Drug therapy. Medical search. Frequent questions

1984). Numerous behavioral interventions have been studied in attempts to improve the efficacy of drug abuse treatment. (nih.gov)
In the course of clinical practice, DTPs are often identified, prevented, and/or resolved by pharmacists in the course of medication therapy management, as experts on the safety and efficacy of medications, but other healthcare professionals may also manage DTPs. (wikipedia.org)
Analyze the efficacy of a 2-drug regimen to prevent infection with multidrug-resistant tuberculosis among household contacts. (cdc.gov)
South Africa have shown efficacy of fluoroquino- prevalence of tuberculosis (TB) and low HIV prevalence, lone-based preventive therapy in adults and children we assessed the effectiveness of fluoroquinolone-based preventive therapy for drug-resistant (DR) TB exposure. (cdc.gov)
However, because no data exist regarding the efficacy of this therapy for persons with nonoccupational HIV exposure, it should be considered an unproven clinical intervention. (cdc.gov)
SEONGNAM, South Korea & MOUNTAIN VIEW, Calif.- 1ST Biotherapeutics Inc. , a clinical-stage biotechnology company focused on neurodegenerative diseases, immuno-oncology and orphan diseases, and twoXAR Pharmaceuticals , a company that discovers drugs with artificial intelligence (AI), announced recently that they would advance three novel drug leads for the potential treatment of glioblastoma into in-vivo efficacy testing less than one year from launching their drug discovery collaboration. (drugdiscoverynews.com)
The combination of different therapeutic strategies aiming to target several different pathways within cancer cells, as well as the use of drug delivery platforms fostered by nanotechnology, might improve efficacy, however there are several hurdles for their effective translation. (frontiersin.org)
Despite the evidence on the efficacy of short-term osteoporosis drug treatment for reducing fracture risk in appropriate patients, there is uncertainty about the balance of benefits and harms of long-term or continued treatment. (nih.gov)
FDA "Approval" occurs after "Designation," involving assessment of the safety and efficacy of a new drug and determination that the benefits of the product outweigh known risks. (acponline.org)
L í via Yamashiro, a postdoctoral researcher working with Stanley, said their screening provided evidence that hepatitis C drugs combined with remdesivir can greatly increase the efficacy and potency of potential treatments. (dailycal.org)
The effect of these drug therapies has not yet been tested against the most recent strains, and conclusions can't be made about its efficacy, according to Yamashiro. (dailycal.org)
So far, Genprex only has data for the therapy from two phase 1 trials, and part of a phase 2 study showing preliminary evidence of safety as well as efficacy in NSCLC. (pharmaphorum.com)

These combinations of protease inhibitors and other anti-HIV medications, called highly active antiretroviral therapy (HAART), also decreased the amount ofHIV in the patients' blood. (nih.gov)
Whitcup SM, Fortin E, Nussenblatt RB, Polis MA, Muccioli C, Belfort R Jr. Therapeutic Effect of Combination Antiretroviral Therapy on Cytomegalovirus Retinitis. (nih.gov)
This report reviews the topics raised at the meeting, provides background information on patient management options, and presents considerations for antiretroviral therapy. (cdc.gov)
Antiretroviral therapy should never replace adopting and maintaining behaviors that guard against HIV exposure (e.g., sexual abstinence, sex only with an uninfected partner, consistent and correct condom use, abstinence from injecting-drug use, and consistent use of sterile equipment by those unable to cease injecting-drug use). (cdc.gov)
In July 1997, CDC sponsored the External Consultants Meeting on Antiretroviral Therapy for Potential Nonoccupational Exposures to HIV. (cdc.gov)

PSYCHOTHERAPY, BEHAVIOR THERAPY, AND COUNSELING IN DRUG DEPENDENCETREATMENT NIH GUIDE, Volume 21, Number 44, December 11, 1992 PA NUMBER: PA-93-27 P.T. 34 Keywords: Psychotherapy Drugs/Drug Abuse Social Psychology National Institute on Drug Abuse PURPOSE The purpose of this Program Announcement (PA) is to encourage the study of psychotherapy, behavior therapy, drug abuse counseling, and other psychosocial interventions in the treatment of drug abuse and dependence. (nih.gov)
Called non-pharmacologic therapies (NPTs) or psychosocial interventions, these treatments do not come in a pill. (huffpost.com)

Chemotherapy (chemo) is the use of drugs for treating a disease such as cancer. (cancer.org)
ZUMA-2 is a single-arm, multicenter, open-label Phase 2 study involving 74 enrolled/leukapheresed adult patients (≥18 years old) with MCL whose disease is refractory to or has relapsed following up to five prior lines of therapy, including anthracycline or bendamustine-containing chemotherapy, anti-CD20 monoclonal antibody therapy and the BTK inhibitors ibrutinib or acalabrutinib. (gilead.com)

