• Liposomal doxorubicin is an anthracycline-type chemotherapy drug that is used to treat certain types of cancer (such as ovarian cancer , AIDS-related Kaposi's sarcoma , multiple myeloma ). (webmd.com)
  • Liposomal doxorubicin may cause heart problems, including possibly fatal heart failure . (webmd.com)
  • Heart problems may occur during liposomal doxorubicin therapy or months to years after receiving this medication . (webmd.com)
  • Depending on how severe your hand-foot syndrome is, your doctor may give you something to reduce the symptoms, or decrease or delay your next dose of liposomal doxorubicin . (webmd.com)
  • Pegylated liposomal doxorubicin (PLD) is an improved formulation of doxorubicin that is associated with fewer and less severe side effects than are seen with non-modified doxorubicin. (cochrane.org)
  • The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
  • Industrial Relevance: This study presents an example of the successful integration of a well- known herbal supplement, AHCC, with traditional western medicine cytotoxic agent, pegylated liposomal doxorubicin, for the treatment of recurrent ovarian cancer. (researchgate.net)
  • alone and evaluate its activity in combinatio n with pegylated liposomal doxorubicin (PLD). (researchgate.net)
  • Liposomal doxorubicin is devoid of the cardiac toxicity associated with doxorubicin, but is associated with predictable muco-cutaneous toxicity. (northwestern.edu)
  • A favorable toxicity profile renders liposomal doxorubicin an ideal partner for combination regimens with other cytotoxics, and more recently with biological agents. (northwestern.edu)
  • Strother, R & Matei, D 2009, ' Pegylated liposomal doxorubicin in ovarian cancer ', Therapeutics and Clinical Risk Management , vol. 5, no. 1, pp. 639-650. (northwestern.edu)
  • Liposomal Doxorubicin and Etoposide. (checkorphan.org)
  • Furthermore, cellular uptake of liposomal doxorubicin enriched with C6 and C8-ceramide was higher than both free doxorubicin and liposome formulation without ceramide. (auburn.edu)
  • Doxil is also known by its drug name, liposomal doxorubicin. (mymyelomateam.com)
  • Doxorubicin, sold under the brand name Adriamycin among others, is a chemotherapy medication used to treat cancer. (wikipedia.org)
  • Chemotherapy can cause reactivation of hepatitis B, and doxorubicin-containing regimens are no exception. (wikipedia.org)
  • Doxorubicin may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications and radiation (x-ray) therapy. (medlineplus.gov)
  • Doxorubicin should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • a polymer-based drug delivery system that could help the current chemotherapy with doxorubicin. (cas.cz)
  • One of them is that chemotherapy with doxorubicin (one of the most successful chemotherapeutic drugs used in the clinic) is toxic to the heart which limits the effectiveness of the treatment. (cas.cz)
  • With an approach to enhance the efficacy of chemotherapy agents against breast cancer treatment, here, we investigated the anti-cancer effects of grape seed extract (GSE) and doxorubicin (Dox), either alone or in combination, in estrogen receptor-positive MCF-7 and receptor-negative MDA-MB468 human breast carcinoma cells. (nih.gov)
  • Doxorubicin should only be given by health care professionals familiar with the use of chemotherapy medications used to treat cancer. (pharmasave.com)
  • The purpose of this study was to determine patient factors associated with the development of kidney damage in cats receiving doxorubicin chemotherapy. (vin.com)
  • Chemotherapy protocols were also associated with the risk of renal toxicity, with animals receiving single-agent doxorubicin more likely than those receiving CHOP (OR 20.0). (vin.com)
  • Doxorubicin (DOX), a widely used anthracycline drug in chemotherapy, is notorious for its cardiotoxicity. (aging-us.com)
  • Doxorubicin (Dox) is a cytotoxic drug widely incorporated in various chemotherapy protocols. (oncotarget.com)
  • We also collected surface wipe samples for cyclophosphamide, ifosfamide, and doxorubicin at the beginning of the work day before the chemotherapy drugs were unpacked and at the end of the work day after the last chemotherapy treatment was completed. (cdc.gov)
  • following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been proposed that doxorubicin-associated cardiomyopathy develops as the result of reactive oxygen species (ROS) production and iron accumulation. (medindia.net)
  • In a mouse model of doxorubicin-associated cardiotoxicity, overexpression of a protein that enhances mitochondrial iron transport reduced mitochondrial iron, ROS, and protected animals from doxorubicin-induced cardiomyopathy. (medindia.net)
  • Treatment of animals with dexrazoxane, which attenuates doxorubicin-induced cardiotoxicity, decreased mitochondrial iron levels and reversed doxorubicin-induced cardiac damage. (medindia.net)
