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  • relapse
  • At least one PSA bounce was seen in 55 patients (70%) but only 3 of them subsequently relapsed, biochemical-relapse-free survival was 100 and 92% for low-risk and intermediate-risk patients, respectively, by ASTRO definition (98 and 92% by Phoenix definition). (urotoday.com)
  • The cure of hematologic disorders by allogeneic hematopoietic stem cell transplantation (HSCT) is often associated with major complications resulting in poor outcome, including graft-versus-host disease (GVHD), relapse, and death. (hindawi.com)
  • A novel composite endpoint of GVHD-free/relapse-free survival (GRFS) in which events include grades 3-4 acute GVHD, chronic GVHD requiring systemic therapy, relapse, or death is censored to completely characterize the survival without mortality or ongoing morbidity. (hindawi.com)
  • Although younger children and children with invasive tumor types generally experience less favorable outcomes, total removal of the tumors is the most conspicuous prognostic factor for both survival and relapse. (wikipedia.org)
  • Another major point to be addressed about this killer disease is the relapse rate which is very high. (wikipedia.org)
  • stem cell transplant
  • Patients with acute myeloid leukemia (AML) who achieve remission with the antibody-targeted chemotherapy agent Mylotarg™ (gemtuzumab ozogamicin for injection) have prolonged disease-free survival following stem cell transplantation according to research presented today at the annual meeting of the American Society of Hematology (ASH). (fredhutch.org)
  • Nonablative versus reduced-intensity conditioning regimens in the treatment of acute myeloid leukemia and high-risk myelodysplastic syndrome: dose is relevant for long-term disease control after allogeneic hematopoietic stem cell transplantation," Blood , vol. 104, no. 3, pp. 865-872, 2004. (hindawi.com)
  • Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation," The Lancet Oncology , vol. 15, no. 8, pp. e327-e340, 2014. (hindawi.com)
  • graft-versus-
  • J. Bolanos-Meade, J. Koreth, and R. Reshef, "A multicenter phase II trial randomizing novel approaches for graft-versus-host disease prevention compared to contemporary controls (BMT CTN 1203)," 2015, https://clinicaltrials.gov/ct2/show/NCT02208037 . (hindawi.com)
  • progression
  • 16-week progression-free survival rates were 59% and 78%, respectively. (ascopost.com)
  • But progression may also be due to the appearance of a new lesion originating from the same tumor or to the appearance of new cancer in the same organ or in a different organ, or due to unequivocal progression in 'non-target' lesions-such as pleural effusions, ascites, leptomeningeal disease etc. (wikipedia.org)
  • Progression-free survival is often used as an alternative to overall survival (OS): this is the most reliable endpoint in clinical studies, but it will only be available after a longer time than PFS. (wikipedia.org)
  • PFS may be considered as an endpoint in itself (the FDA and EMEA consider it such) in situations where overall survival endpoints may be not feasible, and where progression is likely or very likely to be related to symptomatology. (wikipedia.org)
  • Activated Akt promotes cell survival and cell cycle progression by phosphorylating and inactivating p21Cip1/WAF1, p27Kip1, and GSK3β, as well as inhibits apoptosis by preventing the cleavage of caspase-8 and caspase-9, which are involved in the extrinsic and intrinsic pathways of cell death, respectively. (wikipedia.org)
  • cancers
  • Background:We aimed to evaluate survival and disease-free survival in different subtypes of interval cancers by breast density, taking into account clinical and biological characteristics. (aacrjournals.org)
  • While some nasopharyngeal cancers are biologically similar to the common HNSCC, "poorly differentiated" nasopharyngeal carcinoma is lymphoepithelioma, which is distinct in its epidemiology, biology, clinical behavior, and treatment, and is treated as a separate disease by many experts. (wikipedia.org)
  • HPV-positive oropharyngeal cancer generally has a better outcomes than HPV-negative disease with a 54% better survival, but this advantage for HPV associated cancer applies only to oropharyngeal cancers. (wikipedia.org)
  • adjuvant
  • The study involved 1,968 patients with stage III disease from the North Central Cancer Treatment Group phase III trial N0147 examining FOLFOX (infusional fluorouracil, leucovorin, and oxaliplatin) vs FOLFOX plus cetuximab (Erbitux) as adjuvant therapy. (ascopost.com)
  • cell survival
  • The transcription factor PU.1 is known to directly activate transcription of the antiapoptotic BCL2A1 gene or inhibit transcription of the p53 tumor suppressor to promote cell survival, and is proposed to also directly activate HK3 transcription during neutrophil differentiation to support short-term cell survival of mature neutrophils. (wikipedia.org)
  • This interaction leads to the subsequent activation of Akt, cell proliferation, and cell survival. (wikipedia.org)
  • nodular
  • The majority of bilateral tumours can be distinguished according to size and aspect of the nodules: primary pigmented nodular adrenocortical disease which can be sporadic or part of Carney complex and primary bilateral macro nodular adrenal hyperplasia. (wikipedia.org)