These drugs are considered systemic treatment because they enter the bloodstream and reach most areas of the body. (cancer.org)
In most countries, methadone is administered initially in the setting of a drug treatment program, both to prevent diversion (selling) of supply and to assure that counseling and other services also are provided. (medscape.com)
A secondary aim is to encourage the development of instruments to measure the process and outcome of psychotherapy/counseling of drug addicts and instruments that may be useful in determining therapist and patient characteristics predictive of treatment outcome. (nih.gov)
This announcement is intended to encourage the investigation of the treatment of individuals who are dependent upon cocaine, opiates, and other types of drugs (including polydrug abusers). (nih.gov)
This PA, Psychotherapy, Behavior Therapy, and Counseling in Drug Dependence Treatment, is related to the priority area of alcohol and other drugs. (nih.gov)
RESEARCH OBJECTIVES Background Some form of psychotherapy, behavior therapy, or drug abuse counseling occurs in virtually every type of drug abuse/dependence treatment. (nih.gov)
1992). Where the methadone dose has been decreased as a consequence to drug positive urine specimens, treatment dropout has been exacerbated (Stitzer et al. (nih.gov)
Initiate early clinical development for at least 6 existing drugs or drug combinations for the treatment or prevention of AD and AD-related dementias. (nih.gov)
A drug-therapy (related) problem can be defined as an event or circumstance involving drug treatment (pharmacotherapy) that interferes with the optimal provision of medical care. (wikipedia.org)
CMV retinitis had been increasing in frequency as people with AIDS live longer, with up to40% of all adults with AIDS eventually developing the disease.Standard treatment for CMV retinitis, which can cause blindness if left untreated, requires life-long medication with a variety of anti-CMV drugs that can be cumbersome, costly, and toxic. (nih.gov)
The use of anti-HIV drug combinations, when accompanied by an increase in CD4 cell counts, may allow us to change standard treatment for CMV retinitis," Dr. Whitcup said. (nih.gov)
Medical treatment after sexual, injecting-drug-use, or other nonoccupational HIV exposure * is likely to be a relatively ineffective method for preventing HIV infection compared with preventing exposure in the first place. (cdc.gov)
Data obtained with that funding supported Xiao's application for the M.J. Murdock Charitable Trust grant, which will allow Xiao to further evaluate and develop the drug as a possible treatment for ovarian cancer. (ohsu.edu)
To assess the effects of drug therapy for chronic idiopathic axonal polyneuropathy for reducing disability and ameliorating neurological symptoms and associated impairments, and to assess any adverse effects of treatment. (cochrane.org)
We sought all randomised or quasi-randomised (alternate or other systematic treatment allocation) trials that examined the effects of any drug therapy in people with CIAP at least one year after the onset of treatment. (cochrane.org)
She noted that many injection drug users need opioid substitution therapy and many also have HCV, but have not been candidates for treatment, except in very specialized centers. (medpagetoday.com)
Seven patients reduced the dose of ribavirin during therapy owing to reduced hemoglobin or anemia -- a known effect of ribavirin -- but the change did not affect treatment success. (medpagetoday.com)
Improving quality of life for individuals with dementia and their families is a fundamental treatment goal, but consistently receives far less attention and funding than drug research. (huffpost.com)
In the first head-to-head comparison between two commonly used HIV treatments, researchers found one triple-drug therapy was significantly more effective at reducing HIV viral load in the blood when used as a first-line treatment. (health.am)
Results of the clinical trial, which sought to determine from among three different therapies the optimal approach for patients beginning HIV treatment for the first time, will be reported at the XVI International AIDS Conference (AIDS 2006). (health.am)
Each participant was randomly assigned to one of the three treatment arms: 250 were selected to receive the efavirenz-based triple drug therapy, 253 the lopinavir/ritonavir-based triple drug therapy, and 250 were assigned to the group receiving the NRTI-sparing regimen of efavirenz and lopinavir/ritonavir. (health.am)
After 96 weeks of treatment, 33 percent of participants in the lopinavir/ritonavir group had virologic failure compared to 24 percent of the participants receiving the efavirenz-based therapy and 27 percent of those in the NRTI-sparing group. (health.am)
In recent years, metal compounds have gained an undisputed role in therapy, particularly in cancer treatment. (frontiersin.org)
View cart "Brief Strategic / Interactional Therapies in the Treatment of Substance Abuse" has been added to your cart. (athealth.com)
This treatment manual was written by Jose Szapocznik, PhD, Olga Hervis, MSW, and Seth Schwartz, PhD, of the Center for Family Studies, Department of Psychiatry and Behavioral Sciences, at the University of Miami, under contract to the National Institute on Drug Abuse (NIDA). (athealth.com)
Although a recent randomized trial provided evidence in favor of dexamethasone treatment, few randomized clinical studies are available for other adjunctive therapies in adults with bacterial meningitis. (nih.gov)
These results further position the drug as a development candidate for the treatment of behavioral disturbances in patients with dementia and other neuropsychiatric and neurological conditions. (drugdiscoverynews.com)
Although improvements in stent design have not eliminated restenosis, the use of antiproliferative treatment with drug-coated balloons (DCB) or drug eluting stents (DES) to disrupt cell division has produced more successful results [19] . (bostonscientific.com)
Uncertainties about the most appropriate use of long-term osteoporosis drug treatment and of osteoporosis drug holidays led to scheduling a National Institutes of Health ( NIH ) Office of Disease Prevention ( ODP ) Pathways to Prevention ( P2P ) workshop. (nih.gov)
Hummingbird Bioscience is focused on developing precision therapies against hard-to-drug targets to improve treatment outcomes. (frazierhealthcare.com)
The estimated average cost of antihypertensive drug treatment ranged from $375 per year for hydrochlorothiazide to $1,051 per year for propranolol hydrochloride, whereas the estimated average cost of treatment with the TM ® technique was $286 per year. (mapi.com)
SANTA MONICA, Calif. --(BUSINESS WIRE)--Dec. 11, 2019-- Kite, a Gilead Company (Nasdaq: GILD), today announced that it has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration ( FDA ) for the investigational chimeric antigen receptor (CAR) T cell therapy, KTE-X19, for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL). (gilead.com)
Researchers with Nationwide Children's Hospital indicate that this trend runs counter to established mental health standards, which recommend medication as a supplement to therapy for the management of anxiety in youths, and not as a standalone treatment. (aboutlawsuits.com)
They also noted that Medicaid and other insurer reimbursements and incentives for drug prescriptions have risen over the last decade, making child drug treatment more profitable for doctors and more acceptable to parents possibly influenced by pharmaceutical marketing campaigns. (aboutlawsuits.com)
As treatments progress from third to second and then front-line treatment, this would be facilitated by changes in the healthcare system to increase access to therapies when they are prescribed, meaning that awareness of these important but oft-limited availability therapies must increase beyond the specialist treatment centres. (ddw-online.com)
Its purpose is to assist the whole continuum of medical treatment and provide its users with insights into their drug therapies. (icb.bg)
The combination drug therapy has not yet been approved by the FDA as a treatment for COVID-19 as the results are preliminary and still need clinical trials, according to Yamashiro. (dailycal.org)
The World Health Organization (WHO) is recommending an alternative three drug treatment to accelerate the global elimination of lymphatic filariasis-a disabling and disfiguring neglected tropical disease. (mectizan.org)
An experimental gene therapy developed by Texas biotech Genprex will be paired with AstraZeneca's Tagrisso and Merck & Co's Keytruda - both leading their respective drug classes in the treatment of non-small cell lung cancer (NSCLC). (pharmaphorum.com)
The FDA awarded fast-track status to the Tagrisso/Reqorsa for the treatment of EHGFR-mutated NSCLC earlier this year, as nearly all patients receiving AZ's drug eventually experience disease progression. (pharmaphorum.com)
In addition to fight back against its reputation, this new drug is also historical in that it's the first new depression treatment in 35 years. (delraycenter.com)
If you want to learn more about ketamine therapy, or are wondering is ketamine treatment can help with your depression, please feel free to contact us ! (delraycenter.com)

