What Is Deoxyguanosine Triphosphate (dGTP)? (excedr.com)
Deoxyguanosine triphosphate (dGTP) is a nucleotide with a purine base (guanine), deoxyribose sugar, and three phosphate groups. (excedr.com)
dGTP is also referred to using the names 2′-deoxyguanosine-5′-triphosphate, 2′-deoxyguanosine triphosphate, and deoxy-GTP. (excedr.com)
PNP deficiency results in the accumulation of deoxyguanosine, which is converted to deoxyguanosine triphosphate (dGTP) by deoxycytidine kinase specific to lymphocytes. (frontiersin.org)
Kinase3
Deoxyguanosine kinase deficiency is an inherited disorder that can cause liver disease and neurological problems in 2 forms. (amedes-genetics.de)
Newborns with the hepatocerebral form of deoxyguanosine kinase deficiency may develop lactic acidosis with weakness, decreased activity and hypoglycemia in the first few days after birth as a result of liver dysfunction, which can lead to liver failure. (amedes-genetics.de)
Decreased deoxyguanosine kinase activity leads to problems in mitochondrial DNA production and maintenance, and it is inherited in an autosomal recessive manner. (amedes-genetics.de)
Monophosphate3
If a phosphate group is attached at the 5' position, it becomes deoxyguanosine monophosphate. (wikipedia.org)
During DNA synthesis, the two phosphates, alpha, and beta are removed in the reaction, leading to the formation of dGMP (deoxyguanosine monophosphate). (excedr.com)
During the primer extension reaction in the presence of four dNTPs, pol κ promoted one-base deletion (6.4%), accompanied by the misincorporation of 2′-deoxyguanosine monophosphate (5.5%), dAMP (3.7%), and dTMP (3.5%) opposite the lesion. (elsevierpure.com)
It also reacted with 2'-deoxyguanosine to give 1,N(2)-etheno-2'-deoxyguanosine and other 2'-deoxyguanosine adducts. (nih.gov)
Genotoxicity2
In this study, we examined the genotoxicity of waterpipe smoking using an 8-hydroxy deoxyguanosine (8-OHdG) assay. (who.int)
However, HPPH alternatively may be bioactivated by peroxidases, such as prostaglandin H synthase, to a reactive intermediate that initiates DNA oxidation (reflected by 8-hydroxy-2′-deoxyguanosine), genotoxicity (reflected by micronuclei) and embryopathy. (aspetjournals.org)
Deoxyadenosine3
Therefore, trans-4,5-epoxy-2(E)-decenal, a primary product of lipid peroxidation, is a precursor to the formation of 1,N(6)-etheno-2'-deoxyadenosine and 1,N(2)-etheno-2'-deoxyguanosine. (nih.gov)
Deficiency of purine nucleoside phosphorylase (PNP) and adenosine deaminase (ADA) elevates intracellular levels of deoxyguanosine and deoxyadenosine, respectively. (medscape.com)
[ 1 ] Deoxyguanosine and deoxyadenosine are more toxic in lymphocytes than in other cell types. (medscape.com)
Guanosine2
PNP is expressed at high levels in lymphocytes and causes the release of ribose phosphate by converting inosine to hypoxanthine, guanosine to guanine, and deoxyguanosine to guanine. (frontiersin.org)
Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. (nih.gov)
Chemical synthesis1
2'-deoxyguanosine phosphoramidite is a nucleoside building block used for chemical synthesis of isotopically labeled DNA and oligonucleotides. (isotope.com)
Guanine1
Deoxyguanosine is composed of the purine nucleobase guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. (wikipedia.org)
Urinary1
Methods: We studied two Interagency Hotshot Crews with questionnaires, pulse wave analysis for arterial stiffness, spirometry, urinary 8-iso-prostaglandin F2a (8-isoprostane) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the smoke exposure marker (urinary levoglucosan). (cdc.gov)
Levels1
Evaluation of 8-Hydroxy Deoxyguanosine Levels, as a Marker of Oxidative Stress in Chronic Gingivitis and Chronic Periodontitis Individuals During the Course of Phase 1 Periodontal Therapy in Comparison with Periodontally Healthy Individuals. (rifanalitica.it)
Formation1
The reaction of the antitumor octahedral complex trans-RuCl 2 (DMSO) 4 with 2′deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. (nyu.edu)
Kinase deficiency9
Deoxyguanosine kinase deficiency is an inherited disorder that can cause liver disease and neurological problems. (medlineplus.gov)
Newborns with the hepatocerebral form of deoxyguanosine kinase deficiency may have a buildup of lactic acid in the body (lactic acidosis) within the first few days after birth. (medlineplus.gov)
