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  • chemotherapy
  • This system could, for instance, enable single-administration vaccines that do not require boosters as well as a new method to deliver hormone therapy, chemotherapy, or drugs that assist wound healing. (azonano.com)
  • These conjugates are used in immunotherapy[citation needed] and to develop monoclonal antibody therapy as a targeted form of chemotherapy when they are often known as antibody-drug conjugates. (wikipedia.org)
  • Gemcitabine is a chemotherapy drug that works by killing any cells that are dividing. (wikipedia.org)
  • However, its mechanism of inhibiting the sphingomyelin apoptotic pathway may also interfere with the apoptosis action of chemotherapy drugs. (wikipedia.org)
  • curtailing systemic
  • Nanometer-scale vehicles known as nanocarriers can be programmed to travel the body and selectively target cancer and other sites of disease and therefore, can convey higher concentrations of drugs to bombard specific areas of the body while curtailing systemic side effects. (azonano.com)
  • biocompatible
  • New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. (nih.gov)
  • This study intended to describe the development of two novel, biocompatible and potential surface hydroxylated quaternary ammonium chloride based poly(propylene imine) (PPI) dendrimers for effective delivery of the drug Norfloxacin (NFN). (nih.gov)
  • These results indicate that the QPPI-OH (G2) and QPPI-OH (G3) dendrimers might be considered as potential biocompatible drug carriers of fluoroquinolines under suitable conditions. (nih.gov)
  • By addition of at least one bilayer softening component (such as a biocompatible surfactant or an amphiphile drug) lipid bilayer flexibility and permeability are greatly increased. (wikipedia.org)
  • membrane-permeability
  • Drugs which have high membrane-permeability can readily 'leak' from the carrier, while optimization of in vivo stability can cause drug release by diffusion to be a slow and inefficient process. (wikipedia.org)
  • To promote chemotherapeutic efficacy, a dynamic drug delivery system was prepared, which remained stealthy and stable in blood vessels, improved drug penetration and retention in response to extracellular stimuli, enhanced membrane permeability through unique functional groups, and then achieved rapid drug release to improve toxicity to tumor cells in response to intracellular stimuli. (rsc.org)
  • tissue
  • The gel itself re-assembles into the nanocarriers, so after the entire drug has been delivered, no residual material is left to trigger fibrous tissue formation or inflammation. (azonano.com)
  • Drug delivery systems would allow more precise targeting of diseased tissue, thus making medicines more effective and requiring lower doses with fewer side effects. (nsf.gov)
  • They are used in tissue engineering, drug delivery, cancer diagnosis, lithium-air battery, optical sensors and air filtration. (wikipedia.org)
  • aqueous
  • It was observed that the QPPI-OH (G2)/QPPI-OH (G3) dendrimers have excellent solubilising potential/drug loading abilities of NFN in aqueous medium and can also sustain delivery of NFN. (nih.gov)
  • The carrier aggregate is composed of at least one amphiphat (such as phosphatidylcholine), which in aqueous solvents self-assembles into a lipid bilayer that closes into a simple lipid vesicle. (wikipedia.org)
  • Adsorption
  • Different methods of attaching the drug to the carrier have been implemented, including adsorption, integration into the bulk structure, encapsulation, and covalent bonding. (wikipedia.org)
  • Their unique structures with high surface area and microporosity make SWNHs become a promising material for gas adsorption, biosensing, drug delivery, gas storage and catalyst support for fuel cell. (wikipedia.org)
  • 2018
  • The 2018 Gordon Conference on Drug Carriers in Medicine and Biology builds on a rich tradition encompassing chemical, biological, physical and engineering principles through clinical application. (grc.org)
  • Release
  • This can be accomplished either by slow release of the drug over a long period of time (typically diffusion) or by triggered release at the drug's target by some stimulus, such as changes in pH, application of heat, and activation by light. (wikipedia.org)
  • Drug release is often achieved by diffusion through pores in the microsphere structure or by degradation of the microsphere shell. (wikipedia.org)
  • Their further functional studies using HP-a as an anticancer drug carrier demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry. (nanotech-now.com)
  • The potential of these dendrimers were examined as drug carrier for NFN, by carrying out solubility, in vitro release, cytotoxicity and anti-bacterial studies. (nih.gov)
  • The aim of the study was to develop a small-scale in situ method to determine drug release and supersaturation in highly concentrated suspensions of enabling formulations. (springer.com)
  • The μDiss Profiler was used to study the drug release from MMC in fasted-state simulated intestinal fluid. (springer.com)
