• SIGNIFICANCE: The joint effects of common variants in genomic regions containing susceptibility loci for inflammatory bowel disease and chronic pancreatitis are associated with PDAC and may provide insights to understanding pancreatic cancer etiology. (upf.edu)
  • Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. (mcw.edu)
  • The F(2) progeny of the BN x GH intercross were used to identify susceptibility loci for the lesions as well as exacerbating loci. (mcw.edu)
  • This is the first study to identify susceptibility loci for vascular elastic tissue fragility. (mcw.edu)
  • Indeed, genome-wide studies have identified disease-associated loci and genes in many human diseases. (nature.com)
  • Genome-wide analysis of genetic loci associated with Alzheimer disease. (jamanetwork.com)
  • These data indicate that the gynomonoecious trait increases susceptibility to anthracnose in several genetic backgrounds. (landinstitute.org)
  • First, the investigators will use induced pluripotent stem cell (iPSC) cell lines exposed to toxins such as paraquat and permethrin to determine whether glutathione S‐transferase theta-1 (GSTT1) deletion increases susceptibility. (health.mil)
  • All of these DNA samples were run on a 770,000 single nucleotide polymorphism (770K SNP) genotyping chip and the profiles of the sick cattle were then compared to those that were healthy to see if there were any genetic markers associated with reduced susceptibility to BRDC. (extension.org)
  • They at first set out to test the hypothesis that susceptibility was due to common factors, yet a search for common genes that might influence clinical outcome failed to give statistically significant results with the exception of two genes, OR4C5 and ZNF717. (genomeweb.com)
  • Still, they felt that different variations in different individuals were more likely to underpin disease susceptibility, and using other machine-learning tools they determined that rare variants in genes such as JAK2 and CCDC114 were present in some cases. (genomeweb.com)
  • Complex, multi factorial diseases of modern day (diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. (wjgnet.com)
  • Candidate gene studies represent the most common form of genetic association study performed to find asthma-susceptibility genes. (medscape.com)
  • [ 1 ] These studies focus on genes thought to contribute to the pathobiology of a disease and are therefore unlikely to identify novel biology. (medscape.com)
  • Although they only minimally advance the field, studies such as these are the most commonly performed scientific investigation of asthma-susceptibility genes. (medscape.com)
  • [ 4 ] These genes are thought to be involved in atopy, bronchial hyperresponsiveness, elevated IgE levels, and other asthma-related traits, although the effect of each gene on asthma susceptibility seems to be small. (medscape.com)
  • [ 6 , 13 ] All of the genes identified seemed to support a role for disordered inflammatory/immunologic responses, but the precise mechanism and impact of each gene on asthma susceptibility has yet to be elucidated. (medscape.com)
  • They will also assess samples from the National Institute of Environmental Health Sciences Farming and Movement Evaluation (FAME) study database to examine other genes that contribute to increased susceptibility to pesticides and other persistent organic pollutant exposures, which will be characterized both historically and through serum analysis. (health.mil)
  • They will use iPSC‐derived neuronal cell lines to confirm the genes that are shown to confer susceptibility and the extent to which those genes play a role in individuals of varying genetic backgrounds. (health.mil)
  • Predisposition to vitiligo and its associated autoimmune diseases may be related to single nucleotide polymorphisms (SNPs) of genes, such as rs12150220, rs2670660, rs6502867, and rs8182352 of the NLRP1 gene on chromosome 17p13.2, which is also named NALP1 (NACHT, LRR, and PYD Domains-Containing Protein 1) [ 8 - 12 ]. (oncotarget.com)
  • Complex diseases such as BRDC involve the influence of many genes and are by definition hard to predict. (extension.org)
  • The fact that so many regions of interest were identified supports the idea that many genes are associated with susceptibility to this complex disease. (extension.org)
  • A strong inverse correlation was obeserved between the susceptibility to infection and the basal expression of the antiviral genes RIG-I, IRF3, IRF7 and IFN-beta. (iozk.de)
