• Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. (wikipedia.org)
  • Dantrium (dantrolene). (drugs.com)
  • Revonto is supplied in 65 mL vials containing 20 mg dantrolene sodium, 3000 mg mannitol, and sufficient sodium hydroxide to yield a pH of approximately 9.5 when reconstituted with 60 ml sterile water for injection USP (without a bacteriostatic agent). (nih.gov)
  • The recommendation is that 36 dantrolene vials (containing 20 mg/vial) should be immediately available wherever general anesthesia is administered. (medscape.com)
  • Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants. (definitions.net)
  • Due to its mechanism of action, muscle weakness can occur with the administration of dantrolene [ 6 ]. (ekja.org)
  • The mechanism of action of dantrolene sodium. (aspetjournals.org)
  • medical citation needed] Dantrolene may interact with the following drugs: Calcium channel blockers of the diltiazem/verapamil type: Intravenous treatment with dantrolene and concomitant calcium channel blocker treatment may lead to severe cardiovascular collapse, abnormal heart rhythms, myocardial depressions, and high blood potassium. (wikipedia.org)
  • The administration of intravenous dantrolene sodium to human volunteers is associated with loss of grip strength and weakness in the legs, as well as subjective CNS complaints (see also PRECAUTIONS, Information for Patients ). (nih.gov)
  • When prophylactic intravenous dantrolene is administered as directed, whole blood concentrations remain at a near steady state level for 3 or more hours after the infusion is completed. (nih.gov)
  • The administration of the recommended prophylactic dose of intravenous dantrolene to healthy volunteers was not associated with clinically significant cardiorespiratory changes. (nih.gov)
  • The combination of therapeutic doses of intravenous dantrolene sodium and verapamil in halothane/ a -chloralose anesthetized swine has resulted in ventricular fibrillation and cardiovascular collapse in association with marked hyperkalemia. (druglib.com)
  • It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis until the relevance of these findings to humans is established. (druglib.com)
  • Dantrolene is a hydantoin derivative that directly interferes with muscle contraction by inhibiting calcium ion release from the sarcoplasmic reticulum, possibly by binding to ryanodine receptor type 1 (RYR-1). (medscape.com)
  • The Malignant Hyperthermia Association of the United States has issued guidelines recommending that 36 vials (20 mg per vial) of dantrolene remain in stock at every surgery center. (sciencedaily.com)
  • Pfizer Australia has informed there is a shortage of Australian registered DANTROLENE (as sodium hemiheptahydrate) 20 mg powder for injection vial due to unexpected increase in consumer demand. (edu.au)
  • The Practi-Dantrolene for clinical training comes in a 100 mL vial with yellow powder simulating Dantrolene Teach your students the skills needed for drug intervention of malignant hyperthermia. (anatomywarehouse.com)
  • Revonto is a sterile, non-pyrogenic, lyophilized formulation of dantrolene sodium for injection. (nih.gov)
  • It is also used to prevent, treat, or reduce the risk of malignant hyperthermia (disorder that causes a fast rise in body temperature and muscle contractions), Dantrolene is in a class of medications called skeletal muscle relaxants. (medlineplus.gov)
  • Dantrolene depresses excitation-contraction coupling in skeletal muscle by acting as a receptor antagonist to the ryanodine receptor, and decreasing free intracellular calcium concentration. (wikipedia.org)
  • It is hypothesized that addition of dantrolene sodium to the "triggered" malignant hyperthermic muscle cell reestablishes a normal level of ionized calcium in the myoplasm. (nih.gov)
  • Inhibition of calcium release from the sarcoplasmic reticulum by dantrolene sodium reestablishes the myoplasmic calcium equilibrium, increasing the percentage of bound calcium. (nih.gov)
  • Calcium-channel blockers should be avoided if dantrolene is used, because they may cause hyperkalemia. (medscape.com)
  • Dantrolene blocks this function and inhibits the release of calcium from the sarcoplasmic reticulum to the sarcoplasm. (ekja.org)
  • Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis? (cdc.gov)
  • Guohua Li, MD, PhD, Columbia University, New York who authored the article "Cost-Effectiveness Analysis of Stocking Dantrolene in Ambulatory Surgery Centers" that was recently published in the latest official journal of the American Society of Anesthesiologists, Anesthesiology . (sciencedaily.com)
  • However, the cost of stocking dantrolene in ambulatory surgery centers has been a concern. (sciencedaily.com)
  • The purpose of this analysis is to assess the cost-effectiveness of stocking dantrolene in ambulatory surgery centers as recommended by the Malignant Hyperthermia Association of the United States. (sciencedaily.com)
  • The results of this analysis suggest that stocking dantrolene for the treatment of MH in ambulatory surgery centers as recommended by the Malignant Hyperthermia Association of the United States is cost-effective when compared with the estimated values of statistical life used by U.S. regulatory agencies. (sciencedaily.com)
  • Stocking dantrolene and a [malignant hyperthermia] cart in every anesthetizing location…no matter the frequency of use of these drugs, should be reconsidered. (asahq.org)
  • 7 addresses the cost-effectiveness of maintaining a fully stocked MH cart on the maternity unit compared to other less-expensive strategies, including stocking an initial dose of dantrolene on the unit with the plan to retrieve a centrally located MH cart during an MH crisis. (asahq.org)
  • Ryanodex (dantrolene sodium) is a skeletal muscle relaxant used to treat malignant hyperthermia in conjunction with appropriate supportive measures, and to prevent malignant hyperthermia in patients at high risk. (rxlist.com)
  • Our Ryanodex (dantrolene sodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • RYANODEX® (dantrolene sodium) for injectable suspension is a sterile lyophilized powder. (rxlist.com)
  • RYANODEX is supplied in 20 mL vials containing 250 mg dantrolene sodium and the following inactive ingredients: 125 mg mannitol, 25 mg polysorbate 80, 4 mg povidone K12 and sufficient sodium hydroxide or hydrochloric acid for pH adjustment. (rxlist.com)
  • The US Food and Drug Administration (FDA) has approved an injectable form of dantrolene sodium ( Ryanodex , Eagle Pharmaceuticals) for rapid treatment of malignant hyperthermia (MH), along with the appropriate supportive measures, the company announced in a news release today. (medscape.com)
  • Ryanodex - which can be administered much more quickly than current formulations of dantrolene - is the first significant enhancement to MH treatment options in more than 3 decades, according to the company. (medscape.com)
  • Ryanodex will be available in single-use vials containing 250 mg of dantrolene sodium in lyophilized powder form. (medscape.com)
  • Ryanodex allows anesthesiologists to deliver a therapeutic dose of dantrolene sodium in a much more expedient manner than currently possible with existing IV formulations of dantrolene sodium, "potentially saving lives and reducing MH-related morbidity," according to the company. (medscape.com)
  • A decision tree model was used to compare treatment with dantrolene to a supportive care-only strategy. (sciencedaily.com)
  • Model assumptions include the incidence of MH, MH case fatality with dantrolene treatment and with supportive care-only. (sciencedaily.com)
  • The incremental effectiveness of dantrolene compared with supportive care was 33 more lives saved per year. (sciencedaily.com)
  • Dantrolene is used to treat spasticity (muscle stiffness and tightness) or muscle spasms associated with spinal cord injuries, stroke, multiple sclerosis, or cerebral palsy. (medlineplus.gov)
  • Dantrolene acts on the spinal cord nerves to treat spasticity and to prevent and treat malignant hyperthermia. (medlineplus.gov)
  • Furthermore, dantrolene is used to treat spasticity due to spinal cord damage. (ekja.org)
  • Dantrolene often causes sedation severe enough to incapacitate the patient to drive or operate machinery. (wikipedia.org)
  • A more water-soluble analog of dantrolene, azumolene, is under development for similar indications. (wikipedia.org)
