• Upon further investigation, it was discovered that the amino acid composition of HU resembles that of eukaryotic histones, thus prompting further research into the exact function of bacterial DNA binding proteins and discoveries of other related proteins in bacteria. (wikipedia.org)
  • Currently, many more functions of bacteria DNA binding proteins have been discovered, including the regulation of gene expression by histone-like nucleoid-structuring protein, H-NS. (wikipedia.org)
  • H-NS is about 15.6 kDa and assists in the regulation of bacterial transcription in bacteria by repressing and activating certain genes. (wikipedia.org)
  • Evidence that bacterial small molecules also target viruses provides fresh insights into how bacteria thwart viral infection. (nature.com)
  • This is essential for downstream applications that require accurate DNA input including quantifying bacteria DNA template for Next-generation sequencing library preparation and metagenomic analysis amongst others. (zymoresearch.com)
  • Norgen's Salmonella enterica Quantified Bacterial DNA Standard is prepared from cultured bacteria using Norgen's sample preparation technology. (norgenbiotek.com)
  • A protein secreted by bacteria to kill other microbes has been re-engineered to tweak DNA inaccessible to other gene editors, scientists report online July 8 in Nature . (sciencenews.org)
  • A new study has found that areas surrounding active salmon farms in the Broughton Archipelago and the Discovery Islands were 2.72 times more likely to contain DNA from disease-causing viruses and bacteria. (thefishsite.com)
  • As I understand it, naturally competent bacteria carry genes that encode the machinery necessary to facilitate the transport of this DNA across the membrane and into the cell. (stackexchange.com)
  • Can bacteria release free DNA into their environment? (stackexchange.com)
  • Others result from mobile genetic elements snippets of DNA that are able to move between bacteria. (cdc.gov)
  • This study determined the prevalence of bacterial contamination of mobile phones of health workers and the predisposing factors, in order to ascertain the risk of transmission of pathogenic bacteria through mobile phones. (bvsalud.org)
  • Bacterial DNA gyrase, a type II DNA topoisomerase found in all bacteria is a proven target for antibacterial chemotherapy. (bvsalud.org)
  • In DNA replication at the lagging strand site, DNA polymerase III removes nucleotides individually from the DNA binding protein. (wikipedia.org)
  • HU is a small (10 kDa) bacterial DNA-binding protein, which structurally differs from a eukaryotic histone but functionally acts similarly to a histone by inducing negative supercoiling into circular DNA with the assistance of topoisomerase. (wikipedia.org)
  • ParB is an unusual DNA binding protein. (elifesciences.org)
  • I remember reading something about a transformation-specific DNA binding protein that coats the entire length of the DNA strand and prevents degradation. (stackexchange.com)
  • AllPrep Bacterial/Fungal. (qiagen.com)
  • Easy-to-use AllPrep Bacterial/Fungal DNA/RNA/Protein Kits isolate total nucleic acids and cellular proteins from Gram (+/-) bacterial cultures and fungal cell cultures. (qiagen.com)
  • Cultured bacterial and fungal cells are first lysed using glass bead tubes, and nucleic acids and proteins are solubilized and mixed with a binding solution. (qiagen.com)
  • Bacterial DNA can be reliably quantified in a background of non-bacterial DNA such as fungal, animal, and plant DNA, etc. (zymoresearch.com)
  • We assessed the alterations in gut bacterial and fungal populations associated with a history of appendectomy. (frontiersin.org)
  • Compared with those in samples from HwoA, the abundance correlation networks in samples from HwA displayed more complex fungal-fungal and fungal-bacterial community interactions. (frontiersin.org)
  • Nail fungus treatments may be failing because what we have identified as a fungal nail is actually a mixed bacterial and fungal infection (polymicrobial onychopathy). (nova.edu)
  • It can be caused by a large variety of microorganisms, but has essentially two distinct etiologies: bacterial and fungal. (who.int)
  • In molecular biology, bacterial DNA binding proteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like proteins. (wikipedia.org)
  • Since bacterial binding proteins have a diversity of functions, it has been difficult to develop a common function for all of them. (wikipedia.org)
  • Eukaryotic histones package DNA to help it to fit in the nucleus, and they are known to be the most conserved proteins in nature. (wikipedia.org)