ALLOB is an off-the-shelf allogenic cell therapy platform consisting of human allogeneic bone-forming cells derived from ex-vivo cultured bone marrow mesenchymal stromal cells (MSC) from healthy adult donors. (ddw-online.com)
Previously, there were a lot of the primary cell-based allogeneic therapies. (ddw-online.com)

KTE-X19 is an investigational, autologous, anti-CD19 CAR T cell therapy. (gilead.com)
Another opportunity White sees is shortened processes with autologous therapies. (ddw-online.com)

In some MDS patients, using one of these drugs can improve blood counts (sometimes enough so that blood transfusions aren't needed), improve quality of life, lower the chance of getting leukemia, and even help a person live longer. (cancer.org)
The primary endpoint was driven by reduction in guideline eligibility for SRT, but 95% of patients in the study chose to continue with medical therapy. (medscape.com)
For groups of patients such as health care professionals or business executives for whom external incentives to stay away from drugs are important, naltrexone therapy has been very effective. (medscape.com)
As we move toward personalized medicine, there's a lot of interest in knowing whether drugs can target mutated genes in particular patients or in certain diseases, like breast or lung cancer. (sciencedaily.com)
However, even high doses of H1 antihistamine drugs aren't enough to alleviate the symptoms of some patients. (medindia.net)
We are encouraged that some patients having favorable immune responses to this new drug therapy may be able to stop standard anti-CMV retinitis medication fora period of time. (nih.gov)
Health-care providers and their patients may opt to consider using antiretroviral drugs after nonoccupational HIV exposures that carry a high risk for infection, but only after careful consideration of the potential risks and benefits and with a full awareness of the gaps in current knowledge. (cdc.gov)
Health-care providers may want to provide their patients with a system for promptly initiating evaluation, counseling, and follow-up services after a reported sexual, injecting-drug-use, or other nonoccupational HIV exposure that might put a patient at high risk for acquiring infection. (cdc.gov)
Patients, all with chronic genotype 1 HCV, were treated for 12 weeks, and the primary endpoint was the proportion who had undetectable virus 12 weeks after the end of therapy -- the so-called SVR 12 , which is regarded as a cure. (medpagetoday.com)
Eli Lilly suspended clinical trials for its once promising drug Semagacestat because it was actually making patients worse. (huffpost.com)
Moreover, a third regimen, efavirenz and lopinavir/ritonavir, performed nearly as well as the three-drug cocktail with efavirenz, suggesting initial therapy need not include NRTIs, a class of drugs that can produce intolerable side effects in some patients. (health.am)
Our findings suggest that the efavirenz plus two-NRTI regimen was the best of the three approaches as initial therapy, even in patients with relatively advanced HIV disease," said Sharon Riddler, M.D., M.P.H., assistant professor of medicine in the division of infectious diseases at the University of Pittsburgh School of Medicine, who will present the findings at AIDS 2006. (health.am)
Millennium Laboratories, a leader in the science of medication monitoring and pharmacogenetic testing, is transforming the way health care professionals monitor and manage their patients' medication therapy. (prnewswire.com)
The first pooled analysis using patient-level data from randomized clinical trials demonstrated that adding Lantus (insulin glargine [rDNA] injection) to patients with type 2 diabetes, uncontrolled on oral antidiabetic drug therapy (OADs), was associated with a greater reduction in A1C levels and lower incidence of any hypoglycemia versus all comparators (OADs, NPH, lispro, premix). (finchannel.com)
Various adjunctive therapies have been described to improve outcome in such patients, including anti-inflammatory agents, anticoagulant therapies, and strategies to reduce intracranial pressure. (nih.gov)
Sandison reports on group therapy in patients who were treated individually with LSD. (erowid.org)
This group therapy was undertaken to eliminate certain fears, to solve the problems of transference and to incorporate the new patients in the group. (erowid.org)
During Cognitive Behavioral Therapy, patients are instructed to change their sleep habits, as well as their daytime habits. (lifespa.com)
We look forward to working with the FDA to bring KTE-X19 to appropriate patients as quickly as possible and continuing to deliver on the promise of our industry-leading cell therapy development program with a second CAR T therapy. (gilead.com)
This review aimed to assess the potential of molecular abnormalities in understanding pathogenesis, prognosis, diagnosis and in guiding choice of proper therapy in MDS patients. (aamds.org)
Doctors and patients cannot keep track of the medicines and drug interactions. (icb.bg)
While remdesivir, a medication that has been given emergency approval by the Food and Drug Administration, could help treat patients with COVID-19, it is not currently effective in humans. (dailycal.org)
Remdesivir, which was granted emergency approval by the Food and Drug Administration, or FDA, is a medication used to help treat patients that have contracted COVID-19, but it currently does not work well in humans, according to Julia Schaletzky, executive director of UC Berkeley's Henry Wheeler Center for Emerging and Neglected Diseases and founder of the Drug Discovery Center. (dailycal.org)
The individual drugs have already been FDA-approved for various diseases (the ones we focus on are for Hep C patients), which means there will be plenty of pre-existing clinical data for these compounds," Xammy Nguyenla, a staff research associate in the Stanley lab, said in an email. (dailycal.org)
The two phase 1/2 trials are zeroing in on NSCLC patients with specific molecular biomarkers, to see if adding Genprex' Reqorsa (quaratusugene ozeplasmid) - which delivers a gene that suppresses tumour growth - can enhance the activity of the AZ and Merck drugs. (pharmaphorum.com)

