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  • binds
  • Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. (wikipedia.org)
  • differentiation
  • Similarly, histone acetylation through histone deacetylase (HDAC) inhibitor Valproic Acid, an epilepsy therapeutic, in mouse embryonic stem cell (ESC) derived neural proginetors not only induces neuronal differentiation, but also selectively enriched the upper layer neuronal population. (wikipedia.org)
  • embryonic
  • Studies of human embryonic stem cells (hESCs) commonly report the nonfunctional p53-p21 axis of the G1/S checkpoint pathway, and its relevance for cell cycle regulation and the DNA damage response (DDR). (wikipedia.org)
  • CUL4A deletion results in delayed S phase entry in mouse embryonic fibroblasts, which is rescued by deletion of p21. (wikipedia.org)
  • activation
  • Specifically it contains a Cy1 motif in the N-terminal half, and weaker Cy2 motif in the C-terminal domain that allow it to bind CDK in a region that blocks its ability to complex with cyclins and thus prevent CDK activation. (wikipedia.org)
  • Recent work exploring p21 activation in response to DNA damage at a single-cell level have demonstrated that pulsatile p53 activity leads to subsequent pulses of p21, and that the strength of p21 activation is cell cycle phase dependent. (wikipedia.org)
  • In 1996, Aggarwal patented curcumin as an inhibitor of NF-κB activation, and he co-founded a company in 2004 called Curry Pharmaceuticals, based in Research Triangle Park, N.C., which was seeking to develop drugs based on synthetic analogs of curcumin. (wikipedia.org)
  • The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. (wikipedia.org)
  • negatively
  • p21 is negatively regulated by ubiquitin ligases both over the course of the cell cycle and in response to DNA damage. (wikipedia.org)
  • growth
  • In this study we tested the expression of CDKIs p15, p16, p21 and p27 by immunohistochemistry to determine the role of CDKIs in the initiation of primordial follicle growth. (biomedcentral.com)
  • p15, p16, p21 and p27 in mouse ovaries by immunohistochemistry to assess whether the initiation of primordial follicle growth was associated with the expression of CDKIs. (biomedcentral.com)
  • pathway
  • FEN1 is an essential enzyme in an inaccurate pathway for repair of double-strand breaks in DNA called microhomology-dependent alternative end joining or microhomology-mediated end joining (MMEJ). (wikipedia.org)
  • In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (wikipedia.org)
  • absence
  • In the absence of p21, DNA-damaged cells arrest in a G2-like state, but then undergo additional S phases without intervening normal mitoses. (biomedsearch.com)