment not by the E2F proteins but by a THAP11-ZNF143 transcriptional complex. (northwestern.edu)
  • These studies are highly significant because it changes the paradigm that E2F mediated HCFC1 recruitment is critical for expression of cell cycle target genes, and raises the possibility that E2F participates in this process by recruiting factors other than HCFC1, thereby promoting new directions of research in this highly active field. (northwestern.edu)
  • E2F transcription factors regulate genes involved in cell-cycle progression. (uu.nl)
  • These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. (wikipedia.org)
  • The E2F proteins contain several evolutionally conserved domains found in most members of the family. (wikipedia.org)
  • These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. (wikipedia.org)
  • DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
  • Transcription factors and co-activator proteins in co-ordinating the cell cycle and other physiological processes. (lister-institute.org.uk)
  • One of Chakravarti's major research interests is to determine the mechanisms of steroid hormone and vitamin signaling with special emphasis on the role of the nuclear hormone receptor co-regulatory proteins in gene transcription. (northwestern.edu)
  • Thus, DP-4 forms a heterodimer with E2F subunits, binds to the E2F site and associates with pocket proteins including pRb. (uu.nl)
  • Minato Y, Tashiro E, Kanai M, Imoto M. Involvement of E2F in cellular proliferation by regulating growth factor receptor expression. (go.jp)
  • Mechanisms regulating cancer cell growth and proliferation (particularly the pRb/E2F pathway). (lister-institute.org.uk)
  • He then did post-doctoral studies with Joseph Nevins at Duke University studying the control of Rb/E2F induction of proliferation and apoptosis. (umn.edu)
  • Furthermore, GSEA analysis of CDK1-hi tumor cells identified a pathway signature common in all three cancer types, including E2F, G2M, MYC, and spermatogenesis, confirming a stem-like nature of CDK1-hi tumor cells. (genengnews.com)
  • This cancer is caused by deregulation of the Rb/E2F pathway. (umn.edu)
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
  • It was verified that the risk score constructed by 7 GNG7-related regulators might be used as an independent prognostic risk factor for CCRCC. (biomedcentral.com)
  • E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. (avivasysbio.com)
  • These results highlight an emerging complexity in the DP family of E2F subunits, and suggest that DP-4 may endow E2F heterodimers with distinct transcription properties. (uu.nl)
  • TFDP1 may be the first example of a family of related transcription factors and may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells. (avivasysbio.com)
  • Furthermore, DP-4 interferes with E2F-1-dependent transcription and delays cell-cycle progression. (uu.nl)
  • We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • Instead, the CU scientists asked which factors could cause these cells to initiate tumor growth in the first place. (genengnews.com)
  • Moreover, immune infiltrations analysis showed that transcriptional levels and somatic copy number alterations (SCNA) in E2F family were significantly correlated with several immune cell recruitments, including B cells, CD8+ T cells, CD4+ T cells, neutrophils, macrophages, and dendritic cells. (fortunepublish.com)
  • A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. (bvsalud.org)
  • SNPC-4 is a transcription factor known to stimulate the activity of both RNA polymerase II and III, and we have found that RNA polymerase III (pol III) also exhibits increased occupancy in piRNA clusters. (yale.edu)
  • Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • Downstream targets of CDKs include transcription factor E2F and its regulator Rb. (kegg.jp)
  • A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
  • High impact information on E2f Negative regulation of d E 2 F 1 by cyclin- dependent kinases controls cell cycle timing. (wikigenes.org)
  • Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
  • Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. (wikipedia.org)
  • The protein encoded by this gene is a member of the E2F family of transcription factors. (wikipedia.org)
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
  • The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. (antibodies-online.com)
  • Therefore, it is of great significance to explore the mechanism of tumorigenesis in breast cancer and further identify key regulatory factors. (researchsquare.com)
  • All the cyclin A binding E2F family members can interact. (wikigenes.org)
  • Sox2 is a transcription factor that helps embryonic and neural stem cells keep their stem-ness. (genengnews.com)
  • In mammalian cells, physiological E2F exists as an E2F/DP heterodimer. (uu.nl)
  • This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)
  • We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
  • Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
  • Studies show that replicative senescence or cellular senescence is induced by intrinsic or extrinsic environmental factors [ 11 ]. (hindawi.com)
  • UVI4 is expressed in an S phase-dependent fashion, likely through the action of E2F transcription factors. (ugent.be)
  • Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
  • Ultimately, the CU scientists conducted a proteomic analysis that revealed an interaction between CDK1 and the pluripotent stem cell transcription factor Sox2. (genengnews.com)
  • Understanding factors required for DNA replication will enrich our knowledge of this important process and potentially identify vulnerabilities that can be exploited in cancer therapy. (aacrjournals.org)
  • It is a binding partner for E2F TRANSCRIPTION FACTORS and enhances the DNA binding and transactivation function of the DP-E2F complex. (bvsalud.org)
  • In contrast to DP-1, however, DP-4/E2F-1 complexes exhibit reduced DNA binding activity. (uu.nl)
  • In the animation below, these signals would be represented by the the 'X' shaped growth factor and the foot in the video portion. (cancerquest.org)
  • As shown below, binding of the growth factor can lead to cell division. (cancerquest.org)