  • These dinoflagellate histone-like proteins replace histone in some dinoflagellates and package DNA into a liquid-crystalline state. (wikipedia.org)
  • in these processes, bacterial DNA binding proteins have an architectural role, maintaining structural integrity as transcription, recombination, replication, or any other DNA-dependent process proceeds. (wikipedia.org)
  • Initially, bacterial DNA binding proteins were thought to help stabilize bacterial DNA. (wikipedia.org)
  • Therefore we can speculate that DNA repair proteins will be prevalent and DNAses will be low in the cell, under these conditions. (stackexchange.com)
  • Here we report two groups of TnpB-like proteins (Fanzor1 and Fanzor2) that are widespread in diverse eukaryotic transposable elements (TEs), and in large double-stranded DNA (dsDNA) viruses infecting eukaryotes. (biomedcentral.com)
  • Fanzor1 proteins are frequently captured by DNA transposons from different superfamilies including Helitron , Mariner , IS4 -like, Sola and MuDr . (biomedcentral.com)
  • Proteins are major chromophores and targets for damage due to their abundance, but the role of proteins in inducing damage to bound DNA, and the effects on DNA-protein interactions is less well characterized. (ku.dk)
  • The study identified the ways in which proteins cross a cell membrane, a finding that could create a scientific foundation for better ways of delivering drugs into cells in the future, or for treating illnesses caused by bacterial toxins. (scitechdaily.com)
  • The full article, published under the title Environmental DNA from multiple pathogens is elevated near active Atlantic salmon farms , is now available via Proceedings of the Royal Society B: Biological Sciences . (thefishsite.com)
  • I am a researcher in bacterial genetics and my interest is in understanding the development of resistance in bacterial pathogens using next generation sequencing techniques. (wellcomeconnectingscience.org)
  • I am a graduate student at the Wellcome Sanger Institute, where I research the virulence and the molecular genetics of bacterial pathogens as part of the Infection Genomics programme. (wellcomeconnectingscience.org)
  • The labs develop and compare DNA patterns from bacterial pathogens submitted by state, Food and Drug Administration, and the U.S. Department of Agriculture laboratories from across the nation. (cdc.gov)
  • Molecular (DNA) diagnostics, targeting the genome of microorganisms, have shown that there are often more and different pathogens causing nail disease than what we currently identify via cultivation in lab. (nova.edu)
  • But FDA's findings are potentially trivial besides another recent discovery about gene-editing: that foreign DNA from surprising sources can routinely find its way into the genome of edited animals. (greenmedinfo.com)
  • Ultimately, all DNA 'editing' is really the cutting of DNA by enzymes, called nucleases, that are supposed to act only at chosen sites in the genome of a living cell. (greenmedinfo.com)
  • Genome copy # = DNA (g) / (g_to_bp const. (zymoresearch.com)
  • This process of inducing virulence in an otherwise harmless bacterium through prophage infection and integration of the prophage genome into the bacterial host genome is called lysogenic conversion 8 . (nature.com)
  • For most commercial applications gene-editing's appeal is simplicity and precision: it alters genomes at precise sites and without inserting foreign DNA. (greenmedinfo.com)
  • Use bioinformatics to probe genomes, to explore and represent DNA and protein sequences. (mooc.es)
  • The course will be of interest to undergraduates, post-graduates, researchers, bioinformaticians, biomedical researchers, microbiologists, healthcare professionals and all those who are interested in learning about the underlying mechanisms of bacterial disease, DNA sequences and protein data, or how to use online analytical tools to probe genomes. (mooc.es)
  • The opportunity to use online computational tools in the context of bacterial genomes will also be of interest to teachers and their 16-18-year-old science and computing students. (mooc.es)
  • Thus, apparently unbeknownst to Recombinetics, adjacent to its edited site were 4,000 base pairs of DNA that originated from the plasmid vector used to introduce the DNA required for the hornless trait. (greenmedinfo.com)
  • The origin of this foreign DNA, as with Recombinetics' calves, was the plasmid vector used in the editing process. (greenmedinfo.com)
  • CloneStable ® enables the long-term storage of unpurified bacterial plasmid and genomic DNA. (sigmaaldrich.com)
  • Solu provides a platform that includes: a "genomics bench in the cloud" for analysing bacterial DNA, a global pathogen database that can match sample DNA to thousands of known strains, and tools for detecting and managing outbreaks. (springwise.com)