  • A strong expression of these genes can explain the resistance of normal cells to NDV infection and a weak antiviral gene expression the broad susceptibility of tumor cells. (iozk.de)
  • Current knowledge of chromosome 12 susceptibility genes for late-onset Alzheimer's disease. (unifg.it)
  • n the last decade, it has become more apparent the important role genes play in the development of late-onset Alzheimer's disease (AD). (unifg.it)
  • Great efforts, involving human genome scans and candidate gene studies, have been given towards identifying susceptibility genes for AD. (unifg.it)
  • There are an increasing number of reports showing that mutations in the ATG genes were identified in various human diseases such as neurodegenerative diseases, infectious diseases, and cancers. (nature.com)
  • Here, we review the major advances in identification of mutations or polymorphisms of the ATG genes in human diseases. (nature.com)
  • Table 1 summarizes the association between genetic variants of autophagy-related genes and selected human diseases. (nature.com)
  • It is understood that HLA-DR/DQ is a disease-susceptibility gene for this syndrome, however susceptibility genes outside the HLA have not been illuminated. (healthonlinenow.com)
  • s research up until now has revealed that HLA-DR/DQ is a disease-susceptibility gene, however susceptibility genes outside the HLA region have yet to be illuminated. (healthonlinenow.com)
  • The genomic map locations of the dysregulated genes may identify novel candidates for UC and CD genetic susceptibility. (johnshopkins.edu)
  • Following symptoms and signs are: recurrent wheezing dyspnea asthma-like symptoms recurring fever productive cough endobronchial mycobacterial infection low hemoglobin Patients with IFNγR1 deficiency can also suffer of disorders of the lung, parenchymal lung diseases caused by mycobacterial infections, hylar lymphadenopathy, or endobronchial disease. (wikipedia.org)
  • In con- barriers for CWD by using transgenic mice expressing trast, cynomolgus macaques have not shown evidence of species-specific prion protein (PrP), by direct infection into clinical disease as of 70 months postinfection. (cdc.gov)
  • Using this Mendelian-like approach, they identified for each patient about three pathogenic mutations involved in virus infection susceptibility. (genomeweb.com)
  • Ozone exposure (200 nl l-1, 8 h d-1 for 28 d) increased disease incidence significantly, but mycorrhizal infection completely prevented this negative effect. (eurekamag.com)
  • We report that CC strains vary dramatically in their susceptibility to infection and produce qualitatively distinct immune states. (elifesciences.org)
  • Emerging infectious diseases, focus on infection prevention, environmental survival and germicide susceptibility: SARS-CoV-2, Mpox, and Candida auris. (bvsalud.org)
  • We searched the published English literature and reviewed the selected articles on SARS-CoV-2 , Mpox, and Candida auris with a focus on environmental survival , contamination of the patient 's hospital environment , susceptibility of the pathogen to antiseptics and disinfectants and infection prevention recommendations. (bvsalud.org)
  • Rare cases of infection in the United States (1) have been caused by coagulase-negative staphylococci with reduced susceptibility to vancomycin (minimum inhibitory concentration {MIC} greater than or equal to 8 ug/mL) * (2). (cdc.gov)
  • Because the occurrence of fully vancomycin-resistant staphylococcal infection in a hospital could result in serious public health consequences, CDC and the Hospital Infection Control Practices Advisory Committee have developed interim guidelines to direct medical and public health responses when isolates of staphylococci with reduced vancomycin susceptibility are identified. (cdc.gov)
  • Some (relatively few) microbes can infect essentially all human hosts who are exposed to the particular microbe AND cause essentially the same sort of infection and disease symptoms in every infected person. (wikiversity.org)
  • Most microbes are more efficient at infecting some people than others and many microbes can cause several different types of disease depending on the type of infection (for example, depending on the site of infection) and variations in host-microbe interactions. (wikiversity.org)
