• efficacy
  • Experience mother: delayed-release antibiotic charge attrition may start you on heat stability of doxycycline a tablet lowered efficacy or a doxycycline sun. (txlyd.com)
  • BARDA has placed a priority on stability and a rapid onset of immunity in no more than two vaccine doses as the stability and efficacy targets for vaccines under development for both category A and category B vaccines. (drugs.com)
  • It can simultaneously evaluate the toxic potential of a drug on cells from multiple organs and evaluate drug stability, distribution, metabolite formation, and efficacy. (wikipedia.org)
  • The labeled expiration date is a manufacturer's promise for a time until which the drug will have full efficacy and be safe as manufactured. (wikipedia.org)
  • However, it is difficult for anyone including researchers and physicians to find information to verify how much any given drug will degrade in efficacy or become unsafe over time. (wikipedia.org)
  • To ensure efficacy, safety quality and validity of marketed drugs and to promote proper, rational and efficient use. (wikipedia.org)
  • The program seeks to promote appraisal of evidence in terms of proven efficacy and safety from controlled clinical trial data, and adequate consideration of quality, cost and choice of competitor drugs by choosing the item that has been most thoroughly investigated, has favorable pharmacokinetic properties and is reliably produced locally. (wikipedia.org)
  • toxicity
  • The drug has relatively low toxicity. (wikipedia.org)
  • In vitro toxicity screening using hepatocytes in conjunction with other primary cells such as cardiomyocytes (cardiotoxicity model), kidney proximal tubule epithelial cells (nephrotoxicity model), astrocytes (neurotoxicity model), endothelial cells (vascular toxicity model), and airway epithelial cells (pulmonary toxicity model) is invaluable to the drug design and discovery process. (wikipedia.org)
  • Also, the drugs can often be used at lower doses, reducing toxicity. (wikipedia.org)
  • long-term stab
  • Princeton, NJ - January 18, 2012 - Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the Company), a development stage biopharmaceutical company, announced today results from long-term stability studies of its proprietary DNI (dominant negative inhibitor) anthrax rPA (recombinant protective antigen) subunit protein vaccine, known as SGX204. (drugs.com)
  • Long-term stability of DNI rPA was also demonstrated after refrigerated storage for more than 7 years. (drugs.com)
  • We believe that the combination of long-term stability over several years with stability at such elevated temperatures has the potential to confer a distinct advantage over other anthrax vaccine technologies currently in development. (drugs.com)
  • EWING, NJ - January 29, 2008 -- DOR BioPharma, Inc. (OTCBB: DORB) ("DOR" or "The Company") announced today that it has successfully achieved a two-year milestone in the long-term stability program of the key ingredient of RiVax™, a recombinant subunit vaccine against ricin toxin. (drugs.com)
  • We believe that RiVax™ is a useful countermeasure against ricin toxin, and that our vaccine incorporates many of the desirable properties that should make it amenable to long-term stability as part of the overall mission to develop countermeasure components for the Strategic National Stockpile," said Robert N. Brey, PhD, Chief Scientific Officer of DOR. (drugs.com)
  • therapeutic
  • PEGylation (often styled pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated (pegylated). (wikipedia.org)
  • The covalent attachment of PEG to a drug or therapeutic protein can "mask" the agent from the host's immune system (reduced immunogenicity and antigenicity), and increase the hydrodynamic size (size in solution) of the agent which prolongs its circulatory time by reducing renal clearance. (wikipedia.org)
  • By encapsulating the drug compound in the nanostructures, injectable depots are able to deliver therapeutic levels of drug substance over extended periods from a single injection. (wikipedia.org)
  • degradation
  • The results of the two-year analysis undertaken as part of the formal stability program demonstrate that the immunogen component of RiVax™, a recombinant derivative of the ricin A chain, is stable under storage conditions for at least two years without loss of its natural configuration or the appearance of any detectable degradation products. (drugs.com)
  • Applications discussed range from measurement of slow oxidative degradation of polymers and instability of hazardous industrial chemicals to detection of bacteria in urine and evaluation of the effects of drugs on parasitic worms. (wikipedia.org)
  • The structures also allow for the use of controlled release and prevention of degradation of fragile short half live molecules, a serious issue for amino-acid based drugs. (wikipedia.org)
  • liquid
  • This work was divided in three sections: The first step was to develop a Liquid Chromatography coupled to tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of dipyrone, tramadol and metoclopramide in physiological saline with the purpose of performing a stability study during 24 hours of the mixture prior to intravenous administration. (uji.es)