  • The aim of this study was to evaluate the performance of a novel multiplex PCR assay for diagnosis of late-onset sepsis and to investigate the value of bacterial DNA load (BDL) determination as a measure of infection severity. (maastrichtuniversity.nl)
  • a 2-year-old boy died.¹ E. coli bacterial infection is a growing concern for public health officials in the North Carolina Department of Health and Human Services and other local health departments. (bartleby.com)
  • In Vibrio cholerae , infection by a bacterial virus (bacteriophage) results in the conversion of non-pathogenic strains to pathogenic strains and this can lead to cholera pandemics. (nature.com)
  • One such example is diphtheria toxin, which is produced by Corynebacterium diphtheriae and causes diphtheria, a serious and potentially fatal bacterial infection of the nose and throat. (scitechdaily.com)
  • An important concept in the evaluation of data regarding transfusion-transmitted bacterial infections (TTBIs) is the definition of a case. (medscape.com)
  • ceptible to urinary tract infections with The second phase of our study included multiresistant bacterial strains [ 7-9 ]. (who.int)
  • The gene-editing of DNA inside living cells is considered by many to be the preeminent technological breakthrough of the new millennium. (greenmedinfo.com)
  • They imply, at the very least, the need for strong measures to prevent contamination by stray DNA, along with thorough scrutiny of gene-edited cells and gene-edited organisms. (greenmedinfo.com)
  • One can back calculate from the amount of genomic DNA to determine genomic copies, and then multiply by a factor of 7 to determine total copies of the 16S rRNA gene. (zymoresearch.com)
  • Scientists report a new gene-editing tool that can target DNA in mitochondria (red). (sciencenews.org)
  • We have investigated the application of bacterial magnetite particles as DNA carriers for microprojectile based gene transfer. (elsevierpure.com)
  • A small fraction of bacterial species are known to be naturally competent, meaning that they can engage in this sort of horizontal gene transfer in their natural environments. (stackexchange.com)
  • A blood sample was collected from a peripheral vein and from the central venous catheter (CVC) or the arteriovenous fistula (AVF) and examined for presence of BDNAs by 16S rRNA gene PCR amplification, bacterial growth, and measurement of C-reactive protein and IL-6. (unicatt.it)
  • The DNA quantity and purity were determined using real-time PCR targeting the bacterial 16S rDNA gene. (knaw.nl)
  • The emergence of certain bacterial strains resistant to antibiotics has become a major public health problem, hence the need to develop new antibiotic molecules. (bvsalud.org)
  • 1 report their analysis of an antiviral defence system that can protect more than one bacterial species. (nature.com)
  • Analysis showed that the gut bacterial composition of samples from HwA was less diverse than that of samples from HwoA and had a lower abundance of Roseburia , Barnesiella , Butyricicoccus , Odoribacter , and Butyricimonas species, most of which were short-chain fatty acids-producing microbes. (frontiersin.org)
  • Interventions such as improving oral hygiene may lead to decreased S. aureus carriage by reducing other bacterial species such as Porphyomonas. (cdc.gov)
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • Patients on antibiotics had higher relative abundance of phylum Firmicutes with bacterial species, Streptococcus intermedius, Lactobacillus gasseri, Mogibacterium timidum, and Solobacterium moorei, whereas patients without antibiotics had greater amounts of Parvimonas micra and Streptococcus anginosus. (nih.gov)
  • They used FISH probes informed by publicly available bacterial 16S ribosomal RNA databases to search for Fusobacterium species found in some vaginal samples in past studies. (genomeweb.com)
  • The modifications at the CRP dimer interface, and the site-specific DNA strand cleavage are proposed to occur via oxidation of two species Met residues (Met114 and Met189, respectively) to reactive persulfoxides that damage neighbouring amino acids and DNA bases. (ku.dk)
  • The laboratory (18.8%, 21/112) and medical wards (16.1%, 18/112) had the highest bacterial contamination of mobile phones (p=0.041), and more bacterial species were isolated from smartphones (68.8%, n=77/112) than keypad phones (31.2%, n=35/112) (p=0.032). (bvsalud.org)
  • When thinking about genetics, most of us think of the DNA helix. (gentaur.co.uk)
