• Bedaquiline fumarate (Sirturo or bedaquiline) is an oral diarylquinoline. (cdc.gov)
  • Bedaquiline is a diarylquinoline discovered by scientists at Janssen. (jnj.com)
  • Bedaquiline is a diarylquinoline antimycobacterial which inhibits the proton transfer chain of mycobacterial ATP synthase, an enzyme necessary for energy generation in Mycobacterium tuberculosis . (azurewebsites.net)
  • Sirturo (Bedaquiline)® is a diarylquinoline antimycobacterial drug indicated as part of combination therapy in the treatment of adult and pediatric patients (12 to less than 18 years of age and weighing at least 30 kg) with pulmonary multi-drug resistant tuberculosis (MDR-TB). (pharmacyexam.com)
  • [9] It is in the diarylquinoline antimycobacterial class of medications. (mdwiki.org)
  • Although ATP synthase in bacteria is similar to its eukaryotic analogue, diarylquinoline agents (such as TMC207) are very specific to the bacterial enzyme, so were expected to be safe for use in humans and other eukaryotes. (wikipedia.org)
  • 6] Diacon AH, Pym A, Grobusch M, et al.The diarylquinoline TMC207 for multidrug-resistant tuberculosis[J]. N Engl J Med, 2009, 360(23): 2397-2405. (rsghb.cn)
  • An efficient and expedient synthetic protocol is reported for the synthesis of 2,3-diarylquinoline derivatives from readily available aryl amines, aryl aldehydes and styrene oxides using 10 mol% copper(ii) triflate by employing three-component reaction. (utmb.edu)
  • Ali, S & Khan, AT 2021, ' Copper(ii) triflate catalyzed three-component reaction for the synthesis of 2,3-diarylquinoline derivatives using aryl amines, aryl aldehydes and styrene oxides ', Organic and Biomolecular Chemistry , vol. 19, no. 14, pp. 3255-3262. (utmb.edu)
  • citation needed] The reaction of aryl aldehyde, malonodinitrile, and 3‐arylamino‐5,5‐dimethylcyclohex‐2‐enone can produce 1,4-diarylquinolines. (wikipedia.org)
  • Although ATP synthase in bacteria is similar to its eukaryotic analogue, diarylquinoline agents (such as TMC207) are very specific to the bacterial enzyme, so were expected to be safe for use in humans and other eukaryotes. (wikipedia.org)
  • The diarylquinoline TMC207 offers a new mechanism of antituberculosis action by inhibiting mycobacterial ATP synthase. (nih.gov)
  • Diarylquinoline inhibits ATP synthase. (nih.gov)