  • These data suggest that therapies that limit mitochondrial iron accumulation have potential to limit doxorubicin-associated cardiotoxicity. (medindia.net)
  • 319, 745 (1988)] as a cardioprotective agent against what may be an iron-based doxorubicin (Adriamycin)-induced cardiotoxicity. (aspetjournals.org)
  • The possible mechanism underlying doxorubicin (DOX)-mediated cardiotoxicity has been investigated in this study. (ntu.edu.sg)
  • Background and Purpose: Doxorubicin anti-cancer therapy is associated with cardiotoxicity, resulting from DNA damage response (DDR). (unito.it)
  • In this study, we have investigated whether the activation of the HGF receptor-encoded by the Met gene-by an agonist monoclonal antibody (mAb) could protect against doxorubicin-induced cardiotoxicity. (unito.it)
  • Oxidative stress and apoptosis contribute to the pathological basis of doxorubicin (DOX)-induced cardiotoxicity . (bvsalud.org)
  • Doxorubicin is in a class of medications called anthracyclines. (medlineplus.gov)
  • Secondary acute myelogenous leukemia and myelodysplastic syndrome occur at a higher incidence in patients treated with anthracyclines, including doxorubicin. (medilib.ir)
  • Anthracyclines, e. g. daunorubicin, doxorubicin, and idarubicin, consist of a tetracycline moiety linked via a glycosidic bond to a sugar residue, usually the aminosugar daunosamine. (lu.se)
  • Doxorubicin hydrochloride (as Myocet liposomal) is indicated to treat breast cancer in combination with cyclophosphamide. (wikipedia.org)
  • The patients received doxorubicin hydrochloride as a sterile, pyrogen-free solution in two concentrations (16 mg/mL and 24 mg/mL) in an ethanol/water vehicle using the OncoMyst delivery device. (cancernetwork.com)
  • The risk of developing secondary acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) is increased following treatment with doxorubicin hydrochloride. (medscape.com)
  • Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive doxorubicin. (medlineplus.gov)
  • If you miss an appointment to receive doxorubicin, contact your doctor as soon as possible to reschedule your appointment. (pharmasave.com)
  • There are several ways in which doxorubicin is believed to cause cardiomyopathy, including oxidative stress, downregulation of genes for contractile proteins, and p53-mediated apoptosis. (wikipedia.org)
  • In the article titled "Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling" [ 1 ], there are errors in the cleaved caspase-3 panel of Figure 4(a) and the DOX+Nrf2 siRNA panel of Figure 4(g) . (hindawi.com)
  • Orosomucoid 1 attenuates doxorubicin-induced oxidative stress and apoptosis in cardiomyocytes via Nrf2 signaling," BioMed Research International , vol. 2020, Article ID 5923572, 2020. (hindawi.com)
  • Methods: Mouse embryonic fibroblasts (MEFs) were cultured and treated with Doxorubicin to induce apoptosis and senescence respectively. (sun.ac.za)
  • Results and discussion: Doxorubicin (1 μM) was able to significantly induce apoptosis in MEFs after 24 hours. (sun.ac.za)
  • The western blot analyses show that the expression of many apoptosis and senescence markers significantly increased or decreased after Doxorubicin treatment. (sun.ac.za)
  • Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway. (bvsalud.org)
  • Recently, the United States (US) Food and Drug Administration conditionally approved olaratumab in combination with doxorubicin (Olara + Dox) based on a randomized phase II trial that reported a significant 11.8-month improvement in median survival versus single-agent doxorubicin (Dox). (rti.org)
  • Furthermore, heart samples from patients undergoing doxorubicin therapy revealed higher levels of mitochondrial iron in patients with cardiomyopathies compared to patients without cardiac complications. (medindia.net)
  • The authors conclude that the above factors increase the risk of kidney damage in cats undergoing doxorubicin therapy. (vin.com)
  • Herein, we report in vitro anticancerous effects of doxorubicin (DOX) loaded on gold nanorods coated with the polyelectrolyte poly(sodium-4-styrenesulfonate) (PSS-GNRs) with and without NIR laser (808 nm, power density = 1.5 W/cm 2 for 2 min) irradiation. (beilstein-journals.org)
  • MAb (100 nM) was administered in vitro to H9c2 cardiomyoblasts before addition of doxorubicin (25 μM). (unito.it)
  • The most dangerous side effect of doxorubicin is dilated cardiomyopathy, leading to congestive heart failure. (wikipedia.org)
  • apalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • darolutamide will increase the level or effect of doxorubicin by Other (see comment). (medscape.com)
