• In 1971, the U.S. Food and Drug Administration issued a warning about the use of diethylstilbestrol during pregnancy after a relationship between exposure to this synthetic estrogen and the development of clear cell adenocarcinoma of the vagina and cervix was found in young women whose mothers had taken diethylstilbestrol while they were pregnant. (aafp.org)
  • Because of the higher risk of spontaneous abortion, ectopic pregnancy, and preterm delivery, obstetric consultation may be required for pregnant women who had in utero diethylstilbestrol exposure. (aafp.org)
  • Prenatal exposure to diethylstilbestrol (DES), an endocrine-disrupting chemical, may be associated with depression in adulthood, but previous findings are inconsistent. (nih.gov)
  • Twenty infertile women with a history of diethylstilbestrol exposure in utero were seen in Norfolk for the purpose of in vitro fertilization. (duke.edu)
  • The purpose of this paper is to report the occurrence of gynecomastia in a 3-year-old boy and pseudoprecocious puberty in his 23-month-old sister following exposure to diethylstilbestrol (stilbestrol). (diethylstilbestrol.co.uk)
  • The association between in utero exposure to diethylstilbestrol (DES) and clear cell adenocarcinoma (CCA) of the vagina and cervix is well known, yet there has been no systematic study of DES-exposed daughters to determine whether they have an increased risk of other cancers. (desdaughter.com)
  • Data from lower mammals suggest a masculinizing or defeminizing influence of pre- or perinatal diethylstilbestrol (DES) exposure on various aspects of the sex-dimorphic behavior (including juvenile rough-and-tumble play) of genetic females. (mssm.edu)
  • We analyzed data collected by interview and medical record review for 200 women exposed to diethylstilbestrol (DES) and 12,240 unexposed women to evaluate the relation between maternal DES exposure and outcomes of pregnancy. (mainehealth.org)
  • One known risk factor for vaginal adenosis is in-utero diethylstilbestrol (DES) exposure. (bmj.com)
  • The 24 hours urinary creatinine (60275) levels provide a good guide for monitoring of diethylstilbestrol exposure. (cdc.gov)
  • Low dose effect of in utero exposure to bisphenol A and diethylstilbestrol on female mouse reproduction. (bvsalud.org)
  • Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. (wikipedia.org)
  • Diethylstilbestrol is a synthetic nonsteroidal estrogen that was used to prevent miscarriage and other pregnancy complications between 1938 and 1971 in the United States. (aafp.org)
  • Between 1938 and 1971, as many as 4 million women in the United States took diethylstilbestrol (DES), an oral synthetic non-steroidal estrogen, for the purpose of improving pregnancy outcomes. (aafp.org)
  • DES is short for diethylstilbestrol, a synthetic estrogen commonly prescribed to help prevent miscarriage and other problems with pregnancy during the years 1938 to 1971. (healthday.com)
  • Diethylstilbestrol (DES), a synthetic estrogen, was widely used by pregnant women in the 1950s and 1960s. (aacrjournals.org)
  • Diethylstilbestrol (DES) is a hormone classified as a synthetic, nonsteroidal estrogen. (thrivingpets.com)
  • Diethylstilbestrol (DES) is a nonsteroidal synthetic estrogen that disrupts the morphology and proliferation of gubernaculum testis cells , but the underlying mechanism is unclear. (bvsalud.org)
  • Background: Subchronic administration of the potent pharmaceutical estrogen diethylstilbestrol (DES) to female Fischer 344 (F344) rats induces growth of large, hemorrhagic pituitaries that progress to tumors. (utmb.edu)
  • In 1978, the U.S. Department of Health, Education, and Welfare set up a DES (diethylstilbestrol (a synthetic estrogen)) Task Force to review all aspects of the DES question and to develop recommendations regarding health issues of DES and research gaps that exist. (cdc.gov)
  • The effect of various dosages of ethinyl estradiol or diethylstilbestrol on sebaceous gland secretion was studied in 54 women, 15 of whom had acne. (jamanetwork.com)
  • The maximum suppressive effect in terms of the percent reduction of sebum was seen with the highest doses, 33.7% for ethinyl estradiol (0.25 mg daily) and 35.4% for diethylstilbestrol (5.0 mg daily). (jamanetwork.com)
  • prenatal and intergenerational exposures (e.g., diethylstilbestrol and sleep). (cdc.gov)
  • This patient-friendly article is about chemotherapy drug, Stilboestrol (DES, Diethylstilbestrol) which is a synthetic oestrogen, given in tablet form, for the treatment of advanced prostate cancer. (canceractive.com)
  • Discovery of synthetic oestrogens, especially stilboestrol (diethylstilbestrol, DES) and their effects. (nobelprize.org)
  • Women who took diethylstilbestrol during pregnancy have a slightly higher risk of breast cancer than the general population and therefore should be encouraged to have regular mammography. (aafp.org)
  • Women who were exposed to diethylstilbestrol in utero may have structural reproductive tract anomalies, an increased infertility rate, and poor pregnancy outcomes. (aafp.org)
  • The male offspring of women who took diethylstilbestrol during pregnancy have an increased incidence of genital abnormalities and a possibly increased risk of prostate and testicular cancer. (aafp.org)
  • San Diego, CA A federal study found that the pregnancy drug Diethylstilbestrol has been targeted as a medication that may potentially raise cancer risks, according to ABC 9 News Syracuse . (lawyersandsettlements.com)
  • A malformation syndrome reported in offspring (children and grandchildren) of women exposed to diethylstilbestrol (DES) during pregnancy and is characterized by reproductive tract malformations, decreased fertility and increased risk of developing clear cell carcinoma of the vagina and cervix in young women. (orpha.net)
  • Adverse Outcomes of Pregnancy in Women Exposed to Diethylstilbestrol I" by S Linn, E Lieberman et al. (mainehealth.org)
