• This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar's malaria case notification surveillance system. (biomedcentral.com)
  • For the treatment of falciparum malaria, WHO is recommending the use of a type of drug called artemisinin-based combination therapy, or ACTs. (cdc.gov)
  • These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. (biomedcentral.com)
  • After finding that triple-combination therapy may help to prevent resistance acquisition in colorectal cancer cells, the researchers said that future studies should look into questions of timing, dosage and tolerability. (pharmaceutical-journal.com)
  • Treating colorectal cancer with a trio of targeted drugs reduces the acquisition of drug resistance, in vitro research published in Oncogene shows (25 March 2019) [1] . (pharmaceutical-journal.com)
  • However, adding a low concentration of navitoclax, a BCL2-family inhibitor, to the MEK-PI3K regimen in previously untreated cells resulted in improved synergistic interaction between the therapies and blocked the acquisition of resistance. (pharmaceutical-journal.com)
  • The researchers said the findings indicated that triple-combination therapy may help to prevent resistance acquisition, rather than overcoming pre-existing resistance. (pharmaceutical-journal.com)
  • It is possible that the addition of a third agent may be tolerated clinically in such a dosing regimen and provide the opportunity to overcome, or ameliorate, the major clinical problem of resistance to targeted therapies," they concluded. (pharmaceutical-journal.com)
  • Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer. (pharmaceutical-journal.com)
  • Empirical combination therapy is recommended for patients with known or suspected Pseudomonas aeruginosa (PA) infections as a means to decrease the likelihood of administering inadequate antimicrobial treatment, to prevent the emergence of resistance, and to achieve a possible additive or even synergistic effect. (wustl.edu)
  • Combination therapy has been shown to dramatically reduce the likelihood of drug resistance (many drug-resistant mutations are mutually exclusive) and to suppress viral replication to the point that progression to AIDS is significantly slowed. (medscape.com)
  • Antiviral-resistance mutations often affect more than one drug simultaneously because of similar development pipelines and the ultimate molecular structure of the drug, and combination choices should account for this possibility. (medscape.com)
  • Thirteen pharmaceutical companies have agreed to phase out a single-drug treatment for malaria in a bid to control rates of drug-resistance in the disease. (newscientist.com)
  • These artemisinin combination therapies (ACTs) reduce the chance that drug-resistant malaria will develop because there is a much lower probability that the malaria parasite will evolve resistance to multiple drugs at once. (newscientist.com)
  • To combat drug resistance the Ugandan ministry of health announced on Friday that it was changing its treatment policy from the less effective combination of chlorine and fansidar to ACTs. (newscientist.com)
  • Charlotte Rasmussen] The resistance to antimalarial drugs has long been a challenge in Southeast Asia. (cdc.gov)
  • Unfortunately, in parts of Southeast Asia, we've seen resistance to both artemisinin and to most of the ACT partner drugs. (cdc.gov)
  • Resistance to partner drugs used together with an artemisinin is a particularly big problem in Cambodia. (cdc.gov)
  • The development of a fixed dose combination aims to reduce the number of daily tablets, and therefore enhance adherence to therapy and thereby minimizing the risk of emergence of resistance. (who.int)
  • Both of these sublineages contain a mutation (K444T) in the spike protein that confers resistance to the monoclonal antibody bebtelovimab [2], which was previously authorized as one of the second-line therapies to treat COVID-19. (cdc.gov)
  • Among the advantages of multitarget drugs vs drug combinations are the more predictable pharmacokinetic (PK) and pharmacodynamic (PD) relationship of the components of a single medicine, the possibility that one motif might improve the bioavailability of the second entity, the greater efficacy against advanced-stage diseases, the lower toxicities, the simultaneous presence of the chemical entities in multiple tissues, and the improved patient compliance [ 2 ]. (biomedcentral.com)