Abstract: DESCRIPTION: Deficiency of zinc is prevalent in HAART and non-HAART treated HIV-1 seropositive males and female drug users and has been shown to have a profound impact on HIV disease status. (nih.gov)
The investigators estimate that only 20 percent of the study population will be on newer therapies such as HAART. (nih.gov)

Xiao, a professor in the Department of Physiology and Pharmacology, School of Medicine, and his team have an issued patent on the drug-resistant therapy. (ohsu.edu)
The course is a lecture series covering the fundamentals of clinical pharmacology as a translational scientific discipline focused on rational drug development and utilization in therapeutics. (nih.gov)
More importantly, this is not the way that we would find drugs organized and classified in a modern textbook of pharmacology. (nih.gov)

Researchers have created a massive online database that matches thousands of genes linked to cancer and other diseases with drugs that target those genes. (sciencedaily.com)
The database is easy to search and geared toward researchers and physician-scientists who want to know whether errors in disease genes -- identified through genome sequencing or other methods -- potentially could be targeted with existing drug therapies. (sciencedaily.com)
Before now, researchers wanting to find out whether disease genes could be targeted with drugs had to search piecemeal through scientific literature, clinical trials databases or other sources of information, some of which were not publicly available or easily searchable. (sciencedaily.com)
Several target molecules that are suitable for the development of new allergy drugs have been identified by researchers. (medindia.net)
Over the past years, researchers have identified several mast cell molecules which can be targets of new drugs. (medindia.net)
Researchers at the National Institutes of Health have discovered that a combination of protease inhibitors and other anti-HIV drugs used to treat people with AIDS can prevent or delay the progression of cytomegalovirus (CMV) retinitis, a potentially blinding eye complication of AIDS. (nih.gov)
The collaborative project teams receive in-kind support and gain access to TRND researchers with rare disease drug development capabilities, expertise, and clinical and regulatory resources. (nih.gov)
MELBOURNE, Australia -- People on opioid substitution therapy for drug addiction can be safely and effectively treated for hepatitis C (HCV) with an investigational combination of medications, researchers said here. (medpagetoday.com)
This is a ground-breaking therapy that researchers are encouraging insurance companies to allow reimbursement for. (lifespa.com)
New screening standards recommend anxiety evaluations for children as young as 8, which could result in even more drug prescriptions, researchers warn. (aboutlawsuits.com)
Researchers indicate the reduction in child psychotherapy stems from an overburdened health care system, and drug manufacturers providing incentives that encourage doctors to prescribe anxiety drugs, such as selective serotonin reuptake inhibitors (SSRIs), benzodiazepines, serotonin-norepinephrine reuptake inhibitors (SNRIs), and antihistamines as primary treatments for youth mental health disorders. (aboutlawsuits.com)
Based on this data, researchers determined the number of children whose doctors recommended only drugs, and not therapy, to treat anxiety increased by over 16% from 2006 to 2018. (aboutlawsuits.com)
The researchers concluded that the overall rise in children with anxiety and other mental health disorders has overburdened health providers, resulting in over reliance on drug prescriptions without the recommended supplemental therapy. (aboutlawsuits.com)
To prevent further overreliance on anxiety drugs for children, the researchers recommend additional studies on the growing youth mental health crisis and how healthcare providers can increase access to resources like psychotherapy. (aboutlawsuits.com)
The researchers in this latest study noted that the U.S. Preventative Task Force updated anxiety screening guidelines issued last year, recommending anxiety evaluations for children as young as 8, which could potentially increase prescriptions of drugs to treat youth anxiety even further. (aboutlawsuits.com)
Researchers found about 23 drugs that were synergistic with remdesivir and enhanced its effect, Biering added. (dailycal.org)