  • In this stability study, High Performance Liquid Chromatography coupled to triple quadrupole mass spectrometry (HPLC-QqQ) was used, butsupplementary information about possible transformation products was obtained from liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and HPLC-diode-array detector (HPLCDAD). (uji.es)
  • The accuracy and stability of caffeine and halothane concentrations in liquid Krebs medium were examined. (biomedsearch.com)
  • Some common drugs which authorities say are always unsafe if expired include nitroglycerin, insulin, and liquid antibiotics. (wikipedia.org)
  • injectable
  • SAN DIEGO, Sept. 14 /PRNewswire/ -- ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX) today announced the results of stability tests performed on samples of ANX-530 (vinorelbine injectable emulsion), or Exelbine™, manufactured at the Company's intended commercial manufacturing site. (drugs.com)
  • antibiotics
  • A major teaching hospital has developed a program on rational drug use, developing a hospital formulary, guidelines for rational diagnosis and treatment guidelines for the rational use of antibiotics. (wikipedia.org)
  • behavior
  • The shape is chosen to strike a balance between cost, hydrostatic considerations (accommodation, load carrying and stability), hydrodynamics (speed, power requirements, and motion and behavior in a seaway) and special considerations for the ship's role, such as the rounded bow of an icebreaker or the flat bottom of a landing craft. (wikipedia.org)
  • As well as producing training programs and publications, the group is undertaking research in a number of member countries, focused primarily on changing behavior to improve drug use. (wikipedia.org)
  • Factors
  • Robust stability is one of the key factors stipulated by the Biomedical Advanced Research and Development Authority (BARDA) for vaccines to be included in the Strategic National Stockpile. (drugs.com)
  • dosage
  • Product: like doxycycline dosage samples, doxycycline may cause doxycycline to doxycycline of stability heat the developing tootake if this genitalium is taken during help. (txlyd.com)
  • substance
  • Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C. Furonazide was prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product. (wikipedia.org)
  • PROPERTIES
  • To this end, BARDA has solicited proposals in a number of key areas, including development of vaccines for category categories B and A that have enhanced stability properties that address long-term storage and the benefit of rapid onset of immunity. (drugs.com)
  • FVA-9 Blaue Maus II (Blue Mouse II) In 1933 the FVA students turned their attention to a lightweight soaring glider designed to have good aerodynamic, stability and control properties, as well as a high L/D ratio at a reasonably high speed to allow flight between thermals. (wikipedia.org)
  • Artemisinin and its endoperoxides derivatives have been used for the treatment of P. falciparum related infections but low bioavailability, poor pharmacokinetic properties and high cost of the drugs are a major drawback of their use. (wikipedia.org)
  • evaluate
  • Depending on the pain level suffered by the patient after a surgical intervention, the department of Anaesthesiology, Resuscitation and Pain therapy of the General University Hospital of Castellon must evaluate two procedures of drugs administration in post-operatory analgesia. (uji.es)
  • interactions
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • high
  • Positive stability was demonstrated when DNI rPA was subjected to temperatures as high as 70?C for one month. (drugs.com)
  • Everything was shaped to reduce drag and increase stability at high speed. (wikipedia.org)
  • Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. (wikipedia.org)
  • medications
  • Just, a presc good jedan of the book with those medications will however become immune by using an nmr voldoende based on heat stability of doxycycline the belt of response expression characteristics. (txlyd.com)
  • To reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals, the United States Department of Defense and the Food and Drug Administration operate a joint initiative known as the Shelf Life Protection Program (SLEP), which evaluates the long-term effectiveness of medications stockpiled by the DoD and other government agencies. (wikipedia.org)
  • tablet
  • The tablet counter aided the pharmacy industry with time-consuming manual counting of drug prescriptions. (wikipedia.org)
  • These early devices became known as tablet counter, capsule counter, pill counter, or drug counter. (wikipedia.org)
  • organizations
  • We discuss the advantages and disadvantages of open source descriptors and the opportunity for their use as a tool for organizations to share data precompetitively, avoiding repetition and assisting drug discovery. (aspetjournals.org)
  • Standard advice from drug manufacturers and some health organizations is to dispose of drugs after the expiration date printed on the packaging. (wikipedia.org)
  • Consumers and organizations sometimes use expired drugs for medical treatment either as a cost saving measure or because they otherwise cannot access drugs which are not expired. (wikipedia.org)
  • characteristics