  • As a pediatric endocrinologist, I can tell you we're seeing more and more Type 2 diabetes in kids and adolescents, and it seems to be a more aggressive form than adult onset diabetes, so we do need better therapies to achieve even greater efficacy and degree of weight loss," said Andrea Haqq , a professor in the University of Alberta's Faculty of Medicine & Dentistry . (eurekalert.org)
  • Further studies should also focus on how differences in biological sex affect drug efficacy and safety. (eurekalert.org)
  • An important step is to monitor the efficacy of this drug. (cdc.gov)
  • The support we provide can include financial support, training in how to do efficacy monitoring, providing quality assured drug, and reviewing the data. (cdc.gov)
  • The company unveiled on Tuesday positive data from Phase I and Phase II studies for three different triple combination regimens for CF patients with certain types of gene mutations with one F508del mutation and one minimal function mutation (F508del/Min). (drugdiscoverytrends.com)
  • Results from a three year double-blinded trial which compared antiretroviral therapies show that the combination regimens of tenofovir DF and stavudine, are equally effective, though tenofovir DF has more favorable outcomes with respect to cholesterol levels and the nervous system. (news-medical.net)
  • Although combination chemotherapy regimens, including the nucleoside analogue fludarabine, were once the most commonly used first-line therapy in CLL, non-chemotherapy regimens (eg, with Bruton tyrosine kinase [BTK] inhibitors) are currently preferred in most cases. (medscape.com)
  • The success of complex antiretroviral regimens is dependent on consistent adherence of patients to the drugs. (who.int)
  • HA060 trade name] provides a combination of drugs i.e. lamivudine and zidovudine, that are already established as a backbone of the triple drug regimens. (who.int)
  • Several combination products that contain tenofovir alafenamide (TAF) are now approved in the United States. (medscape.com)
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432835/all/Tenofovir_or_zidovudine_in_three_drug_combination_therapy_with_one_nucleoside_reverse_transcriptase_inhibitor_and_one_non_nucleoside_reverse_transcriptase_inhibitor_for_initial_treatment_of_HIV_infection_in_antiretroviral_na��ve_individuals:_Cochrane_systematic_review. (unboundmedicine.com)
  • An expert shares her take on emerging strategies for combination treatment for NAFLD and NASH with GLP-1 receptor agonists plus SGLT2 inhibitors. (clinicaloptions.com)
  • Researchers treated a panel of 47 human colorectal cancer cell lines with combinations of MEK- PI3K- and ERK-inhibitors. (pharmaceutical-journal.com)
  • Lev combines high-throughput screening with a library of chemotherapies and small molecule inhibitors to identify combination therapies for TNBC. (wikipedia.org)
  • Considering other non-statin drugs, including ezetimibe and PCSK9 inhibitors. (healthywomen.org)
  • Four drug classes were evaluated in the trials: thiazides (21 trials), beta-adrenergic blockers (5), calcium-channel blockers (4) and angiotensin-converting-enzyme (ACE) inhibitors (1). (cmaj.ca)
  • The same cannot be said for high-dose thiazide therapy, beta-blockers, calcium-channel blockers or ACE inhibitors. (cmaj.ca)
  • The drugs for treatment of HIV infection are categorized as nucleoside reverse transcriptase inhibitors (NRTIs), protease inhibitors (PIs) and non- nucleoside reverse transcriptase inhibitors (NNRTIs). (who.int)
  • HA060 trade name] is a generic version of Combivir®, the first fixed-dose combination containing two known antiretroviral agents belonging to the RT inhibitors class. (who.int)
  • The available evidence about the effectiveness of specific first-line antihypertensive drugs in lowering blood pressure and preventing adverse outcomes has not been systematically quantified in a manner that would assist clinicians in choosing a first-line drug. (cmaj.ca)
  • Selected were randomized controlled trials of at least 1 year's duration that provided morbidity or mortality data and that compared 1 of 6 possible first-line antihypertensive therapies either with another 1 of the 6 drug therapies (drug-drug comparison) or with no treatment, including placebo (drug-no treatment comparison). (cmaj.ca)
  • There have been a number of systematic reviews of the effectiveness of antihypertensive therapy, but most have focused on overall effectiveness [ 1 , 2 ] or effectiveness in special groups such as elderly patients. (cmaj.ca)
  • Only 2 reviews have attempted to distinguish between the effectiveness of antihypertensive therapies used as first-line agents. (cmaj.ca)
