• biocompatible
  • New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin. (nih.gov)
  • This study intended to describe the development of two novel, biocompatible and potential surface hydroxylated quaternary ammonium chloride based poly(propylene imine) (PPI) dendrimers for effective delivery of the drug Norfloxacin (NFN). (nih.gov)
  • These results indicate that the QPPI-OH (G2) and QPPI-OH (G3) dendrimers might be considered as potential biocompatible drug carriers of fluoroquinolines under suitable conditions. (nih.gov)
  • By addition of at least one bilayer softening component (such as a biocompatible surfactant or an amphiphile drug) lipid bilayer flexibility and permeability are greatly increased. (wikipedia.org)
  • tissue
  • Drug delivery systems would allow more precise targeting of diseased tissue, thus making medicines more effective and requiring lower doses with fewer side effects. (nsf.gov)
  • They are used in tissue engineering, drug delivery, cancer diagnosis, lithium-air battery, optical sensors and air filtration. (wikipedia.org)
  • gemcitabine
  • A multiscale computational study is reported that investigates the microscopic behavior of the anti-cancer drug gemcitabine (GEM) stored in metal organic frameworks IRMOF-74-III and the functionalized OH-IRMOF-74-III. (rsc.org)
  • aqueous
  • It was observed that the QPPI-OH (G2)/QPPI-OH (G3) dendrimers have excellent solubilising potential/drug loading abilities of NFN in aqueous medium and can also sustain delivery of NFN. (nih.gov)
  • Liposomes that contain low (or high) pH can be constructed such that dissolved aqueous drugs will be charged in solution (i.e., the pH is outside the drug's pI range). (wikipedia.org)
  • The carrier aggregate is composed of at least one amphiphat (such as phosphatidylcholine), which in aqueous solvents self-assembles into a lipid bilayer that closes into a simple lipid vesicle. (wikipedia.org)
  • stability
  • This viral protein not only confers structural stability and homogeneity to virosome-based formulations, but it significantly contributes to the immunological properties of virosomes, which are clearly distinct from other liposomal and proteoliposomal carrier systems. (wikipedia.org)
  • vitro
  • From in vitro degradation tests, it was found that drug-immobilized α-CDs are completely released by hydrolysis of the terminal peptide linkages in the polyrotaxane without any steric hindrance. (nii.ac.jp)
  • interactions
  • The obtained drug-polyrotaxane conjugate formed a specific association under physiological conditions, depending on interactions between drugs and/or terminals of the polyrotaxane in the conjugate. (nii.ac.jp)
  • As of 2014 drug interactions had not been studied. (wikipedia.org)
  • specific
  • These carriers form at some high concentration specific to the compounds used, called the critical micelle concentration. (wikipedia.org)
  • Nanophase ceramic drug carriers are also able to target specific cells. (wikipedia.org)
  • This can be done by manufacturing a material to bond to the specific cell or by applying an external magnetic field, attracting the carrier to a specific location. (wikipedia.org)
  • Therefore, a topical formulation based on specific drug carriers has been considered inevitable. (wikipedia.org)
  • applications
  • This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy. (mdpi.com)
  • We report an unusual homopolymer vesicle, which has a soft bilayer membrane composed of oligo(ethyleneoxy) side chains (OEs) with a gradually decreased packing density from the centre of the membrane to both margins, exhibiting thermo-responsive zeta potential and dispersibility and showing potential applications for anti-cancer drug delivery. (rsc.org)
  • Virosomes therefore represent an innovative, broadly applicable adjuvant and carrier system with prospective applications in areas beyond conventional vaccines. (wikipedia.org)
  • cells
  • Cellular imaging experiments show that Fc-NDs are readily ingested by breast adenocarcinoma (BA) cells and cell viability tests prove that they can be utilized as a safe drug delivery vehicle. (rsc.org)
  • A virosome is a drug or vaccine delivery mechanism consisting of unilamellar phospholipid membrane (either a mono- or bi-layer) vesicle incorporating virus derived proteins to allow the virosomes to fuse with target cells. (wikipedia.org)
  • effective
  • This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. (hindawi.com)
  • Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. (mdpi.com)
  • The effective complexation of NFN with QPPI-OH (G2) and QPPI-OH (G3) increased the solubility of NFN and thus elevates the NFN drug from Class 4 to Class 3 (according to BCS). (nih.gov)
  • Therefore, due to its active nature, the pH-sensitive 5-FU-loaded GG- g -L-β-CD carrier is a potential drug delivery system for safe and effective cancer therapy, and it can be useful for inhibiting tumour cell growth. (rsc.org)
  • systems
  • Key factors promoting growth include the rapidly expanding injectables market, the growing incidence of chronic diseases and the expected significant increase in the use of complex biologic drugs that necessitate novel delivery systems. (businesswire.com)
  • BERKELEY, Calif.--(BUSINESS WIRE)--DSM, a global leader in biomedical materials, and Svelte® Medical Systems, Inc., a privately held company developing next generation endovascular therapies, today announced they have entered into a license and supply agreement granting Svelte the right to use DSM's proprietary bioerodible amino acid based drug carrier in the design of a non-thrombogenic, non-inflammatory drug-eluting stent. (biospace.com)
  • 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. (begellhouse.com)
  • include
  • Risks for developing osteomyelitis include diabetes, intravenous drug use, prior removal of the spleen, and trauma to the area. (wikipedia.org)
  • functional
  • The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. (mdpi.com)
  • Route
  • Drugs may also be administered intravaginally as an alternative to oral route in the cause of nausea or other digestive problems. (wikipedia.org)
  • different
  • Different types of drug carrier utilize different methods of attachment, and some carriers can even implement a variety of attachment methods. (wikipedia.org)
  • Numerous groups have since been working with similar carriers, frequently using different names (e.g., elastic vesicle, flexible vesicle, etc.) to describe them. (wikipedia.org)
  • Volume
  • The large surface area to volume ratio of nanophase materials makes it possible for large amounts of drugs to be released over long periods of time. (wikipedia.org)
  • model
  • Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. (uni-regensburg.de)