• toxicity
  • The drug has relatively low toxicity. (wikipedia.org)
  • In vitro toxicity screening using hepatocytes in conjunction with other primary cells such as cardiomyocytes (cardiotoxicity model), kidney proximal tubule epithelial cells (nephrotoxicity model), astrocytes (neurotoxicity model), endothelial cells (vascular toxicity model), and airway epithelial cells (pulmonary toxicity model) is invaluable to the drug design and discovery process. (wikipedia.org)
  • Also, the drugs can often be used at lower doses, reducing toxicity. (wikipedia.org)
  • efficacy
  • Experience mother: delayed-release antibiotic charge attrition may start you on heat stability of doxycycline a tablet lowered efficacy or a doxycycline sun. (txlyd.com)
  • It can simultaneously evaluate the toxic potential of a drug on cells from multiple organs and evaluate drug stability, distribution, metabolite formation, and efficacy. (wikipedia.org)
  • The labeled expiration date is a manufacturer's promise for a time until which the drug will have full efficacy and be safe as manufactured. (wikipedia.org)
  • However, it is difficult for anyone including researchers and physicians to find information to verify how much any given drug will degrade in efficacy or become unsafe over time. (wikipedia.org)
  • To ensure efficacy, safety quality and validity of marketed drugs and to promote proper, rational and efficient use. (wikipedia.org)
  • The program seeks to promote appraisal of evidence in terms of proven efficacy and safety from controlled clinical trial data, and adequate consideration of quality, cost and choice of competitor drugs by choosing the item that has been most thoroughly investigated, has favorable pharmacokinetic properties and is reliably produced locally. (wikipedia.org)
  • substance
  • Finally, specifications for the API (drug substance), excipient(s) and the drug product are part of the quality section of the marketing authorisation application which has to be submitted to the competent authority. (gmp-compliance.org)
  • Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C. Furonazide was prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product. (wikipedia.org)
  • By encapsulating the drug compound in the nanostructures, injectable depots are able to deliver therapeutic levels of drug substance over extended periods from a single injection. (wikipedia.org)
  • therapeutic
  • PEGylation (often styled pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated (pegylated). (wikipedia.org)
  • The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reduced immunogenicity and antigenicity), and increase the hydrodynamic size (size in solution) of the agent which prolongs its circulatory time by reducing renal clearance. (wikipedia.org)
  • shelf-life
  • The Shelf Life Extension Program (SLEP) is a joint program of the United States Department of Defense and the Food and Drug Administration which aims to reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals by researching the expiration of drugs. (wikipedia.org)
  • Drugs which are past their shelf life can decompose and either be ineffective or even harmful. (wikipedia.org)
  • To reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals, the United States Department of Defense and the Food and Drug Administration operate a joint initiative known as the Shelf Life Protection Program (SLEP), which evaluates the long-term effectiveness of medications stockpiled by the DoD and other government agencies. (wikipedia.org)
  • Considerations
  • The shape is chosen to strike a balance between cost, hydrostatic considerations (accommodation, load carrying and stability), hydrodynamics (speed, power requirements, and motion and behavior in a seaway) and special considerations for the ship's role, such as the rounded bow of an icebreaker or the flat bottom of a landing craft. (wikipedia.org)
  • liquid
  • This work was divided in three sections: The first step was to develop a Liquid Chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of dipyrone, tramadol and metoclopramide in physiological saline with the purpose of performing a stability study during 24 hours of the mixture prior to intravenous administration. (uji.es)
  • In this stability study, High Performance Liquid Chromatography coupled to triple quadrupole mass spectrometry (HPLC-QqQ) was used, butsupplementary information about possible transformation products was obtained from liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and HPLC-diode-array detector (HPLCDAD). (uji.es)
  • The accuracy and stability of caffeine and halothane concentrations in liquid Krebs medium were examined. (biomedsearch.com)
  • Some common drugs which authorities say are always unsafe if expired include nitroglycerin, insulin, and liquid antibiotics. (wikipedia.org)
  • injectable
  • SAN DIEGO, Sept. 14 /PRNewswire/ -- ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX) today announced the results of stability tests performed on samples of ANX-530 (vinorelbine injectable emulsion), or Exelbine™, manufactured at the Company's intended commercial manufacturing site. (drugs.com)
  • antibiotics
  • A major teaching hospital has developed a program on rational drug use, developing a hospital formulary, guidelines for rational diagnosis and treatment guidelines for the rational use of antibiotics. (wikipedia.org)
  • behavior
  • As well as producing training programs and publications, the group is undertaking research in a number of member countries, focused primarily on changing behavior to improve drug use. (wikipedia.org)
  • biopharmaceutical
  • Princeton, NJ - January 18, 2012 - Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today results from long-term stability studies of its proprietary DNI (dominant negative inhibitor) anthrax rPA (recombinant protective antigen) subunit protein vaccine, known as SGX204. (drugs.com)
  • dosage
  • Product: like doxycycline dosage samples, doxycycline may cause doxycycline to doxycycline of stability heat the developing tootake if this genitalium is taken during help. (txlyd.com)
  • evaluate
  • Depending on the pain level suffered by the patient after a surgical intervention, the department of Anaesthesiology, Resuscitation and Pain therapy of the General University Hospital of Castellon must evaluate two procedures of drugs administration in post-operatory analgesia. (uji.es)
  • interactions
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • high
  • Positive stability was demonstrated when DNI rPA was subjected to temperatures as high as 70?C for one month. (drugs.com)