Treatments such as personal counseling and occupational therapy-based strategies support families and teach them the skills they need to protect their own health and cope with the demands of caregiving for those with dementia. (huffpost.com)
Instead, treatments such as personal counseling and occupational therapy-based strategies support families and teach them the skills they need to protect their own health and cope with the intense demands of caregiving, while helping people with dementia stay independent and safe for as long as possible. (huffpost.com)
These programs meet the gold standard for both drug and non-drug treatments: they have been proven effective in randomized controlled trials. (huffpost.com)
Causes and risk factors for restenosis, as well as current treatments including the Eluvia™ drug-eluting stent (DES). (bostonscientific.com)
Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. (wjgnet.com)

[ 1 ] The mechanisms of drug interactions with each ARV are briefly mentioned below. (medscape.com)
In preclinical studies, the gene therapy also seems to block mechanisms involved in drug resistance, including TIM3, a bypass pathway that can lead to failure of PD-1-based therapy. (pharmaphorum.com)

and SAN DIEGO , April 24, 2014 /PRNewswire/ -- Clinical interventions performed in conjunction with laboratory quantitative drug testing and monitoring were shown to reduce utilization of high risk medications in injured workers on chronic opioid therapy, according to a clinical study released by the merged entity of Progressive Medical and PMSI, in partnership with Millennium Laboratories. (prnewswire.com)

Adverse drug reaction. (wikipedia.org)
Coadministration with drugs that induce or inhibit these enzymes can alter NNRTI drug concentrations, resulting in virologic failure or adverse effects. (medscape.com)
There were only two serious adverse events -- neither related to the study drugs -- and only one patient stopped therapy, again for a reason not associated with the medications, Cohen reported at the International AIDS Conference . (medpagetoday.com)
And, unlike drug therapy, there are no adverse side effects. (huffpost.com)
When to report adverse drug reactions in children? (bmj.com)

This announcement is not intended to support therapy development research. (nih.gov)
Some of the drugs are approved by the U.S. Food and Drug Administration, while others are in clinical trials or just entering the drug development pipeline. (sciencedaily.com)
Additional genes included in the database could be the focus of future drug development efforts because they belong to classes of genes that are thought to make promising drug targets. (sciencedaily.com)
Four new pre-clinical drug development projects at the National Institutes of Health will target a form of blindness and diseases characterized by cardiac problems. (nih.gov)
Working in collaboration, scientists conduct pre-clinical development of new drugs and then advance them to first-in-human clinical trials," said NCATS Director Christopher P. Austin, M.D. "Like all NCATS programs, TRND seeks to develop new technologies and more efficient paradigms for translation, in the context of important unmet medical needs. (nih.gov)
This strategy can make possible new drugs more commercially viable and attractive to outside partners, who can invest in their further development and additional clinical trials. (nih.gov)
The traditional drug development approach takes four to six years on average to go from target identification to Investigational New Drug (IND)-enabling studies, including years until the first preclinical in-vivo study. (drugdiscoverynews.com)
The US Food and Drug Administration (FDA) administers various programs to expedite the development and review of new drugs that aim to treat serious or life-threatening conditions. (acponline.org)
The team's findings, published in Nature Communications Biology, open up a new avenue for the development of selective drug therapies to fight a variety of cancers such as those that begin in the breast and stomach. (ecancer.org)
ICB implemented the "MedXchange - a platform for rational drug therapy" project under the Grant Agreement BG16RFOP002-1.005-0110-C01 under the procedure "Development of product and production innovations", Priority Axis 2: Technological development and innovation, Specific objective 1.1: Technological development and innovation. (icb.bg)

Targeted drug therapy is the use of medicines that target or are directed at proteins on cancer cells that help them grow, spread, and live longer. (cancer.org)
Scientists report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size -- even hefty ones attached to the gene-editing tool called CRISPR. (nih.gov)
KTE-X19 has been granted Breakthrough Therapy Designation (BTD) by the FDA and Priority Medicines (PRIME) by the European Medicines Agency (EMA) for relapsed or refractory MCL. (gilead.com)

One drug that targets EGFR can be used to treat some nasopharyngeal cancers. (cancer.org)

Clinical Outcomes after Basal Insulin Initiation Correlate with Baseline Oral Antidiabetic Drug Therapy: A Pooled Analysis of Clinical Trial Data" [presentation number 960]: This analysis included data from 11 prospective randomized controlled trials of Lantus with or without OADs in adults with type 2 diabetes. (finchannel.com)

Individuals who have injected heroin or other opioids for long periods may need referral for opioid replacement therapy with methadone, buprenorphine, or buprenorphine/naloxone where such programs are available. (medscape.com)
Levo-alpha-acetylmethadol (LAAM) has also been used for opioid replacement therapy, but use of LAAM has been less common because of concerns about severe QT prolongation secondary to LAAM. (medscape.com)
Opioid replacement therapy reduces injecting drug use and thus reduces the mortality and morbidity associated with injecting drug use, including the transmission of HIV and HCV. (medscape.com)
It's especially important, she said, to know that the 3D combination does not interfere with drugs used for opioid substitution -- in this study, either methadone or buprenorphine, with or without naloxone. (medpagetoday.com)
The drug has been tested in more than 2,700 people, Cohen noted, but none of them has been on opioid substitution. (medpagetoday.com)

