• therapy
  • Evaluation of ovarian follicle development demonstrates that administration of combination therapy using VEGF and FSH-CTP failed to increase follicle vasculature above levels seen with FSH-CTP monotherapy. (biomedsearch.com)
  • Although alternative Bcr-Abl tyrosine kinase inhibitors have been developed to overcome drug resistance, a cocktail therapy of different kinase inhibitors and additional chemotherapeutics may be needed for complete remission of CML in some cases. (nih.gov)
  • After many trials and analyses with successful results equivalent to those of cisplatin but with a more tolerable toxicity profile making the drug more desirable for therapy. (wikipedia.org)
  • analogs
  • The drug discovery process generally follows the following path that includes a hit to lead stage: target validation (TV) → assay development → high-throughput screening → hit to lead (H2L) → lead optimization (LO) → preclinical drug development → clinical drug development The hit to lead stage starts with confirmation and evaluation of the initial screening hits and is followed by synthesis of analogs (hit expansion). (wikipedia.org)
  • The objective of this drug discovery phase is to synthesize lead compounds, new analogs with improved potency, reduced off-target activities, and physiochemical/metabolic properties suggestive of reasonable in vivo pharmacokinetics. (wikipedia.org)
  • Mutation
  • Given the ancestor's role of TEM-1 in the TEM family, the fluorescent TEM-1 drug sensor represents a good model to demonstrate the general combined strategy of Val216→Cys216 mutation and fluorophore labelling for fabricating tailor-made fluorescent drug sensors from other clinically significant TEM-type β-lactamase variants for in vitro drug screening. (nih.gov)
  • Although many strains of MRSA remain sensitive to fusidic acid, there is a low genetic barrier to drug resistance (a single point mutation is all that is required), fusidic acid should never be used on its own to treat serious MRSA infection and should be combined with another antimicrobial such as rifampicin when administering oral or topical dosing regimens approved in Europe, Canada, and elsewhere. (wikipedia.org)
  • therapeutic
  • The program seeks to develop prophylactic and therapeutic drugs, such as Ex-Rad, that prevent and treat radiation injuries and to develop rapid high-precision analytical methods that assess radiation exposure doses from clinical samples and thus aid in the triage and medical management of radiological casualties. (wikipedia.org)
  • metabolism
  • In recent years, new drugs have been developed, based on continuing research into the mechanism of insulin production and regulation of the metabolism of sugar in the body. (wikipedia.org)
  • molecular
  • Numerous molecular markets in the pre-clinical evaluation as cancer drug targets. (bigsandybasin.org)
  • Mass spectrometric, molecular modelling and trypsin digestion results indicate that drug binding at the active site is likely to cause the fluorescein label to stay away from the active site and experience weaker fluorescence quenching by the residues around the active site, thus making the labelled V216C mutant to give stronger fluorescence in the drug-bound state. (nih.gov)
  • Current investigations at IITRI are focused on biomedicine as a contract research organization (CRO), with particular emphasis on non-clinical toxicology, inhalation toxicology and technology, microbiology and molecular biology, and drug discovery and development for cancer and infectious diseases. (wikipedia.org)
  • IITRI currently performs research in five Technical Divisions: Toxicology, Inhalation Toxicology, Microbiology and Molecular Biology, Carcinogenesis and Cancer Chemoprevention, and Drug Discovery. (wikipedia.org)
  • Effects
  • The drug proved to have only modest anti-asthma effects, but produced sensations of exhilaration and palpitations. (wikipedia.org)
  • Quazepam may cause less rebound effects than other type1 benzodiazepine receptor selective nonbenzodiazepine drugs due to its longer half-life. (wikipedia.org)
  • Discovery
  • Since 2002, research at IITRI has been entirely focused on biomedical research, with particular emphasis on pre-clinical toxicology, safety evaluations, and drug discovery and development. (wikipedia.org)
  • Nature Reviews Drug Discovery (8): 255. (wikipedia.org)
  • It is important to use effective contraception while taking this drug and for at least a few months afterwards Platinum-based chemotherapy was an accidental discovery in the laboratory by Barnett Rosenberg. (wikipedia.org)
  • The first step in drug discovery is often the screening of a library drug candidate for MICs against bacteria of interest. (wikipedia.org)
  • Rational drug discovery from plants started particularly with the isolation of morphine, analgesic and sleep-inducing agent from opium, by the German apothecary assistant Friedrich Sertürner, who named the compound after the Greek god of dreams, Morpheus. (wikipedia.org)
  • Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated and undergo limited optimization to identify promising lead compounds. (wikipedia.org)
  • These lead compounds undergo more extensive optimization in a subsequent step of drug discovery called lead optimization (LO). (wikipedia.org)
  • On average, only one in every 5,000 compounds that enters drug discovery to the stage of pre-clinical development becomes an approved drug. (wikipedia.org)