  • It is believed that an immunological trigger, such as an infection, stimulates the syndrome's occurrence in people who have some kind of genetic susceptibility (disease-susceptibility gene. (healthonlinenow.com)
  • It is thought to occur due to a combination of some kind of genetic factor (disease-susceptibility gene) and an immunological trigger, such as an infection. (healthonlinenow.com)
  • characterized by intermediate susceptibility to temporary treatment, up to 10 months post-infection. (computationalscience.nl)
  • This is in addition to the acute phase of about 1 month post-infection which is already known to be characterized by a high susceptibility to temporary treatments. (computationalscience.nl)
  • Clinical trials have contradicting reposts about the effect of cART during primary HIV infection on the disease progression. (computationalscience.nl)
  • This report summarizes the laboratory and epidemiologic findings associated with this reduced susceptibility to azithromycin. (cdc.gov)
  • The Hawaii Department of Health State Laboratory (HSL) routinely performs antimicrobial susceptibility testing on all gonococcal isolates identified by culture. (cdc.gov)
  • The 26 sexually transmitted disease (STD) clinics in the United States that participate in GISP collect male urethral gonococcal cultures and submit them to one of five regional GISP laboratories for antimicrobial susceptibility testing. (cdc.gov)
  • Of these, 256 (50%) were diagnosed by culture and underwent antimicrobial susceptibility testing at HSL. (cdc.gov)
  • Antimicrobial susceptibility testing records of gonococcal isolates originating in Hawaii from HSL, GISP, and CDC were reviewed to identify CipR gonococcal isolates and determine their prevalence in Hawaii. (cdc.gov)
  • Use of recommended laboratory methods (including media and incubation methods, antimicrobial susceptibility testing methods, and susceptibility breakpoints) for identifying such strains is essential. (cdc.gov)
  • The most accurate form of antimicrobial susceptibility testing for staphylococci is a minimal inhibitory concentration method (broth dilution, agar dilution, or agar-gradient diffusion) using a full 24-hour incubation. (cdc.gov)
  • This study aims to evaluate the first-line antibiotic susceptibility pattern of toxigenic Corynebacterium diphtheriae isolates. (biomedcentral.com)
  • NEW YORK - An Italian research team has identified multiple genetic variants that may play a role in determining the severity of COVID-19, the disease caused by the virus SARS-CoV-2. (genomeweb.com)
  • Whole-exome sequencing showed that a combination of common and rare, or even private variants, is responsible for COVID-19 susceptibility and severity," said Renieri. (genomeweb.com)
  • In addition to looking at common and rare variants and how they might impact disease susceptibility and severity, Renieri noted that the researchers will also look at gender in the second validation phase, as men are typically considered to experience more severe reactions to the virus. (genomeweb.com)
  • As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. (upf.edu)
  • We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. (upf.edu)
  • Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC. (upf.edu)
  • The team will use whole‐genome sequencing and bioinformatics to investigate the genetic variants involved in susceptibility to PD. (health.mil)
  • Genetic variants are linked to vitiligo and associated autoimmune diseases. (oncotarget.com)
  • While most differences in peoples' genomes - called variants - are harmless, some are beneficial, while others contribute to diseases and conditions, ranging from cognitive disabilities to susceptibilities to cancer, obesity, diabetes, heart disease and other disorders. (genome.gov)
  • Understanding how genomic variants contribute to disease may help clinicians develop improved diagnostics and treatments, in addition to new methods of prevention. (genome.gov)
  • The 1000 Genomes Project data are a resource for any study in which scientists are looking for genomic contributions to disease, including the study of both common and rare variants. (genome.gov)
  • One of the more immediate uses of 1000 Genomes Project data is for genome-wide association studies (GWAS), which compare the genomes of people with and without a disease to search for regions of the genome that contain genomic variants associated with that disease. (genome.gov)