  • enzyme
  • We previously reported that peroxiredoxin 4 (PRDX4), a secretory-type antioxidant enzyme, can protect against the development of various diseases, including potential malignancies. (medsci.org)
  • pathways
  • Specifically, we found that up-regulation of the IL17RA, IGF2BP2 and ABCC2 genes, and of genes acting in the mTOR and cytokine receptor pathways, were strongly associated with a poor survival. (springer.com)
  • Up-regulation of the IL17RA, IGF2BP2 and ABCC2 genes, and of genes acting in the mTOR and cytokine receptor pathways, appear to be associated with a poor survival. (springer.com)
  • rates
  • Survival rates in the developed world are high, with between 80% and 90% of those in England and the United States alive for at least 5 years. (wikipedia.org)
  • data
  • Gnant noted that this analysis was performed as a result of a recommendation from the Independent Data Monitoring Committee (IDMC) and was based on only 370 disease-free survival events. (eurekalert.org)
  • Treatment
  • This study shows us that we can offer our high-risk patients tolerable treatment that may prolong their chances of survival. (fredhutch.org)
  • TUESDAY, Oct. 11, 2016 (HealthDay News) - The duration of disease-free survival is increased with sunitinib treatment for patients with locoregional, high-risk clear-cell renal-cell carcinoma, according to a study published online Oct. 10 in the New England Journal of Medicine . (physiciansweekly.com)
  • The relationship between PFS and OS is altered in any case in which a successive treatment may influence survival. (wikipedia.org)
  • Treatment with docetaxel increasing survival time in people with certain types of cancer. (wikipedia.org)
  • Conjunctive treatment of prednisone with docetaxel has been shown to lead to improved survival rate as well as improved quality of life and reduction of pain compared with treatments with mitoxantrone. (wikipedia.org)
  • rate
  • The cumulative relative survival rate for all age groups and histology follow-up was 60%, 52%, and 32% at 5 years, 10 years, and 20 years, respectively, with children doing better than adults. (wikipedia.org)
  • cancer
  • A lymphoma vaccine uniquely tailored for each patient extends disease-free survival by 14 months, with signs of an even better response for patients with a specific biological marker, a team led by scientists at The University of Texas MD Anderson Cancer Center reported today in the online version of Journal of Clinical Oncology. (mdanderson.org)
  • That's significant because most cancer drugs are approved on the basis of extending survival only a few months," said Larry Kwak, M.D., Ph.D., corresponding author of the study. (mdanderson.org)
  • According to an analysis reported by Amanda Phipps, PhD, MPH , Assistant Professor of Epidemiology at the University of Washington and Assistant Member at Fred Hutchinson Cancer Research Center, Seattle, and colleagues in the Journal of Clinical Oncology , patients with stage III colon cancer who ever smoked had significantly reduced disease-free survival compared with never-smokers. (ascopost.com)
  • 1 The association between smoking and reduced disease-free survival was most marked in patients with BRAF wild-type or KRAS mutant colon cancer. (ascopost.com)
  • The Fred Hutchinson Cancer Research Center is an independent, non-profit research institution dedicated to the development and advancement of biomedical technology to eliminate cancer and other potentially fatal diseases. (fredhutch.org)
  • When the immune system is weaker then cancer evolves as a disease and starts growing. (wikipedia.org)
  • PELP1 is a proto-oncogene that provides cancer cells with a distinct growth and survival advantage. (wikipedia.org)
  • The level of XB130 expression influences the expression of multiple genes related to cell proliferation and survival, and microRNAs miR-33a, 149a, and 193a-3p, all of which exhibit tumor suppressive function in thyroid cancer cells. (wikipedia.org)
  • XB130 expression is significantly correlated with the survival time and disease-free period in gastric cancer patients. (wikipedia.org)
  • extent
  • Radiological studies of the abdomen, such as CT scans and magnetic resonance imaging are useful for identifying the site of the tumor, differentiating it from other diseases, such as adrenocortical adenoma, and determining the extent of invasion of the tumor into surrounding organs and tissues. (wikipedia.org)
  • women
  • Approximately half of women diagnosed with Paget's disease of the breast also have a lump in the breast. (wikipedia.org)
  • found
  • Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), have been found to be more frequently afflicted with this class of tumors, but a firm genetic link remains to be established. (wikipedia.org)
  • and EBV does not appear to play a role in the transformation process of Castleman's disease to FDC sarcoma because all cases the report found associated with Castleman's disease were EBV negative. (wikipedia.org)
  • long-term
  • Moreover, multivariate stepwise logistic regression analysis identified an absence of satellite lesions and an uneventful postoperative course as the two main independently significant predictors of HCC patients undergoing hepatectomy with long-term disease-free survival. (springer.com)