  • Indications for treatment of malignant hyperthermia (MH) with dantrolene include signs of hypermetabolism, a rapid rise in carbon dioxide in the face of an increase in the minute ventilation, tachycardia, muscle and or jaw rigidity (after succinylcholine), and fever (a late sign). (medscape.com)
  • Your doctor will probably start you on a low dose of dantrolene for spasticity and gradually increase your dose, not more than once every 7 days. (medlineplus.gov)
  • Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. (ekja.org)
  • A small dose of oral dantrolene does not prolong the duration of action and recovery of rocuronium. (ekja.org)
  • The median total dose of dantrolene was 400 mg for patients who experienced a muscle weakness complication. (ekja.org)
  • In addition, based on logistic regression, it was reported that the likelihood of a muscle weakness complication increased by 27% when the total dose of dantrolene doubled [ 7 ]. (ekja.org)
  • In this case report, the muscle relaxant action was assessed during administration of the optimized dose of rocuronium under nerve root monitoring in general anesthesia for a patient with long-term dantrolene administration. (ekja.org)
  • However, high-dose oral dantrolene has been associated with severe hepatotoxicity. (bvsalud.org)
  • Clinical experience has shown that early vital sign and/or blood gas changes characteristic of malignant hyperthermia may appear during or after anesthesia and surgery despite the prophylactic use of dantrolene and adherence to currently accepted patient management practices. (nih.gov)
  • Our aim was to investigate the occurrence of serious adverse effects and the adherence to oral dantrolene therapy. (bvsalud.org)
  • Dantrolene can cause severe liver damage. (medlineplus.gov)
  • The ability for healthcare professionals in hospitals and surgery centers to more quickly prepare and administer this new formulation of the antidote dantrolene sodium is expected to bring the crisis under control more rapidly and prevent severe complications from MH," he said. (medscape.com)
  • Dantrolene (infusion for severe body temperature abnormalities). (dokteronline.com)
  • A 52-year-old man treated with oral dantrolene for spasticity after spinal cord injury was scheduled to undergo irrigation and drainage of a thigh abscess under general anesthesia. (ekja.org)
  • Because dantrolene is essential for the treatment of MH and the prevention of death and complications, the Malignant Hyperthermia Association of the United States has stated that "dantrolene must be available for all anesthetizing locations within 10 minutes of the decision to treat for MH. (asahq.org)
  • Clinical observations suggest that oral dantrolene may relief myopathic symptoms in MH-susceptible (MHS) patients. (bvsalud.org)
  • Combined oral contraceptives and hormone replacement therapy with estrogens may enhance liver toxicity of dantrolene, particularly in women over 35 years of age. (wikipedia.org)
  • He had taken 50 mg oral dantrolene per day for 3 years. (ekja.org)
  • METHODS: In a retrospective database review (1994-2018), we investigated a cohort of patients who were diagnosed as MHS by a positive caffeine-halothane contracture test (CHCT), had myopathic manifestations, and received oral dantrolene. (bvsalud.org)
  • RESULTS: Among 476 MHS patients with positive CHCT, 193 had muscle symptoms, 164 started oral dantrolene, 27 refused treatment, and 2 were excluded due to abnormal liver function before starting therapy. (bvsalud.org)
  • Administration of dantrolene may potentiate vecuronium-induced neuromuscular block. (druglib.com)
  • Experts say storing the drug dantrolene at ambulatory surgical centers will save lives and is very cost effective. (sciencedaily.com)
  • Dantrolene, an emergency drug that is kept in only one location within most institutions, is an appropriate parallel to that situation and is relatively inexpensive when prorated. (mhaus.org)
  • 6 However, dantrolene is an expensive drug, and it often expires before use. (asahq.org)