  • enzalutamide will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • erdafitinib will increase the level or effect of doxorubicin by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • We studied the effect of doxorubicin (Dox) on cell cycle progression and its correlation with DNA damage and cytotoxicity in p53-mutant P388 cells. (aspetjournals.org)
  • Doxorubicin-induced cardiomyopathy typically results in dilated cardiomyopathy, with all four cardiac chambers being enlarged. (wikipedia.org)
  • ORLANDO-Inhaled doxorubicin has clinical activity and can be delivered without major toxicity to adults with advanced solid tumors affecting the lungs, according to a multicenter phase I study reported at the 38th Annual Meeting of the American Society of Clinical Oncology (abstract 1204). (cancernetwork.com)
  • abstract = "The encapsulation of doxorubicin in a pegylated liposomal matrix led to a reformulated agent with a different toxicity profile and improved clinical utility. (northwestern.edu)
  • Doxorubicin is one of the more commonly used chemotherapeutic drugs in veterinary medicine. (vin.com)
  • Doxorubicin toxicity increased if given after paclitaxel infusion (give doxorubicin dose first). (empr.com)
  • The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500-550 mg/m2, 18% when the dose is 551-600 mg/m2 and 36% when the dose exceeds 600 mg/m2. (wikipedia.org)
  • One of the major adverse effects of doxorubicin in cats is cumulative renal damage- ie, the propensity for cats to develop kidney disease with large total doses of medication. (vin.com)
  • The risk of cardiomyopathy is proportional to the cumulative exposure with incidences from 1% to 20% for cumulative doses from 300 mg/m 2 to 500 mg/m 2 when doxorubicin is administered every 3 weeks. (medilib.ir)
  • Liposomes, containing disparate ceramides, were prepared in a molar ratio of 44:40:4:12 mol% of DOTAP/ cholesterol/PEG2000-DSPE/Ceramide, respectively using lipid film hydration method and loaded with doxorubicin (ratio of 0.2:1). (auburn.edu)
  • Liposomes were characterized by measuring size, polydispersity index, release profile and doxorubicin content. (auburn.edu)
  • Each single-dose vial of sterile, lyophilized red powder, contains doxorubicin HCl 10 mg. (pharmasave.com)
  • In cats where creatinine increased, the mean time to increase was 119 days (Mean of 2.8 doses of doxorubicin). (vin.com)
  • This may be due to the higher number of doxorubicin doses received by cats on single agent therapy. (vin.com)
  • This is a phase 1b open-label study evaluating the preliminary safety and maximum tolerated dose of a new formulation of INNO-206 administered at doses of 230 mg/m2, 350 mg/m2 and 450 mg/m2 (165, 260, 325 mg/m2 doxorubicin equivalents, respectively) through intravenous infusion on Day 1 every 21 days for up to 6 cycles. (drugpatentwatch.com)
  • Experimental Approach: The mAb (5 mg·kg−1) was injected in vivo into C57BL/6J mice, before doxorubicin (three doses of 7 mg·kg−1). (unito.it)
  • We have now investigated their role in the biliary and intestinal secretion of the anticancer drugs doxorubicin (unlabeled: 5 mg/kg) and vinblastine ( 3 H-labeled: 1 mg/kg) i.v. administered to wild-type and mdr1a P-glycoprotein knockout [ mdr1a (−/−)] mice. (aspetjournals.org)
  • Extravasation of doxorubicin can result in severe local tissue injury and necrosis requiring wide excision of the affected area and skin grafting. (medilib.ir)
  • In the EU doxorubicin pegylated liposomal (as Caelyx) is indicated to treat breast cancer, ovarian cancer, and AIDS-related Kaposi's sarcoma. (wikipedia.org)
  • Doxorubicin can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • This finding is potentially important clinically, because doxorubicinol may contribute significantly to cardiac toxicity after doxorubicin administration. (nih.gov)
  • Another common and potentially fatal complication of doxorubicin is typhlitis, an acute life-threatening inflammation of the bowel. (wikipedia.org)
  • Wang L , Liu Y , Li S , Zha Z , Chen Y , Wang Q , Zhou S , Huang X , Xu M , . Capsaicin alleviates doxorubicin-induced acute myocardial injury by regulating iron homeostasis and PI3K-Akt signaling pathway. (aging-us.com)
  • Myocardial damage, including acute left ventricular failure, can occur with doxorubicin. (medilib.ir)
  • The differential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer drugs temozolomide (TMZ) and doxorubicin (DOX) were investigated. (nature.com)
  • We studied the relationship between doxorubicin pharmacokinetics and body composition in children with cancer. (nih.gov)
  • Further study of the body composition on doxorubicin and doxorubicinol pharmacokinetics and on clinical outcomes is warranted. (nih.gov)
  • Doxorubicin is also used alone and in combination with other medications to treat certain types of thyroid cancer and certain types of soft tissue or bone sarcomas (cancer that forms in muscles and bones). (medlineplus.gov)