The study showed a decrease in all measures of utilization, driven primarily by opioids (a 32 percent decrease) and benzodiazepines (a 51 percent decrease), as well as a 26 percent reduction in total utilization of all medications, regardless of drug class. (prnewswire.com)

Initiate at least three Phase 3 trials with repurposed drugs or drug combinations. (nih.gov)
New drugs targeting the histamine H4 receptor are also undergoing clinical trials. (medindia.net)
There have not been any randomised trials of drug therapy for CIAP. (cochrane.org)
Austin-based Genprex has been preparing for the Reqorsa clinical trials programme, over the last few months, ramping up its manufacturing capacity for the gene therapy via an agreement with contract manufacturing organisation (CMO) Aldevron. (pharmaphorum.com)

It includes more than 14,000 drug-gene interactions involving 2,600 genes and 6,300 drugs that target those genes. (sciencedaily.com)
Possible drug-drug interactions should be taken into consideration when selecting an antiretroviral (ARV) regimen. (medscape.com)
The potential for drug interactions should be assessed when any new drug (including over-the-counter agents) is added to an existing ARV regimen. (medscape.com)
Most drug interactions with ARV drugs are mediated through inhibition or induction of hepatic drug metabolism. (medscape.com)
The role of drug transporters is evolving, revealing more drug interactions. (medscape.com)
Transporters aid hepatic, renal, and biliary clearance of drugs and may be susceptible to drug interactions. (medscape.com)
The influence of drug transporters on drug-drug interactions is complex and requires further understanding. (medscape.com)
For more information regarding specific drug interactions, see the Medscape Drug Interaction Checker or the NIH Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents . (medscape.com)

The Center for Drug Evaluation and Research (CDER) publicly available data on BT Designation Requests as well as BT Approvals from 2012- 2020 was used for this analysis. (acponline.org)

They also hope to find a class of therapeutic drugs that inhibit these regulatory elements, providing another way to put the brakes on cancer-causing genes. (drugdiscoverynews.com)
Dr. Foster and Brooke Mueller , PharmD from Progressive Medical/PMSI identified more than 100 injured workers in need of additional clinical oversight based on laboratory quantitative urine drug test results that were deemed inconsistent compared to the therapeutic regimen reported by the prescribing physician. (prnewswire.com)
This program describes brief family therapy and provides strategies for creating a therapeutic relationship with families, assessing and diagnosing destructive patterns of family interaction, and changing patterns of family interaction from maladaptive to adaptive. (athealth.com)

It's one of a wave of new drugs and drug combinations, some approved and some still experimental, aimed at curing the virus. (medpagetoday.com)
But earlier studies with other drug combinations suggested the approach would be safe. (health.am)

This study shows the value of medication monitoring and quantitative drug detection services in helping to identify injured workers potentially at risk for addiction and to enable early intervention," said Lemay Rodriguez , director of corporate accounts for managed care at Millennium Laboratories. (prnewswire.com)
New research suggests doctors often recommend prescription drugs, not therapy, for anxiety disorders among children and teenagers, even though most mental health experts do not recommend the use of medication alone to treat youth anxiety. (aboutlawsuits.com)
Recent data indicates children are particularly vulnerable to drug side effects and dosing errors, with prescription mental health drugs like ADHD medication posing a heightened risk for a potentially fatal overdose . (aboutlawsuits.com)
Otherwise taking a large number of drugs without regular medication reviews can have a devastating impact on quality of life and patient safety, especially in older people. (icb.bg)

Smith's Food and Drug is not responsible for the content provided in customer ratings and reviews. (smithsfoodanddrug.com)
MedXchange is an innovative platform based on manual, automated and IoT data collection and processing, providing information on the content, effect and interaction of various substances in drugs and related products. (icb.bg)

The Food and Drug Administration is expected to approve a new gene therapy drug from pharmaceutical company Novartis by the end of May. (marketplace.org)
In view of these studies, and the inherently better fracture resistance of polymers, COP-based vial containment systems are an excellent choice for many gene therapy drug products. (westpharma.com)

These types of chemo drugs affect the way certain genes inside a cell are controlled. (cancer.org)
These drugs activate some genes that help cells mature. (cancer.org)
The database was developed by identical twin brothers, Obi Griffith, PhD, and Malachi Griffith, PhD, whose interest in pairing drugs with genes is as much personal as it is scientific. (sciencedaily.com)
Another 6,700 genes are in the database because they potentially could be targeted with future drugs. (sciencedaily.com)
Further, many of the existing databases have different ways of identifying genes and drugs, a "language" barrier that can turn a definitive search into an exhaustive exercise. (sciencedaily.com)
The brothers got the idea for the drug-gene interaction database after they repeatedly were asked whether lists of genes identified through cancer genome sequencing could be targeted with existing drugs. (sciencedaily.com)
Users can enter the name of a single gene or lists of many genes to retrieve drugs targeting those genes. (sciencedaily.com)

Using small-molecule drugs that inhibit this process, the investigators were able to turn off REST and partially restore hearing. (nih.gov)

This risky practice of dose escalation can lead to drug overdoses. (wikipedia.org)
This review briefly summarizes the pathogenesis and pathophysiology of bacterial meningitis, and focuses on the evidence for and against use of the available adjunctive therapies in clinical practice. (nih.gov)
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. (wjgnet.com)

The labs screened thousands of drugs through combinatorial high-throughput screening and were looking for drugs that were synergistic with remdesivir, according to Biering. (dailycal.org)