  • These changes included the following: a validated hypertension population registry, a simple drug treatment algorithm based on a combination antihypertensive medication, regular performance feedback, alerts to providers that the patient has an elevated blood pressure measure, improved staff competency in blood pressure monitoring, expansion of patient access to primary care by using medical assistants to check blood pressure, and strong leadership support for health care delivery changes to improve hypertension control. (cdc.gov)
  • Charlotte Rasmussen] I work for WHO which supports countries in monitoring that the antimalarial drug that is recommended by a country continues to work in that country. (cdc.gov)
  • In April 2009, a new treatment option for second-stage T. b. gambiense HAT, nifurtimox-eflornithine combination therapy (NECT), was added to the WHO Essential Medicines List (EML). (dndi.org)
  • spironolactone is an effective treatment for primary hyperaldosteronism (defined as an elevated plasma aldosterone-to-renin ratio) - thus if a patient is uncontrolled despite triple therapy then a plasma renin should be measured off beta-blockade (which suppresses renin) as part of consideration of secondary causes of hypertension (2). (gpnotebook.com)
  • After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
  • Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. (biomedcentral.com)
  • People with obsessions and compulsions experience considerable benefit from a combined treatment of drugs and behavioural therapy. (scienceblog.com)
  • Treatment with drugs alone is less effective. (scienceblog.com)
  • With the invention and development of laser technology, photo-based therapeutic modalities such as photodynamic therapy (PDT) and photothermal therapy (PTT) have become prospective minimally invasive approaches for cancer treatment [ 1 - 5 ]. (thno.org)
  • Shares of Myovant Sciences traded 40% higher after the company reported that it has submitted a New Drug Application to the FDA for once-daily relugolix combination tablet for the treatment of women with uterine fibroids. (stockhouse.com)
  • These results suggests that treatment with combination antimicrobial therapy did not reduce the mortality risk compared with single-drug therapy in PA bloodstream infections. (wustl.edu)
  • Cationic amphiphilic drugs (CADs) can be repurposed as anti-cancer drugs via induction of lysosomal cell death (LCD), but combination treatment and improved tumor targeting are key to boost antitumor effects. (ugent.be)
  • The treatment duration for patients who previously failed therapy is 48 weeks, regardless of HCV genotype. (drugs.com)
  • The duration of treatment should be individualized to the patient depending on baseline disease characteristics, response to therapy, and tolerability of the regimen [see Indications and Usage (1.1) , Adverse Reactions (6.1) , and Clinical Studies (14) ]. (drugs.com)
  • Multi-modal combination therapies are often used in cancer treatment to leverage different treatment approaches and reduce the likelihood that drug-resistant cancer cells develop. (wikipedia.org)
  • The appropriate therapy for neurogenic bladder and a successful treatment outcome are predicated upon an accurate diagnosis through a careful medical and voiding history, together with a variety of clinical examinations, including urodynamics and selective radiographic imaging studies. (medscape.com)
  • Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (news-medical.net)
  • Increasing the body's production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • However, Ringwald acknowledges that combination therapy costs more than single-drug treatment. (newscientist.com)
  • Laxminarayan says that it is important to secure these funds as the single-drug option is phased out so that poorer people with malaria still have treatment options. (newscientist.com)
  • Creating a value statement that highlights the need for patients and health care providers to factor in the cost of drugs when determining treatment. (healthywomen.org)
  • Relief may be found by using a combination of treatment options. (webmd.com)
  • Increased travel distance to a cancer treatment facility negatively impacts the likelihood that patients with stage II/III rectal cancer will receive radiation therapy (RT) to treat their disease, according to a study analyzing 26,845 patient records. (sciencedaily.com)
  • Standard treatment for stage II/III rectal cancer, as outlined in National Comprehensive Cancer Network (NCCN) guidelines, includes RT, chemotherapy and surgery (i.e., trimodality therapy), yet as this retrospective study of NCDB patient records indicates, many eligible patients do not receive RT to treat their cancer. (sciencedaily.com)