  • However, although genetics is actually based on genetic material in the form of DNA, many different processes are involved. (gentaur.co.uk)
  • Gould, 2011) E. coli 0157 is a member of a large group of bacterial germs that inhibit the intestinal tract of humans and other warm - blooded animals. (bartleby.com)
  • The effectiveness of three commercially available direct DNA isolation kits (Mobio, Fast, Qiagen) and one published direct DNA extraction protocol (Bead) for extracting bacterial DNA from different types of activated sludge was investigated and mutually compared. (knaw.nl)
  • Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA. (medlineplus.gov)
  • The remaining genes provide instructions for making molecules called transfer RNA (tRNA) and ribosomal RNA (rRNA), which are chemical cousins of DNA. (medlineplus.gov)
  • Each of Recombinetics' calves possessed two antibiotic resistance genes, along with other segments of superfluous bacterial DNA. (greenmedinfo.com)
  • Mitochondrial DNA contains 37 genes, all of which are essential for normal mitochondrial function. (medlineplus.gov)
  • Standards are QC tested serial dilutions of genomic DNA. (zymoresearch.com)
  • The standards included in the Femto Bacterial DNA Quantification kit are serial dilutions of E. coli genomic DNA. (zymoresearch.com)
  • Two micro-liters of Norgens Salmonella enterica Quantified Bacterial DNA Standard and various serial dilutions (blue curves) were used in a 20 µL Salmonella enterica -specific PCR reaction using Norgens 2X PCR Master Mix (#28007), supplemented with SYBR Green I. The real-time PCR reactions were performed on a Bio-Rad CFXReal-Time PCR System. (norgenbiotek.com)
  • Norgens Salmonella enterica Quantified Bacterial DNA Standard and various serial dilutions showed consistent amplification down to fewer than 40 copies per reaction. (norgenbiotek.com)
  • This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. (nih.gov)
  • Two bacterial virulence factors are required for effective induction of apoptosis by extracellular GAS: (i) hyaluronic acid capsule that inhibits bacterial internalization and (ii) secreted cytolysin, streptolysin O (SLO), that forms. (lu.se)
  • Two bacterial virulence factors are required for effective induction of apoptosis by extracellular GAS: (i) hyaluronic acid capsule that inhibits bacterial internalization and (ii) secreted cytolysin, streptolysin O (SLO), that forms transmembrane pores that permit extracellular calcium influx into the cytosol. (lu.se)
  • Use bioinformatics to explore DNA sequences and protein functions, to find the determinants of virulence in microbes. (wellcomeconnectingscience.org)
  • Quinolones inhibit two enzymes that are required for bacterial DNA synthesis, i.e. (cdc.gov)
  • they inhibit bacterial DNA-dependent RNA polymerase, suppressing RNA synthesis. (msdmanuals.com)
  • by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)
  • High specificity and sensitivity for bacterial DNA in a background of non-target DNA. (zymoresearch.com)
  • The Femto Bacterial DNA Quantification Kit can be used to detect and quantify bacterial DNA with high specificity and sensitivity. (zymoresearch.com)
  • During transformation, a bacterium can take up DNA from its environment. (stackexchange.com)
  • With the Femto Bacterial DNA Quantification Kit, one can dependably quantify as little as 20 fg DNA from 1 µl purified from biological liquids, bacterial cultures, or environmental DNA samples. (zymoresearch.com)
  • Research has shown that the ssDNA is stabilized by the interaction of SSB and the χ subunit of DNA polymerase III in E. coli, thus preparing for replication by maintaining the correct conformation that increases the binding affinity of enzymes to ssDNA. (wikipedia.org)
  • The targets of quinolone activity are the bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. (cdc.gov)
  • Following elution, the protein readily binds DNA, indicating the protein's high affinity for DNA. (wikipedia.org)
  • H-NS binds to DNA with an intrinsic curvature. (wikipedia.org)
  • DNA binds to the first spin column and the flow-through is combined with a solution to bind the total RNA on a second spin column. (qiagen.com)
  • Structural analysis of the C-terminal domain reveals a dimer with a lysine-rich surface that binds DNA non-specifically and is essential for DNA condensation in vitro. (elifesciences.org)
  • The exogenous DNA binds to a receptor located on the surface of competent cells, gets fragmented into small pieces, and then one strand is degraded while the other strand is transported across the membrane into the cytoplasm with the aid of a DNA translocase enzyme. (stackexchange.com)