  • involve
  • A vaccine candidate drug is first identified through preclinical evaluations that could involve high throughput screening and selecting the proper antigen to invoke an immune response. (wikipedia.org)
  • Current programs involve acute, subchronic and chronic studies in both rodent and non-rodent model systems to support new drug research. (wikipedia.org)
  • Study endpoints are similar to those performed by scientists of the Toxicology Division, and commonly involve safety evaluations. (wikipedia.org)
  • development
  • Since 2001, he has been Director of Drug Safety Evaluation and Research at the Academy of Medical Sciences, Peking Union Medical College and was also made General Manager of Technological development at Peking Union Medical College's Jianhao Pharmaceutical Technology Development Co., Ltd. He has published papers, whilst also being responsible for four successful international patent applications. (wikipedia.org)
  • By the 1890s, the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. (wikipedia.org)
  • The drug has reportedly been in pre-clinical development for all medical indications since 2008. (wikipedia.org)
  • a number of clinically successful drugs in the market have had the tendency to inhibit hERG, and create a concomitant risk of sudden death, as a side-effect, which has made hERG inhibition an important antitarget that must be avoided during drug development. (wikipedia.org)
  • research
  • Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. (curehunter.com)
  • Realize the full power of the drug-disease research network! (curehunter.com)
  • Her work included evaluation and communication of DNA research and Pharmacogenetics. (wikipedia.org)
  • From 2001 to date he was appointed Director and researcher of Drug Safety Evaluation and Research, at the Academy of Medical Sciences, Peking Union Medical College, Beijing. (wikipedia.org)
  • GW-803430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. (wikipedia.org)
  • Crown Bioscience International, also known as CrownBio, is a contract research organization focused on patient derived xenografts used in drug screening. (wikipedia.org)
  • targets
  • The combination of the structure-based antisense design and extension of the lacZ assay to include gene fusions will be applicable to high-throughput gene functional screening, and to the identification of new drug targets in pathogenic microbes. (nih.gov)
  • Food and Drug Admin
  • In the United States, the Food and Drug Administration (FDA) is responsible for approving vaccines. (wikipedia.org)
  • It has not yet received approval from the U.S. Food and Drug Administration. (wikipedia.org)
  • Satraplatin may provide a palliative benefit for patients in terms of progression-free survival according to the most recent analyses of the phase III SPARC trial, and is currently under Food and Drug Administration review for this indication. (wikipedia.org)
  • A biologics license application (BLA) is defined by the U.S. Food and Drug Administration (FDA) as follows: The biologics license application is a request for permission to introduce, or deliver for introduction, a biologic product into interstate commerce (21 CFR 601.2). (wikipedia.org)
  • orally
  • Most people absorb the drug extremely well after taking it orally, so, if a patient can swallow, there is not much need to administer it intravenously, even if used to treat endocarditis (infection of the heart chambers). (wikipedia.org)
  • high
  • However, resistance selection is low when pathogens are challenged at high drug exposure. (wikipedia.org)
  • 1970s
  • Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014, remains on the World Health Organizations list of essential medications. (wikipedia.org)
  • Quazepam (marketed under brand names Doral, Dormalin) is a relatively long-acting benzodiazepine derivative drug developed by the Schering Corporation in the 1970s. (wikipedia.org)
  • widely
  • The drug is available widely throughout the world, but is notably not approved for use in the United States. (wikipedia.org)
  • treatments
  • An extensive review of the medical literature regarding the management of insomnia and the elderly found that there is considerable evidence of the effectiveness and durability of non-drug treatments for insomnia in adults of all ages and that these interventions are underutilized. (wikipedia.org)
  • cancer
  • The Company believes that these Tumorgrafts closely reflect human cancer biology and their response to drugs is more predictive of clinical outcomes in cancer patients. (bio-medicine.org)
  • In the U.S., where CPA is not available, other drugs with antiandrogen properties like the diuretic spironolactone and the progestin medroxyprogesterone acetate are used instead to treat androgen-dependent conditions besides prostate cancer. (wikipedia.org)
  • include
  • Among the drugs that can cause QT prolongation, the more common ones include antiarrhythmics (especially Class 1A and Class III), anti-psychotic agents, and certain antibiotics (including quinolones and macrolides). (wikipedia.org)
  • available
  • In medicine, culturing the organism infecting a patient with available antibiotic drugs and determining the MICs, is important to identify the correct drug to administer to the patient. (wikipedia.org)