  • DES (diethylstilbestrol) - exposed daughters of women who took DES during pregnancy. (cms.gov)
  • Diethylstilbestrol (DES) is a synthetic form of the female hormone oestrogen first manufactured in 1938. (wa.gov.au)
  • Scholars@Duke publication: Experience with diethylstilbestrol-exposed infertile women in a program of in vitro fertilization. (duke.edu)
  • Although diethylstilbestrol has not been given to pregnant women in the United States for more than 30 years, its effects continue to be seen. (aafp.org)
  • The drug may not just affect women, as sons of Diethylstilbestrol users may also be at risk of potential side effects from their mother taking the medication years ago. (lawyersandsettlements.com)
  • Genital tract anomalies and cancer in females exposed in utero to diethylstilbestrol. (cdc.gov)
  • In 1974, the National Cancer Institute began a multi-institutional cooperative research study, the National Cooperative Diethylstilbestrol Adenosis Project (DESAD Project). (cdc.gov)
  • If you or a loved one have suffered losses in this case, please click the link below and your complaint will be sent to a drugs & medical lawyer who may evaluate your Diethylstilbestrol (DES) claim at no cost or obligation. (lawyersandsettlements.com)
  • Diethylstilbestrol (DES) has been marketed in many countries by several pharmaceutical companies under different brand names. (des-is-it.org)
  • The estrogenic effects here were presumably due to inhalation of the diethylstilbestrol dust and contact with the mother's contaminated clothing. (diethylstilbestrol.co.uk)
  • Effects of diethylstilbestrol in human l. (gazi.edu.tr)
  • Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells . (bvsalud.org)
  • DES Info: DES (Diethylstilbestrol) was a unique drug? (aarp.org)
  • Emergency Central , emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109116/all/diethylstilbestrol. (unboundmedicine.com)
  • Diethylstilbestrol DES studies by topics. (diethylstilbestrol.co.uk)
  • News from D.E.S is it and scientific research on diethylstilbestrol (DES): articles, studies, press releases, events. (des-is-it.org)
  • For diethylstilbestrol, in addition to a persistent history of characteristic reactions, high urine levels and adverse reactions were found in the workers examined, and there was widespread diethylstilbestrol contamination over the entire plant and auxiliary facilities. (cdc.gov)
  • These findings provide new insight into the role of diethylstilbestrol in the aetiology of male reproductive dysfunction and will help develop better approaches for the prevention and therapy of male reproductive malformation. (bvsalud.org)
  • DES Info: DES (Diethylstilbestrol) was a unique dr. (aarp.org)
  • Here we explore potential mechanisms how the proliferation and contractility of gubernaculum testis cells are regulated by diethylstilbestrol . (bvsalud.org)
  • Genital tract anomalies and cancer in females exposed in utero to diethylstilbestrol. (cdc.gov)
  • Design and preliminary observations of National Cooperative Diethylstilbestrol Adenosis (DESAD) Project. (uchicago.edu)
  • DES-or diethylstilbestrol-was prescribed to pregnant women during between the 1940s and the early 1970s to help prevent miscarriage. (lawyersandsettlements.com)
  • Want to know more about the pregnancy drug DiEthylStilbestrol? (desdaughter.com)
  • It's a startling reality that DES Mothers, DES Daughters and DES Sons live with-that not many people know about or have heard about the pregnancy drug DES-diethylstilbestrol -or the harmful effects its had on both mothers who took the drug, and children who were exposed to the drug in utero. (lawyersandsettlements.com)
  • Being exposed to a drug called diethylstilbestrol (DES) in the womb is an independent risk factor for a type of cervical cancer called clear cell adenocarcinoma . (oncolink.org)
  • These findings provide new insight into the role of diethylstilbestrol in the aetiology of male reproductive dysfunction and will help develop better approaches for the prevention and therapy of male reproductive malformation. (bvsalud.org)
  • For diethylstilbestrol, in addition to a persistent history of characteristic reactions, high urine levels and adverse reactions were found in the workers examined, and there was widespread diethylstilbestrol contamination over the entire plant and auxiliary facilities. (cdc.gov)
  • Celebrate the courage of women affected by diethylstilbestrol. (desdaughter.com)
  • Uterine anomalies were demonstrated by hystero‐salpingography (HSG) in 4 of 5 diethylstilbestrol (DES) exposed young women with fertility disturbances. (tau.ac.il)
  • 17. Hypospadias in sons of women exposed to diethylstilbestrol in utero. (nih.gov)
  • 18. Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study. (nih.gov)
  • An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Diethylstilbestrol (56-53-1). (nih.gov)
  • Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells . (bvsalud.org)
  • News from D.E.S is it and scientific research on diethylstilbestrol (DES): articles, studies, press releases, events. (des-is-it.org)
  • Soon, the sphincter incontinence that is common in spayed female dogs was also being treated with diethylstilbestrol (DES) with good success. (vin.com)
  • Summary of the changes in the human female genital tract as a consequence of maternal diethylstilbestrol therapy. (uchicago.edu)
  • M. Henderson (US FDA ) and C. McCarthy (screenwriter) communication about the health benefits of limiting the use of DES diethylstilbestrol in pregnancy. (desdaughter.com)
  • Results of environmental sampling at a chemical company revealed a significant hazard to the health and well being of the workers exposed to benzene (71432) and diethylstilbestrol (56531). (cdc.gov)
  • Compounded diethylstilbestrol was prescribed and dispensed to achieve successful clinical results. (ijpc.com)