  • Such studies generally find several genomic regions associated with a disease and many variants in each of those regions. (genome.gov)
  • Instead of sequencing the genomes of all the people in a study, which remains expensive, researchers can use the 1000 Genomes Project data to find most of the variants in those regions that are associated with the disease. (genome.gov)
  • Non-coding regions are known to regulate gene expression, and the finding indicates that alterations in regulation networks play a larger role in disease risk than protein-coding variants. (jax.org)
  • Role of common and rare APP DNA sequence variants in Alzheimer disease. (jamanetwork.com)
  • Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP). (jamanetwork.com)
  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. (jamanetwork.com)
  • Common variants at ABCA7 , MS4A6A/MS4A4E , EPHA1 , CD33 and CD2AP are associated with Alzheimer's disease. (jamanetwork.com)
  • Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease. (jamanetwork.com)
  • Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers. (lu.se)
  • Among isolates tested for susceptibility to other antimicrobial agents, no evidence was found of decreased susceptibility to ceftriaxone, cefixime, or azithromycin, or resistance to spectinomycin. (cdc.gov)
  • The SNP assays are finding genomic regions associated with BRDC susceptibility, suggesting that genetic progress in these traits could be made by including the specific SNP markers that are indicators of BRDC disease risk in national cattle genetic evaluations. (extension.org)
  • Bovine respiratory disease is considered a complex because many different viral and bacterial pathogens are known to be involved in causing disease symptoms. (extension.org)
  • Penicillin and macrolide are groups of empirical antibiotics used to eradicate toxigenic C. diphtheriae based on the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) guidelines for the treatment of diphtheria [ 9 , 10 ]. (biomedcentral.com)
  • Cases of ASCVD - defined as coronary artery disease (CAD), ischemic stroke , or acute complications - were identified via hospital records and death registry. (medscape.com)
  • Disease severity and basal circumference were evaluated for all individuals. (landinstitute.org)
  • Experimental findings indicated that the incidence and severity of fungal diseases varied considerably among the growing seasons. (tubitak.gov.tr)
  • Fungicide spray applications significantly decreased the incidence and severity of fungal diseases and significantly increased the seed yield of winter rape. (tubitak.gov.tr)
  • Here, we identify that host factors allow increased virus replication and cytokine production, providing a mechanism for understanding the severity of virus disease in CF. Increased virus is due to lack of nitric oxide synthase 2 (NOS2) and 2', 5' oligoadenylate synthetase (OAS) 1 induction in response to virus or IFNgamma. (nih.gov)
  • The Gompertz model obtained a better adjustment to the severity and incidence data, and clones 1 and 2 showed greater susceptibility to eucalyptus powdery mildew. (ufrgs.br)
  • Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. (medscape.com)
  • Susceptibility to the development of Crohn's disease involves a combination of genetic and environmental factors. (medscape.com)
  • The association of Crohn's disease with westernization has implicated lifestyle factors in pathogenesis. (medscape.com)
  • A new hypothesis is proposed, by which excessive delivery of highly fermentable but poorly absorbed short-chain carbohydrates and polyols (designated FODMAPs--Fermentable Oligo-, Di- and Mono-saccharides And Polyols) to the distal small intestinal and colonic lumen is a dietary factor underlying susceptibility to Crohn's disease. (medscape.com)
  • The subsequent rapid fermentation of FODMAPs in the distal small and proximal large intestine induces conditions in the bowel that lead to increased intestinal permeability, a predisposing factor to the development of Crohn's disease. (medscape.com)
  • Evidence supporting this hypothesis includes the increasing intake of FODMAPs in western societies, the association of increased intake of sugars in the development of Crohn's disease, and the previously documented effects of the ingestion of excessive FODMAPs on the bowel. (medscape.com)
  • One of the greatest challenges in defining the pathogenesis of Crohn's disease is to identify predisposing environmental factors. (medscape.com)
