• Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor. (wikipedia.org)
  • In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
  • It is activated intracellularly by deoxycytidine kinase (dCK), which adds a phosphate group to the 5' position of the deoxyribose group. (biomedcentral.com)
  • Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis. (bvsalud.org)
  • The deoxyribonucleoside salvage pathway with the rate-limiting enzyme deoxycytidine kinase (dCK) captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism . (bvsalud.org)
  • Requirement for deoxycytidine kinase in T and B lymphocyte development. (uclahealth.org)
  • China 2'-Deoxycytidine-5'-monophosphate disodium salt CAS:13085-50-2 manufacturer supplier producer and factory-NINGBO INNO PHARMCHEM CO.,LTD. (nbinno.com)
  • One to 30 microliters (microl) of styrene -oxide were reacted with 0.5 milligram calf thymus DNA, 2'- deoxyguanosine-3'-monophosphate (dGp), 2'-deoxyadenosine-3'- monophosphate (dAp), 2'-deoxycytidine-3'-monophosphate (dCp), or 2'- deoxythymidine-3'-monophosphate (dTp) in a Tris/hydrochloric-acid buffer, pH 7.5, at 37 degrees-C for about 15 hours. (cdc.gov)
  • Decitabine (5-aza-2-deoxycytidine) is a DNA methyltransferase inhibitor and an archetypal epigenetic medication for the therapy of myeloid leukemias. (woofahs.com)
  • Intro The cytidine analog decitabine (5-aza-2-deoxycytidine, DAC) represents a Foretinib potent anticancer medication for the treatment of myelodysplastic syndromes (MDS) and severe myelogenous leukemia (AML) (1,2). (woofahs.com)
  • 2-Deoxycytidine 5-triphosphate disodium salt is one of the nucleoside triphosphates used for DNA polymerase driven reactions such as polymerase chain reaction, DNA sequencing and other molecular biology methods. (nacchemical.com)
  • Deoxycytidine 5'-[alpha-32P] triphosphate (dCTP [alpha-32P]) / s.A. 3000 Ci/mmol, Conc. (biotrend.com)
  • 3′,4′-didehydro-3′-deoxycytidine duphosphate is a metabolite of 3′,4′-didehydro-3′-deoxycytidine triphosphate that has been proven to have antiviral properties. (santiago-lab.com)
  • Since this epigenetic change is reversible, it is a potential target for chemotherapeutic intervention using an inhibitor of DNA methylation, such as 5-aza-2'-deoxycytidine (DAC). (biomedcentral.com)
  • Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. (wikipedia.org)
  • Deoxycytidine can also serve as a biomarker for tumor diagnosis. (wikipedia.org)
  • This work strongly suggests that a direct pharmacological inhibition of DNMT1, unlike the use of 5-aza-2′-deoxycytidine, should lead to tumor suppressor gene hypomethylation and re-expression without inducing major DNA damage in leukemia. (pasteur.fr)
  • 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) are intermediates in the DNA demethylation pathway and can act as biomarkers. (wikipedia.org)
  • In addition we addressed the role of DNA damage formation in DNA demethylation by 5-aza-2′-deoxycytidine. (pasteur.fr)
  • Most interestingly, by combining DNMT1 siRNA and treatment with low dose of 5-aza-2′-deoxycytidine, it is possible to uncouple DNA damage formation from DNA demethylation. (pasteur.fr)
  • Our data show that DNMT1 is the main DNMT involved in DNA methylation maintenance in KG1 cells and in mediating DNA damage formation upon exposure to 5-aza-2′-deoxycytidine. (pasteur.fr)
  • Our aim was to analyze 2'-deoxycytidine activated rat umbilical cord derived mesenchymal stem cells (UC-MSCs) for their potential role in adhesion and cardiac differentiation. (magnusconferences.com)
  • 3′,4′-didehydro-3′-deoxycytidine diphosphate is provided as triethylammonium salt. (santiago-lab.com)
  • China 5-methyl-2'-deoxycytidine CAS:838-07-3 manufacturer supplier producer and factory-NINGBO INNO PHARMCHEM CO.,LTD. (nbinno.com)
  • Are you looking for China or India manufacturers of 5-methyl-2-deoxycytidine CAS:838-07-3, 5-methyl-2-deoxycytidine factory or 2-Deoxy-5-methylcytidine supplier? (nbinno.com)
  • Where can buy 5-methyl-2-deoxycytidine or if you want to know the price market of 2-Deoxy-5-methylcytidine? (nbinno.com)
  • Treatment of GBC cell lines with demethylating agent 5-Aza- 2'-deoxycytidine enhances its expression, establishing impact of methylation on DKK3 expression. (amrita.edu)
  • It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. (wikipedia.org)
  • Deoxycytidine can be used as a biomarker for breast cancer patients and healthy individuals. (wikipedia.org)
  • 5-azacytidine and 5-aza-2′-deoxycytidine are clinically used to treat patients with blood neoplasia. (pasteur.fr)