Home Topics Drug Discovery Aestus Gains Rights to Prosidion's Neuropathic Pain Drug and Expands Collaboration with. (genengnews.com)
The firm's collaboration with ALS TDI, signed in March 2010, centered on evaluation of a compound identified using Aestus' gene-based drug discovery platform in an animal model of ALS. (genengnews.com)
The company is advancing a pipeline of potentially first- and best-in-class precision therapies in oncology and autoimmunity, in collaboration with global partners in academia and industry. (frazierhealthcare.com)

Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury. (medindia.net)
Randomized studies indicate that the Transcendental Meditation ® (TM ® ) technique reduces mild hypertension (the predominant form of hypertension) as effectively as do drug therapies. (mapi.com)

However, their severe side-effects and the rise of drug resistance, has led to a real revolution in cancer drug research based on the rational design of non-platinum metal compounds aiming to overcome these limitations. (frontiersin.org)

A major side effect of these drugs is usually an early drop in blood cell counts, which tends to get better as the drug begins to work. (cancer.org)
Different drug molecules make it possible to affect the function of these receptors and, consequently, to prevent cell activation and mediator release. (medindia.net)
Clinical and laboratory markers will be assessed at either 3 or 6 month intervals over the 30 month study.The specific aims will determine if zinc therapy in HIV-1 infected men and women who abuse drugs and have low plasma zinc levels will have higher CD4 cell counts, lower viral loads and prolonged time to events, including AIDS defining opportunistic infections, or AIDS-related death. (nih.gov)
The study, published Nov. 21, 2019, in Cell , could explain why drugs will often work for some cancer types but not others. (drugdiscoverynews.com)
Cell therapies offer a powerful new approach to treat cancer and other serious conditions. (westpharma.com)
The company is focused on chimeric antigen receptor and T cell receptor engineered cell therapies. (gilead.com)
Cell therapy company Bone Therapeutics has announced it is shifting its R&D activities towards its most advanced clinical asset, the allogenic cell therapy platform, ALLOB. (ddw-online.com)
DDW's Megan Thomas caught up with George White , General Manager, Product Management, Cell & Gene Therapy at Cytiva, to learn more about the company's insight into the CGT market. (ddw-online.com)
In order for cell and gene (CGT) therapies to succeed, George White identifies several challenges to overcome. (ddw-online.com)
George White is the General Manager, Product Management, Cell & Gene Therapy at Cytiva. (ddw-online.com)

The Rosalynn Carter Institute for Caregiving states that there are proven programs which are actually more effective than any known drugs for Alzheimer's disease and adds, "to not make them widely available to caregivers is shortsighted and a violation of the best principles of public health. (huffpost.com)
Who will end up paying the price for Biogen's new Alzheimer's drug? (marketplace.org)
Medicare rejected a controversial Alzheimer's drug. (marketplace.org)

Ovarian cancer is the deadliest gynecological cancer in the U.S., and drug resistance is a major contributing factor to the high mortality rate. (ohsu.edu)
The NRTI-sparing combination of lopinavir/ritonavir and efavirenz had never before been studied as first-line therapy in a large randomized clinical trial, in part because a general belief that combining an NNRTI with a protease inhibitor could result in resistance to two important classes of drugs. (health.am)

The still-nameless third drug is ABT-450, a protease inhibitor boosted with ritonavir (Norvir). (medpagetoday.com)
Of the two triple-drug approaches evaluated in the randomized trial, the therapy consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) with efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI), suppressed the virus to undetectable levels in more participants than the three-drug combination of two NRTIs and a protease inhibitor called lopinavir/ritonavir. (health.am)

Together with Express Scripts - the company chosen to manage your pharmacy benefit plan - they review the most current research on thousands of drugs tested and approved by the FDA for safety and effectiveness. (umsystem.edu)

The twoXAR process, propelled by the company's proprietary AI-driven platform to identify promising first-in-class drug discovery hits, initiates preclinical in-vivo screening within months and programs advance to IND-enabling studies in one to three years. (drugdiscoverynews.com)

A newer form of this drug, known as Inqovi , combines decitabine with cedazuridine, which helps stop the decitabine from being broken down in the digestive system. (cancer.org)

Some targeted drugs, for example, monoclonal antibodies, work in more than one way to control cancer cells and may also be considered immunotherapy because they boost the immune system. (cancer.org)

Among the risk factors evaluated were morphine equivalency dosing (MED), number of prescribers, number of drug classes, and number of opioids. (prnewswire.com)
A four-state sample of 435 prescribers of these drugs was identified through Medicaid records and randomly assigned to one of three groups. (nih.gov)

Improving precision and economy in the prescribing of drugs is a goal whose importance has increased with the proliferation of new and potent agents and with growing economic pressures to contain health-care costs. (nih.gov)

We've been targeting the cancer-causing gene for therapy, but it turns out we should also think about targeting the switches that are carried along with it," said co-senior author Dr. Peter Scacheri, the Gertrude Donnelly Hess Professor of Oncology at Case Western Reserve University School of Medicine and member of the Case Comprehensive Cancer Center. (drugdiscoverynews.com)

Disrupting the right signal is one of the biggest challenges in developing new cancer therapies, said ORNL geneticist Wellington Muchero. (ecancer.org)

The chemo drug most often used for MDS is cytarabine (ara-C) . It can be given by itself at a low-dose, which can often help control the disease, but doesn't often put it into remission. (cancer.org)
If future studies show that teriparatide has a favorable risk-benefit profile in people with OA, it would be the first disease-modifying drug for this debilitating disease that affects millions of Americans. (nih.gov)
In fact, their whole way of viewing disease and drug therapy was very different from the way we understand these subjects today. (nih.gov)
However, balloon-based drug delivery is unable to provide scaffolding for the artery, which is often required in long lesions or calcified femoropopliteal disease [23] . (bostonscientific.com)