  • It wouldn't be rocket science to try it to treat crohn's disease in a study, so it's odd there haven't been any so far. (crohnsforum.com)
  • Many people with crohn's disease on anti-TNF would have been prescribed itraconazole to deal with fungi infections. (crohnsforum.com)
  • I have been on a course of itraconazole but my crohn's is in remission so it's impossible to judge if that treatment had any effect on my crohn's disease. (crohnsforum.com)
  • ASCA tests are sometimes done to differentiate between Crohn's and UC, ASCA test is positive in over half of Crohn's patients and in about 30 percent of people who later develop crohn's disease. (crohnsforum.com)
  • At lease one study has shown that IgG tests against S. cerevisiae are associated with intestinal presence of Malassezia, specifically M. restricta, correlating with disease activity in crohn's disease. (crohnsforum.com)
  • It's interesting to look at Paracoccidioidomycosis studies from South America, especially in young adults, an age groups that match crohn's disease unset. (crohnsforum.com)
  • They can develop intestinal manifestation of fungi infections that closely mimic crohn's disease, typical transmural inflammation with pockets of granuloma. (crohnsforum.com)
  • Not too long ago, IL-17 blockers which are used to treat other inflammatory diseases, were tried to treat to crohn's disease, with rather disastrous consequences, crohn's disease patients became much sicker on IL-17 blockers, even though IL-17 is highly elevated in crohn's disease tissue. (crohnsforum.com)
  • It can not be overstated how sick crohn's disease patient became when IL-17 was blocked, trials had to be immediately stopped. (crohnsforum.com)
  • Th17 also secrete IL-23, IL-23 blockers are sometimes used to treat crohn's disease. (crohnsforum.com)
  • Even thought these cells are involved in inflammaton, blocking IL-17 is disastrous in crohn's disease. (crohnsforum.com)
  • To elucidate the biological dysregulation underlying two forms of inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD), we examined global gene expression profiles of inflamed colonic tissue using DNA microarrays. (johnshopkins.edu)
  • Quercus robur , a tree species integrated in most forest regeneration strategies, shows high vulnerability to powdery mildew (PM) disease at the seedling stage. (portlandpress.com)
  • Powdery mildew is one of the main diseases in eucalyptus clonal nursery. (ufrgs.br)
  • The clear relationship we've discovered between this kind of bacteria and disease resistance in Caribbean staghorn coral is a crucial piece of the puzzle for coral restoration efforts in that region," said study co-author Becca Maher, a Ph.D. candidate at Oregon State. (sciencedaily.com)
  • There is growing interest in the selective breeding of livestock for enhanced disease resistance. (extension.org)
  • Incorporating disease-resistance into breeding decisions offers a sustainable, long-term approach to reduce disease incidence and improve animal health. (extension.org)
  • This meta-analysis demonstrates that within the Caucasian population, the NLRP1 rs12150220 polymorphism may correlate with a decreased risk of vitiligo-associated autoimmune diseases, especially autoimmune Addison's disease, type 1 diabetes, or systemic lupus erythematosus. (oncotarget.com)
  • Chronic wasting disease (CWD) is a transmissible in sheep and goats, Creutzfeldt-Jakob disease (CJD) in spongiform encephalopathy, or prion disease, that affects humans, and chronic wasting disease (CWD) in cervids. (cdc.gov)
  • Because humans sensitive method for testing susceptibility to TSE agents is are evolutionarily closer to macaques than to squirrel mon- intracerebral injection. (cdc.gov)
  • An international team of scientists from the 1000 Genomes Project Consortium has created the world's largest catalog of genomic differences among humans, providing researchers with powerful clues to help them establish why some people are susceptible to various diseases. (genome.gov)
  • Emerging infectious disease threats include pathogens increasing in range (eg, Mpox), zoonotic microbes jumping species lines to cause sustained infections in humans via person-to-person transmission ( SARS-CoV-2 ) and multidrug-resistant pathogens (eg, Candida auris ). (bvsalud.org)
  • The interaction of humans with disease-causing bacteria is often thought of in terms of a host-invader interaction. (wikiversity.org)