  • MH during surgery is a "life-threatening emergency requiring immediate treatment including the administration of the 'antidote' drug dantrolene sodium," Henry Rosenberg, MD, C PE , a founder and president of the Malignant Hyperthermia Association of the United States, said in the release. (medscape.com)
  • Our study indicates that requiring ambulatory surgery centers to stockpile Dantrolene as recommended by Malignant Hyperthermia Association of the United States (MHAUS) is a cost-effective measure for treating malignant hyperthermia -- an infrequent but potentially fatal complication. (sciencedaily.com)
  • Your doctor will order certain lab tests before and during your treatment to check your response to dantrolene. (medlineplus.gov)
  • Dantrolene is currently the only specific treatment for MH. (sciencedaily.com)
  • Without proper and prompt treatment with dantrolene sodium, mortality is extremely high. (sciencedaily.com)
  • If an acute MH reaction appears likely, it is best to start giving dantrolene and other recommended treatment modalities promptly rather than wait too long and have a bad outcome. (medscape.com)
  • A newer version of dantrolene dissolves in 15 seconds and thereby improves the rapidity of treatment. (medscape.com)
  • tell your doctor and pharmacist if you are allergic to dantrolene, any other medications, or any of the ingredients in dantrolene capsules. (medlineplus.gov)
  • These signs are compatible with attenuated malignant hyperthermia and respond to the administration of additional i.v. dantrolene (see DOSAGE AND ADMINISTRATION ). (nih.gov)
  • A fulminant, rapidly progressive MH reaction requires early diagnosis and early rapid administration of dantrolene, discontinuance of triggering agents, and assistance from extra personnel. (medscape.com)
  • Once the initial reaction is controlled, continued monitoring in the intensive care unit (ICU) for 24-48 hours is recommended, along with administration of dantrolene (1 mg/kg every 4-6 hours, or an equivalent amount given as a continuous infusion). (medscape.com)
  • A fundamental aspect of successfully treating MH is the early administration of dantrolene. (asahq.org)
  • This was successfully managed by assisted ventilation, aggressive fluid therapy, and the early administration of dantrolene, in addition to cooling measures. (erowid.org)
  • Dantrolene sodium is classified as a direct-acting skeletal muscle relaxant. (nih.gov)
  • In isolated nerve-muscle preparation, dantrolene sodium has been shown to produce relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. (nih.gov)
  • In skeletal muscle, dantrolene sodium dissociates the excitation-contraction coupling, probably by interfering with the release of Ca ++ from the sarcoplasmic reticulum. (nih.gov)
  • Dantrolene sodium is a muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor. (definitions.net)
  • 1 ] identified dantrolene as a new class of muscle relaxant. (ekja.org)
  • It is assumed that the muscle relaxant action of dantrolene affected this patient, but there are extremely few studies or reported cases with regard to this effect. (ekja.org)
  • The effect of dantrolene on muscle relaxation will be discussed. (ekja.org)
  • Specific metabolic pathways for the degradation and elimination of dantrolene sodium in humans have been established. (nih.gov)
  • Patients on chronic dantrolene therapy should routinely have LFTs monitored. (wikipedia.org)
  • Cardiovascular collapse in patients treated simultaneously with varapamil and dantrolene sodium is rare. (druglib.com)
  • Other dantrolene sodium formulations require multiple 20-mg vials reconstituted in large volumes of sterile water, a process that can take 15 to 20 minutes to mix reconstitute and administer, the company notes. (medscape.com)
  • medical citation needed] It is unclear whether dantrolene has carcinogenic effects. (wikipedia.org)
  • If you become pregnant while taking dantrolene, call your doctor immediately. (medlineplus.gov)
  • A hospital is recommended to keep a minimum stock of 36 dantrolene vials totaling 720 mg, sufficient for a 70-kg person. (wikipedia.org)
  • An MH tote or cart containing dantrolene and the necessary supplies should be readily available to help reverse the process more quickly. (medscape.com)