  • Three types of release experiments were conducted for each compound: micronized crystalline drug with MMC present, drug-loaded MMC, and drug-loaded MMC with 0.01% w / w hydroxypropyl methyl cellulose. (springer.com)
  • Based on this characteristic, we have introduced a model drug (theophylline) into the α-CDs in the polyrotaxane to examine drug release via the supramolecular dissociatio … More n. (nii.ac.jp)
  • Unlike polymers, slow degradation of ceramics allows for longer release of the drug. (wikipedia.org)
  • The subsequent gradual release of the active agent from the drug carrier allows the drug molecules to diffuse and finally bind to their targets. (wikipedia.org)
  • researchers
  • During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. (hindawi.com)
  • In a study published in January, researchers at the University of Pennsylvania researchers said that drugs the loading of "many drugs" has been successfully demonstrated, both inside red blood cells as well as onto the cells' surface. (xconomy.com)
  • vivo
  • The measured surface hydrophobicities of particles and fat emulsions were well in agreement with the in vivo organ distribution data obtained after i. v. injection of the carriers. (uni-regensburg.de)
  • proteins
  • A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. (wikipedia.org)
  • advantages
  • A wide variety of drug carrier systems have been developed and studied, each of which has unique advantages and disadvantages. (wikipedia.org)
  • What Are the Various Advantages, Limitations & Applications of the Currently Available Drug Carriers? (businesswire.com)
  • The report covers the currently available drug delivery technologies and recent advances in the field, with granular analyses of the different types of delivery systems, their advantages, disadvantages and opportunities for future development. (businesswire.com)
  • applications
  • This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy. (mdpi.com)
  • We report an unusual homopolymer vesicle, which has a soft bilayer membrane composed of oligo(ethyleneoxy) side chains (OEs) with a gradually decreased packing density from the centre of the membrane to both margins, exhibiting thermo-responsive zeta potential and dispersibility and showing potential applications for anti-cancer drug delivery. (rsc.org)
  • Virosomes therefore represent an innovative, broadly applicable adjuvant and carrier system with prospective applications in areas beyond conventional vaccines. (wikipedia.org)
  • suitable
  • Hydrophobic interaction chromatography (HIC) is presented as a suitable method to determine the surface hydrophobicity of colloidal drug carriers. (uni-regensburg.de)
  • A Transfersome carrier is an artificial vesicle designed to exhibit the characteristics of a cell vesicle or a cell engaged in exocytosis, and thus suitable for controlled and, potentially, targeted drug delivery. (wikipedia.org)
  • stability
  • This viral protein not only confers structural stability and homogeneity to virosome-based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. (wikipedia.org)
  • formulations
  • Effective and compound-sparing methods to evaluate promising drug delivery systems are a prerequisite for successful selection of formulations in early development stages. (springer.com)
  • vitro
  • From in vitro degradation tests, it was found that drug-immobilized α-CDs are completely released by hydrolysis of the terminal peptide linkages in the polyrotaxane without any steric hindrance. (nii.ac.jp)
  • specific
  • Register your specific details and specific drugs of interest and we will match the information you provide to articles from our extensive database and email PDF copies to you promptly. (dovepress.com)
  • These carriers form at some high concentration specific to the compounds used, called the critical micelle concentration. (wikipedia.org)
  • The obtained drug-polyrotaxane conjugate formed a specific association under physiological conditions, depending on interactions between drugs and/or terminals of the polyrotaxane in the conjugate. (nii.ac.jp)
  • Nanophase ceramic drug carriers are also able to target specific cells. (wikipedia.org)
  • This can be done by manufacturing a material to bond to the specific cell or by applying an external magnetic field, attracting the carrier to a specific location. (wikipedia.org)
  • Therefore, a topical formulation based on specific drug carriers has been considered inevitable. (wikipedia.org)
  • injection
  • Scott's team prepared a nanocarrier formulation that - after rapidly forming into a gel inside the body at the site of injection - can continuously discharge nanoscale drug-loaded vehicles for months. (azonano.com)
  • include
  • These drugs include anti-inflammatory, anti-microbial, and anti-clotting medicines. (xconomy.com)
  • Key factors promoting growth include the rapidly expanding injectables market, the growing incidence of chronic diseases and the expected significant increase in the use of complex biologic drugs that necessitate novel delivery systems. (businesswire.com)