  • This pipeline analysis report provides a detailed analysis of the companies that are involved in the development of drug molecules for the treatment of Encephalopathy. (technavio.com)
  • Treatment for ADHD has traditionally involved a combination of behavioral therapy and drug therapy. (peta.org)
  • Treatment typically involves a combination of pain-relieving drugs and physical therapy. (healthline.com)
  • The following outcomes were pooled according to trial design (drug-drug or drug-no treatment comparison) and the drug therapy: death, stroke, coronary artery disease, total cardiovascular events, withdrawal due to adverse effect, and decrease in systolic and diastolic blood pressure. (cmaj.ca)
  • In both the drug-drug and the drug-no treatment comparison trials, thiazides were significantly better at reducing systolic blood pressure than the other drug classes. (cmaj.ca)
  • Low-dose thiazide therapy can be prescribed as the first-line treatment of hypertension with confidence that the risk of death, coronary artery disease and stroke will be reduced. (cmaj.ca)
  • Health Organization, about drug resistant malaria treatment in Vietnam. (cdc.gov)
  • HA060 trade name] is indicated for the treatment of HIV infection, as a part of combination therapy. (who.int)
  • Early outpatient treatment of mild-to-moderate COVID-19 with a recommended first-line therapy , ritonavir-boosted nirmatrelvir (Paxlovid™) or remdesivir (Veklury®), or the second-line therapy, molnupiravir (Lagevrio™) have been shown to prevent hospitalizations and deaths [4-6]. (cdc.gov)
  • image: Andrea Haqq (right) is bringing her clinical experience working with patients to an international collaboration aimed at identifying personalized drug combinations to better treat people with obesity and Type 2 diabetes. (eurekalert.org)
  • Canadian and German researchers are teaming up to identify new drug combinations to treat people with obesity and Type 2 diabetes. (eurekalert.org)
  • Called lipin, the gene may provide a new target for therapies to control obesity, diabetes and other weight-related disorders. (news-medical.net)
  • Disparities in combination drug therapy use in older adults with coronary heart disease: a cross-sectional time-series in a nationally representative US sample. (umassmed.edu)
  • Milder forms of pain may be relieved by over-the-counter medications such as Tylenol (acetaminophen) or nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen. (webmd.com)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) can help lower both pain and swelling. (healthline.com)
  • Haqq and Tan recommend further research to identify why some individuals respond differently to the drugs. (eurekalert.org)
  • Different individuals respond differently to therapies, making it challenging for those seeking assistance. (peta.org)
  • Effective antiretroviral therapy is the most important intervention in terms of improving longevity and preventing opportunistic infections in patients with human immunodeficiency virus (HIV) infection. (medscape.com)
  • Almost 90% of HIV-positive TB patients were receiving cotrimoxazole preventive therapy and the coverage of antiretroviral therapy among TB patients coinfected with HIV reached 77% in 2014. (who.int)
  • Effect of adequate single-drug versus combination antimicrobial therapy on mortality in Pseudomonas aeruginosa bloodstream infections. (wustl.edu)
  • APG-115-US-002 is an open-label, multi-center, Phase Ib/II study in U.S. , which was designed to assess safety, toxicity, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of APG-115 in combination with pembrolizumab in patients with advanced solid tumors. (pharmiweb.com)
  • The application of GNS@CaCO 3 /ICG for in vitro and in vivo therapy achieved the combined antitumor effects upon the NIR irradiation, which was superior to the single PDT or PTT. (thno.org)
  • Multidrug therapy against leprosy : development and implementation over the past 25 years / [editor]: H. Sansarricq. (who.int)
  • As of April 1, 2020, in the Phase Ib study, 19 patients were treated with APG-115 in 4 alternate-day (QOD) dose cohorts (50 mg, 100 mg, 150 mg, and 200 mg) in combination with pembrolizumab. (pharmiweb.com)
  • Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. (biomedcentral.com)
  • They found that treating cells with a MEK-PI3K-inhibitor combination led to a synergistic effect in cell growth inhibition. (pharmaceutical-journal.com)