  • Home 1 / First Page 2 / 2′-Deoxycytidine-5′-triphosphate trisodium salt CAS 109909. (watson-bio.com)
  • dFdCTP is also known to incorporate into RNA and competes with deoxycytidine triphosphate (dCTP) for the binding site of POLA and POLE. (medscape.com)
  • Combined inhibition of ribonucleotide reductase and deoxycytidine kinase (dCK) in multiple cancer cell lines depletes deoxycytidine triphosphate pools leading to DNA replication stress, cell cycle arrest and apoptosis. (trethera.com)
  • The present study examines the effects on embryogenesis of microinjecting Xenopus laevis fertilized eggs with 5-aza-2′-deoxycytidine (5-Aza-CdR), which induces hypomethylation of DNA, and 5-methyl-2′-deoxycytidine-5′-triphosphate (5-methyl-dCTP), which induces hypermethylation of DNA. (elsevierpure.com)
  • 2. Intracellular cytarabine triphosphate production correlates to deoxycytidine kinase/cytosolic 5'-nucleotidase II expression ratio in primary acute myeloid leukemia cells. (nih.gov)
  • After intracellular metabolism to its active nucleotide, it inhibits ribonucleotide reductase and competes with deoxycytidine triphosphate for incorporation into DNA. (medscape.com)
  • 1984) Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase. (jenabioscience.com)
  • 1983) Incorporation of 5-Aza-2'-deoxycytidine-5'-triphosphate into DNA. (jenabioscience.com)
  • 5-Aza-20 -deoxycytidine (DAC), a nucleoside analogue, could in-corporate into DNA and exert direct cytotoxic and antiproliferative effects on tumor cells [8]. (1library.net)
  • 16. Activation of deoxycytidine kinase by various nucleoside analogues. (nih.gov)
  • 3H]Deoxycytidine was used as the labeled nucleoside to avoid possible complications arising from [3H]thymidine labeling of megaloblastic cells. (jci.org)
  • This band is similarly present in the UV resonance Raman spectra of the imino cytidine analogs N 3 -methylcytidine at high pH and N 4 -methoxy-2′-deoxycytidine at pH 7 and displays features attributable to the imino form of C residues and their derivatives. (utmb.edu)
  • p-BQ reacts with DNA to form benzetheno adducts with deoxycytidine, deoxyadenosine, and deoxyguanosine. (nih.gov)
  • deoxyadenosine (p-BQ-dAdo), respectively, by reacting deoxycytidine and deoxyadenosine with p-BQ. (nih.gov)
  • 5. Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression. (nih.gov)
  • Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor. (wikipedia.org)
  • We studied the effect of 5-aza-2'-deoxycytidine (5-AZA-CdR) on the differentiation of murine 41A3 neuroblastoma cells. (unina.it)
  • We previously demonstrated that 5-aza-20-deoxycytidine (DAC) could significantly increase the susceptibility of renal cell carcinoma (RCC) cells to paclitaxel (PTX) treatmentin vitro, and showed the synergy of DAC and PTX against RCC. (1library.net)
  • Here, we explored whether 5-aza-2′-deoxycytidine (5-aza-CdR), a demethylating agent, could enhance the susceptibility of EC cells to medroxyprogesterone acetate (MPA). (bmj.com)
  • Results 5-Aza-2′-deoxycytidine significantly increased the expression of PR and its downstream targets by demethylating PR promoter in both Ishikawa and KLE cells. (bmj.com)
  • Essentially, the control bands for α-tubulin had been duplicated across from Fig. 2A to Fig. 2B , and from Fig. 2D to Fig. 2E [the experiments showing treatment of the cells with (A) manumycin A, (B) U0126, (D) 5-aza-2-deoxycytidine (DAC) and (E) trichostatin A (TSA)], respectively. (spandidos-publications.com)
  • 1997. Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3' deoxycytidine and 3'-azido-3'-deoxythymidine. (invivogen.com)
  • It can also be used as a precursor for 5-aza-2′-deoxycytidine, a treatment for MDS patients. (wikipedia.org)
  • dFdC) is a pyrimidine analogue of deoxycytidine that has antitumor activity against various solid tumors, including pancreatic cancer, non-small-cell lung cancer, breast cancer and ovarian cancer. (medscape.com)
  • Deoxycytidine prevents or delays (but does not reverse) the cytotoxic activity. (nih.gov)
  • An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 5-Fluoro-2'-deoxycytidine (10356-76-0). (nih.gov)
  • 5-Aza-2′-deoxycytidine combined with MPA synergistically suppressed the EC cell growth by inducing cell cycle arrest at G2/M phase and apoptosis. (bmj.com)
  • Conclusions 5-Aza-2′-deoxycytidine and MPA synergistically inhibit EC cell growth and invasion. (bmj.com)
  • 12. Melatonin overcomes resistance to clofarabine in two leukemic cell lines by increased expression of deoxycytidine kinase. (nih.gov)