Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis. (greenmedinfo.com)
2002 ▶ ). It has been reported that TQ supplementation prevents the development of diethylnitrosamine-induced initiation of liver cancer in rats by decreasing oxidative stress biomarkers such as NO (Sayed-Ahmed et al. (weeksmd.com)
Hepatocarcinogenesis2
In this study, we investigated the molecular mechanism of the inhibitory effects of dietary supplementation with AUR on N,N-diethylnitrosamine (DEN)-initiated hepatocarcinogenesis. (nih.gov)
Kinetics of Diethylnitrosamine Hepatocarcinogenesis in the Infant Mouse. (aacrjournals.org)
Liver6
Diethylnitrosamine is well known for its toxic and carcinogenic properties affecting mainly liver and kidneys. (vfu.cz)
In this study we used diethylnitrosamine induced mouse experimental model of liver and kidney damage to assess the potential chemopreventive effect of capsaicin in vivo . (vfu.cz)
Histological evaluation of the liver and kidneys revealed toxic damage of diethylnitrosamine treated animals, whereas mice that received the combination of the substances showed milder lesions. (vfu.cz)
Proliferating cell nuclear antigen expression was lower in diethylnitrosamine treated animals compared to the control and capsaicin groups, pointing to a disruption of the proliferative activity of hepatocytes in the juvenile liver. (vfu.cz)
In conclusion, our experiment demonstrated the toxic properties of diethylnitrosamine in mice liver and kidneys, with the promising beneficial effect of capsaicin. (vfu.cz)
Peroxisome proliferator-activated receptor γ ligands suppress liver carcinogenesis induced by diethylnitrosamine in rats. (wjgnet.com)
Hepatocellular carcinoma1
Furthermore, we found that part of hepatocyte express SOX9 during formation of hepatocellular carcinoma induced by diethylnitrosamine. (nii.ac.jp)
Carcinogenesis1
paniala seeds attenuated the early stage of diethylnitrosamine and 1,2-dimethylhydrazine-induced colorectal carcinogenesis. (bvsalud.org)
DENA1
Background: Diethylnitrosamine (DENA), a well-known dietary carcinogen, related to cancer initiation of various<br />organs. (waocp.org)
Rats2
Quantitative Image Cytometry of Hepatocytes Expressing Gamma-Glutamyl Transpeptidase and Glutathione S-Transferase in Diethylnitrosamine-Initiated Rats Treated with Phenobarbitol and/or Phthalate Esters. (epa.gov)
By using the modified Ito medium-term bioassay protocol, male F344 rats were given a single ip dose of 200 mg/kg of diethylnitrosamine (DEN) as an initiator. (cdc.gov)
Administration1
The system is fundamentally based on the two-stage hypothesis of oarcinogenesis : intiation with diethylnitrosamine (200 mg/kg bw, ip) is follwed by test chemical administration during the second, in combination with 2/3 partial hepatectomy. (go.jp)
Hepatocarcinogenesis in rats1
14. Suppressive effects of thymoquinone on the initiation stage of diethylnitrosamine hepatocarcinogenesis in rats. (nih.gov)
Hepatocellular carcinoma rat model1
3. Standardization of diethylnitrosamine-induced hepatocellular carcinoma rat model with time based molecular assessment. (nih.gov)
Rats9
6. Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats. (nih.gov)
10. Effect of two selenium sources on hepatocarcinogenesis and several angiogenic cytokines in diethylnitrosamine-induced hepatocarcinoma rats. (nih.gov)
12. Piperlongumine inhibits diethylnitrosamine induced hepatocellular carcinoma in rats. (nih.gov)
13. Involvement of NF-κB/PI3K/AKT signaling pathway in the protective effect of prunetin against a diethylnitrosamine induced hepatocellular carcinogenesis in rats. (nih.gov)
15. Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms. (nih.gov)
18. Chemopreventive and Therapeutic Efficacy of Enhalus acoroides against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats. (nih.gov)
By using the modified Ito medium-term bioassay protocol, male F344 rats were given a single ip dose of 200 mg/kg of diethylnitrosamine (DEN) as an initiator. (cdc.gov)