  • This is in strict concordance with the global action plan and European response plan to combat gonococcal AMR published by the WHO [ 19 , 20 ] and the European Centre for Disease Prevention and Control (ECDC) [ 21 ], respectively. (biomedcentral.com)
  • Western diseases : their emergence and prevention / edited by H. C. Trowell, D. P. Burkitt. (who.int)
  • Epidemiologic evidence suggests that caques and squirrel monkeys, as human models for CWD CWD continues to spread among cervid populations in susceptibility. (cdc.gov)
  • Title : An epidemiologic approach to inherited disease susceptibility Personal Author(s) : Dublin, Thomas D.;Blumberg, Baruch S. (cdc.gov)
  • Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). (upf.edu)
  • After repeat testing, if species identification and vancomycin test results are consistent, immediately contact the state health department (SHD) and CDC's Hospital Infections Program, National Center for Infectious Diseases, telephone (404) 639-6400, to report the occurrence of a 'presumptive' staphylococcal strain with reduced susceptibility to vancomycin and to obtain epidemiologic and laboratory assistance. (cdc.gov)
  • All strains with a MIC greater than or equal to 4 ug/mL should be considered candidate strains for reduced vancomycin susceptibility. (cdc.gov)
  • Other than the isolate reported in Japan (4), all Staphylococcus aureus strains with putative reduced vancomycin susceptibility sent to CDC for confirmation have been misidentified or mixed with other microorganisms. (cdc.gov)
  • This report summarizes investigations of an increase in fluoroquinolone-resistant Neisseria gonorrhoeae in Hawaii and of a cluster of N. gonorrhoeae infections with decreased susceptibility to azithromycin in Missouri. (cdc.gov)
  • Gallstone disease is one of the most common diseases affecting the gastrointestinal tract. (nepjol.info)
  • Of the cancer susceptibility syndromes affecting the gastrointestinal tract, the two best defined syndromes are Lynch syndrome (LS) and familial adenomatous polyposis (FAP). (aacrjournals.org)
  • GISP conducts susceptibility testing of urethral N. gonorrhoeae isolates obtained from men with symptomatic urethritis seeking care at 29 U.S. STD clinics, including San Diego County's main municipal STD clinic. (cdc.gov)
  • During August--October 2009, five of 55 (9.1%) N. gonorrhoeae isolates obtained from men with symptomatic urethritis tested at San Diego County's main municipal sexually transmitted disease (STD) clinic had high azithromycin MICs: three with 8 µ g/mL and two with 16 µ g/mL. (cdc.gov)
  • The susceptibility of N. gonorrhoeae to ciprofloxacin is used to assess susceptibility to all equivalent fluoroquinolone antimicrobials. (cdc.gov)
  • Thus, the host range of CWD and brains showed spongiform encephalopathy and protease- the level of protection provided by species barriers should resistant prion protein (PrPres) diagnostic of prion disease. (cdc.gov)
  • The most species differed in susceptibility to CWD. (cdc.gov)
  • infected cattle and sheep with CWD by the intracerebral prion diseases, are neurodegenerative diseases that route and found protease-resistant PrP (PrPres) in 5 of 13 affect many mammalian species. (cdc.gov)
  • ABSTRACT This study aimed to carry out a malaria situation analysis, species composition and susceptibility levels of the main malaria vector, Anopheles stephensi, to different insecticides in Bashagard. (who.int)
  • We have tested the hypothesis that there is a common susceptibility for the development of COPD and facial wrinkling in cigarette smokers. (bmj.com)
  • The objective of our study was to test the hypothesis that there is a common susceptibility for the development of airflow obstruction and facial wrinkling in cigarette smokers. (bmj.com)
  • In 2019, scientists in the lab of OSU microbiologist Rebecca Vega Thurber identified a new genus of parasitic bacteria that flourishes when reefs become polluted with nutrients, siphoning energy from the corals and making them more susceptible to disease. (sciencedaily.com)
  • The original GSF plant is an unthrifty, highly disease susceptible plant, collected from a wild population in Ottawa County, KS. (landinstitute.org)
  • Newly-available genomic tools offer an opportunity to employ novel genetic approaches to select for cattle that are less susceptible to disease. (extension.org)