  • The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. (rxreasoner.com)
  • Another current trend in therapy is drug repurposing or the re-discovery of a new therapeutic area for a drug used traditionally to treat a given pathology, either through the ability to modulate an additional target or by the involvement of the primary target in multiple pathologies. (biomedcentral.com)
  • The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
  • To benefit from those effects, it is required that the multitarget drug exhibit balanced in vitro and in vivo activities to match potency for the corresponding targets, as well as optimized PK and safety profiles. (biomedcentral.com)
  • Also, the researchers explored the safety and tolerability of VX-659 as a component of a triple combination for two weeks in 12 patients with CF that were ages 18 and older with one F508del mutation and one minimal function mutation (3 in placebo and 9 in VX-659 120 mg), according to the announcement. (drugdiscoverytrends.com)
  • The researchers recently published a paper that examines the potential of several drugs that control incretins. (eurekalert.org)
  • The researchers conclude that combining the drugs has several advantages, including higher effectiveness in at least some patients and fewer side-effects. (eurekalert.org)
  • In addition to drug combinations, the researchers are looking for non-pharmacological solutions, such as how adding fibre to a person's diet can slow weight gain and improve the effectiveness of existing diabetes medications. (eurekalert.org)
  • There is no syndrome that causes increased belly fat and decreased facial and limb fat among HIV-positive men who take antiretroviral drugs, according to a study by researchers at the San Francisco VA Medical Center and the University of California, San Francisco. (news-medical.net)
  • The 2018 ACC/AHA Guidelines on the Management of Blood Cholesterol allow for more personalized care for patients, including more detailed risk assessments and new cholesterol-lowering drug options for people at the highest risk for heart disease. (healthywomen.org)
  • The 2018 guidelines recommend that health care providers use coronary artery calcium scores as a secondary tool when deciding whether to prescribe statin drugs. (healthywomen.org)
  • One of the main components of managing a patient with hypertension is deciding which drug to prescribe for first-line therapy. (cmaj.ca)
  • Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. (biomedcentral.com)
  • Mass drug administration for malaria was well accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates. (biomedcentral.com)
  • One potential strategy for targeted interventions in a malaria elimination setting is focal mass drug administration (MDA) in high-risk populations. (biomedcentral.com)
  • Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar. (ajtmh.org)
  • HA060 trade name] is a fixed dose combination tablet containing 150 mg of lamivudine and 300 mg of zidovudine in each film-coated tablet. (who.int)
  • Control medicines for asthma are drugs you take to control your asthma symptoms. (medlineplus.gov)
  • When standard medicines and physical therapy fail to offer adequate pain relief, you may be a candidate for a surgical implant to help you control pain. (webmd.com)
  • In the trials that had an untreated control group, low-dose thiazide therapy was associated with a significant reduction in the risk of death (RR 0.89, 95% CI 0.81-0.99), stroke (RR 0.66, 95% CI 0.56-0.79), coronary artery disease (RR 0.71, 95% CI 0.60-0.84) and cardiovascular events (RR 0.68, 95% CI 0.62-0.75). (cmaj.ca)
  • Too often, nursing facilities use antipsychotic drugs to control residents when they do not have sufficient numbers of nursing staff - professional registered nurses, licensed practical nurses, and certified nursing assistants - to provide direct, hands-on care to residents. (medicareadvocacy.org)
  • [12] Simply stated, in the absence of sufficient numbers of professional and paraprofessional nursing staff, facilities inappropriately use antipsychotic drugs to quiet and control residents. (medicareadvocacy.org)
  • Interactions between Chinese herbal medicinal products and orthodox drugs / Kelvin Chang and Lily Cheung. (who.int)
  • Use of an oral antidiabetes medication produced significant improvement in a group of patients with HIV lipodsytrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • The standard of care in Human Immunodeficiency Virus (HIV) infection is the use of a triple drug antiretroviral regimen. (who.int)