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. (herbshealthhappiness.com)
In this research, a homeopathic model was employed to detect - through the behavior of lab rats during the period of 30 days of the experiment, as well as through hepatic cytology and histology - the influence of ultradilutions 30 CH of Dexamethazon, Diethylnitrosamine (DEN) and Acetylaminofluorene (AAF) applied in animals with previously induced carcinogenesis by the carcinogenic drugs Diethylnitrosamine and Acetylaminofluorene. (unesp.br)
Wistar1
Behavioural and brain tissue-associated biochemical changes on LPS challenge have been assayed in a Diethylnitrosamine (DEN)-treated Wistar rat model of hepatic cancer. (ijpsr.com)
Induction3
Highly susceptible to the induction of liver tumours by N,N-diethylnitrosamine. (jax.org)
Molecular Changes Following Induction of Hepatocellular Carcinoma by Diethylnitrosamine and Thioacetamide, and Subsequent Treatment with Dioscorea membranacea Extract. (nih.gov)
Ces patientes ont été soumises à une induction d'ovulation et ont reçu, sur la base d'une répartition aléatoire et en aveugle, de la silymarine (70 mg × 3 fois par jour) ou un placebo, dès le début du cycle d'induction. (who.int)
Liver2
Diethylnitrosamine was used to induce liver cancer in a rat model. (nih.gov)
19. Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model. (nih.gov)
Assay1
We also detected the high expression pattern of GAS2L3 , SEMA3F , SNRPA , and SNRPD2 in the datasets of GSE102079, GSE76427, GSE64041, GSE121248, GSE84005, and the qPCR assay using diethylnitrosamine-induced HCC mouse model. (biomedcentral.com)
Hepatic3
objectives: the current study aimed to investigate the hepatic and renal protective effects of aerial parts of echinacea purpurea extract (epe) on injury induced by diethylnitrosamine (den). (gov.ir)
8. Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine. (nih.gov)
We will treat mice (male and female) with a single injection of a hepatic carcinogen, diethylnitrosamine (DEN), followed by continued exposure to HRCD with or without BCX (or SRPE) intervention. (usda.gov)
Extract1
Diethylnitrosamine (DEN) of 15 mg/kg body weight was injected to newborn Sprague-Dawley rat subcutaneously within 24 hours, and after 3 weeks, Chinese cabbage (95% ethanol extract) was given at a dose of 2 mg/ml in drinking water. (e-crt.org)
Mice2
Preneoplastic and neoplastic progression during hepatocarcinogenesis in mice injected with diethylnitrosamine in infancy. (nih.gov)
9. Maotai ameliorates diethylnitrosamine-initiated hepatocellular carcinoma formation in mice. (nih.gov)
Exposure1
We found that the expression of vasa is induced in the gut and regenerating fin by exposure to a carcinogen, diethylnitrosamine (DEN). (elsevierpure.com)
Model4
1. Dietary modulations of folic acid affect the development of diethylnitrosamine induced hepatocellular carcinoma in a rat model. (nih.gov)
4. Attenuation of diethylnitrosamine-induced hepatocellular carcinoma in a rat model by combination therapy of diacerein and gold nanoparticles: a histopathological and immunohistochemical study. (nih.gov)
The expression patterns of several targeting genes were also verified by analyzing the Chinese HLivH060PG02 HCC cohort, several GEO datasets, HPA database, and diethylnitrosamine-induced HCC mouse model. (biomedcentral.com)
Furthermore, we confirmed the expression feature and prognostic value of several novel targeting genes, using our Chinese HLivH060PG02 HCC cohort, the Diethylnitrosamine-induced HCC mouse model, the available datasets of TCGA, GEO, and HPA database, respectively. (biomedcentral.com)
Formation1
Glandular/acinar formation in a diethylnitrosamine-induced hepatocellular adenoma. (nih.gov)
Activity1
Previously we showed that inappropriate expression and chronic activity of FGF receptor (FGFR) 1 in hepatocytes accelerated diethylnitrosamine (DEN)-initiated hepatocarcinogenesis. (elsevierpure.com)