Some individuals with deoxyguanosine kinase deficiency have a milder form of the disorder without severe neurological problems. (medlineplus.gov)
The prevalence of deoxyguanosine kinase deficiency is unknown. (medlineplus.gov)
These problems lead to the neurological and liver dysfunction associated with deoxyguanosine kinase deficiency. (medlineplus.gov)
Deoxyguanosine kinase deficiency: a report of four patients. (nih.gov)
2. Neonatal liver failure due to deoxyguanosine kinase deficiency. (nih.gov)
4. Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis. (nih.gov)
11. The clinical variations and diagnostic challenges of deoxyguanosine kinase deficiency: a descriptive case series. (nih.gov)
DGUOK6
The DGUOK gene provides instructions for making the enzyme deoxyguanosine kinase. (medlineplus.gov)
Mutations in the DGUOK gene reduce or eliminate the activity of the deoxyguanosine kinase enzyme. (medlineplus.gov)
The two forms of deoxyguanosine kinase (DGUOK) deficiency are a neonatal multisystem disorder and an isolated hepatic disorder that presents later in infancy or childhood. (nih.gov)
Deoxyguanosine kinase (DGUOK) deficiency ( DGUOK -related hepatocerebral mitochondrial DNA depletion syndrome) should be suspected in individuals with a combination of the following clinical, supportive laboratory, and liver biopsy findings. (nih.gov)
Post mortem identification of deoxyguanosine kinase (DGUOK) gene mutations combined with impaired glucose homeostasis and iron overload features in four infants with severe progressive liver failure. (nih.gov)
6. Hepatocerebral mitochondrial DNA depletion syndrome caused by deoxyguanosine kinase (DGUOK) mutations. (nih.gov)
Thymidine kinase1
17. Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. (nih.gov)
Derivatives1
Synthetic and oxidative studies on 8-(arylamino)-2'-deoxyguanosine and -guanosine derivatives. (nih.gov)
Mitochondrial DNA depletion2
15. Novel deoxyguanosine kinase gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome. (nih.gov)
16. Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase. (nih.gov)
Hepatocerebral1
10. The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. (nih.gov)
DGTP1
A protein called MTH1 dephosphorylates 8-oxo-dGTP to 8-hydroxy-2′-deoxyguanosine-monophosphate (8-oxo-dGMP). (biomedcentral.com)
Oxidative damage4
Little is known about whether mitochondria 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of mitochondrial DNA (mtDNA) oxidative damage, contributes to the development of coronary artery disease (CAD) in diabetic patients. (biomedcentral.com)
Among numerous types of mtDNA oxidative lesions, the formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the most abundant one, reflecting a steady-state level of oxidative damage occurring within mtDNA [ 15 ]. (biomedcentral.com)
Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome. (nel.edu)
8-hydroxy-2-deoxyguanosine (8-OHdG) is produced by the oxidative damage of DNA by reactive oxygen and nitrogen species and serves as an established marker of oxidative stress. (immunochemistry.com)
Biomarkers1
Assessments made were circulating 25-hydroxyvitamin D [25(OH)D], immunohistochemistry for cyclobutane pyrimidine dimer (CPD)-positive nuclei and urinary biomarkers of direct and oxidative (8-oxo-deoxyguanosine) DNA damage. (nih.gov)
Inhibits1
Valcyte is a synthetic analog of 2'-deoxyguanosine that inhibits cytomegalovirus replication in cell culture and in vivo. (onlinepharmaciescanada.com)
Serum2
Serum nitrotyrosine, conjugated dienes, 8-hydroxy-2′-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) levels were determined. (hindawi.com)
The level of oxidative stress was determined using serum 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxo-dG) and plasma reactive oxygen metabolite-derived compounds (d-ROMs). (biomedcentral.com)
Genes1
13. Muscle glycogenosis and mitochondrial hepatopathy in an infant with mutations in both the myophosphorylase and deoxyguanosine kinase genes. (nih.gov)
Urinary1
A biomarker for oxidative stress, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) level, was analyzed using isotope-dilution LC-MS/MS in 64 betel quid chewers and 129 non-betel quid chewers. (tmu.edu.tw)
MtDNA1
12. Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion. (nih.gov)
Position1
If a phosphate group is attached at the 5' position, it becomes deoxyguanosine monophosphate. (wikipedia.org)