The drug, which Aestus will designate as ATx09-002, has already undergone Phase I and II evaluation by Prosidion, and will initially be evaluated by Aestus in Phase II studies against postherpetic neuralgia. (genengnews.com)

As given by Shargel, they are: Unnecessary drug therapy. (wikipedia.org)
Academically based "detailing" may represent a useful and cost-effective way to improve the quality of drug-therapy decisions and reduce unnecessary expenditures. (nih.gov)

Protease inhibitors are a class of promising drugs recently introduced that, when taken with other HIV-fighting medications, have shown success in prolonging the lives of people with AIDS. (nih.gov)

Preventive behaviors include sexual abstinence, sex only with an uninfected partner, consistent and correct condom use, abstinence from injecting-drug use, and consistent use of sterile equipment by those unable to cease injecting-drug use. (cdc.gov)
Injecting-drug-use exposure through shared injection equipment can put a patient at risk for acquiring other viral infections (e.g., hepatitis B and hepatitis C). All persons evaluated for possible nonoccupational HIV exposure should be counseled to initiate, resume, or improve risk-reduction behaviors to avoid future exposure and to prevent possible secondary transmission until their current HIV infection status is determined. (cdc.gov)
Benzodiazepines like Xanax, Halcion, Ativan, and Klonopin have also been shown to increase risk of "drug seeking behaviors" in children , with potentially lethal overdose consequences. (aboutlawsuits.com)

In completing the previous study of the role of psychotropic drugs in individual therapy, Sandison describes the role of deep insulin therapy, of LSD and of tranquilizers in group psychotherapy. (erowid.org)
But while the proportion of anxiety drugs prescribed during all three time groups remained steady at 60%, the rate of doctor's office visits for anxiety that included psychotherapy decreased, from 48.8% in 2006-2009 to 32.6% in 2014-2018. (aboutlawsuits.com)

He says: "There's extreme potential within the emerging therapies and if we do our part to help expand capabilities and overcome challenges, then oncologists, clinicians and other types of physicians can harness the immune system and keep us all healthy. (ddw-online.com)

The photochemical behavior of a drug provides guidance for handling, packaging, and labeling of drug products. (westpharma.com)

Continue to develop resources, capabilities and partnerships to advance data-driven drug repositioning and combination therapy. (nih.gov)
In the near future, it is possible that drug therapy for allergy is a combination of H1 and H4 receptor blockers. (medindia.net)
Until recently, the combination was known by a soup of numbers and letters, because the drugs involved had yet to be named. (medpagetoday.com)
The combination is given with ribavirin, a nonspecific drug that modifies host factors in viral infections. (medpagetoday.com)
Also, we found that the NRTI-sparing two-drug combination of efavirenz and lopinavir had a similar level of effectiveness to the efavirenz plus two-NRTI regimen. (health.am)

In order to give you some idea of the drug therapy of that day, however, we can examine one of the textbooks of materia medica and therapeutics of the period. (nih.gov)

Hypomethylating agents can have some of the same side effects as standard chemo drugs (see below), but these side effects are usually milder. (cancer.org)

Some health-care providers have proposed offering antiretroviral drugs to persons with unanticipated sexual or injecting-drug-use HIV exposure to prevent transmission. (cdc.gov)
Pharmacokinetic enhancers (boosters) are used to increase exposure of an ARV by concomitantly administering a drug that inhibits the enzymes that metabolize the ARV. (medscape.com)

The findings of this latest study are similar to previous research suggesting child antipsychotic drug prescriptions for anxiety, depression, ADHD, and similar disorders are too high . (aboutlawsuits.com)

The aim of this Research Topic is to cover the most recent developments in the field of metal compounds for cancer therapy. (frontiersin.org)
He studied genetics at the University of Newcastle (UK) and has held commercial roles for more than 15 years, supporting customers in research and the translation of therapies to clinical and commercial production. (ddw-online.com)
Schaletzky said she began research alongside campus public health associate professor Sarah Stanley into drug therapies that could augment the effect of remdesivir. (dailycal.org)

Anatomy3

Organisms1

Diseases41

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Psychiatry and Psychology5

Phenomena and Processes12

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena6

Humanities1

Information Science9

Named Groups1

Health Care59

Geographicals3

Efficacy12

Antiretroviral Therapy5

Psychosocial interventions2

Chemotherapy2

Treatment42

Allogeneic2

Autologous2

Patients25

HAART2

Pharmacology3

Researchers16

Treatments5

Mechanisms2

Interventions1

Adverse5

Development10

Medicines3

Targets1

Type 2 diabet1

Opioid5

Utilization1

Trials4

Interactions8

20201

Therapeutic3

Combinations2

Medication4

Content2

Gene therapy drug2

Genes7

Inhibit1

Practice3

Synergistic1

Collaboration3

Effectively2

Severe side-effects1

Cell10

Alzheimer's3

Resistance2

Ritonavir2

Safety and Effective1

Discovery1

Newer1

Monoclonal1

Prescribers2

Precision1

Cancer-caus1

Developing1

Disease4

Phase1

Unnecessary2

Protease1

Behaviors3

Psychotherapy2

Potential1

Behavior1

Combination5

Therapeutics1

Side effects1

Exposure2

Prescriptions1

Research3