  • The remaining 106 respiratory samples represented all specimens submitted for investigation of bacterial pneumonia during a one-week period in August 1999, at the Department of Clinical Microbiology, Herlev University Hospital. (biomedcentral.com)
  • Salmonella enterica Quantified Bacterial DNA Standard (Cat. (norgenbiotek.com)
  • Upon receipt, store Norgen's Salmonella enterica Quantified Bacterial DNA Standard at -20 o C or lower. (norgenbiotek.com)
  • Salmonella enterica DNA Standard . (norgenbiotek.com)
  • What does a viral DNA becomes after being associated with the bacterial chromosome? (mcqsmaster.com)
  • DNA gyrase and topoisomerase IV. (cdc.gov)
  • The ParB protein forms DNA bridging interactions around parS to condense DNA and earmark the bacterial chromosome for segregation. (elifesciences.org)
  • This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions. (nih.gov)
  • In collaboration with Stanford University and the University of Hamburg, Solu has developed software to better track, analyse, and manage bacterial genomics. (springwise.com)
  • Although the use of polycation to complex and purify DNA has been described in the literature, elution often requires a high ionic strength or pH levels not compatible with molecular analyses. (mdpi.com)
  • the protein is involved in stabilizing the lagging strand as well as interacting with DNA polymerase III. (wikipedia.org)
  • The role of single-stranded DNA binding (SSB) protein during DNA replication in Escherichia coli cells has been studied, specifically the interactions between SSB and the χ subunit of DNA polymerase III in environments of varying salt concentrations. (wikipedia.org)
  • Furthermore, binding of SSB to DNA polymerase III at the replication fork prevents dissociation of SSB, consequently increasing the efficiency of DNA polymerase III to synthesize a new DNA strand. (wikipedia.org)
  • When H-NS is bound with RNA Polymerase to the promoter region, there are structural differences in the DNA that are accessible. (wikipedia.org)
  • However, the main limitations of such a tools are that they extract low levels of DNA and they do not remove the inhibitors of polymerase chain reaction (PCR). (mdpi.com)
  • These 'networks' were inferred to be dynamic and poorly-ordered, consisting of several DNA loops between distally bound ParB molecules. (elifesciences.org)
  • Four molecules were chosen to be docked into DNA Gyrase active site using AutoDockTools. (bvsalud.org)
  • The team subsequently observed that two structurally different bacterial toxins also employed this same mechanism. (scitechdaily.com)
  • The liquid storage reagent rapidly permeates cell membranes to stabilize and protect genomic DNA. (sigmaaldrich.com)
  • Detection of Pneumocystis-DNA was associated with a worse prognosis: seven (44%) of patients with positive PCR died within one month compared to nine (14%) of the controls (p = 0.01). (biomedcentral.com)
  • In order to increase sensitivity in non-invasive specimens, several experimental studies have evaluated PCR detection of P. jiroveci DNA as a potential diagnostic test. (biomedcentral.com)
  • DNA and RNA are ready for qPCR, RT-PCR and next-generation sequencing, while protein is ready for 1D SDS-PAGE and mass spectrometry following in-gel trypsin digestion. (qiagen.com)
  • abstract = "BACKGROUND AND OBJECTIVES: Bacterial-derived DNA fragments (BDNAs) have been shown to be present in dialysis fluid, to pass through dialyzer membranes, and to induce IL-6 (IL-6) in mononuclear cells. (unicatt.it)
  • The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. (nih.gov)
  • The estimated residual risk of contamination of blood products with bacterial agents is 1 in 5,000 for platelets and 1 in 30,000 for red blood cells. (medscape.com)
  • Also important is the duration of storage, which has a direct correlation with the likelihood of bacterial contamination. (medscape.com)
  • A meta-analysis of 22 studies of bacterial contamination rate estimates for apheresis (AP), platelet-rich plasma (PRP), and buffy coat (BC) collection methods found an overall mean contamination rate of 0.51 per 1000 components (95% confidence index [CI], 0.38-0.67). (medscape.com)
  • Probable contamination - The blood culture from the recipient is negative or could not be done, but there is definite bacterial growth in the donor blood product. (medscape.com)
  • In these high salt concentrations, the eukaryotic histone protein is eluted from a DNA solution in which single stranded DNA is bound covalently to cellulose. (wikipedia.org)
  • The most common type is the DDE-transposase encoded by most bacterial insertion sequences (IS), eukaryotic DNA transposons, and LTR retrotransposons. (biomedcentral.com)