  • Abstract Recently, a plethora of life-prolonging cytotoxic, next-generation hormonal, immunotherapeutical as well as radionuclide therapies has emerged as a standard care for metastasized castration-resistant prostate cancer. (cristiansurcel.ro)
  • According to this pipeline analysis report, most of the molecules that are currently in the drug development for encephalopathy are being developed as monotherapy drugs and most of these molecules are in the pre-clinical stage of development. (technavio.com)
  • We describe the clinical courses and detail treatments of 20 critically ill patients with invasive mechanical ventilation, which may be valuable for determining future therapies and intensive care of critically ill patients with COVID-19. (fortunejournals.com)
  • Conclusion: We conducted multidisciplinary treatments using a single protocol, including antiviral drugs, methylprednisolone and daily proning, for critically ill COVID-19 patients who required invasive mechanical ventilation. (fortunejournals.com)
  • Even a five per cent weight loss is considered clinically meaningful, and patients in some of the combination drug trials are achieving 10 or 15 per cent, said Haqq, who is a member of the Alberta Diabetes Institute and the Women and Children's Health Research Institute . (eurekalert.org)
  • This study investigated combined prescriptions of drugs for mood disorders and physical comorbidities that need special attention in the light of frequent physical comorbidities in patients with mood disorders. (nih.gov)
  • Devimistat in combination with GC is well tolerated and has an acceptable safety profile in patients with untreated advanced BTC. (nih.gov)
  • Mortality was compared in patients treated with adequate empirical and definitive combination therapy (AECT, ADCT), and adequate empirical and definitive single-drug therapy (AESD, ADSD). (wustl.edu)
  • The unadjusted probabilities of survival until day 30 were 69.4% (95% confidence interval [CI]: 59.1-81.6) for the patients which receiving AECT, 73.5% (95% CI: 68.4-79.0) for the AESD group, and 66.7% (95% CI: 61.2-72.7) for patients who received inadequate empirical therapy (P=0.17, log-rank test). (wustl.edu)
  • Numerous antiretroviral combination products are available on the market to assist patients with compliance and decrease the daily number of tablets and capsules required (see Table 2, below). (medscape.com)
  • Discontinuation of therapy should be considered in patients who do not achieve at least a 2 log 10 drop or loss of hepatitis C virus (HCV)-RNA at 12 weeks, or if HCV-RNA remains detectable after 24 weeks of therapy. (drugs.com)
  • Re-treated patients who fail to achieve undetectable HCV-RNA at Week 12 of therapy, or whose HCV-RNA remains detectable after 24 weeks of therapy, are highly unlikely to achieve SVR and discontinuation of therapy should be considered [see Clinical Studies (14.1) ]. (drugs.com)
  • The recommended dose of REBETOL when used in combination with PegIntron in pediatric patients ages 3-17 years is 15 mg/kg/day in two divided doses (see Table 2 ). (drugs.com)
  • Sur les 655 patients fébriles, 35,9 % ont été recensés comme étant atteints de paludisme en se fondant sur les résultats de laboratoire de l'hôpital. (who.int)
  • Nutritional therapy for HIV-infected patients is shifting focus. (news-medical.net)
  • Travel burden clearly creates a barrier to radiation therapy access for rectal cancer patients, but this barrier is far from absolute," said lead author Chun Chieh "Anna" Lin, PhD, MBA, director of health services research at the American Cancer Society. (sciencedaily.com)
  • This drug was chosen partly because genetic analysis of the parasites in the study showed that the parasites from all 46 patients had a single copy of the gene Pfmdr1 , confirming that all parasites were sensitive to mefloquine. (cdc.gov)
  • Patients frequently encounter practical difficulties in adhering to the complex combination due to various reasons like dosing frequency, daily pill burden, food restriction etc. (who.int)
  • It is not indicated for use in paediatric patients less than 12 years of age and patients with renal impairment, since it is a fixed dose combination that cannot e titrated for these patients. (who.int)
  • High-dose thiazide therapy, beta-blocker therapy and calcium-channel blocker therapy did not significantly reduce the risk of death or coronary artery disease. (cmaj.ca)