  • Risks for developing osteomyelitis include diabetes, intravenous drug use, prior removal of the spleen, and trauma to the area. (wikipedia.org)
  • readily
  • Cellular imaging experiments show that Fc-NDs are readily ingested by breast adenocarcinoma (BA) cells and cell viability tests prove that they can be utilized as a safe drug delivery vehicle. (rsc.org)
  • cells
  • PFE ) executive who joined Rubius as its president in January, calls red blood cells a "potent and convenient" way to deliver a drug and likens them to engineered immune cells that are becoming cancer-fighting drugs in their own right. (xconomy.com)
  • compounds
  • The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. (mdpi.com)
  • widely
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used to inhibit COX-2 and can be a promising additive for the management of aggressive cancers. (rsc.org)
  • model
  • Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. (uni-regensburg.de)
  • effective
  • Nanocarriers can also convey drugs and diagnostic agents that are normally not soluble in blood or water as well as considerably decrease the effective dosage. (azonano.com)
  • This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. (hindawi.com)
  • The effective complexation of NFN with QPPI-OH (G2) and QPPI-OH (G3) increased the solubility of NFN and thus elevates the NFN drug from Class 4 to Class 3 (according to BCS). (nih.gov)
  • agent
  • To avoid this issue, Scott created a nanocarrier using self-assembled, filament-shaped nanomaterials, which are loaded with an imaging or drug agent. (azonano.com)
  • different
  • Different types of drug carrier utilize different methods of attachment, and some carriers can even implement a variety of attachment methods. (wikipedia.org)
  • Numerous groups have since been working with similar carriers, frequently using different names (e.g., elastic vesicle, flexible vesicle, etc.) to describe them. (wikipedia.org)
  • Patients
  • In some subpopulations, including intravenous drug users and splenectomized patients, Gram-negative bacteria, including enteric bacteria, are significant pathogens. (wikipedia.org)
  • conventional
  • The added benefits included no dangerous asymmetrical thrust if one unit fails, as happens in a conventional twin that loses an engine, and the drag of both engine nacelles can be eliminated and combined within the cross-section of the fuselage. (wikipedia.org)
  • Unlike conventional disc mastering, where the mechanical audio modulation is cut onto a lacquer-coated aluminum disc, DMM cuts straight into metal (copper), utilizing a high frequency carrier system and specialized diamond styli, vibrating at more than 40 kHz (i.e. 60 kHz) to facilitate the cutting. (wikipedia.org)
  • high
  • The drug has also been assessed at steroid hormone-associated carrier proteins, and shows very low binding to sex hormone-binding globulin (SHBG) but high affinity for corticosteroid-binding globulin (CBG) approximately equal to that of progesterone. (wikipedia.org)
  • Operating from the Navy's fleet carriers, and attacking at high speed and low level, it would offer a solution to the Sverdlov problem. (wikipedia.org)
  • For ultra long range precision target shooting with high-powered rifles and military sniping, radically designed very-low-drag (VLD) bullets are available that are generally produced out of rods of mono-metal alloys on CNC lathes. (wikipedia.org)
  • Examination of early DMM discs revealed what appeared to be a high frequency modulation in the groove, thought to be caused by the use of an ultrasonic carrier tone. (wikipedia.org)
  • group
  • It is a derivative of progesterone (pregn-4-ene-3,20-dione) with a thio (sulfur) substitution at the C7α position, and is related to the spirolactone group of drugs but lacks a γ-lactone ring. (wikipedia.org)
  • In addition, VMFA-142 integrated the Department of the Navy TACAIR concept which integrates USMC and USN tactical jets into the Carrier Air Wing Group. (wikipedia.org)
  • production
  • According to Dr. Mehdi Shafi ee Ardestani, one of the researchers, the most important achievements of the research is the production of a molecular carrier at nanometric scale that is cheaper than other materials in the market to be used for molecular imaging purposes. (nanowerk.com)
  • higher
  • When Gadoboutrol drug is attached to the surface of the dendrimer and a stronger contrast substance is formed with the ability of higher resolution and efficiency. (nanowerk.com)
  • Air brakes differ from spoilers in that air brakes are designed to increase drag while making little change to lift, whereas spoilers reduce the lift-to-drag ratio and require a higher angle of attack to maintain lift, resulting in a higher stall speed. (wikipedia.org)
  • last
  • The Royal Navy retired the last of its large aircraft carriers in 1978, moving their strike role to the British Aerospace Sea Harrier, and passing their Buccaneers to the Royal Air Force. (wikipedia.org)