  • S ince the early months of the COVID-19 pandemic, some researchers and organizations have been mulling the possibility of organizing human challenge trials on the disease, meaning that people would be deliberately infected under controlled conditions in order to better study its course. (the-scientist.com)
  • Researchers at that MMFS are experimentally determining the impacts of high PCB body burdens on the immunocompetency and disease susceptibility of Pacific herring. (usgs.gov)
  • With the completion of the Human Genome Project in 2003 and the International HapMap Project in 2005, researchers now have a powerful set of research tools, including the high-speed DNA sequencing technology that make it possible to identify the genetic contributions to specific diseases, even if they are rare. (nature.com)
  • Genetics plays an important role in determining the susceptibility of an individual to develop a disease. (wjgnet.com)
  • Ertekin-Taner N. Genetics of Alzheimer's disease: a centennial review. (jamanetwork.com)
  • Susceptibility testing can be done qualitatively, semiquantitatively, or using nucleic acid-based methods. (msdmanuals.com)
  • Susceptibility tests determine a microbe's vulnerability to antimicrobial drugs by exposing a standardized concentration of organism to specific concentrations of antimicrobial drugs. (msdmanuals.com)
  • The MIC allows correlation between drug susceptibility of the organism and the achievable tissue concentration of free drug (ie, drug not bound to protein). (msdmanuals.com)
  • Nucleic Acid-Based Identification Methods for Infectious Disease Nucleic acid-based methods detect organism-specific DNA or RNA sequences extracted from the microorganism. (msdmanuals.com)
  • Our study aims to decipher the effect of eCO 2 on plant responses to PM. Oak seedlings were grown in controlled environment at ambient (aCO 2 , ∼400 ppm) and eCO 2 (∼1000 ppm), and infected with Erysiphe alphitoides, the causal agent of oak PM. Plant growth, physiological parameters and disease progression were monitored. (portlandpress.com)
  • Susceptibility of clonal seedlings of Eucalyptus spp. (ufrgs.br)
  • Thus, it has become particularly important to understand the genetic basis of putative human autophagy-related diseases. (nature.com)
  • It is a primary immunodeficiency featured by molecular defects in IL12/IFNγ dependent signalling pathway, leading to increased susceptibility to local or disseminated infections by environmental mycobacteria, Mycobacterium bovis Bacille Calmette-Guerin strain, nontyphoidal and typhoidal Salmonella serotypes. (wikipedia.org)
  • Genetic defects impairing the IL12/IFNγ pathway increase the susceptibility to mycobacterial infections by impeding either the production or the response to IFNγ. (wikipedia.org)
  • Mendelian susceptibility to mycobacterial disease may be suspected in people with disseminated infections caused by environmental mycobacteria or BCG. (wikipedia.org)
  • There has been only one study that suggested the patients that were being treated with itraconazole for secondary fungi infections also had improvement in crohn' disease. (crohnsforum.com)
  • In unborn and newborn children chlamydial infections, gonorrhoea and syphilis can produce serious and often life-threatening conditions including congenital disease, pneumonia and low birth weight. (who.int)
  • Athan ES, Lee JH, Arriaga A, Mayeux RP, Tycko B. Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease. (jamanetwork.com)
  • Screen for genetic susceptibility to non-alcoholic fatty liver disease and cirrhosis progression in alcoholic liver disease. (rchsd.org)
  • While behavioral and pharmaceutical interventions can moderate disease progression, there is no cure. (jax.org)
  • However, as expected, the knowledge that resulted from these candidate gene studies has been limited to understanding molecular mechanisms related to known disease pathobiologic processes. (medscape.com)
  • Parkin, an E2-dependent ubiquitin protein ligase, carries pathogenic mutations in patients with autosomal recessive juvenile parkinsonism, but its role in the late-onset form of Parkinson's disease (PD) is not firmly established. (houstonmethodist.org)
  • These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease. (houstonmethodist.org)
  • Statistical map of rs2829887 T association with fibrillar amyloid projected onto the medial and lateral surfaces of a standardized brain, based on joint analysis of Pittsburgh Compound B or Avid-45 standard uptake value ratio images from 114 cognitively normal subjects in the Arizona APOE and Alzheimer's Disease Neuroimaging Initiative cohorts. (jamanetwork.com)
