• structures
  • Several depsipeptides have been found to inhibit HIV,[clarification needed] including papuamide, neamphamide A, callipeltin A, and mirabamides A-D. An early practical, and sustaining use of desipeptides as research tools has been as an alternative type of substrates for families of proteases, in order to broaden the observable range of substrate structures and kinetics. (wikipedia.org)
  • activity
  • Microviridins are characterized by a tricyclic depsipeptide structure resulting from the enzymatic activity of two dedicated ATP-grasp ligases, which form two lactone and one lactam rings in the core region of the precursor peptide. (wikipedia.org)
  • natural
  • As well, nature has many pathways for production of this structural motif, and so depsipeptide natural products are relatively common, and are being studied in a variety of early preclinical therapeutic discovery contexts, including antiinfectives (toward discover of antibacterials and antivirals). (wikipedia.org)
  • citation needed] The array of depsipeptide natural products discovered to date is extensive, and many have been tested as entry points into particular areas of therapeutic discovery. (wikipedia.org)