  • An unstable SSB/DNA system would result in rapid disintegration of the SSB, which stalls DNA replication. (wikipedia.org)
  • Some DNA differences result from the blunders during the DNA replication necessary for cell division. (cdc.gov)
  • RESUME Nous avons étudié la résistance aux antimicrobiens et les profils plasmidiques des isolats d' Escherichia coli uropathogénique chez des malades hospitalisés et des malades externes à l'Hôpital universitaire jordanien en 2000 et 2001. (who.int)
  • To date, there have not been any studies which identify the bacterial presence within healthy, non-abscessed liver tissue. (asas.org)
  • The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. (nih.gov)
  • The Bacterial Genomic Dna Extraction Protocol reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (abeurope.info)
  • Respiratory samples from 367 patients suspected of bacterial pneumonia were analysed by PCR amplification of Pneumocystis jiroveci . (biomedcentral.com)
  • The aim of the current study was to evaluate the clinical significance and prevalence of a PCR positive signal in a broad spectrum of clinical samples from HIV-negative patients with suspected bacterial pneumonia by means of an age and sex matched nested case-control study. (biomedcentral.com)
  • The results indicated that the dominant bacterial phyla in the samples were Acidobacteriota , Proteobacteria , Actinobacteriota , Chloroflexi . (researchsquare.com)
  • The bacterial communities' structure of the samples treated with TC, g-C 3 N 4 or TC/g-C 3 N 4 were distinguishable. (researchsquare.com)
  • Clinicians treating these conditions have performed molecular testing of the nails and have been surprised to find clinically significant numbers of bacterial organisms in their samples (see picture appendices 1-2). (nova.edu)
  • Taking into account our results, we recommend Fast as the most suitable DNA extraction method for activated sludge samples used for bacterial community studies. (knaw.nl)
  • Some of the genetic changes alter single DNA building blocks (nucleotides), whereas others rearrange larger segments of mitochondrial DNA. (medlineplus.gov)
  • Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes. (nih.gov)
  • Our objective is designing novel DNA Gyrase inhibitors using Quantitative StructureActivity Relationships and Structure-Based Drug Design Approaches. (bvsalud.org)
  • The 3D crystal structure of DNA Gyrase was extracted from PDB (code: 4DHU) and we characterized the active site. (bvsalud.org)
  • Bacterial Standards are generated from E. coli strain JM109. (zymoresearch.com)
  • Description: The Cell Biolabs Bacterial Protein Extraction Reagents contain a gentle, nonionic detergent formulation which quickly extracts functional, recombinant protein from E. coli without mechanical disruption. (abeurope.info)
  • Non-LTR retrotransposons need both RT and endonuclease (EN) in their transposition process termed target site-primed reverse transcription (TPRT) [ 12 ]. (biomedcentral.com)
  • Complementary DNA was generated from RNA by reverse transcription with random priming. (uea.ac.uk)
  • These data suggest that modification to CRP, and bound DNA, contributes to UV sensitivity. (ku.dk)
  • Mutations in mitochondrial DNA cause over 150 distinct syndromes and affect 1,000 to 4,000 children born in the United States each year. (sciencenews.org)
  • This genetic material is known as mitochondrial DNA or mtDNA. (medlineplus.gov)
  • In humans, mitochondrial DNA spans about 16,500 DNA building blocks (base pairs), representing a small fraction of the total DNA in cells. (medlineplus.gov)
  • The following chromosomal conditions are associated with changes in the structure or number of copies of mitochondrial dna. (medlineplus.gov)
  • Changes in mitochondrial DNA are among the best-studied genetic factors associated with age-related hearing loss. (medlineplus.gov)
  • As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes. (medlineplus.gov)
  • Mitochondrial DNA is especially vulnerable because it has a limited ability to repair itself. (medlineplus.gov)
  • Cells that have high energy demands, such as those in the inner ear that are critical for hearing, are particularly sensitive to the effects of mitochondrial DNA damage. (medlineplus.gov)
  • Some cases of cyclic vomiting syndrome, particularly those that begin in childhood, may be related to changes in mitochondrial DNA. (medlineplus.gov)
  • Bacterial insertion sequences (IS) of IS200 / IS605 and IS607 family often encode a transposase (TnpA) and a protein of unknown function, TnpB. (biomedcentral.com)
  • Then one of those cells mutates through a DNA insertion, deletion, or point mutation, and suddenly a new pattern appears. (cdc.gov)