  • An absence of satellite lesions and an uneventful postoperative course are the two main independent predictors for long-term disease-free survival in HCC patients undergoing hepatic resection. (springer.com)
  • infectious
  • Frictional lichenoid dermatitis immunologic wiskott-aldrich syndrome hyperimmunoglobulin e syndrome omenn syndrome severe combined immunodeficiency obgynebooks graft-versus-host disease agammaglobulinemia immune dysregulation, polyendocrinopathy, enteropathy, x-linked (ipex) infectious seborrheic dermatitis contact dermatitis (see chapter 73 allergic emergencies). (aconyc.org)
  • Moreover, the country's topographical and sociological diversification helps to promote periodic epidemics of infectious diseases, epizootics and natural hazards like floods, forest fires, landslides and earthquakes. (wikipedia.org)
  • overall survival
  • XTANDI is currently approved for the treatment of metastatic CRPC based on clinical data from previous studies that showed a statistically significant overall survival benefit for XTANDI versus placebo in the metastatic CRPC setting. (yahoo.com)
  • metastases
  • We are delighted with the significant results seen in the PROSPER study, showing that XTANDI plus ADT delayed clinically detectable metastases compared to ADT alone in patients with non-metastatic CRPC whose only sign of underlying disease was a rapidly rising prostate-specific antigen (PSA) level. (yahoo.com)
  • resistant
  • Higher Karnofsky scores (P less than .01, Mann-Whitney U test) and less resistant disease status at transplantation (P = .04, chi 2 test) were significant when calculations were limited to complete responses. (uni-bonn.de)
  • Tuberculosis (TB) disease rates in some parts of London are as high as in Sub-Saharan Africa, and drug-resistant strains are becoming increasingly common. (medicalnewstoday.com)
  • Pfizer Inc. ( PFE ) and Astellas Pharma Inc. (TSE: 4503, President and CEO: Yoshihiko Hatanaka, "Astellas") announced today that the Phase 3 PROSPER trial evaluating XTANDI ® (enzalutamide) plus androgen deprivation therapy (ADT) versus ADT alone in patients with non-metastatic (M0) Castration-Resistant Prostate Cancer (CRPC) met its primary endpoint of improved metastasis-free survival (MFS). (yahoo.com)
  • Carbon-ion RT has shown excellent local control for X-ray resistant diseases such as recurrent rectal carcinoma, skull-base tumors, uveal melanoma, non-squamous cell carcinomas of the head and neck, and sarcomas. (biomedcentral.com)
  • immune
  • Although senescent cells can no longer replicate, they remain metabolically active and commonly adopt an immunogenic phenotype consisting of a pro-inflammatory secretome, the up-regulation of immune ligands, a pro-survival response, promiscuous gene expression (pGE) and stain positive for senescence-associated β-galactosidase activity. (wikipedia.org)
  • illness
  • Jeff Schwan died from a mysterious illness called Sporadic Creutzfeldt-Jakob disease or Sporadic C.J.D. It's a rare and fatal brain-wasting disease that seems to strike out of nowhere. (blogspot.com)
  • This was the only time when she was relatively free of the chronic intestinal illness that afflicted her throughout the rest of her life. (wikipedia.org)
  • children
  • Older children often tried to keep their siblings together, and survival-searching for food and shelter became their number-one priority. (wikipedia.org)
  • After Soviet occupation and orphaned by hunger and disease, these orphan children had to care for themselves. (wikipedia.org)
  • During this time, Chisholm developed his strong Marxist view that children should be raised in an "as intellectually free environment" as possible, independent of the prejudices and biases (political, moral and religious) of their parents. (wikipedia.org)
  • common
  • A contributing factor to deteriorating nutrition is high diarrheal disease morbidity, exacerbated by the lack of access to proper sanitation and the common practice of open defecation (44 percent) in Nepal. (wikipedia.org)
  • basis
  • An admirer of the pre-1914 Third French Republic, he wanted the Second Spanish Republic to emulate it, make secular schooling free and compulsory, and construct a non-religious basis for national culture and citizenship, part of the necessary updating and Europeanising of Spain. (wikipedia.org)
  • studies
  • British epidemiologist Simon Cousins worked on two scientific studies that documented clusters of the disease in both England and France. (blogspot.com)
  • The studies concluded that it must be caused by something on the outside, that it can't be just a spontaneous disease. (blogspot.com)
  • back
  • It was first realized here in Papua New Guinea back in 1957 where a brain-wasting disease called Curu was sweeping through a tribe of cannibals. (blogspot.com)
  • often
  • Many went on food-scrounging trips into neighboring Lithuania and were adopted by the rural Lithuanian farmers, who often give them food and shelter for free. (wikipedia.org)
  • health
  • He defined health for the WHO as "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity. (wikipedia.org)