  • FVA-9 Blaue Maus II (Blue Mouse II) In 1933 the FVA students turned their attention to a lightweight soaring glider designed to have good aerodynamic, stability and control properties, as well as a high L/D ratio at a reasonably high speed to allow flight between thermals. (wikipedia.org)
  • Everything was shaped to reduce drag and increase stability at high speed. (wikipedia.org)
  • Artemisinin and its endoperoxides derivatives have been used for the treatment of P. falciparum related infections but low bioavailability, poor pharmacokinetic properties and high cost of the drugs are a major drawback of their use. (wikipedia.org)
  • Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. (wikipedia.org)
  • medications
  • Just, a presc good jedan of the book with those medications will however become immune by using an nmr voldoende based on heat stability of doxycycline the belt of response expression characteristics. (txlyd.com)
  • Essential
  • To achieve these objectives in Indonesia, the following changes were implemented: A national list of essential drugs was established and implemented in all public sector institutions. (wikipedia.org)
  • District hospitals and health centers have to procure their drugs based on the essential drugs list. (wikipedia.org)
  • tablet
  • The tablet counter aided the pharmacy industry with time-consuming manual counting of drug prescriptions. (wikipedia.org)
  • These early devices became known as tablet counter, capsule counter, pill counter, or drug counter. (wikipedia.org)
  • organizations
  • We discuss the advantages and disadvantages of open source descriptors and the opportunity for their use as a tool for organizations to share data precompetitively, avoiding repetition and assisting drug discovery. (aspetjournals.org)
  • Standard advice from drug manufacturers and some health organizations is to dispose of drugs after the expiration date printed on the packaging. (wikipedia.org)
  • Consumers and organizations sometimes use expired drugs for medical treatment either as a cost saving measure or because they otherwise cannot access drugs which are not expired. (wikipedia.org)
  • characteristics
  • Since products continually change over time, the characteristics of any drug are not unchanging but instead estimated with assay measurements to be within the specification required by the government regulator where the drug is sold. (wikipedia.org)
  • increase
  • A sander increase genotype was performed at the heat stability of doxycycline shedding of each patient to insurance assess the lyme farif. (txlyd.com)
  • induction
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)
  • resistance
  • Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. (wikipedia.org)
  • The World Health Organization (WHO) is pressuring manufacturers to stop making the uncompounded drug available to the medical community at large, aware of the catastrophe that would result if the malaria parasite developed resistance to artemisinins. (wikipedia.org)
  • Pharmaceuticals
  • ADAGEN (pegademase bovine) manufactured by Enzon Pharmaceuticals, Inc., US was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) in March 1990, to enter the market. (wikipedia.org)
  • combination
  • We believe that the combination of long-term stability over several years with stability at such elevated temperatures has the potential to confer a distinct advantage over other anthrax vaccine technologies currently in development. (drugs.com)
  • The avoidance of combination drugs is also encouraged. (wikipedia.org)
  • The drugs used in combination therapies can contribute to the adverse effects experienced by those undergoing treatment. (wikipedia.org)
  • immune
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • support
  • The 12-month stability data are consistent with the stability data collected at 6 and 9 months and will support the Company's submission of a New Drug Application (NDA) for Exelbine, which the Company expects to take place in the fourth quarter of this year. (drugs.com)
  • Drug manufacturers never support the use of drugs after the expiration date because that could make them liable if something went wrong. (wikipedia.org)
  • Results
  • We are very excited about these extraordinary stability results," stated Robert N. Brey, PhD, Chief Scientific Officer of Soligenix. (drugs.com)
  • development
  • In the subsequent presentations, practical aspects of stability testing for drug substances and throughout drug development are discussed. (gmp-compliance.org)
  • CAM2032 is a new drug being developed for long-term treatment of prostate cancer, with development also initiated for endometriosis. (wikipedia.org)
  • anti-cancer drugs
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • study
  • Naturally, medical linings are cure needed over the doxycycline of stability heat additional study to ensure that inflammation is controlled. (txlyd.com)
  • effective
  • The printed expiration date will always be sooner than the true expiration date, because the drug should always be effective and safe before the labeled expiration date if kept properly. (wikipedia.org)
  • Therapies that combine artemisinin or its derivatives with some other antimalarial drug are the preferred treatment for malaria and are both effective and well tolerated in patients. (wikipedia.org)
  • Combinations are effective because the artemisinin component kills the majority of parasites at the start of the treatment, while the more slowly eliminated partner drug clears the remaining parasites. (wikipedia.org)
  • human
  • Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. (biomedsearch.com)
  • available
  • Several fixed-dose ACTs are now available containing an artemisinin component and a partner drug which has a long half-life, such as mefloquine (ASMQ), lumefantrine (Coartem), amodiaquine (ASAQ), piperaquine (Duo-Cotecxin), and pyronaridine (Pyramax). (wikipedia.org)
  • medical
  • Medical authorities find it difficult to discuss when consumers can safely use drugs after the printed expiration date because it is hard to get clear information. (wikipedia.org)
  • reduce
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • The fuselage was 8 ft (2.4 m) longer and area ruled to reduce transonic drag, being thinner in the region of the wing roots. (wikipedia.org)
  • treatment
  • In doxycycline, much 994 bm segments were other in heat stability of doxycycline treated but antibiotic in treatment worms. (txlyd.com)