  • VX-659 was tested in a randomized, double-blind, placebo-controlled study where investigators evaluated the safety and tolerability of single and multiple ascending doses of VX-659 alone as well as in triple combination with tezacaftor and ivacaftor in healthy volunteers. (drugdiscoverytrends.com)
  • In rat models of acute lipopolysaccharide-induced endotoxemia and delayed-type hypersensitivity, and in chronic models of collagen-induced and adjuvant-induced arthritis, the combination produced anti-inflammatory activity that required only a subtherapeutic dose of prednisolone. (biomedcentral.com)
  • We review the state of the art with such combinations that have an epigenetic target as one of their mechanisms of action. (biomedcentral.com)
  • Ex vivo models for the noninvasive study of myelin-related diseases represent an essential tool to understand the mechanisms of diseases and develop therapies against them. (researchgate.net)
  • Many of the antiretroviral drugs that have been approved for HIV-infected adults and adolescents are gaining FDA approval for use in younger children. (medscape.com)
  • In this study, the calcium carbonate worked not only a drug keeper to entrap ICG on the surface of GNSs in the form of a stable aggregate which was protected from blood clearance, but also as the a pH-responder to achieve highly effective tumor-triggered drug release locally. (thno.org)
  • Meanwhile, the distinct pH-triggered drug release performance of GNS@CaCO 3 /ICG implemented the tumor-targeted NIR fluorescence imaging. (thno.org)
  • In addition, we monitored the bio-distribution and excretion pathway of GNS@CaCO 3 /ICG based on the NIR fluorescence from ICG and two-photon fluorescence and photoacoustic signal from GNSs, and the results proved that GNS@CaCO 3 /ICG had a great ability for tumor-specific and tumor-triggered drug release. (thno.org)
  • We therefore conclude that the GNS@CaCO 3 /ICG holds great promise for clinical applications in anti-tumor therapy with tumor imaging or drug tracing. (thno.org)
  • The companies, which represent some of the main producers of the drug artemisinin, bowed to pressure from the World Health Organization. (newscientist.com)
  • However, the use of cocktails or multicomponent drugs to address several targets simultaneously is also popular to treat multifactorial diseases such as cancer and neurological disorders. (biomedcentral.com)
  • Combining anticancer drugs with osteoprotective agents in prostate cancer-A contemporary update. (cristiansurcel.ro)
  • Combining drugs and therapy also did not lead to better depression outcomes than therapy alone. (madinamerica.com)
  • Sub-optimal adherence may reduce the effectiveness of the regimen by allowing viral replication and the emergence of drug resistant strains. (who.int)
  • [ 9 ] Antiretroviral drug classes and agents within each class are listed in Table 1, below (see individual medication tables for more detail). (medscape.com)
  • There is a need to develop neuroprotective drugs which slow or stop the progression of the disease. (edu.au)
  • While two clinical trials of SCID-X1 gene therapy have shown success, some infants developed leukaemia as a result of the integrating virus used for gene delivery, a risk previously estimated as insignificant. (edu.au)
  • My project also includes an ethics component to investigate risk and uncertainty in clinical gene therapy, which allows me to draw on my undergraduate training in science and law. (edu.au)
  • Doses will be escalated or de-escalated based on the dose limiting toxicities (DLTs) and the recommended Phase 2 combination dose (RP2CD) will be determined by the study evaluation team (SET). (drugtrialsformoney.com)
  • In addition, the regulatory requirements are more complex when the agents are used in combination, since the safety profile of each drug needs to be demonstrated before clinical trials, and this can be further delayed due to regulatory and IP issues, in particular if the two drugs are being developed by different companies [ 1 ]. (biomedcentral.com)
  • Out protocol was effective in our ICU and may be valuable for determining future therapies of COVID-19. (fortunejournals.com)
  • The goal is to develop personalized prescriptions that are more effective than single drugs and that can potentially replace more invasive treatments such as bariatric surgery, especially for children. (eurekalert.org)
  • Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. (biomedcentral.com)
  • Efforts are underway to use chemoinformatics to help understand drug effects from a signal transduction network perspective [ 3 ], to confidently predict new molecular targets for known drugs, and to explain polypharmacology. (biomedcentral.com)