  • Inhaled doxorubicin will be further developed as therapy for bron-chioloalveolar carcinoma, in sarcomas metastatic to the lung, and as combination treatment with systemic therapy. (cancernetwork.com)
  • The selenium-deficient state, which was characterized by markedly decreased cardiac glutathione peroxidase levels, led to significantly enhanced doxorubicin toxicity at a dose of 15 mg/kg i.p. (jci.org)
  • Accumulation and efflux of doxorubicin was concentration dependent, and tariquidar significantly inhibited efflux by 57%, 61%, and 50% in the 125, 75, and 25 μM groups. (sfu.ca)
  • P-gp efflux of doxorubicin significantly reduced intracellular ATP concentration, adenylate energy charge, and phosphorylation potential with highest percent decreases of 25%, 11%, and 53% respectively, and increased concentrations of ADP, AMP, and Pi with highest percent increases of 26%, 36%, and 11% respectively compared to controls and tariquidar-treated groups. (sfu.ca)
  • Doxorubicin (Dox), a non-selective class I anthracycline antibiotic, is a potent chemotherapeutic agent which is used for the treatment of numerous cancers [ 1 ]. (oncotarget.com)
  • The rate of this side effect limits the dose of this formulation that can be given as compared with plain doxorubicin in the same treatment regimen, thereby limiting potential substitution. (wikipedia.org)
  • Doxorubicin enriched with C6 and C8-ceramide exhibited the highest cytotoxicity against MDA-MB-231 and PC3 cells compared to liposome formulation that does not contain ceramide and free doxorubicin. (auburn.edu)
  • Chronic kidney disease (CKD) was diagnosed in 41% of cats prior to the initiation of therapy with doxorubicin. (vin.com)
  • Approximately 10% of the dose was secreted as unchanged doxorubicin into the intestinal contents of both types of mice. (aspetjournals.org)
  • 35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemothe. (oncolink.org)
  • Co-delivery of short chain ceramide, C6-Ceramide (C6-Cer) and C8-Ceramide (C8-Cer) and doxorubicin (DOX) using a liposomal system in MDA-MB-231 breast cancer and PC3 prostate cancer cell lines for synergistic cytotoxic effects was investigated. (auburn.edu)
  • Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. (wikipedia.org)
  • Doxorubicin (DOX) is a commonly used anthracycline broad-spectrum antitumor antibiotic with strong antitumor effect and definite curative effect. (frontiersin.org)
  • Doxorubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. (medlineplus.gov)
  • The amount of aerosolized doxorubicin was determined by a Tc-99m DTPA deposition test performed within 1 week prior to the first treatment. (cancernetwork.com)
  • Therefore, we think that PTP1B may play an important role in the development of heart failure induced by doxorubicin and can be used as a potential target for the treatment of heart failure. (frontiersin.org)
  • To overcome this, we demonstrate that doxorubicin (DOX), a cornerstone drug used for osteosarcoma treatment, shows reversible accretion to hydroxyapatite (HA) of both nano (nHA) and micro (mHA) size. (lu.se)
  • During chemotherapeutic treatment with Doxorubicin, normal and healthy neighbouring cells are also damaged. (sun.ac.za)
  • During senescence induction, 2 μM of Doxorubicin treatment for 4 hours was unable to induce 80% of senescence in the MEF population. (sun.ac.za)
  • Doxorubicin (DOX) has been used in the treatment of variety of cancers but its administration is limited by a dose-dependent toxicity. (journalcra.com)
  • Assess left ventricular ejection fraction before and regularly during and after treatment with doxorubicin. (medilib.ir)
  • The ground- and excited-state dissociation constants and the electronic absorption and fluorescence spectra of doxorubicin were investigated by spectrophotometry. (chemicalforums.com)
  • The recommended dose of doxorubicin varies according to the specific condition being treated, the response to therapy, the other medications being used, and body size. (pharmasave.com)
  • In this issue of the Journal of Clinical Investigation , Hossein Ardehali and colleagues at Northwestern University determined that doxorubicin accumulates within the mitochondria of cardiomyocytes and this accumulation promotes mitochondrial ROS production and iron accumulation. (medindia.net)
  • Following administration of this form of doxorubicin, small amounts of the drug can leak from capillaries in the palms of the hands and soles of the feet. (wikipedia.org)
  • Thus, the absence of mdr1a P-glycoprotein affects the fate of vinblastine chiefly by diminishing secretion into the lumen of the small intestine, whereas it affects the fate of doxorubicin chiefly by diminishing secretion of parent drug into bile. (aspetjournals.org)
  • Nrf2 knockdown reverses the protective effects of ORM1 in doxorubicin- (DOX-) treated H9c2 cells. (hindawi.com)