  • Since products continually change over time, the characteristics of any drug are not unchanging but instead estimated with assay measurements to be within the specification required by the government regulator where the drug is sold. (wikipedia.org)
  • increase
  • A sander increase genotype was performed at the heat stability of doxycycline shedding of each patient to insurance assess the lyme farif. (txlyd.com)
  • induction
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)
  • resistance
  • Use of the drug by itself as a monotherapy is explicitly discouraged by the World Health Organization, as there have been signs that malarial parasites are developing resistance to the drug. (wikipedia.org)
  • The World Health Organization (WHO) is pressuring manufacturers to stop making the uncompounded drug available to the medical community at large, aware of the catastrophe that would result if the malaria parasite developed resistance to artemisinins. (wikipedia.org)
  • immune
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • Food and Drug Admin
  • ADAGEN (pegademase bovine) manufactured by Enzon Pharmaceuticals, Inc., US was the first PEGylated protein approved by the U.S. Food and Drug Administration (FDA) in March 1990, to enter the market. (wikipedia.org)
  • The Shelf Life Extension Program (SLEP) is a joint program of the United States Department of Defense and the Food and Drug Administration which aims to reduce the cost to the military of maintaining stockpiles of certain pharmaceuticals by researching the expiration of drugs. (wikipedia.org)
  • development
  • CAM2032 is a new drug being developed for long-term treatment of prostate cancer, with development also initiated for endometriosis. (wikipedia.org)
  • improve
  • Captisol, a chemically modified cyclodextrin, is proven to improve the solubility and stability of drugs and is currently used in six marketed products. (epmmagazine.com)
  • Hovione offers particle engineering technologies to improve the solubility of modern drugs. (epmmagazine.com)
  • To improve the distribution of drugs in order to make them accessible to the whole population. (wikipedia.org)
  • protein
  • DOR has studied the stability of the RiVax™ immunogen using a variety of spectral techniques aimed at examining the three-dimensional and two-dimensional structure of the protein, as well as other techniques that detect small changes in the nature of the protein during exposure to elevated temperature conditions. (drugs.com)
  • anti-cancer drugs
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a category of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • study
  • Naturally, medical linings are cure needed over the doxycycline of stability heat additional study to ensure that inflammation is controlled. (txlyd.com)
  • effective
  • The printed expiration date will always be sooner than the true expiration date, because the drug should always be effective and safe before the labeled expiration date if kept properly. (wikipedia.org)
  • Therapies that combine artemisinin or its derivatives with some other antimalarial drug are the preferred treatment for malaria and are both effective and well tolerated in patients. (wikipedia.org)
  • Combinations are effective because the artemisinin component kills the majority of parasites at the start of the treatment, while the more slowly eliminated partner drug clears the remaining parasites. (wikipedia.org)
  • human
  • Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. (biomedsearch.com)
  • data
  • The 12-month stability data are consistent with the stability data collected at 6 and 9 months and will support the Company's submission of a New Drug Application (NDA) for Exelbine, which the Company expects to take place in the fourth quarter of this year. (drugs.com)
  • available
  • Generic drugs have been available at affordable costs to low-income groups. (wikipedia.org)
  • Several fixed-dose ACTs are now available containing an artemisinin component and a partner drug which has a long half-life, such as mefloquine (ASMQ), lumefantrine (Coartem), amodiaquine (ASAQ), piperaquine (Duo-Cotecxin), and pyronaridine (Pyramax). (wikipedia.org)
  • support
  • Drug manufacturers never support the use of drugs after the expiration date because that could make them liable if something went wrong. (wikipedia.org)
  • medical
  • Medical authorities find it difficult to discuss when consumers can safely use drugs after the printed expiration date because it is hard to get clear information. (wikipedia.org)
  • results
  • We are very excited about these extraordinary stability results," stated Robert N. Brey, PhD, Chief Scientific Officer of Soligenix. (drugs.com)
  • reduce
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • The fuselage was 8 ft (2.4 m) longer and area ruled to reduce transonic drag, being thinner in the region of the wing roots. (wikipedia.org)
  • treatment
  • In doxycycline, much 994 bm segments were other in heat stability of doxycycline treated but antibiotic in treatment worms. (txlyd.com)
  • life
  • Drugs which are past their shelf life can decompose and either be ineffective or even harmful. (wikipedia.org)
  • Artemisinins are not used for malaria prophylaxis (prevention) because of the extremely short activity (half-life) of the drug. (wikipedia.org)