• molecules
  • Here strand switching occurs by the second round of PCR and larger single stranded DNA molecules are built up extending from the outer primers until they overlap. (biomedcentral.com)
  • In tumor specimens such as those from neuroblastoma, ovarian, and lung carcinoma patients, the prevalence of extrachromosomal circular DNA molecules harboring amplified genes has been well established. (aacrjournals.org)
  • The aim of this study was to investigate the effect of fractionated radiation treatment, given in daily doses similar to those administered clinically, on the stability of extrachromosomal circular DNA molecules in cancer cells. (aacrjournals.org)
  • Our studies were conducted with multidrug-resistant KB cells, which harbor extrachromosomal copies of the multidrug resistance gene ( MDR 1) almost exclusively on circular DNA molecules of ∼750 and 1500 kb pairs. (aacrjournals.org)
  • This size range is representative of extrachromosomal circular DNA molecules that have been shown to harbor amplified oncogenes in vivo . (aacrjournals.org)
  • Fluorescence in situ hybridization studies further determined that extrachromosomal circular DNA loss correlated to the entrapment of these DNA molecules in radiation-induced micronuclei. (aacrjournals.org)