  • Different stimulus including pH, light and temperature have been used for controlled drug release to prevent drug inactivation and minimize side-effects. (thno.org)
  • Furthermore, they can cause unwanted side effects, and the effects of taking these drugs long-term still aren't clear. (peta.org)
  • In 5 drug-drug trials comparing thiazides with beta-blockers, the former were associated with a significantly lower rate of withdrawal due to adverse effects (relative risk [RR] 0.69, 95% confidence interval [CI] 0.63-0.76). (cmaj.ca)
  • This assumption has not been proven, and it is likely that the mechanism by which a drug lowers blood pressure will have effects that are independent of the blood-pressure-lowering effect. (cmaj.ca)
  • The review by Psaty and colleagues [8] had a number of deficiencies: drug-drug comparison trials were not included, trials were misclassified to drug therapy groups, and data on the effects of lowering blood pressure were not included. (cmaj.ca)
  • Avoid combination because corticosteroids can potentially diminish the antineoplastic effects of aldesleukin. (medscape.com)
  • Results of search for 'su:{Drug therapy, Combination. (who.int)
  • The primary challenge of the photo-based anti-cancer therapy is to define a method that ensures the specific killing effect of malignant tissues, while minimizing the side-effect to normal tissues or organs. (thno.org)
  • Recent research has identified CADs as cellular delivery enhancers of RNA drugs via non-lethal lysosomal membrane permeabilization (LMP), thus enabling cancer combination therapy. (ugent.be)
  • My PhD project is to determine if the cellular protein dynamin II (dynII) is a potential anti-cancer drug target. (edu.au)
  • Combination drug therapy may be needed to combat non-small cell lung cancer (NSCLC), according to a study by the Translational Genomics Research Institute (TGen) and Van Andel Research Institute (VARI). (medicalxpress.com)
  • Although polypharmacology might be associated with compound promiscuity, it should be considered a different category since the so-called promiscuous drugs are instead a class of compound that show a wide spectrum of biological activities and adverse reactions [ 1 ]. (biomedcentral.com)
  • Majority of adverse events were mild or moderate, but the data had shown there was an absolute improvement in ppFEV1 of 9.6 percentage points from the baseline in individuals receiving the triple combination of VX-659 (120mg q12h), tezacaftor, and ivacaftor. (drugdiscoverytrends.com)
  • 1 , 8 ] Collins and associates [1] reviewed drug-drug comparison trials, but only 2 of the 3 trials included were appropriate to make that comparison. (cmaj.ca)
  • This permits a reduced dosage of the coadministered drug. (medscape.com)
  • Results from this trial indicated the drug was generally well tolerated as part of the triple combination with tezacaftor and ivacaftor. (drugdiscoverytrends.com)
  • In addition, ligands are being discovered which, as single chemical entities, are able to modulate multiple epigenetic targets simultaneously (multitarget epigenetic drugs). (biomedcentral.com)
  • In addition to providing information on the various stages of molecules developed by companies for different indications, this pipeline analysis report also provides information about the drug molecules discontinued by companies. (technavio.com)
  • In addition, all anti-hypertensive drugs have actions other than lowering blood pressure. (cmaj.ca)
  • In phase Ib, devimistat was infused over 2 hours in combination with GC on days 1 and 8 every 21 days with a primary objective to determine the recommended phase II dose (RP2D). (nih.gov)
  • Participants will receive amivantamab low dose or high dose intravenous (IV) infusion based on body weight from Cycle 1 Day 1, Day 2, and subsequently Day 8, Day 15, and Day 22 and then every 2 weeks from Cycle 2 in combination with cetrelimab IV infusion from Cycle 1 Day 2 (after the Day 2 infusion of amivantamab). (drugtrialsformoney.com)
  • The recommended dose of REBETOL when used in combination with PegIntron is 800 mg to 1,400 mg based on patient body weight in two divided doses (see Table 1 ). (drugs.com)
  • The recommended dose of REBETOL when used in combination with INTRON A depends on the patient's body weight (see Table 3 ). (drugs.com)
  • Pediatrics The recommended dose of REBETOL when used in combination with INTRON A is 15 mg/kg per day orally in two divided doses (see Table 2 ). (drugs.com)