• Vascular complications of cystathionine beta-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research. (esmed.org)
  • Reversible heme-dependent regulation of human cystathionine beta-synthase by a flavoprotein oxidoreductase. (esmed.org)
  • In that article I discussed how there appears to be two differing perspectives on the nature of CBS (cystathionine beta synthase) gene mutations: the literature's contention of "down-regulated" CBS enzyme activity among carriers of certain mutations, and certain empirical, clinical observations of the opposite situation, specifically that certain CBS gene mutations can cause an "up-regulation" to enzyme activity. (metabolichealing.com)
  • This article is a follow-up, based upon my own current hypotheses as well as literature-cited observations regarding these complex yet seemingly critical discussions regarding CBS (cystathionine beta synthase) and the transsulfuration pathway. (metabolichealing.com)
  • Cystathionine γ-lyase also catalyses the following elimination reactions: L-homoserine to form H2O, NH3 and 2-oxobutanoate L-cystine, producing thiocysteine, pyruvate and NH3 L-cysteine producing pyruvate, NH3 and H2S In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide. (wikipedia.org)
  • Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H 2 S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis. (utmb.edu)
  • abstract = "Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (H2S) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis. (utmb.edu)
  • In addition, L-cysteine can be converted into hydrogen sulfide and pyruvic acid through the action of the enzyme cystathionine gamma-lyase. (cannabisdatabase.ca)
  • Bioenergetic effects of hydrogen sulfide suppress soluble Flt-1 and soluble endoglin in cystathionine gamma-lyase compromised endothelial cells. (aston.ac.uk)
  • Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. (scienceopen.com)
  • Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer. (scienceopen.com)
  • 2-oxobutanoate-forming)) breaks down cystathionine into cysteine, 2-oxobutanoate (α-ketobutyrate), and ammonia: L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction) (1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate (1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous) (1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) Pyridoxal phosphate is a prosthetic group of this enzyme. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Cystathionine Gamma Lyase (CSE) in Tissue homogenates, cell lysates and other biological fluids. (youngresearch.eu)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Cystathionine Gamma Lyase (CSE) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (youngresearch.eu)
  • The enzyme that produces H2S, cystathionine γ-lyase (CSE), is decreased in rat mesenteric artery endothelial cells (EC) following in vivo IH exposure. (unboundmedicine.com)
  • The activity is pyridoxal-5'-phosphate dependent and the enzyme catalyzes the alpha,gamma-elimination reaction of L-cystathionine producing L-cysteine, ammonia and alpha- ketobutyrate. (unipr.it)
  • We therefore determined the role for the endogenous H 2 S producing enzyme cystathionine-β-synthetase (CBS) in a validated rat model of IBS-like chronic visceral hyperalgesia (CVH). (biomedcentral.com)
  • Through the CBS enzyme reaction, the substrate that is generated from homocysteine is cystathionine. (metabolichealing.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Cystathionine Gamma Lyase (CSE) in samples from tissue homogenates, cell lysates or other biological fluids. (youngresearch.eu)
  • Cystathionine γ-lyase is a member of the Cys/Met metabolism PLP-dependent enzymes family. (wikipedia.org)
  • Like many other PLP-dependent enzymes, cystathionine γ-lyase is a tetramer with D2 symmetry. (wikipedia.org)
  • H2S is biosynthesized from two enzymes: CBS and CTH (cystathionine gamma lyase), with P5P as the cofactor. (metabolichealing.com)
  • Using Inflammatory Multi- Analyte Cytokines ELISArray Kit we investigated the release of cytokines under basal conditions, after PGF 2α treatment for 24 hours to induce pro-inflammatory phenotype, and after PGF 2α treatment and incubation in the presence of L-C-Propargylglycine (PGG, 1 mmol/l), a selective inhibitor of cystathionine-gamma-lyase (CSE). (pensoft.net)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • The lone pair from the pyridine nitrogen pushes electron density to the gamma carbon, which is protonated by lysine. (wikipedia.org)
  • Description: A sandwich ELISA kit for detection of Cystathionine Gamma Lyase from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (youngresearch.eu)
  • Cystathionine gamma-lyase is the key enzyme in the endogenous production of H(2)S. Up to now, the reports on the relationship between the polymorphisms of cystathionine gamma-lyase gene (CTH) and essential hypertension (EH) are limited. (nih.gov)
  • The importance of rs1021737 and rs482843 polymorphisms of cystathionine gamma-lyase in the etiology of preeclampsia in the Caucasian population. (cdc.gov)
  • Impact of reduced O-acetylserine(thiol)lyase isoform contents on potato plant metabolism. (mpg.de)
  • O-acetylserine(thiol)lyase regulates cysteine homeostasis in potato plants (Solanum tuberosum L.). In: Sulfur transport and assimilation in plants in the postgenomic era, S. 95 - 99 (Hg. (mpg.de)
  • 2-oxobutanoate-forming)) breaks down cystathionine into cysteine, 2-oxobutanoate (α-ketobutyrate), and ammonia: L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction) (1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate (1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous) (1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous) Pyridoxal phosphate is a prosthetic group of this enzyme. (wikipedia.org)
  • In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. (wakehealth.edu)
  • Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. (nih.gov)
  • Cystathionine beta-lyase OS=Lactococcus lactis subsp. (uu.nl)
  • lyase from Lactococcus lactis subsp. (dairy-journal.org)
  • Dobric N., Limsowtin G.K.Y., Hillier A.J., Dudman N.P.B., Davidson B.E., Identification and characterization of a cystathionine beta/gamma-lyase from Lactococcus lactis ssp. (dairy-journal.org)
  • This disorder is characterized by a large accumulation of L-Cystathionine in the cell. (smpdb.ca)
  • Cystathionine gamma-Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • The amino group on cystathionine is deprotonated and undergoes a nucleophilic attack of the internal aldimine. (wikipedia.org)
  • 16211) para-aminobenzoate synthetase/4-amino-4-deoxychorismate lyase pabBC BBZA01000002 CDS ARMA_0015 192. (go.jp)
  • To reform the aldimine, this lone pair pushes back down, cleaving the sulfur-gamma carbon bond, resulting in the release of cysteine. (wikipedia.org)
  • In the gamma synthase mechanism, the gamma carbon is attacked by a sulfur nucleophile, resulting in the formation of a new sulfur-gamma carbon bond. (wikipedia.org)
  • Cystathionine gamma lyase also shows gamma-synthase activity depending on the concentrations of reactants present. (wikipedia.org)
  • This graph shows the total number of publications written about "Cystathionine gamma-Lyase" by people in this website by year, and whether "Cystathionine gamma-Lyase" was a major or minor topic of these publications. (wakehealth.edu)