• Phase I data reported by National Cancer Institute (NCI) investigators showed responses in all patients treated with depsipeptide (FR901228). (cancernetwork.com)
  • I. Determine the response rate (complete and partial) in patients with relapsed or refractory Burkitt's, mantle cell or diffuse large cell non-Hodgkin's lymphoma treated with FR901228 (depsipeptide). (knowcancer.com)
  • Patients receive FR901228 (depsipeptide) IV over 4 hours on days 1, 8, and 15. (knowcancer.com)
  • The cyclization reaction of the dimethylamides 2b, 5, 6 and 7, resulting from the reaction of mandelic acid with the aminoazirine 1, yields the 6-, 9-, 12- and 15-membered cyclic depsipeptides 10 - 13, respectively. (uzh.ch)
  • Hassan HM, Degen D , Jang KH, Ebright RH , Fenical W. Correction to: Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp. (academictree.org)
  • The chromatograms of the ALT strains showed some patterns similar to fusaricidin, a depsipeptide antibiotic, while MR1 appeared to produce a new unknown small molecule. (usda.gov)
  • The library included peptides, depsipeptides, macrolides, and lignans, and 476 of the 510 compounds had a molecular weight in the range of 500-2000 Da. (elsevierpure.com)
  • A depsipeptide enzyme inhibitor includes romidepsin, a member of the bicyclic peptide class, a known histone deacetylase inhibitors (HDACi). (wikipedia.org)
  • The NCI group has recently begun a phase II trial of depsipeptide in patients with either cutaneous or peripheral T-cell lymphoma. (cancernetwork.com)
  • Following promising in vitro and in vivo studies, the NCI researchers opened a phase I trial in which patients received depsipeptide by 4-hour infusion on days 1 and 5 of a 21-day cycle. (cancernetwork.com)
  • The circulating Sézary cells of two patients were CD25 negative at the start of treatment but CD25 positive after the second dose of depsipeptide in one patient and after several cycles of treatment in the other. (cancernetwork.com)
  • The structures of the phoriospongins were determined by detailed spectroscopic analysis and comparison with the previously reported sponge depsipeptide cyclolithistide A. The initial experimental data was then submitted to the Structure Elucidator Challenge to determine if the software could propose the same structure. (acdlabs.com)
  • The BE-43547 project sprang from studies that were initially focused on the natural depsipeptide rakicidin A, a compound that was previously reported to selectively kill both hypoxic cancer cells and stem-like leukaemia cells. (thieme.de)
  • The ring conformations of all observed cyclic tetra -peptides and -depsipeptides were found to correspond, more or less exactly, to some conformation in the calculated low energy set of cyclotetraglycyl. (gla.ac.uk)
  • Emodepside belongs to a relatively new class of anthelmintics (depsipeptides) which achieve their antiparasitic effect against nematodes by a novel mechanism of action. (vin.com)
  • Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. (nature.com)
  • 11. Cryptophycins: a novel class of potent antimitotic antitumor depsipeptides. (nih.gov)
  • 1] J.S. Davies: "The cyclization of peptides and depsipeptides", J. Peptide Sci. (edu.pl)
  • Once these depsipeptide mechanisms are identified, you can predict behavior of similar peptides used to create biopolymers for pharmaceutical purposes such as drug delivery and tissue engineering. (gatech.edu)
  • This review surveys the biological activities and the iterative and recursive biosynthetic mechanisms of fungal cyclooligomer depsipeptides, and their structural diversification by various combinatorial biosynthetic methods. (tu-berlin.de)
  • The model provides helpful predictions for future synthesis of other depsipeptides, and it consists of a complex Kinetic Monte Carlo (KMC) framework that simulates growth and degradation of chiral depsipeptides. (gatech.edu)
  • Many depsipeptides have both peptide and ester linkages. (wikipedia.org)
  • An application with non-ribosomal depsipeptide plipastatin revealed that a pair of the peptide and the corresponding methyl ester at the C-terminus was also applicable to IDP method giving spectrum with enough quality. (iomcworld.com)
  • To investigate the kinetic mechanisms of ester reactions in depsipeptides, high performance liquid chromatography (HPLC) data of two test molecules are collected and quantified at different pH values and temperatures: multiple oligomers of an HO-dipeptide called glycolic acid alanine (gA) and a methylated molecule of the gA dimer called propionic acid alanine glycolic acid alanine ((PA)AgA). (gatech.edu)
  • A depsipeptide enzyme inhibitor includes romidepsin, a member of the bicyclic peptide class, a known histone deacetylase inhibitors (HDACi). (wikipedia.org)
  • Notably, the pleiotropic HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and depsipeptide, have shown efficacy in a wide range of cancers, in particular for cutaneous T-cell lymphoma (CTCL), and are progressing in phase II clinical studies. (nature.com)
  • Piekarz R, Bates S . A review of depsipeptide and other histone deacetylase inhibitors in clinical trials. (nature.com)
  • abstract = "Echinomycin is the prototypical bisintercalator, a molecule that binds to DNA by inserting two planar chromophores between the base-pairs of duplex DNA, placing its cyclic depsipeptide backbone in the minor groove. (uea.ac.uk)
  • To date, nearly 150 patients with thoracic malignancies (mostly lung cancers) have received deoxyazacytidine (DAC), Depsipeptide (DP), sequential DAC/DP, or sequential DP/Flavopiridol infusions on protocols initiated in the Thoracic Oncology Section. (nih.gov)
  • 2. Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials. (nih.gov)
  • My research focuses on the investigation of the relevant kinetic mechanisms of chiral depsipeptide polymerization and degradation. (gatech.edu)