  • It will be interesting to determine if there is any overlap between the regions of the genome that are associated with decreased susceptibility in pre-weaned Holstein calves as compared to feedlot beef cattle. (extension.org)
  • Human susceptibility to CWD remains CWD was first found in captive deer in Colorado in 1967 unproven despite likely exposure to CWD-infected cervids. (cdc.gov)
  • However, oral exposure in these hosts apparently does not cause disease ( 2 ). (cdc.gov)
  • Example: intravenous drug use allows exposure to disease-causing microbes. (wikiversity.org)
  • Results from the BRD CAP illustrate that by using the 770K SNP assay and accurate case diagnosis, the genomic heritability estimates of BRDC susceptibility in Holstein dairy calves is moderately heritable (0.21). (extension.org)
  • Reduction of overuse and misuse of antimicrobials will decrease the risk for emergence of staphylococci with reduced susceptibility to vancomycin. (cdc.gov)
  • Climbing more than five flights of stairs daily is associated with a reduced risk of atherosclerotic cardiovascular disease (ASCVD) of about 20%, new observational data suggest. (medscape.com)
  • One hundred three patients with pneumonia and 360 patients with autoimmune diseases (ADs) were recruited as disease controls. (nih.gov)
  • NLRP1 protein is a member of the nucleotide oligomerization domain-like receptors (NLRs) family and regulates inflammasome activation, cellular apoptosis, innate immune system [ 13 , 14 ], and some inflammatory disorders or autoimmune diseases [ 15 ]. (oncotarget.com)
  • Here, we studied the associations between rs12150220, rs2670660, and rs6502867 of NLRP1 gene and the risks of vitiligo or associated autoimmune diseases via meta-analysis. (oncotarget.com)
  • Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. (medscape.com)
  • Bovine respiratory disease complex (BRDC), also referred to as pneumonia or shipping fever, is the leading natural cause of death in U.S. beef and dairy cattle, causing the annual loss of more than one million animals and financial losses in excess of 1 billion dollars per year. (extension.org)
  • With this problem in mind, a group of scientists at several large U.S. universities obtained USDA funding for a project called the Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) to address this problem using the tools of genomics. (extension.org)
  • According to Renieri, the GEN-COVID project aims to develop a patient registry and biobank for studying COVID-19 and is focused on understanding the genetic and molecular basis of susceptibility to the virus as well as better comprehending the genetic profiles of patients to guide future therapy decisions. (genomeweb.com)
  • Our results suggested that, in vitro, the impairing autophagic process with quinacrine, a compound able to cross the blood-brain barrier, increased GSC susceptibility to TMZ. (nature.com)
  • Susceptibility testing occurs in vitro and may not account for many in vivo factors (eg, pharmacodynamics and pharmacokinetics, site-specific drug concentrations, host immune status, site-specific host defenses) that influence treatment success. (msdmanuals.com)
  • Lipoxygenase (LOX) activity has been implicated in neurodegenerative disorders such as Alzheimer's disease, but its effects in Parkinson's disease (PD) pathogenesis are less understood. (sri.com)
  • However, these experimental results do not directly demonstrate that defects in autophagy contribute to pathogenesis of human diseases. (nature.com)
  • New and emerging infectious diseases continue to represent a public health threat. (bvsalud.org)
  • Facial wrinkling is associated with COPD in smokers, and both disease processes may share a common susceptibility. (bmj.com)
  • However, there are many types of human-microbe interactions, so we need a more complex understanding of micro-organisms and their roles in normal human health and disease processes. (wikiversity.org)
  • and to evaluate the susceptibility reaction of clones to this disease. (ufrgs.br)
  • Parkinson's disease (PD) is a neurodegenerative disease that progresses over time as small clusters of dopamine‐producing brain cells deteriorate, causing motor issues such as tremors, loss of coordination, and difficulty speaking. (health.mil)